UHSP Collections (University of Health Sciences and Pharmacy)
Not a member yet
1490 research outputs found
Sort by
Novel Inhibitors for a Novel Binding Site in Respiratory Complex III
No full textA new binding site and potential novel inhibitors of the respiratory complex III are described. The site is located at the opposite side of the enzyme with respect to ubiquinol binding site (Qo site), and distinctly different from both Qo and Qi sites (hence designated as Non-Q binding site, NQ). NQ site binding pocket extends up close to Phe90 residue, an internal switch (LH switch) that regulates electron transfer between heme bL and heme bH of the low potential redox chain. Docking studies and molecular dynamics simulations of different molecules to the NQ site revealed potential ligands which exhibit a novel inhibitory effect for bc1 complex by switching the LH switch to off conformation, thereby shutting down electron transfer in the low potential redox chain. Moreover, the novel inhibitors have lower binding affinity for both Qo and Qi sites, and hence do not interfere with binding of the natural ligands to those sites. The inhibitory activity of those novel ligands in bc1 complex is suggested to promote the production of reactive oxygen species (ROS) at the Qo site. Hence those ligands are potential candidates for designing new mitocan drugs
Relationalism about perceptible properties and the principle of charity
No full textColor relationalism holds that the colors are constituted by relations to subjects. The introspective rejoinder against this view claims that it is opposed to our phenomenally-informed, pre-theoretic intuitions. The rejoinder seems to be correct about how colors appear when looking at how participants respond to an item about the metaphysical nature of color but not when looking at an item about the ascription of colors. The present article expands the properties investigated to sound and taste and inspects the mentioned asymmetry, with a particular focus on the principle of charity. Using a metaphysical item, we find that color and sound are no different from shape, our control for a clearly anti-relational property. Taste, on the other hand, is no different from likability, our control for a clearly relational property. Importantly, we find that the disparity between metaphysical and ascription items is due to participants using a principle of charity to interpret disagreement cases such that both parties can be correct
NF-κB decoy polyplexes decrease P-glycoprotein-mediated multidrug resistance in colorectal cancer cells
No full textMultidrug resistance (MDR), a major cause for chemotherapy failure, has been linked to upregulation of ATP-dependent membrane efflux systems that limit intracellular accumulation of cytotoxic anticancer agents. P-glycoprotein (P-gp) encoded by the human ABCB1 gene was the first efflux transporter identified to contribute to MDR. ABCB1 gene expression is correlated with constitutive activation of the NF-κB signaling pathway in tumor cells. The objective of this research is to modulate P-gp activity in colon cancer cells using NF-κB decoy oligodeoxynucleotides (ODNs) that are effectively delivered into the nucleus of colorectal cancer cells by self-assembling nonviral nanoparticles comprising the novel poly N-(2-hydroxypropyl)methacrylamide-poly(N,N-dimethylaminoethylmethacrylate) diblock copolymer (pHPMA-b-pDMAEMA). Ethidium bromide intercalation and gel retardation assays demonstrated high DNA condensation capacity of pHPMA-b-pDMAEMA. Nanoparticles prepared with and without decoy ODNs did not significantly compromise cellular safety at N/P ratios ≤4. Transfection efficiency of pHPMA-b-pDMAEMA polyplexes (N/P=4) in Caco-2 cells was comparable to TurboFect transfection standard, resulting in a 98% reduction in P-gp protein levels. As a pharmacodynamic consequence, intracellular accumulation of the P-gp substrate Rhodamine123 significantly increased by almost twofold. In conclusion, NF-κB ODN polyplexes fabricated with pHPMA-b-pDMAEMA polymer effectively reduced P-gp-mediated efflux activity in Caco-2 cells, suggesting successful interference with NF-κB-binding sites in the promoter region of the ABCB1 gene
Meropenem-induced neutropenia in a neonate
No full textPostmarketing surveillance has associated meropenem with the development of hematologic abnormalities, including agranulocytosis, neutropenia, and leukopenia, but the exact incidence in children is unknown. The case describes a full-term, 26-day-old neonate admitted for a sepsis workup. She was found to have a blood culture positive for Enterobacter cloacae and suspected meningitis and was initiated on meropenem 40 mg/kg/dose intravenously every 8 hours. On day 14 of antibiotic treatment, the patient developed an isolated neutropenia with an absolute neutrophil count of 288 cells/mm 3 . Meropenem was discontinued on hospital day 20, and a follow-up complete blood cell count 2 months later confirmed resolution of the hematologic abnormality. Clinicians should monitor complete blood cell counts diligently in children who receive large doses and prolonged courses of meropenem
Communicable Disease Outbreak Control Policy
No full textThe Communicable Disease Outbreak Control Policy is designed to:
• Inform, educate, and advise the University of Health Sciences and Pharmacy in St. Louis community on communicable disease prevention
• Outline actions and processes to protect the health and well-being of faculty, staff, students, visitors, and contracted employees
• Establish communication channels of reporting communicable diseases among faculty, staff, and students to appropriate personnel
In the event that a communicable disease significantly impacts the UHSP community, the Incident Management Team will activate to implement necessary practices outlined in this policy to cease continued spread of disease
Data Protection Standards - Identity Theft Prevention Program Policy
No full textThe University is committed to protecting personally identifying information of its customers by maintaining an effective identity theft prevention program as required by the Fair and Accurate Credit Transactions Act of 2003 and the Federal Trade Commission’s Red Flags Rule
Security Incident Response Policy
No full textUniversity of Health Sciences and Pharmacy in St. Louis (“University”) has adopted this policy to establish an Incident Response Plan (“IRP”) to manage the process for responding to a possible Security Incident involving Customer Information (“CI”) or Personally Identifying Information (“PII”) as defined below. The policy is intended to ensure a consistent process to follow when responding to any Security Incident, to mitigate potential risk and harm to affected parties, and to provide for post-incident review to facilitate appropriate changes to improve business practices for safeguarding and handling of Personal Information
Relocation and Moving Expense Policy
No full textThe purpose of this policy is to outline the guidelines to be followed related to moving expense reimbursements for new faculty and staff
Deep-deep neural network language models for predicting mild cognitive impairment
No full textEarly diagnosis of Mild Cognitive Impairment (MCI) is currently a challenge. Currently, MCI is diagnosed using specific clinical diagnostic criteria and neuropsychological examinations. As such we propose an automated diagnostic technique using a variant of deep neural networks language models (DNNLM) on the verbal utterances of MCI patients. Motivated by the success of DNNLM on natural language tasks, we propose a combination of deep neural network and deep language models (D2NNLM) to predict MCI. Results on the DementiaBank language transcript clinical dataset show that D2NNLM sufficiently learned several linguistic biomarkers in the form of higher order n-grams and skip-grams to distinguish the MCI group from the healthy group with reasonable accuracy, which could help clinical diagnosis even in the absence of sufficient training data