Daegu Gyeongbuk Institute of Science and Technology
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In silico 예측을 기반으로 한 헌팅틴 독성을 완화하는 새로운 신경보호 인자 발견
No full textHuntington’s disease;cytoplasmic mHtt aggregates;Q-rich proteinsMasterdCollectio
Negative Electrode for Secondary Battery, Secondary Battery Comprising the Same and Manufacturing Method Thereof
No full textART EXHIBITION AND BROKERAGE SYSTEM FOR EXHIVITING AND SELLING WORKS OF ART TO CONSUMER COMMUNITY GROUPS AND METHOD THEREOF
No full textElemental-Doped Catalysts for Photoelectrochemical CO2 Conversion to Solar Fuels
No full textSolar-driven photoelectrochemical (PEC) carbon dioxide (CO2) conversion to valuable chemicals, combining the advantages of photocatalysis and electrocatalysis, represents a promising approach toward establishing a carbon-neutral society and harnessing solar energy. Photoelectrode materials doped with metals and/or nonmetals have shown promise in achieving high CO2 reduction efficiency. Metal or nonmetal doping entails introducing a heteroelement into the semiconductor, thereby modifying the band potentials of the semiconductor through the addition of a defective state. This alteration may improve the charge transfer kinetics of the catalysis. Furthermore, doping aids in creating active CO2 adsorption offers anchoring sites for CO2 molecules and can promote product selectivity. This review aims to provide a concise summary of elemental-doped photoelectrodes for converting CO2 into fuels through PEC processes. Several key factors affecting the performance of PEC CO2 reduction are discussed, including the interaction of reactants with catalysts, reaction conditions, and the impact of the photoelectrode. Moreover, various PEC CO2 reduction systems are discussed, with a specific focus on enhancing the efficiency of CO2 reduction. Finally, a summary of key considering aspects for further development of the PEC CO2 reduction is provided. © 2024 Wiley-VCH GmbH.FALSEsciescopu
Solvent-Driven Dynamics: Crafting Tailored Transformations of Cu(II)-Based MOFs
No full textMetal-organic frameworks (MOFs), a sort of crystalline porous coordination polymers composed of metal ions and organic linkers, have been intensively studied for their ability to take up nonpolar gas-phase molecules such as ethane and ethylene. In this context, interpenetrated MOFs, where multiple framework nets are entwined, have been considered promising materials for capturing nonpolar molecules due to their relatively higher stability and smaller micropores. This study explores a solvent-assisted reversible strategy to interpenetrate and deinterpenetrate a Cu(II)-based MOF, namely, MOF-143 (noninterpenetrated form) and MOF-14 (doubly interpenetrated forms). Interpenetration was achieved using protic solvents with small molecular sizes such as water, methanol, and ethanol, while deinterpenetration was accomplished with a Lewis-basic solvent, pyridine. Additionally, this study investigates the adsorptive separation of ethane and ethylene, which is a significant application in the chemical industry. The results showed that interpenetrated MOF-14 exhibited higher ethane and ethylene uptakes compared to the noninterpenetrated MOF-143 due to narrower micropores. Furthermore, we demonstrate that pristine MOF-14 displayed higher ethane selectivity than transformed MOF-14 from MOF-143 by identifying the “fraction of micropore volume” as a key factor influencing ethane uptake. These findings highlight the potential of controlled transformations between interpenetrated and noninterpenetrated MOFs, anticipating that larger MOF crystals with narrower micropores and higher crystallinity will be more suitable for selective gas capture and separation applications. © 2024 American Chemical Society.FALSEsciescopu
데이터 패턴 기반의 뱅뱅 위상 검출기를 활용한 이퀄라이저 적용 기법
No full textEqualizer AdaptationThis paper proposes a pattern-dependent accumulator (PDA) based bang-bang (BB) CDR for equalizer adaptation. The proposed structure suppresses the bandwidth reduction of the data path by connecting PDA in parallel with the data path. The output of the bang-bang phase detector (BBPD) and the number of occurrences of specific data sequence patterns are accumulated as the expected value (EV) to utilize the stochastic characteristics of BBPD output. A continuous-time linear equalizer (CTLE) is employed as an equalizer, and the PDA output controls the zero frequency of CTLE. The PDA output is divided into three phases in accordance with the EV of the data sequence pattern, which exhibits the state of each equalizer. The proposed structure is simulated using MATLAB. The result of the simulation exhibits that the proposed standard of EV applies to the five channels. Since each channel has different attenuation, this result introduces that the PDA is capable of detecting the characteristics of each channel. Keywords : Bang-bang phase detector clock and data recovery (BB CDR), Bang-bang phase detector (BBPD), Continuous-time linear equalizer (CTLE), Expected value (EV), Inter-symbol interference (ISI)|본 논문에서는 이퀄라이저 적응을 위한 PDA(pattern-dependent accumulator) 기반 뱅뱅 위상 검출기가 포함된 클럭 및 데이터 복구 회로를 제안한다. 제안된 구조는 PDA를 데이터 경로와 병렬로 연결함으로써 데이터 경로의 대역폭 감소를 방지한다. 또한, 뱅뱅 위상 검출기의 출력과 특정 데이터 시퀀스 패턴의 발생 횟수를 기댓값으로 누적하여 뱅뱅 위상 검출기가 생성한 출력의 확률적 특성을 활용한다. 이퀄라이저로는 연속 시간 선형 이퀄라이저가 사용되며, PDA 출력은 연속 시간 선형 이퀄라이저의 영점 주파수를 제어한다.
PDA 출력은 각 이퀄라이저의 상태를 나타내는 데이터 시퀀스 패턴의 기댓값에 따라 최적의 상태를 포함한 3단계로 구분된다. 제안된 구조는 MATLAB을 사용하여 시뮬레이션 결과를 실험 결과로 정리하였다. 시뮬레이션 결과 제안된 기댓값의 기준이 5개 채널에 적용되며, 각 채널마다 채널 감쇠가 다르기 때문에 PDA가 각 채널의 특성을 감지할 수 있음을 의미한다. 이퀄라이저 적응을 위해 본 논문에서 제안된 방식은 데이터 통신의 품질을 향상시킬 수 있다. 이전 연구에서는 데이터 경로에 이퀄라이저의 상태를 모니터링하는 회로를 추가하고 데이터 신호의 대역폭을 줄였다. 따라서 데이터 상태를 실시간으로 모니터링하고, 데이터 경로에 회로를 추가하지 않는 방식에 대한 연구가 필요했다. 제안된 이퀄라이저 적응 기법은 이퀄라이저의 상태를 모니터링하는 회로를 데이터 경로와 병렬로 연결하여 대역폭을 확보한다. 또한, 뱅뱅 위상 검출기 출력의 확률적 특성을 이용하여 채널에 상관없이 최적화된 등화 상태를 결정할 수 있다.
핵심어: 뱅뱅 위상 검출기 기반 클럭 및 데이터 복구 회로, 뱅뱅 위상 검출기, 연속 시간 선형 이퀄라이저, 기댓값, 기호 간 간섭List of contents
1. Introduction 1
1.1 Motivation and Objectives 1
2. Thesis Outline · 2
2.1 Phase locked loop (PLL) · 2
2.2 Clocking 5
2.3 Clock and data recovery (CDR) 7
2.4 Channel loss compensation · 8
2.5 Continuous-time linear equalizer 9
3. Proposed Equalizer Adaptation 12
3.1 Stochastic characteristic of the BBPD 12
3.2 Data phase under ISI 14
3.3 Pattern-dependent BBPD-based EQ adaptation · 15
3.4 Expected value of 4-bit data pattern and EQ adaptation 16
4. Simulation Results 22
4.1 EQ adaptation in TEC Whisper 40 channel 22
4.2 EQ state determined by BBPD-based EQ adaptation · 24
5. Conclusion 25
6. References 26MasterdCollectio
XBP1s negatively regulates LXRα and cholesterol efflux through an E3 ligase RNF181
No full textMacrophage; Atherosclerosis; LXRα; XBP1s; RNF181Ⅰ. Introduction 1
1.1 Macrophage and Cholesterol efflux 1
1.2 LXR and cholesterol Metabolism 3
1.3 XBP1s and ER stress 6
1.4 RNF181 and E3 ligase 10
1.5 Aims of the Research 12
1.5.1 Aim1: Examine the detailed mechanism of decreased LXRα activity by XBP1s 12
1.5.2 Aim2: Identify a specific mediator of the mechanism behind the decreased LXRα activity by XBP1s 13
1.5.3 Aim3: Assessing the impact of decreased LXRα activity on cholesterol efflux in macrophage cells 13
Ⅱ. Materials and Methods 15
2.1 Mice and Diets 15
2.2 Reagents and plasmids 15
2.3 Cell Culture 16
2.4 Western blot 17
2.5 Luciferase assay 18
2.6 Co-immunoprecipitation and ubiquitination assay 18
2.7 Cycloheximide assay 19
2.8 qRT-PCR 19
2.9 Yeast two-hybrid 20
2.10 Adenovirus 21
2.11 Cholesterol efflux assa 21
2.12 Serum cholesterol quantification 22
2.13 Bone marrow derived macrophage (BMDM) preparation 22
2.14 Primers, siRNA and shRNA 23
2.15 Public CHIP-seq Data Analysis 26
2.16 Statistical Analysis 26
Ⅲ. Results 28
3.1 XBP1s reduce the LXRα stability by promoting ubiquitination 28
3.2 XBP1s Promotes the Expression of RNF181, a potential E3 Ligase Targeting LXRα 37
3.3 RNF181 is the E3 ligase that targets LXRα 51
3.4 RNF181 modulates endogenous LXRα and cholesterol efflux in human macrophage cell line 59
3.5 RNF181 affects in vivo macrophage LXRα and whole-body metabolism 68
Ⅳ. Conclusions and Discussion 72
4.1 Conclusion of Aim1 72
4.2 Conclusion of Aim2 72
4.3 Conclusion of Aim3 73
4.4 Discussion 73
Ⅴ. References 76
Ⅵ. 국문 요약문 83DoctordCollectio
Vitamin C-induced CO2 capture enables high-rate ethylene production in CO2 electroreduction
Get PDFHigh-rate production of multicarbon chemicals via the electrochemical CO2 reduction can be achieved by efficient CO2 mass transport. A key challenge for C−C coupling in high-current-density CO2 reduction is how to promote *CO formation and dimerization. Here, we report molecularly enhanced CO2-to-*CO conversion and *CO dimerization for high-rate ethylene production. Nanoconfinement of ascorbic acid by graphene quantum dots enables immobilization and redox reversibility of ascorbic acid in heterogeneous electrocatalysts. Cu nanowire with ascorbic acid nanoconfined by graphene quantum dots (cAA-CuNW) demonstrates high-rate ethylene production with a Faradaic efficiency of 60.7% and a partial current density of 539 mA/cm2, a 2.9-fold improvement over that of pristine CuNW. Furthermore, under low CO2 ratio of 33%, cAA-CuNW still exhibits efficient ethylene production with a Faradaic efficiency of 41.8%. We find that cAA-CuNW increases *CO coverage and optimizes the *CO binding mode ensemble between atop and bridge for efficient C−C coupling. A mechanistic study reveals that ascorbic acid can facilitate *CO formation and dimerization by favorable electron and proton transfer with strong hydrogen bonding. © 2024, The Author(s).TRUEsciescopu
인-스토리지 인덱싱을 활용한 분산 스토리지 노드의 I/O 스택 최적화
No full textDistributed File Systems; Ceph File System; RADOS Object; Key-value SSD; 분산 파일 시스템; Ceph 파일 시스템; RADOS 오브젝트; 키-밸류 SSDⅠ. Introduction 1
Ⅱ. Background
2.1 Ceph RADOS 2
2.2 Ceph MDS 3
2.3 Ceph OSD 4
2.3.1 BlueStore 5
2.4 KVSSD 6
2.4.1 KEVINSSD 7
Ⅲ. Motivation
3.1 Ineffective Dentry Management 8
3.2 Journaling Overhead 9
Ⅳ. Analysis
4.1. Ceph Operation Flow with BlueStore 10
4.2. SET Operation Traffic 11
Ⅴ. Design 12
Ⅵ. Experiments
6.1. Experiments Setup 13
6.2. Removing Dentry Operation 14
6.3 GET Latency 15
Ⅶ. Conclusion 16MasterdCollectio