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Angular distribution study for high mass dimuon pairs in CMS open 2012 data and for mono- Z′ model
No full textThis analysis uses the Compact Muon Solenoid (CMS) open data to study the angular distribution of high mass dimuon pairs produced during proton-proton interaction at a center of mass energy of 8 TeV. The study uses the cosθCS variable defined in the Collins-Soper frame. In the Standard Model (SM), the production of high mass dimuon pairs is dominated by the Drell-Yan process, which exhibits a strong forward-backward asymmetry. However, many scenarios beyond the SM predict different shapes for the cosθCS distribution. In excess events beyond the SM, the angular distribution can be used to distinguish between those models. The mono-Z′ model has been used to interpret the data, and no deviation from the SM has been observed
Albumin-Based Nanoparticles with Factorial Design as a Promising Approach for Remodeled Repaglinide: Evidence from In Silico, In Vitro, and In Vivo Evaluations
No full textBackground/Objectives: Hyperlipidemia is a silent threat lurking in the bloodstream of millions worldwide. The nano-based platform has emerged as a promising drug delivery technology. Repaglinide, an anti-diabetic drug, was investigated recently as an antihyperlipidemic candidate that could supersede the available antihyperlipidemic drugs. Our goal was to optimize albumin-based nanoparticles loaded with Repaglinide for parenteral delivery and conduct in silico and in vivo studies to explore the efficacy of Repaglinide for the management of hyperlipidemia along with its anti-diabetic effect. Methods: The impact of three independent factors, the albumin%, acetone volume, and glutaraldehyde/albumin, on the particle size, zeta potential, and entrapment efficiency was investigated. Results: The optimized formulation was spherical, homogenous of an average diameter (~181.86 nm) with a narrow size distribution, a zeta potential of −24.26 mV, and 76.37% as the EE%. The in vitro release of Repaglinide from nanoparticles showed a sustained release pattern for 168 h, with an initial burst release after 24 h, and was fitted to the Fickian diffusion mechanism. A molecular docking simulation showed a strong affinity to several protein targets, and the results were very promising, where Repaglinide gave a score of −7.70 Kcal/mol compared to Mevastatin (−6.71 Kcal/mol) and Atorvastatin (−8.36 Kcal/mol). On conducting in vivo studies on animal models, the optimized formula recorded a statistically significant decrease in the serum levels of total cholesterol, triglyceride, and low-density lipoproteins, with an increased high-density lipoprotein. Conclusions: This study suggested albumin nanoparticles as potential nanocarriers for the parenteral delivery of Repaglinide to ameliorate its antihyperlipidemic benefits, especially in diabetic patients
Evaluating the long-term impact of adaptive reuse on heritage spaces: a case study of Aslam square in Cairo, Egypt
No full textReusing heritage spaces as vibrant public areas can signifcantly enhance the quality of life and public spaces within a community. However, there is a notable gap in knowledge regarding evaluations of the success or failure of these upgrading and reuse initiatives. The literature suggests that evaluations should be conducted with comparative analyses of physical characteristics before and after the implementation of such programmes. This study proposes a post-adaptive reuse evaluation method for assessing the quality of heritage spaces and community development. The research employs methodological triangulation by incorporating sociospatial analysis with three methods: 1) deductive reasoning to assess the quality of heritage spaces; 2) in-depth interviews with users of these spaces; and 3) sensitivity to context observations. These methods were applied across three diferent timeframes: before the upgrade, three years after the upgrade, and ten years after the upgrade. This study therefore provides a comprehensive and longitudinal analysis. This study assesses the adaptive reuse of Aslam Square in the Darb Al Ahmar district of Cairo, Egypt. The fndings demonstrate that the post-adaptive reuse evaluation method is appropriate, and its use is recommended as a cause-and-efect indicator to promote heritage spaces and local community development
Tailoring porous structure composed of nano indium oxide and nano zinc ferrite to be act as an efficient humidity sensor
No full textEfficacy of Manuka honey oral rinsein treatment of xerostomia among elderlypatients: a randomized controlled trial
No full textBackground Xerostomia is a common complaint among elderly patients. Due to the anti-inflammatory effect, Manuka honey could be a promising alternative remedy for many medical conditions, including xerostomia. The present study aimed to evaluate the effectiveness of Manuka honey oral rinse as a novel management for xerostomiain elderly patients. Methods This study was designed as a randomized, single-blinded clinical trial. 42 elderly patients who were allevaluated for the presence of xerostomia and hyposalivation were randomly allocated into 3 equal groups. The interventions were used 3 times per day for 1 month as follows: Manuka honey oral rinse in group I, natural honey honey oral rinse in group II, and saline in group III (control). The Summated Xerostomia Inventory (SXI) score, The Clinical Oral Dryness Score (CODS), and the salivary flow rate were evaluated for all groups at different intervals. The Oral Health Impact Profile (OHIP-14) questionnaire was assessed 1 month after the intervention. Results Manuka honey oral rinse caused a significant reduction of the subjective SXI score (2 ± 0.39) and objectiveclinical oral dryness (5.71 ± 0.91) scores compared to the other 2 groups. Moreover, the salivary flow rate wassignificantly higher after one month of using Manuka honey oral rinse (1.51 ± 0.34) than honey oral rinse group (1.01a ± 0.19), and the control group (0.81a ± 0.19). The most significant improvement of OHIP scores was seen in the Manuka honey group (5.50 ± 1.16) compared to the honey group (7.57a ± 1.02), and the control group (9.36ab ± 1.78).Conclusion Manuka honey oral rinse demonstrated high efficiency in the management of xerostomia among elderly patients when compared with natural honey as it relieved the symptoms and severity of xerostomia in the elderly along with a high rate of patient satisfaction
General form of f(R) and (2 + 1)-dimensional charge/non-charge black hole solutions
No full textWe introduce novel black hole (BH) solutions, charge/non-charge, within the framework of f(R) gravity, a theory that does not inherently include a cosmological constant, using equal/different metric ansatzs. Remarkably, these solutions exhibit asymptotically Anti-de Sitter (AdS) or de Sitter (dS) behavior, depending on their parameter values. Unlike the BTZ solutions of General Relativity, which feature a causal singularity and constant scalar invariants, our solutions display strong spacetime singularities, as shown by their scalar invariants. We construct f(R) functions that behave as polynomial functions, emphasizing the unique nature of these solutions. We demonstrate the stability of these solutions in two ways: first, by showing that their heat capacity is positive, which ensures thermodynamic stability; and second, by proving that the second derivative of f(R) is positive, meeting the Ostrogradski criterion for dynamical stability. Furthermore, the solutions satisfy the first law of thermodynamics, confirming their consistency with fundamental thermodynamic principles
Influence of Eichhornia crassipes-Derived Cellulose Nanocrystals and ZnO Nanoparticles on Moisture and Biological Properties of PVA/PVP Nanocomposites for Smart Agriculture
No full textA circular economy framework for reducing construction waste during the design process in Egyptian architectural design firms
No full textPurpose – Construction waste drivers, amplified by the linear economy model, contribute significantly to resource consumption and waste generation across various phases of the construction process. Recognizing the critical influence of the design process on these outcomes, this study aims to develop a framework integrating circular economy to reduce construction waste and promote sustainable practices during the design process within architectural design firms in Egypt.
Design/methodology/approach – A qualitative and quantitative research approach was used to accomplish four objectives. A comprehensive literature review explored the concepts of construction waste, the design process, the circular economy and Egypt’s Sustainable Development Strategy 2030. Case studies examined the effectiveness of circular design strategies in reducing construction waste and the consequences of their absence. An online survey questionnaire gathered insights from Egyptian architectural design firms on circular economy perception and the applicability of circular design strategies during the design process. The findings informed the development of a practical framework to reduce construction waste and promote sustainable practices during the design process.
Findings – The research identified key construction waste drivers, their sources and impacts. In addition, it explored circular design strategies and the challenges of their implementation during the design process. The research highlighted those projects adopting circular design strategies effectively reduced construction waste, whereas those without such strategies observed increased waste. The primary construction waste driver was the insufficient updating and adoption of advanced technological tools and practices, with architects identified as significant contributors. While architectural design firms demonstrated awareness of circular economy principles, the adoption of circular design strategies and knowledge of Egyptian waste management laws remained limited. Effective circular design strategies included reuse, durability, building information modelling, circularity and enhanced communication.
Practical implications – This research develops a framework integrating circular economy principles during the design process in Egyptian architectural design firms to minimize construction waste and enhance sustainability. By addressing key construction waste drivers and promoting circular design strategies, it offers practical solutions for optimizing resources, improving material efficiency and reducing project costs. The study emphasizes the role of innovative technologies like building information modelling and modular construction in driving sustainability and efficiency. It supports Egypt’s Sustainable Development Strategy 2030 while fostering technological advancements and regulatory improvements in the construction sector.
Originality/value – This study bridges a critical gap in construction literature by integrating circular economy principles into the design process, offering a structured approach to minimizing construction waste and promoting sustainable practices during the design process in Egypt’s architectural design firms. It provides practical guidance for architects, emphasizing building information modelling, material reuse and modular construction as effective strategies while supporting policymakers in enhancing waste management regulations. The research promotes sustainability by reducing environmental harm and resource depletion. It highlights the economic advantages of circular economy adoption, including cost savings and job creation in recycling and sustainable materials, aligning with Egypt’s Sustainable Development Strategy 2030
Insights into optical and photoelectrical properties of copper biphthalocyanine for efficient optoelectronic applications
No full textA novel copper biphthalocyanine (CuPc2) compound was synthesized using a facile straightforward approach. Thermally deposited CuPc2 thin films are prepared under vacuum at room temperature. The crystal and molecular structures of the deposited films relative to powder have been investigated using XRD and FTIR spectroscopy, respectively. The nanostructured CuPc2 films, as visualized microscopically via FE-SEM, possess uniform surface morphology and low roughness. The optical properties of the deposited films are evaluated spectrophotometrically in the UV–vis–NIR region. The conventional Q and B-bands were identified with onset and fundamental energy gap of about 1.61, and 2.85 eV, respectively, and confirmed the α-molecular phase with small Urbach energy ∼43.5 meV. The dispersion characteristics were analyzed using the single oscillator and Sellmeier models. The optical dielectric, energy loss, and optical conductivity are deducted and interpreted. The nonlinear optical susceptibility, refractive index, and absorption coefficient were extracted and compared to many other metallophthalocyanines films. The present films exhibit exhibits abnormal PL emission spectrum along the visible region with white point CIE coordinates. Furthermore, the measured current-voltage relation of the designed Au/CuPc2/p-Si/Al heterojunction is analyzed in detail. The ideality factor, reverse current, barrier height, series resistance shunt resistance, and interface state density are deduced. The photodetection features of the designed heterojunction are evaluated under different intensities (20–100) mW/cm2. Fast and efficient responsive performance with high linearity is achieved by the present heterojunction; besides it offers the validity of usage under very low power consumptions (−0.05 V)
Development of a Flexure Based Mechanism for Robotic Micro-Surgical Applications
No full textTraditional robot-assisted surgery, which relies on conventional mechanical mechanisms, has certain drawbacks, including friction, backlash, and the need for lubricants. In contrast, compliant mechanisms utilizing flexure joints can achieve the desired motion while minimizing the disadvantages associated with movable joints. This research introduces a novel approach to address the issues prevalent in robot-assisted surgery. Our device incorporates flexure joints to enhance movement and eliminate complications posed by traditional movable joints. The primary focus of this study is on designing, analyzing, and validating a flexible remote center-of-motion (RCM) mechanism intended for robot-assisted surgery. SolidWorks was used for modeling of the proposed mechanism with different configurations of joints arrangement, and finite element analysis (FEA) was performed using ANSYS to evaluate and compare different design iterations in terms of RCM point drift in X and Y axis. Experimental Results show that the optimized design keeps the RCM point drift within acceptable microsurgical limits, with measured displacements of 1.02 mm along the x-axis and 2.07 mm along the y-axis. These results highlight the potential of compliant mechanism to improve the accuracy and safety of robot-assisted microsurgical procedures and point to a significant improvement over current mechanism