Biomedicine (Journal)
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Biomedicines in Longevity and Aging The Quest to Resist Biological Decline
No full textAging is considered part of the natural process of life, however in recent years medical literature has started to show that specific facets of aging are beginning to be understood and those specific factors may even be considered preventable with various measures as this paper will demonstrate. Aging is also considered the number one cause of poor quality of life, disease, disability, and death, so the importance of understanding the aging process and how to control certain aspects of it cannot be underestimated when age related suffering is factored in. The causes of aging are now becoming well understood, and in recent years many therapies have already become available to the public to attenuate specific corridors of aging. The heterogeneity of the aging process and the biological drivers involved is examined here in parallel with various compounds and therapies to combat biological decay. The benefits for governments in keeping their populations healthy and vibrant are vast, and at the same time offer a great incentive to invest into newly emerging technologies that may prevent the onset of preventable disease. Whilst this paper only discusses nine pathways to the aging process, many more exist
Ethanol leaf extracts of Anogeissus leiocarpus in antioxidants and hepatotoxic effects of Escherichia coli infected Swiss Mice
No full textIntroduction: Diseases caused by bacteria can be managed with medicinal plants with rightful dosage that will not affect body physiology and organs.
Aim: This research aimed to evaluate the antioxidants and the effects of Anogeisus leiocarpus on liver function.
Materials and Methods: Ethanol leaf extracts were processed for antioxidants and hepatotoxic effects using animal models. Group one (negative control) was given access to water and regular feed, group two (positive control) was dosed with 107 CFU/ml of Escherichia coli O157:H7, and groups 3-6 were dosed with 107 E. coli O157:H7 for 3 days and treated with extract concentrations of 12, 25, 50 and 100 mg/kg bw respectively for seven days.
Results: Higher ascorbic acid values in Ferric reducing antioxidant property (FRAP) and Hydroxyl radical scavenging (HRS) were recorded in the positive control (0.05±0.01, 41±0.05) than in the extract-treated (0.02±0.14, 30±0.02). Increase in DPPH (47±0.1268±0.05%), Free radical scavenging property (FRAP) (0.03±0.02-0.08±0.14%), and HRS (38±0.14-68±0.12%) was observed in the extract. The lipid peroxidation (LPO) of the quote was 78.51±2.16, GSH was 36.18±3.18, and catalase was 78.42±4.713. In the extract-treated, decreased values were recorded for LPO ((108.36±1.12-70.19±1.68 µM/g), while increased values were observed in Glutathione (GSH) (25.11±2.64-33.62±1.35 µM/g), and catalase (54.18±2.14-60.25±1.4 µM/g). The values of negative control for Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), and Alkaline phosphate (ALP) were lesser than what was received in the extract treated.
Conclusion: The plant\u27s traditional medicine usage is effective at low dosage and could be a suitable candidate for drug development which will not affect the body\u27s physiology and organs. The subjecting of A. leiocarpus ethanol leaf extract to antioxidants assays and its effect on liver function have further proved its value in folklore medicine
COMPUTATIONAL ANALYSIS OF DIMER G6PD STRUCTURE TO ELUCIDATE PATHOGENICITY OF G6PD VARIANTS
No full textAn inherent genetic enzyme disorder in humans, known as glucose-6-phosphate dehydrogenase (G6PD) deficiency, arises due to specific mutations. While the prevailing approach for investigating G6PD variants involves biochemical analysis, the intricate structural details remain limited, impeding a comprehensive understanding of how different G6PD variants of varying classes impact their functionality. This study examined the dynamic properties of G6PD wild types and six G6PD variants from different classes using molecular dynamic simulation (MDS). The wild-type and variant G6PD structures unveil high fluctuations within the amino acid range of 274-515, the structural NADP+ binding site, pivotal for enzyme dimerization. Specifically, two variants, G6PDZacatecas (R257L) and G6PDDurham (K238R), demonstrate compromised structural stability at the dimer interface, attributable to the disruption of a salt bridge involving Glu 206 and Lys 407, along with the disturbance of hydrogen bonds formed by Asp 421 at the βN-βN sheets. Consequently, this impairment cascades to affect the binding affinity of crucial interactions, such as Lys 171- Glucose6-Phosphate (G6P) and Lys 171-catalytic NADP+, leading to diminished enzyme activity. This study underscores the utility of computational in silico techniques in predicting the structural alterations and flexibility of G6PD variants. This insight holds promise for guiding future endeavors in drug development targeted at mitigating the impacts of G6PD deficiency
Metabolic Abnormality and Sleep Disturbance are Associated with Clinical Severity of Patients with Schizophrenia
No full textIrisflorentin improves α-synuclein accumulation and attenuates 6-OHDA-induced dopaminergic neuron degeneration, implication for Parkinson’s disease therapy
No full textNutrition, psychoneuroimmunology and depression: the therapeutic implications of omega-3 fatty acids in interferon-α-induced depression
No full textMultidetector computed tomography in the evaluation of pediatric acute abdominal pain in the emergency department
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