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Development of High-Frequency Ultrasound Transducers and Signal Processing Algorithms for Integrated Circuit Inspection
No full textultrasound imaging;integrated circuit inspection;ultrasound transducer;synthetic aperture techniqueⅠ. INTRODUCTION 1
II. Method 4
2.1 Screw type lens fabrication 4
2.2 Lens noise simulation 5
2.3 Conventional and screw type lens transducer 7
2.4 Synthetic aperture focusing and coherence factor weighting 8
III. Transducer Evaluation 13
3.1 Pulse-Echo measurement 13
3.2 Resolution measurement 15
3.3 Noise comparison 17
IV. DBC Imaging 18
4.1 CT image 18
4.2 Data processing 19
4.3 Epoxy target imaging 20
4.4 Image comparison of lens type 22
4.5 Image comparison after signal processing (SAF, SACF) 23
V. Discussions and Conclusions 25
References 26MasterdCollectio
이중층 구조의 인조/천연 하이브리드 흑연 음극의 순차적 효과에 대한 리튬이온 배터리 급속 충전 성능 향상
No full textFast-charging batteries;Dual-layered electrodes;Resistance distribution;Hybrid graphite anodes;temporal SOC gradientList of Contents
Abstract i
List of contents ii
List of tables · iii
List of figures vi
Ⅰ. Introduction
1.1 Principles of Li-ion batteries 1
1.2 Promise of thick electrode 2
1.3 Limitation of thick electrode 3
1.4 Enhancing thick electrode design · 4
1.5 Research goals 5
Ⅱ. Experimental method
2.1 Electrode fabrication· 7
2.2 Cell assembly 7
2.3 Electrochemical measurements 8
2.4 Electrode characterization 8
2.5 Computational analysis· 9
Ⅲ. Result and Discussion
3.1 Preliminary comparison of NG and AG· 11
3.2 Electrode structures and binder distributions at SLEs and DLEs 14
3.3 Electrochemical performances of Li-ion cells using SLEs and DLEs 17
3.4 Postmortem analysis 19
3.5 Pseudo-3D model-based simulation 22
3.6 Sequential effect in DLE-NA and DLE-AN hybrid anodes 26
Ⅳ. Conclusion · 27
References 32
Summary in Korean · 37MasterdCollectio
2D-OD-2D HETEROJUNCTION STRUCTURE AND MANUFACTURING METHOD BY THE SAME, PEROVSKITE OPTOELECTRIC DEVICE COMPRISING THE SAME
No full text본 발명은 2D-OD-2D 이종접합 구조체 및 이의 제조방법, 이를 포함하는 광전소자를 개시한다. 본 발명은 P-타입의 2차원 반도체 물질을 포함하는 제1 2차원 반도체 물질층; 상기 제1 2차원 반도체 물질층 상에 형성되고, 0차원 반도체 물질을 포함하는 중간층; 및 상기 중간층 상에 형성되고, n-타입 2차원 반도체 물질을 포함하는 제2 2차원 반도체 물질층;을 포함하고, 상기 0차원 반도체 물질은 양자점을 포함하며, 상기 중간층은 양자점으로 인해 전자 및 홀이 생성되는 것을 특징으로 한다
Exploring postsynaptic CLSTN3 and mitochondrial CLPB: Insights into synapse regulation and neurodegenerative diseases
No full textSynapse formation;hippocampus;CLSTN3;NRXNs;proteostasis;ClpB;Huntington’s disease;striatumGeneral Introduction 1
Part 1. Calsyntenin-3 Regulates Excitatory Synapse Formation in the Mouse Hippocampus by
Interacting with α- and β-Neurexins
I. Introduction 6
1.1 Synapse and Synaptic adhesion molecules 6
1.2 Role of Neurexins as presynaptic hub molecules 7
1.3 Synaptic functions of Calsyntenins 9
1.4 Role of Calsyntenins in Alzheimer's disease 11
II. Materials & Methods 15
2.1 Materials 15
2.1.1 Animals 15
2.1.2 Recombinant DNA 16
2.1.3 Antibodies 17
2.2 Methods 18
2.2.1 Animal husbandry and handling 18
2.2.2 HEK293T cell culture 18
2.2.3 Primary neuron culture 19
2.2.4 Preparation of recombinant adeno-associated viruses (AAV) 19
2.2.5 Titer measure of recombinant adeno-associated viruses 20
2.2.6 Stereotaxic surgery and virus injections 20
2.2.7 Preparation of solubilized proteins 21
2.2.8 Cell Surface-binding assay 21
2.2.9 Pulldown assays 22
2.2.10 Direct protein binding assays 22
2.2.11 Preparation of protein samples (Crude synaptosomal (P2) fractionation) 23
2.2.12 Immunohistochemistry (IHC) 23
2.2.13 Nissl staining 24
2.2.14 Mouse behavioral test 25
2.2.14.1 Open field test 25
2.2.14.2 Novel object recognition test 25
2.2.14.3 Y-maze test 25
2.2.14.4 Elevated plus maze test 25
2.2.14.5 Light and dark transition test 26
2.2.15 Statistical analysis 26
III. Results 27
3.1 Clstn3 exhibits direct interaction with Nrxn1α and Nrxn1β 27
3.2 Generation of anti-CLSTN3 antibodies and Clstn3 localization in the hippocampus 28
3.3 Generation and characterization of Clstn3 Knockout mice 29
3.4 Clstn3 cadherin domains are required for excitatory synapse formation in the hippocampal CA1 region of Clstn3 knockout mice 29
3.5 The generation and characterization of Nestin-Clstn3 mice 31
3.6 Clstn3 cadherin domains are necessary for excitatory synapse formation in the hippocampus CA1 regions of Nestin-Clstn3 mice 31
3.7 Nestin-Clstn3 mice exhibit elevated bright light-induced anxiety 32
IV. Discussion & Conclusion 54
Part 2. ClpB Inhibits Huntingtin Aggregation and Modulates Inhibitory Synapse Formation in a
Mouse Model of Huntington’s Disease
I. Introduction 57
1.1 The Role of Heat Shock Proteins in Maintaining Proteostasis 57
1.2 The heat-shock protein (HSP) family 58
1.3 The role of the Hsp100/Clp subfamily 59
1.4 The role of Hsp104/ClpB in eukaryotes 60
1.5 The role of ClpB (Skd3) in mammals 62
1.6 The structure of Hsp104/ClpB 64
1.7 Neuro-aggregates near mitochondria 65
1.8 Molecular chaperones and neurodegeneration 69
1.9 Disaggregase activity in ClpB-mutant patients 71
II. Materials & Methods 76
2.1 Materials 76
2.1.1 Animals 76
2.1.2 Recombinant DNA 76
2.1.3 Antibodies 77
2.2 Methods 78
2.2.1 HEK293T cell culture 78
2.2.2 Primary neuron culture 78
2.2.3 Preparation of competent cell 79
2.2.4 Preparation of recombinant adeno-associated viruses (AAV) 79
2.2.5 Titer measure of recombinant adeno-associated viruses 80
2.2.6 Preparation of lentiviruses 80
2.2.7 Stereotaxic surgery and virus injections 81
2.2.8 Preparation of protein samples 81
2.2.8.1 Protein extraction from various tissues 81
2.2.8.2 Mitochondrial fractionation 81
2.2.9 Immunohistochemistry (IHC) 82
2.2.10 LDH release assay 82
2.2.11 Mitochondrial membrane potential measurement 82
2.2.12 Quantitative reverse transcription-PCR 83
2.2.13 Statistical analysis 83
III. Results 85
3.1 The role of ClpB in the disaggregation of neurodegenerative disease-associated proteins 85
3.2 ClpB knockout causes Htt aggregation and cytotoxicity in HEK293T cells 86
3.3 Decreased ClpB levels are associated with increased mitochondrial fission and cytotoxicity in cultured neurons 87
3.4 Characterization of ClpB expression in the mouse brain 88
3.5 ClpB regulates WT and mHTT aggregation in the striata of WT mice 89
3.6 ClpB regulates WT and mHTT aggregation in the striatum of a mouse model of HD 90
3.7 ClpB regulates inhibitory synapse formation in the striatum of a mouse model of HD 91
IV. Discussion & Conclusion 114
V. References 117DoctordCollectio
Low-Cost and Easy-to-Build Soft Robotic Skin for Safe and Contact-Rich Human - Robot Collaboration
Get PDFAlthough many soft robotic skins have been introduced, their use has been hindered due to practical limitations, such as difficulties in manufacturing, poor accessibility, and cost inefficiency. To solve this, we present a low-cost, easy-to-build soft robotic skin utilizing air-pressure sensors and 3D-printed pads. In our approach, we utilized digital fabrication and robot operating system (ROS) to facilitate the creation and use of the robotic skin. The skin pad was fabricated by printing thermoplastic urethane (TPU) and postprocessed with an organic solvent to secure air-tightness. Each pad consists of a TPU shell and infill, so the internal air-pressure changes in response to tactile stimuli, such as force and vibration. The internal pressure is measured and processed by a microcontroller and transmitted to the host computer via a serial bus. We conducted experiments to investigate the characteristics of the skin pads, and the results showed that the developed robotic skins are capable of perceiving interaction force and dynamic stimuli. Finally, we developed the dedicated soft robotic skins for our custom robot designed in-house, and demonstrated safe and intuitive physical human-robot interaction. © 2024 The Authors. This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/TRUEsciescopu
Precision Engineering of Polydopamine: Advances in Spatial Fabrication Techniques
No full textCurrently available patterning methods, such as lithographic techniques and inkjet printing approaches, heavily rely on material properties and specific applications. This motivates us to explore and develop patterning strategies tailored to the unique characteristics of materials. In this context, we discuss the advancements in site-specific fabrication and patterning of polydopamine (pDA), a versatile coating material widely utilized in biomedical devices. First, we provide a brief Review of the current understanding of the chemical structure of pDA, addressing the ongoing challenges related to its uncontrollability due to its heterogeneous nature. Following this, we examine the control of the shape and morphology during the growth of pDA in the solution phase. Lastly, we comprehensively cover various patterning strategies specifically developed and optimized for the pDA coating. Our goal is to offer insights into the controllable synthesis and fabrication of pDA. We anticipate that this Review will contribute to the advancement of precise and tailored pDA coatings, opening up possibilities for applications in diverse fields, particularly in integrated devices and molecular architecting. © 2024 American Chemical Society.FALSEsciescopu
Optimal control sensor position calculation device and method for calculating optimum control sensor position using the same
No full text본 발명은 관제 센서 최적 위치 산출 장치 및 이를 이용한 관제 센서 최적 위치 산출 방법에 관한 것으로 더욱 상세하게는 자율 주행 로봇이 감지하지 못하는 실내 환경 내의 객체 검출 사각 지대를 최소화하여 객체와 자율 이동 로봇 간 충돌 사고를 방지할 수 있는 관제 센서 최적 위치 산출 장치 및 이를 이용한 관제 센서 최적 위치 산출 방법에 관한 것이다. 이를 위해 본 발명은 상기 객체의 시간대별 이동 경로 시나리오 정보, 상기 이동체의 시간대별 이동 경로 시나리오 정보 및 감지 영역 시나리오 정보, 상기 관제 센서의 설치 개수와 설치 가능 위치 정보 및 상기 감시영역의 지도 정보를 수신하는 정보 수신부; 상기 정보 수신부가 수신한 정보를 기초로 시뮬레이션을 수행하여 상기 관제 센서의 설치 가능 위치별로, 상기 관제 센서 또는 상기 이동체가 상기 객체를 감지하는 총 시간인 객체 탐지 시간을 산출하는 시간 산출부; 및 산출된 상기 객체 탐지 시간을 기초로 객체 탐지 시간이 가장 긴 것으로 판단되는 관제 센서의 설치 위치 정보를 산출하는 위치 산출부;를 포함한다
Presenilin 2 N141I mutation induces microglia senescence
No full textimmune;microglia;AD;inflammation;senescenceMasterdCollectio
DFT 계산을 이용한 유기광센서의 붉은빛에 대한 선택적 흡수 및 선형동적범위의 개선
No full textOrganic Photodetector;Red selectivity;Narrow-wide copolymer;Diarylethene;Linear dynamic range1. Introduction 1
1.1 Organic photodetector 1
1.2 Full color image sensing 2
1.3 Photo switchable molecules (Diarylethene) · 3
1.4 Increasing linear dynamic range 13
1.5 Narrow-wide copolymer design strategy 15
2. Method 17
2.1 Candidates to calculate 17
2.2 Theoretical backgrounds of Density Functional Theory (DFT) · 20
2.2.1 Many-body approximation · 20
2.2.2 Born-Oppenheimer approximation · 21
2.2.3 Kohn-Sham equation 21
2.2.4 Hohenberg-Kohn theorem 23
2.2.5 Exchange-correlation functional · 24
2.2.6 Gaussian type basis set 25
2.3 Backgrounds of Time Dependent Density Functional Theory (TDDFT) 27
2.4 Transition state searching by Gaussian 30
2.5 Calculation details · 31
3. Result 34
3.1 RS of narrow-wide copolymer & counter unit 34
3.2 Changing wide unit with DPP unit 35
3.3 Non DPP unit · 37
3.4 Cycloreversion energy diagram · 37
3.5 Action of DAE as n-traps 42
4. Conclusion 46MasterdCollectio
