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The role of acinar content at pancreatic resection margin in the development of postoperative pancreatic fistula and acute pancreatitis after pancreaticoduodenectomy
No full textData refer to the paper doi: 10.1016/j.surg.2021.03.047
Data from 388 consecutive patients who underwent pancreaticoduodenectomy in the period 2018–2019. Pancreatic section margins were histologically assessed for acinar, fibrosis, and fat content
Hematopoietic Tumors in a Mouse Model of X-linked Chronic Granulomatous Disease after Lentiviral Vector-Mediated Gene Therapy
No full textData for the paper Hernandez et al 2021 https://doi.org/10.1016/j.ymthe.2020.09.03
Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking
No full textData related to the manuscript entitled "Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking" by Ferrari*, Jacob*, Beretta, [...], Genovese#, Naldini#,. Nature Biotechnology (2020). doi: 10.1038/s41587-020-0551-y . *Share first authorship. #Jointly supervised the work. Corresponding author
Physical and psychological sequelae at three months after acute illness in COVID-19 survivors
No full textRaw data of the publication with the DOI 10.23736/S0031-0808.21.04399-8
Combined plasma levels of IL-10 and testosterone, but not soluble HLA-G5, predict the risk of death in COVID-19 patients
No full textIn the manuscript "Combined plasma levels of IL-10 and testosterone, but not soluble HLA-G5, predict the risk of death in COVID-19 patients" (doi: 10.1111/andr.13334), we reported that the combined evaluation of IL-10 and testosterone predicts the risk of death in men with COVID-19.
The two datasets here loaded (Raw_data_1 and Raw_data_2) contain all the clinical and immunological data, supporting our conclusions, that have been used to build the manuscript. An additional file (raw_data_description) contains the main guidelines to correctly associate the raw data with the corresponding figure/table in the manuscript
Systematic Fluoroscopic-Echocardiographic Fusion Imaging Protocol for Transcatheter Edge-to-Edge Mitral Valve Repair Intraprocedural Monitoring.
No full textDOI: 10.1016/j.echo.2021.01.010
Fluoroscopic-echocardiographic fusion imaging (FI) is able to acquire imaging data from both fluoroscopy and transesophageal images and co-register and align them in the 3D space and time by putting onto the same coordinate system. The aim of this single-center study was to test and validate a FI protocol for intraprocedural monitoring of transcatheter edge-to-edge mitral valve repair and assess its clinical usefulness. Eighty patients underwent MitraClip implantation using FI guidance (FI+) were compared with the last 80 patients before FI introduction.
The study firstly describes the systematic use of an FI protocol for intraprocedural guidance during transcatheter edge-to-edge mitral valve repair, demonstrating a reduction in fluoroscopy time and an improvement in procedural success in a population with a high prevalence of challenging mitral anatomy for percutaneous repair
CXCL10 levels at hospital admission predict COVID-19 outcome- hierarchical assessment of 53 putative inflammatory biomarkers in an observational study
No full text10.1186/s10020-021-00390-
Nanogold Functionalized With Lipoamide-isoDGR: A Simple, Robust and Versatile Nanosystem for αvβ3-Integrin Targeting
No full textRaw data and original images for the article entitled "Nanogold Functionalized With Lipoamide-isoDGR: A Simple, Robust and Versatile Nanosystem for αvβ3-Integrin Targeting " by A. Sacchi et al., Front. Chem., 28 May 2021. DOI: 10.3389/fchem.2021.69035
Deletion of a pseudogene within a fragile site triggers the oncogenic expression of the mitotic CCSER1 gene
No full textPaper published (10.26508/lsa.202101019
Profiling antibody response patterns in COVID-19:Spike S1-reactive IgA signature in the evolution of SARS-CoV-2 infection
No full textDOI for this manuscript is: 10.3389/fimmu.2021.772239
Published in 2021 by Lucia Lopalco et al.
We have investigated in a new statistical perspective the antibody responses to SARS-CoV-2 in 141 COVID-19 patients exhibiting a broad range of clinical manifestations (as described in raw data of all clinical data both at time of entry and followup. Two files are associated to hospitalized -so called COVID patients- and 2 files at pauci/asymptomatic subjects -so called as RSA-) . This cohort accurately reflects the characteristics of the first wave of the SARS-CoV-2 pandemic in Italy. We determined the IgM, IgA and IgG levels towards SARS-CoV-2 S1, S2, and NP antigens, evaluated their neutralizing activity and relationship with clinical signatures (as shown in the same raw data of clinical data). Moreover, we longitudinally followed 72 patients up to 9 months post symptoms onset to study the persistence of antibodies levels (raw data showing follow up of the studied subjects). Our results showed that the majority of COVID-19 patients developed an early virus-specific antibody response. The magnitude and the neutralizing properties of the response was heterogeneous regardless the severity of the disease. Antibody levels dropped over time, even though spike reactive IgG and IgA were still detectable up to 9 months. Early baseline antibody levels were key drivers of the subsequent antibody production and the long-lasting protection against SARS-CoV-2. Importantly, we identified anti-S1 IgA as a good surrogate marker to predict the clinical course of COVID-19. In addition analyses have been performed in purified IgG and IgA fraction of some subjects as shown in panel D of Fig 1 of the manuscript, the relative file with raw data is called IC50 purified fractions. Detailed description of the findings is reported in the published manuscript