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Systematic design of a robust half-W1 photonic crystal waveguide for interfacing slow light and trapped cold atoms
No full textInternational audienceNovel platforms interfacing trapped cold atoms and guided light in nanoscale waveguides are a promising route to achieve a regime of strong coupling between light and atoms in single pass, with applications to quantum non-linear optics and quantum simulation. A strong challenge for the experimental development of this emerging waveguide-QED field of research is to combine facilitated optical access for atom transport, atom trapping via guided modes and robustness to inherent nanofabrication imperfections. In this endeavor, here we propose to interface Rubidium atoms with a photonic crystal waveguide based on a large-index GaInP slab. With a specifically tailored half-W1 design, we show that a large coupling to the waveguide can be obtained and guided modes can be used to form two-color dipole traps for atoms at about 100 nm from the edge of the structure. This optimized device should greatly improve the level of experimental control and facilitate the atom integration
The Institutional Guarantee of the Human Right to Science
No full textInternational audienceThis article identifies and specifies the institutional guarantee of Article 15(1)(b) of the International Covenant on Economic, Social and Cultural Rights’ human right to science and, on that basis, argues for the consolidation of an international law of science. Its contribution may be described as threefold. First, it argues that science should be understood as a public and common good and, more specifically, as a public participatory good in a non-instrumental notion thereof. On that basis, second, the article argues for the collective dimension of the human right to science qua right to a participatory good, specifying what that dimension entails in terms of both individual (collective and personal) scientific rights and group or communal scientific rights. Finally, the article argues for the positive obligations of States to adopt norms of domestic and international law of science and the corresponding domestic and international law statutes of scientific institutions
Connexin 30 locally controls actin cytoskeleton and mechanical remodeling in motile astrocytes
No full textInternational audienceDuring brain maturation, astrocytes establish complex morphologies unveiling intense structural plasticity. Connexin 30 (Cx30), a gap‐junction channel‐forming protein expressed postnatally, dynamically regulates during development astrocyte morphological properties by controlling ramification and extension of fine processes. However, the underlying mechanisms remain unexplored. Here, we found in vitro that Cx30 interacts with the actin cytoskeleton in astrocytes and inhibits its structural reorganization and dynamics during cell migration. This translates into an alteration of local physical surface properties, as assessed by correlative imaging using stimulated emission depletion (STED) super resolution imaging and atomic force microscopy (AFM). Specifically, Cx30 impaired astrocyte cell surface topology and cortical stiffness in motile astrocytes. As Cx30 alters actin organization, dynamics, and membrane physical properties, we assessed whether it controls astrocyte migration. We found that Cx30 reduced persistence and directionality of migrating astrocytes. Altogether, these data reveal Cx30 as a brake for astrocyte structural and mechanical plasticity
Blood Monocyte Phenotype Is A Marker of Cardiovascular Risk in Type 2 Diabetes
No full textInternational audienceBACKGROUND: Diabetes is a major risk factor for atherosclerotic cardiovascular diseases with a 2-fold higher risk of cardiovascular events in people with diabetes compared with those without. Circulating monocytes are inflammatory effector cells involved in both type 2 diabetes (T2D) and atherogenesis. METHODS: We investigated the relationship between circulating monocytes and cardiovascular risk progression in people with T2D, using phenotypic, transcriptomic, and metabolomic analyses. cardiovascular risk progression was estimated with coronary artery calcium score in a cohort of 672 people with T2D. RESULTS: Coronary artery calcium score was positively correlated with blood monocyte count and frequency of the classical monocyte subtype. Unsupervised k-means clustering based on monocyte subtype profiles revealed 3 main endotypes of people with T2D at varying risk of cardiovascular events. These observations were confirmed in a validation cohort of 279 T2D participants. The predictive association between monocyte count and major adverse cardiovascular events was validated through an independent prospective cohort of 757 patients with T2D. Integration of monocyte transcriptome analyses and plasma metabolomes showed a disruption of mitochondrial pathways (tricarboxylic acid cycle, oxidative phosphorylation pathway) that underlined a proatherogenic phenotype. CONCLUSIONS: In this study, we provide evidence that frequency and monocyte phenotypic profile are closely linked to cardiovascular risk in patients with T2D. The assessment of monocyte frequency and count is a valuable predictive marker for risk of cardiovascular events in patients with T2D. REGISTRATION: URL: https://www.clinicaltrials.gov ; Unique identifier: NCT0435386
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No full textAbsence of sympathetic innervation hampers the generation of tertiary lymphoid structures upon acute lung inflammation
No full textInternational audienceTertiary lymphoid structures (TLS) are lymphoid organs present in inflammatory non-lymphoid tissues. Studies have linked TLS to favorable outcomes for patients with cancers or infectious diseases, but the mechanisms underlying their formation are not fully understood. In particular, secondary lymphoid organs innervation raises the question of sympathetic nerve fibers involvement in TLS organogenesis. We established a model of pulmonary inflammation based on 5 daily intranasal instillations of lipopolysaccharide (LPS) in immunocompetent mice. In this setting, lung lymphoid aggregates formed transiently, evolving toward mature TLS and disappearing when inflammation resolved. Sympathetic nerve fibers were then depleted using 6-hydroxydopamine. TLS quantification by immunohistochemistry showed a decrease in LPS-induced TLS number and surface in denervated mouse lungs. Although a reduction in alveolar space was observed, it did not impair overall pulmonary content of transcripts encoding TNF-α, IL-1β and IFN-γ inflammation molecules whose expression was induced by LPS instillations. Immunofluorescence analysis of immune infiltrates in lungs of LPS-treated mice showed a drop in the proportion of CD23+ naive cells among CD19+ B220+ B cells in denervated mice whereas the proportion of other cell subsets remained unchanged. These data support the existence of neuroimmune crosstalk impacting lung TLS neogenesis and local naive B cell pool