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Colloque interdisciplinaire "(Re-)penser la coexistence entre humains et faune sauvage en ville" : Présentation générale et résumés des communications
No full textInternational audienceThis conference, at the intersection of fundamental and action-oriented research, examines the theoretical, methodological, and practical frameworks for understanding interactions between humans and non-human animals in urban environments. It marks the conclusion of the research program “Wild in the City: When Wild Boars and Forest Fauna Blur Boundaries,” led by UMR 5319 Passages and building on previous work in animal geography and related studies. The event brought together around thirty multidisciplinary contributions (geography, anthropology, ecology, veterinary science, biology, law, and architecture), organized around four themes: sensitive approaches, epistemology, methods, and public policy, fostering cross-disciplinary insights into human–urban wildlife coexistence.À l’interface entre recherche fondamentale et recherche-action, ce colloque explore les cadres théoriques, méthodologiques et pratiques permettant d’analyser les interactions entre humains et animaux non humains en milieu urbain. Il marque la clôture du programme de recherche « Sauvage en ville, quand le sanglier et la faune des forêts brouillent les frontières », porté par l’UMR 5319 Passages et s’inscrivant dans la continuité de travaux sur la géographie animale, ou autour de l’animal. L’événement a réuni une trentaine de contributions multidisciplinaires (géographie, anthropologie, écologie, sciences vétérinaires, biologie, droit et architecture), organisées autour de quatre axes : approches sensibles, épistémologie, méthodes et politiques publiques, permettant ainsi de nourrir des réflexions croisées sur la coexistence entre humains et faune urbaine
Du campus à la rue. Mobilisation étudiante et engagement politique en Algérie (2011-2019)
No full textInternational audienceCet article analyse les conditions et les formes de la mobilisation étudiante qui se déploient en Algérie entre les mois de janvier et de mai 2011. À partir d’une enquête au long cours resserrée sur quelques protagonistes, il montre comment cette expérience collective et, en particulier, la participation à la manifestation du 12 avril dans les rues d’Alger, a constitué un moment clé de politisation et d’émancipation. L’étude met en lumière les incidences de cet engagement protestataire dans la durée en s’attardant sur les traces laissées par cet événement dans les discours et les pratiques observées lors d’une mobilisation ultérieure, le hirak de 2019
Utiliser la fiction pour engager les étudiant·es à faire de la physique
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A perspective from the European Network for Bipolar and Emotion Regulation on research and intervention for emotion dysregulation in bipolar disorder: challenges and lessons learned
No full textInternational audienceBipolar disorder (BD) and emotion dysregulation present substantial challenges for individuals and healthcare providers. Although pharmacological treatments remain the primary approach, psychosocial interventions show promise in addressing sub-threshold symptoms and deepening understanding of mood and emotion dysregulation mechanisms. The European Network for Bipolar Emotion Regulation (ENBER) aims to close the gap between research and clinical practice by offering practical insights for clinicians while contributing to scientific discourse on BD and emotion regulation (ER). This perspective paper identifies key questions for the field, suggesting directions for future research and highlighting promising interventions, such as Dialectical Behaviour Therapy (DBT), which have shown potential to reduce emotion dysregulation and improve personal recovery in BD. Future research should explore the flexibility and context-appropriateness of ER strategies, considering how current mood states significantly impact these dynamics. The commentary advocates for personalised treatment approaches that address individual differences in symptoms and ER capabilities, recommending innovative methodologies to better understand and apply ER in BD.Incorporating patient perspectives into research design is also a necessary focus for future research, having the potential to improve recovery and quality of life for individuals with BD
Deciphering the emergence of mutations in Pseudomonas aeruginosa after ceftolozane/tazobactam treatment and evaluating therapeutic alternatives
No full textInternational audienceObjectives Ceftolozane/tazobactam is a relevant option for treating multiresistant Pseudomonas aeruginosa, a major public health problem. Over a 14-month period, we studied the frequency of ceftolozane/tazobactam resistance development and mechanisms underlying resistance in P. aeruginosa isolates after ceftolozane/tazobactam treatment as well as alternative therapeutic options.Methods Antimicrobial susceptibility was assessed with the disc diffusion method and minimum inhibitory concentration (MIC) determination. Resistance genes and sequence types (ST) were determined by whole genome sequencing (WGS). The ceftolozane/tazobactam resistance mechanism was explored by cloning ampC into the ampC-deficient strain PAO1 and bla AmpC expression experiments. ResultsOf 50 patients treated, 9 (18%) acquired one or more ceftolozane/tazobactam-resistant isolates during treatment. WGS revealed various mutations in the ampC gene, namely, Thr70Ile, Phe121Leu, Pro154Leu, Gly157Asp, del210-216, Glu221Lys, and the new mutation, Pro217Gln. Cloning experiments revealed that the Pseudomonasderived cephalosporinase (PDC) polymorphism did not alter mutation effects, mutations did not confer the same resistance level, and those conferring the strongest resistance restored susceptibility to piperacillin, piperacillin/ tazobactam and imipenem despite changes in the oprD gene. In clinical isolates, the resistance level conferred by the same mutations differed, indicating the involvement of other mechanisms, particularly the overproduction of AmpC, which is always present due to mutations mainly in AmpD. Finally, imipenem/relebactam, colistin, amikacin and cefiderocol could be good alternatives for treating ceftolozane/tazobactam-resistant strains. Conclution Ceftolozane/tazobactam resistance development was associated mainly with chromosomal mutations in the ampC gene but also with mutations in its regulatory genes. Knowledge about these mutations and gene polymorphisms is essential for interpreting resistance phenotypes from genomic data.</div
Les Projets Artistiques du Plateau dei Sept-Communes (Italie)
No full textInternational audienceSur le Plateau des Sept-Communes (Vénétie, Italie) de nombreux projets artistiques sont nés au cours des deux dernières décennies. Leur présence rappelle des mécanismes déjà observés dans d’autres territoires de faible densité où un processus de mise en art peut accélérer les reconfigurations sociales et territoriales en place, en la place à émerger de nouveaux enjeux socio-environnementaux, voire en remettant en jeu les équilibres de pouvoir et de domination entre les acteurs. La portée transformative des nombreux projets artistiques in situ présents sur le Plateau a donc été questionnée de manière critique : ce cluster artistique peut-il vraiment alimenter de nouvelles dynamiques territoriales ? Les mutations sont en réalité encore peu visibles, au point que le Plateau des Sept-Communes pourrait constituer un contre-exemple de la portée transformative de la mise en art. Cette dernière induit finalement plus une valeur patrimoniale reproductrice des dynamiques déjà en place qu’une capacité transformatrice capable de proposer un autre récit pour le territoire, exception faite d’une toute petite minorité de projets. On note cependant quelques signaux faibles de transformation reposant sur l’attraction de nouveaux publics ou l’implication de nouveaux acteurs exogènes. Ces différences d’ambitions et de finalités quant aux investissements artistiques viennent renforcer l’idée de mise en art en pointillé sur le Plateau au service d’une identité locale et d’un statu quo politique, bien plus que d’une reconfiguration sociale et politique du territoire
Characterization of a novel SERPINA1 variant carrying two missense mutations: molecular mechanisms and functional impact
No full textOxovanadium(IV) Thiocarboxylate Paddlewheels Containing Ancillary Group 10 Metals: A Comparative Study on Pd and Pt Derivatives
No full textInternational audienceVanadyl-containing paddlewheel structures have recently joined the pool of molecular spin systems showing respectable coherence times (Tm). We extended the investigation of [PtVO(SOCR)4] (R = Me, Ph) by synthesizing the corresponding Pd derivatives. Crystals of [PdVO(SOCMe)4] and [PdVO(SOCPh)4]·DCM are isomorphous to their Pt analogues and comprise staggered and square dimers, respectively. For both Group 10 metals, M···M′ contacts in staggered dimers promote a stronger antiferromagnetic coupling than M···S′ contacts in square dimers, with Pd complexes showing a slightly more effective interaction consistent with DFT predictions. In solution, the paddlewheels exist in monomeric form and undergo a quasi-reversible one-electron reduction, more favorable for M = Pd than Pt and for R = Ph than Me. X-band EPR spectra in frozen CD2Cl2/toluene-d8 show the eight-line hyperfine pattern characteristic of 51V (I = 7/2), with identical spin-Hamiltonian parameters across the series. Unlike the interaction with 195Pt (I = 1/2, 34%), the superhyperfine coupling with 105Pd (I = 5/2, 22%) is unresolved. Tm values are essentially the same for Pt and Pd derivatives and follow the same substituent dependence (Ph > Me). Therefore, the ancillary Group 10 metal affects redox potentials and, to a lesser extent, solid-state magnetic properties, but leaves quantum coherence unchanged
Improved Algorithms for Ascending Isogeny Volcanoes, and Applications
No full textInternational audienceGiven two elliptic curves over Fq, computing an isogeny mapping one to the other is conjectured to be classically and quantumly hard. This problem plays an important role in the security of elliptic curve cryptography. In 2024, Galbraith applied recently developed techniques for isogenies to improve the state-of-the-art for this problem. In this work, we focus on computing ascending isogenies with respect to an orientation. Our results apply to both ordinary and supersingular curves. We give a simplified framework for computing self-pairings, and show how they can be used to improve upon the approach from Galbraith to recover these ascending isogenies and eliminate a heuristic assumption from his work. We show that this new approach gives an improvement to the overall isogeny recovery when the curves have a small crater (super-polynomial in size). We also study how these self-pairings affect the security of the (PEARL)SCALLOP group action, gaining an improvement over the state-of-the-art for some very particular parameter choices. The current SCALLOP parameters remain unaffected.</div