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Data for "In search of different categories of abstract concepts: a fMRI adaptation study"
No full textThe event-related fMRI task was a passive reading task where subjects were presented with abstract or concrete word pairs, consisting of two words belonging to the Same or Different Category conditions. Partcipants were instructed to silently read the words.
When referring to this dataset, please cite the associated publication at https://doi.org/10.1038/s41598-021-02013-8
- Funding:
This study was supported by a European Union Grant (FP6-2004-NESTPATH, Grant 028714 to S.F.C. and G.V.).
- Uploaded Documents:
SR_22587_2021_Materials.pdf
This document includes the following materials associated with Supplementary Information of the publication at https://doi.org/10.1038/s41598-021-02013-8
• List of the experimental stimuli divided by semantic categories
• Variables used for the selection of the experimental stimuli
• Lists of experimental conditions and design set-up
• List of experimental stimuli for the baseline condition
- Sample Size:
36
- Scanner Type:
3 T Intera Philips body scanner
- Data Type included in the fMRI dataset:
Anonymized preprocessed smoothed and normalized fMRI volumes included in the time-series for each subject. All fMRI images included in each time-series are in the Neuroimaging Informatics Technology Initiative (NIfTI) open file format
Right ventricular systolic function in severe tricuspid regurgitation: prognostic relevance of longitudinal strain
No full textdoi: 10.1093/ehjci/jeab030
The aim of this study is to analyse the prognostic implications of right ventricular (RV) dysfunction as detected by strain analysis in patients with severe tricuspid regurgitation (TR). The evaluation of RV systolic function in presence of severe TR is of paramount importance for operative risk stratification; however, it remains challenging, as conventional echocardiographic indexes usually lead to overestimation. The study population included 250 patietns with severe TR. Different ranges of RVFWLS have different implications in patients with severe TR, allowing to identify a preclinical and a clinical window, with correlations to RVHF and survival
Raw data for article Conti et al. "IgE reactivity to house dust mite allergen components in sensitized asymptomatic subjects: a role for Der p 20" doi: 10.23812/21-07-L
No full textFull images of the gel/Western blot used for the generation of the figures in the paper: Conti A, Burastero GJ, Hales BJ, Breda D, Alessio M, Burastero SE. IgE reactivity to house dust mite allergen components in sensitized asymptomatic subjects: a role for Der p 20. J Biol Regul Homeost Agents. 2021 Mar-Apr;35(2):669-676. doi: 10.23812/21-07-L.
List of peptides identified by mass spectrometry that allowed protein identification
Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity
No full textRecent findings in human samples and animal models support the involvement of inflammation in the development of Parkinson’s disease. Nevertheless, it is currently unknown whether microglial activation constitutes a primary event in neurodegeneration. We generated a new mouse model by lentiviral-mediated selective α-synuclein (αSYN) accumulation in microglial cells. Surprisingly, these mice developed progressive degeneration of dopaminergic (DA) neurons without endogenous αSYN aggregation. Transcriptomics and functional assessment revealed that αSYN-accumulating microglial cells developed a strong reactive state with phagocytic exhaustion and excessive production of oxidative and proinflammatory molecules. This inflammatory state created a molecular feed-forward vicious cycle between microglia and IFNγ-secreting immune cells infiltrating the brain parenchyma. Pharmacological inhibition of oxidative and nitrosative molecule production was sufficient to attenuate neurodegeneration. These results suggest that αSYN accumulation in microglia induces selective DA neuronal degeneration by promoting phagocytic exhaustion, an excessively toxic environment and the selective recruitment of peripheral immune cells
Serum Irisin May Predict Cardiovascular Events in Elderly Patients With Chronic Kidney Disease Stage 3-5
No full textIrisin is a circulating myokine released from skeletal muscles after physical exercise. Irisin production decreases during the course of chronic kidney disease (CKD) as a potential consequence of sarcopenia and physical inactivity. In the light of the potential role of irisin in cardiovascular disease of CKD patients, we studied the relationship of serum irisin with cardiovascular risk in a sample of patients at different stages of CKD not undergoing dialysis (n=79). Our findings suggest that serum irisin may be a marker of cardiovascular outcome in CKD patients.
doi: 10.1053/j.jrn.2021.05.007
PMID: 3429455
data for "Integration of clinical and multi-omics multiple sclerosis data into a predictive algorithm of disease activity to accelerate personalized medicine" (GR-2016-02363997)
No full textData refer to the results obtained within the GR-2016-02363997 project funded by the Italian Ministry of Health. Main aim was to combine clinical data with genetic variants, transcriptomic and T lymphocyte repertoires signatures to dissect the biological basis of multiple sclerosis (MS) inflammatory activity.
Two sets of patients were analysed: i) Extended cohort, for the identification of genetic biomarkers, ii) Core Cohort, for the identification of genetic, transcriptomic and immune repertoires biomarkers. Each patient was classified according to the NEDA (No Evidence of Disease Activity) criterion at 4- year follow-up, while time to first relapse (TTFR) was considered as secondary outcome.
Data includes:
- Results: GR-2016-02363997_results.pdf
- uploaded documents.pdf
- Genetic data: GEN_top_SNPs_geno.ped; GEN_top_SNPs_geno.map; GEN_var.txt; GEN_gene-wise.txt
- Transcriptomic data: EXPR_topRNA_CPM.txt; EXPR_var.txt
- Immunosequencing data: IMMSEQ_diversity.txt; IMMSEQ_trbd.txt; IMMSEQ_trbj.txt; IMMSEQ_trbv.txt; IMMSEQ_var.tx
Preliminary Results of an Ongoing Prospective Clinical Trial on the Use of 68Ga-PSMA and 68Ga-DOTA-RM2 PET/MRI in Staging of High-Risk Prostate Cancer Patients
No full textThis dataset was used in the paper "Preliminary Results of an Ongoing Prospective Clinical Trial on the Use of 68Ga-PSMA and 68Ga-DOTA-RM2 PET/MRI in Staging of High-Risk Prostate Cancer Patients" published by Diagnostics in 2021 (doi.org/10.3390/diagnostics11112068). In this work we compared the performance of 68Ga-PSMA, 68Ga-DOTA-RM2 and MRI for the staging of PCa. All quantitative analysis can be reproduced by reading this dataset
Mangiameli et al., Human iPSC-based neurodevelopmental models of globoid cell leukodystrophy uncover patient- and cell type-specific disease phenotypes.
No full textThe dataset includes the row data of graphs shown in figures 1-6 of the paper: Mangiameli E, Cecchele A, Morena F, Sanvito F, Matafora V, Cattaneo A, Della Volpe L, Gnani D, Paulis M, Susani L, Martino S, Di Micco R, Bachi A, Gritti A. Human iPSC-based neurodevelopmental models of globoid cell leukodystrophy uncover patient- and cell type-specific disease phenotypes. Stem Cell Reports. 2021 Jun 8;16(6):1478-1495. doi: 10.1016/j.stemcr.2021.04.011. Epub 2021 May 13. PubMed PMID: 33989519; PubMed Central PMCID: PMC8190599.
The lipidomic dataset reported in the paper (Figure 7) is available at MetaboLights, accession number MTBLS1501 (https://www.ebi.ac.uk/metabolights/MTBLS1501).
Globoid cell leukodystrophy (GLD) is a rare neurodegenerative lysosomal storage disease caused by an inherited deficiency of β-galactocerebrosidase (GALC). GLD pathogenesis and therapeutic correction have been poorly studied in patient neural cells. Here, we investigated the impact of GALC deficiency and lentiviral vector-mediated GALC rescue/overexpression in induced pluripotent stem cell (iPSC)-derived neural progenitors and neuronal/glial progeny obtained from two GLD patients. GLD neural progeny displayed progressive psychosine storage, oligodendroglial and neuronal defects, unbalanced lipid composition, and early activation of cellular senescence, depending on the disease-causing mutation. The partial rescue of the neural differentiation program upon GALC reconstitution and psychosine clearance suggests multiple mechanisms contributing to neural pathology in GLD. Also, the pathological phenotype associated to supraphysiological GALC levels highlights the need of regulated GALC expression for proper human neural commitment/differentiation. These data have important implications for establishing safe therapeutic strategies to enhance disease correction of GLD
Delay in Pancreatic Endoscopic Ultrasound During the COVID-19 Pandemic in a Pancreas/Tertiary Referral Center.
No full textIn our tertiary referral Pancreas Center, we observed a reduction in the number of pancreatic endoscopic ultrasound (EUSP) procedures, mostly performed for neoplastic and pre-neoplastic reasons, during lockdown. We compared the period of major spreading of Covid-19 Infection in Italy, between February 1st and April 30th, 2020, with the same period in 2019
Immunogenic cell death and immunogenic surrender- related but distinct mechanisms of immune surveillance
No full text10.1038/s41419-021-04178-6
original data for figures 1 and 2 of the review: Immunogenic cell death and immunogenic surrender- related but distinct mechanisms of immune surveillance