BUE Scholar (The British University in Egypt)
Not a member yet
4435 research outputs found
Sort by
Solar Absorption Cooling Systems – A Case Study in Egypt
No full textClimate change with Egypt’s increasingly hot weather and plans towards energy transition, addressing an approach for clean HVAC (Heating, Ventilation, and Air Condition) solutions is becoming requisite. This paper examines the potential of utilizing solar absorption cooling systems in institutional buildings by presenting a case study of a proposed solar absorption cooling system for a library building with an area of 4402 m2, located at the British University in Egypt. The proposed solution is to replace 30% of the existing conventional air conditioning units with a hot-water driven single-effect absorption chiller powered by solar thermal vacuum tube solar collectors, coupled with a stratified hot water storage tank. The potential area of the solar collectors was calculated to be 856 m2. A detailed analysis was done using TRNSYS (Transient Simulation System Software) as a simulation tool, to find that the optimum stratified hot water storage tank size is to be 10 m3; with a specific volume per solar collectors’ area of 0.01 m3m-2. The proposed system covers the cooling demand for 8 to 9 months of the year without an auxiliary heater and saves almost 95% of the electrical energy consumed by the replaced conventional air conditioning system
Effect of cisplatin/gold chitosan nanocomposite on oral squamous cell carcinoma and oral epithelial cells
No full textBackground: Oral squamous cell carcinoma (OSCC) treatment represents a great challenge, since platinum-based therapeutic agents have deleterious efects on normal cells and tissues. Employing gold nanoparticles (AuNps) as carriers for cisplatin have proved efective in reducing cisplatin doses. Green synthesis of AuNps from ecofriendly agents like chitosan improves the AuNps’ biocompatibility and cytotoxicity. Thus, we synthesized a novel agent of cisplatin coupled to gold chitosan nanoparticles (Cis/AuCh nanocomposite) and examined its efect in addition to the efect of chitosan-reduced gold nanoparticles (AuCh Nps) on (HNO97) OSCC cell line and normal oral epithelial cells (OEC). Results: Ultraviolet–visible spectroscopic analysis, transmission electron microscope, X-ray difraction, and Fourier transform infrared spectroscopy confrmed the successful synthesis of AuCh Nps and Cis/AuCh nanocomposite. The cytotoxicity assay showed that the IC50 doses of AuCh Nps and Cis/AuCh nanocomposite after 48 h were 12.5 μg/ml, and 6.2 μg/ml, respectively, on the HNO97 cell line. On the other hand, the IC50 doses were 40 μg/ml and 44.5 μg/ml on OEC, respectively. After treating both cell lines with the HNO97–IC50 doses, Cis/AuCh nanocomposite-treated HNO97 cell line revealed a signifcant rise in Caspase 3 immunohistochemical apoptotic index, besides a signifcant elevation in pro-apoptotic proteins and reduction in Bcl-2 compared to cisplatin. Conversely, opposite results were detected in AuCh Nps and Cis/ AuCh nanocomposite-treated OEC. Flow cytometry results revealed S and G2/M shifts in HNO97 and OEC with more shift in the cisplatin-treated group than AuCh Nps and Cis/AuCh nanocomposite-treated groups in both cell lines. The expressions of the reactive oxygen species (ROS) markers; malondialdehyde and nitric oxide were the highest in Cis/AuCh nanocomposite-treated HNO97, while the reduced glutathione expression was the lowest. However, AuCh Nps and Cis/AuCh nanocomposite-treated groups did not display any signifcant changes in ROS markers expression from the untreated group in the OEC.Conclusions: AuCh NPs can be considered a good alternative way of cisplatin transportation for OSCC treatment. Cis/AuCh nanocomposite stimulates apoptosis, cell cycle arrest, and ROS production in oral cancer cells with less undesired efects on normal oral epithelial cell
Integrating digital mapping technologies in urban development: Advancing sustainable and resilient infrastructure for SDG 9 achievement – a systematic review
No full textIntegrating medical plastic waste pyrolysis and circular economy for environmental sustainability
No full text
Comparative Analysis of Gene Expression in Periodontal Ligament Stem Cells Exposed to Biodentine and Bio-C Repair: Implications for Cementogenesis—An In Vitro Study
No full textSearch for the production of dark gauge bosons in the framework of Einstein-Cartan portal in the simulation of proton-proton collisions at TeV
No full textIn this study, we investigate the potential production of a heavy torsion field (TS) at the LHC, which stems from a simplified model rooted in Einstein-Cartan gravity, in connection with dark matter. Within this framework, the torsion field is capable of decaying into pairs of dark matter (DM) particles. Notably, one of these DM particles is heavy enough to decay into dark neutral gauge bosons (A′) alongside another DM particle. The Analysis has been performed by studying events with dimuon plus missing transverse energy produced in the simulated proton-proton collisions at the Large Hadron Collider, at 13.6 TeV center of mass energy and integrated luminosity of 52 fb−1 corresponding to the LHC run 3 circumstances during 2022 and 2023. We provide upper limits, in case no new physics has been discovered, on the masses of various particles in the model as (A′), as well as the heavy mediator (torsion field)
PCSK9–dyslipidemia interplay in children and adolescents with type 1 diabetes: A potential modulator of vasculopathy
No full textBACKGROUND: Proprotein convertase subtilisin/kexin type-9 (PCSK9) has recently emerged as an important vasculopathy modulator. However, limited data exist on its level and expression in children and adolescents with type 1 diabetes (T1D). AIM: To assess serum PCSK9 and gene expression among children and adolescents with T1D and correlate them with glycemia, dyslipidemia, and microvascular complications. METHODS: Fifty children and adolescents with T1D were compared to 50 matched healthy controls. Serum PCSK9 enzyme-linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT-PCR) gene expression, glycated-hemoglobin, fundus, urinary albumin-to-creatinine ratio (uACR) and fasting lipids were assessed with calculation of the estimated-glucose disposal rate (eGDR). RESULTS: Children and adolescents with T1D, particularly those with microvascular complications, have significantly higher PCSK9 and PCSK9 gene expression than controls (P \u3c .05). Serum PCSK9 and PCSK9 gene expression were significantly correlated with diabetes-duration, insulin dose, time above range (TAR), diastolic blood pressure percentile, low-density lipoprotein cholesterol (LDL-C) and uACR (P \u3c .05), being independently correlated with diabetes-duration, LDL-C, and uACR using multivariate regression. CONCLUSION: Serum PCSK9 and PCSK9 gene expression are elevated among children and adolescents with T1D showing significant association with dyslipidemia and microvascular complications. Further studies are warranted to explore the potential role of PCSK9 inhibitors in prevention and treatment of dyslipidemia and vasculopathy in T1D. © 2025 National Lipid Association. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies
Correlation between clinical classification and genetic analysis of familial hypercholesterolemia in premature coronary artery disease in a cohort of Egyptian patients
No full textBackground: Familial Hypercholesterolemia (FH) is a major risk factor for premature Coronary Artery Disease (CAD). Genetic testing is the gold standard for FH diagnosis. The purpose of this Observational Analytical Cross-sectional study was to estimate the proportion of genetically confirmed Familial Hypercholesterolemia in Patients with premature Coronary Artery Disease in a cohort of Egyptian patients.
Methods: Next generation sequencing (NGS) was conducted for 7 genes (LDLR, PCSK9, APOB, APOE, ABCG5, ABCG8 and LDLRAP1) commonly associated with FH in 94 patients with Premature CAD from 2 tertiary hospitals in Cairo and Alexandria, Egypt. Individuals were clinically assessed using the Dutch Lipid Network criteria and genetically-confirmed FH prevalence was analyzed.
Results: Fourteen patients had pathogenic or likely pathogenic mutations in LDLR, APOB, PCSK9 and LDLRAP1 genes. Three patients had homozygous autosomal dominant FH and another 3 patients had autosomal recessive hypercholesterolemia. In addition, 10 patients had rare variants of uncertain significance in LDLR, APOB, APOE, ABCG5 and ABCG8 genes.
Conclusions: The prevalence of genetically confirmed FH in premature CAD (PCAD) patients in this study was found to be 14.89%. The Dutch Lipid Clinic Network (DLCN) scoring system is suggested as a good screening tool for familial hypercholesterolemia but confirmatory genetic testing is essential for the accurate diagnosis and management of the patients. In Egypt, the high rate of consanguinity contributes to the high prevalence of both homozygous autosomal dominant and recessive FH
