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A Joint Fermi-GBM and Swift-BAT Analysis of Gravitational-Wave Candidates from the Third Gravitational-wave Observing Run
No full textInternational audienceWe present Fermi Gamma-ray Burst Monitor (Fermi-GBM) and Swift Burst Alert Telescope (Swift-BAT) searches for gamma-ray/X-ray counterparts to gravitational wave (GW) candidate events identified during the third observing run of the Advanced LIGO and Advanced Virgo detectors. Using Fermi-GBM on-board triggers and sub-threshold gamma-ray burst (GRB) candidates found in the Fermi-GBM ground analyses, the Targeted Search and the Untargeted Search, we investigate whether there are any coincident GRBs associated with the GWs. We also search the Swift-BAT rate data around the GW times to determine whether a GRB counterpart is present. No counterparts are found. Using both the Fermi-GBM Targeted Search and the Swift-BAT search, we calculate flux upper limits and present joint upper limits on the gamma-ray luminosity of each GW. Given these limits, we constrain theoretical models for the emission of gamma-rays from binary black hole mergers
Introduction — Northern Treasures: Lives and Deities — For a Critical History of the Northern Treasures 2
No full textInternational audienc
A spectral dominance approach to large random matrices: part II
No full textInternational audienceThis paper is the second of a series devoted to the study of the dynamics of the spectrum of large random matrices. We study general extensions of the partial differential equation arising to characterize the limit spectral measure of the Dyson Brownian motion. We provide a regularizing result for those generalizations. We also show that several results of part I extend to cases in which there is no spectral dominance property. We then provide several modeling extensions of such models as well as several identities for the Dyson Brownian motion
Characteristics and prognosis of tumor-related epilepsy during tumor evolution in patients with IDH-wildtype glioblastoma
No full textInternational audienceBackground and objectives: Tumor-related epilepsy is a well-known symptom of glioblastoma. However, the particular characteristics of epileptic seizures related to glioblastoma, isocitrate dehydrogenase (IDH)-wild-type is almost unexplored longitudinally during the whole course of the disease. We assessed tumor-related epilepsy and seizure control during tumor evolution and the prognostic significance of tumor-related epilepsy.Methods: We performed an observational, retrospective single-center study at one tertiary referral neuro-oncology surgical center (2000-2020). We included adult patients treated for a newly diagnosed supratentorial glioblastoma, IDH-wild-type with available preoperative and postoperative MRI and with available epileptic seizure status at diagnosis. To determine factors associated with tumor-related epilepsy or seizure control, univariate analyses were performed using the χ2 or Fisher exact tests for categorical variables and the unpaired t test or Mann-Whitney rank-sum test for continuous variables. Predictors associated with tumor-related epilepsy and seizure control in unadjusted analysis were entered into backward stepwise logistic regression models.Results: One thousand six patients were enrolled. The cumulative incidence of tumor-related epilepsy increased during tumor evolution (33.1% at diagnosis, 44.7% after oncologic treatment, 52.4% at progression, and 51.8% at the end-of-life phase) and is related to tumor features (cortex involvement, no necrosis, and small volume). Uncontrolled epileptic seizures increased during tumor evolution (20.1% at diagnosis, 32.0% after oncologic treatment, 46.7% at progression, and 41.1% at the end-of-life phase). Epileptic seizure control after oncologic treatment was related to seizure features (uncontrolled before oncologic treatment and focal-to-bilateral tonic-clonic seizures) and to the extent of resection. Epileptic seizure control at tumor progression was related to seizure features (presence at diagnosis and uncontrolled after oncologic treatment) and to the time to progression. Tumor-related epilepsy at diagnosis was a predictor of a longer overall survival (adjusted hazard ratio, 0.78; 95% CI 0.67-0.90; p < 0.001) independent of age, Karnofsky Performance Status score, tumor location and volume, extent of resection, standard combined chemoradiotherapy, levetiracetam use, and MGMT promoter methylation.Discussion: The progression of tumor-related epilepsy with the evolution of glioblastoma, IDH-wild-type and the effects of surgery on seizure control argue for proper antiseizure medication and maximal safe resection. Tumor-related epilepsy is an independent predictor of a longer survival
Addressing the problem of the LIGO–Virgo–KAGRA visibility in the scientific literature
No full textInternational audienceAs members of the Virgo Collaboration—one of the large scientific collaborations that explore the universe of gravitational waves together with the LIGO Scientific Collaboration and the KAGRA Collaboration—we became aware of biased citation practices that exclude Virgo, as well as KAGRA, from achievements that collectively belong to the wider LIGO/Virgo/KAGRA Collaboration. Here, we frame these practices in the context of Merton’s “Matthew effect”, extending the reach of this well-studied cognitive bias to include large international scientific collaborations. We provide qualitative evidence of its occurrence, displaying the network of links among published papers in the scientific literature related to Gravitational Wave science. We note how the keyword “LIGO” is linked to a much larger number of papers and variety of subjects than the keyword “Virgo”. We support these qualitative observations with a quantitative study based on a year-long monitoring of the relevant literature, where we scan all new preprints appearing in the arXiv electronic preprint database. Over the course of one year, we identified all preprints failing to assign due credits to Virgo. As a further step, we undertook positive actions by asking the authors of problematic papers to correct them. Here, we also report on a more in-depth investigation which we performed on problematic preprints that appeared in the first three months of the period under consideration, checking how frequently their authors reacted positively to our request and corrected their papers. Finally, we measure the global impact of papers classified as problematic and observe that, thanks to the changes implemented in response to our requests, the global impact (measured as the number of citations of papers which still contain Virgo visibility issues) was halved. We conclude the paper with general considerations for future work in a wider perspective
Finite-frequency prethermalization in periodically driven ergodic systems
No full textInternational audienceWe investigate the periodically driven dynamics of many-body systems, either classical or quantum, finite-dimensional or mean-field, displaying an unbounded phase-space. We find that the inclusion of a smooth periodic drive atop an otherwise ergodic dynamics leads to a long-lived prethermalization, even at moderate driving frequencies. In specific asymptotic limits, we compute the corresponding prethermal Hamiltonian from an analytical perturbation scheme
Thunks and Debits in Separation Logic with Time Credits
No full textInternational audienceA thunk is a mutable data structure that offers a simple memoization service:it stores either a suspended computation or the result of this computation.Okasaki (1999) presents many data structures that exploit thunks to achievegood amortized time complexity. He analyzes their complexity by associating adebit with every thunk. A debit can be paid off in several increments; a thunkwhose debit has been fully paid off can be forced. Quite strikingly, a debit isassociated also with future thunks, which do not yet exist in memory. Some ofthe debit of a faraway future thunk can be transferred to a nearer futurethunk. We present a complete machine-checked reconstruction of Okasaki'sreasoning rules in Iris$, a rich separation logic with time credits. Wedemonstrate the applicability of the rules by verifying a few operations onstreams as well as several of Okasaki's data structures, namely thephysicist's queue, implicit queues, and the banker's queue
Compact fermionic quantum state preparation with a natural-orbitalizing variational quantum eigensolving scheme
No full textAssemblies of strongly interacting fermions, whether in a condensed-matter or a quantum chemistry context, range amongst the most promising candidate systems for which quantum computing platforms could provide an advantage. Near-term quantum state preparation is typically realized by means of the variational quantum eigensolver (VQE) algorithm. One of the main challenges to a successful implementation of VQE lies in the sensitivity to noise exhibited by deep variational circuits. On the other hand, sufficient depth must be allowed to be able to reach a good approximation to the target state. In this work, we present a refined VQE scheme that consists in topping VQE with state-informed updates of the elementary fermionic modes (spin-orbitals). These updates consist in moving to the natural-orbital basis of the current, converged variational state, a basis we argue eases the task of state preparation. We test the method on the Hubbard model in the presence of experimentally relevant noise levels. For a fixed circuit structure, the method is shown to enhance the capabilities of the circuit to reach a state close to the target state without incurring too much overhead from shot noise. Moreover, coupled with an adaptive VQE scheme that constructs the circuit on the fly, we evidence reduced requirements on the depth of the circuit as the orbitals get updated
Transient brain activity dynamics discriminate levels of consciousness during anesthesia
No full textInternational audience© The Author(s) 2024.The awake mammalian brain is functionally organized in terms of large-scale distributed networks that are constantly interacting. Loss of consciousness might disrupt this temporal organization leaving patients unresponsive. We hypothesize that characterizing brain activity in terms of transient events may provide a signature of consciousness. For this, we analyze temporal dynamics of spatiotemporally overlapping functional networks obtained from fMRI transient activity across different anesthetics and levels of anesthesia. We first show a striking homology in spatial organization of networks between monkeys and humans, indicating cross-species similarities in resting-state fMRI structure. We then track how network organization shifts under different anesthesia conditions in macaque monkeys. While the spatial aspect of the networks is preserved, their temporal dynamics are highly affected by anesthesia. Networks express for longer durations and co-activate in an anesthetic-specific configuration. Additionally, hierarchical brain organization is disrupted with a consciousness-level-signature role of the default mode network. In conclusion, large-scale brain network temporal dynamics capture differences in anesthetic-specific consciousness-level, paving the way towards a clinical translation of these cortical signature
Microglia maintain structural integrity during fetal brain morphogenesis
No full textInternational audienceMicroglia (MG), the brain-resident macrophages, play major roles in health and disease via a diversity of cellular states. While embryonic MG display a large heterogeneity of cellular distribution and transcriptomic states, their functions remain poorly characterized. Here, we uncovered a role for MG in the maintenance of structural integrity at two fetal cortical boundaries. At these boundaries between structures that grow in distinct directions, embryonic MG accumulate, display a state resembling post-natal axon-tract-associated microglia (ATM) and prevent the progression of microcavities into large cavitary lesions, in part via a mechanism involving the ATM-factor Spp1. MG and Spp1 furthermore contribute to the rapid repair of lesions, collectively highlighting protective functions that preserve the fetal brain from physiological morphogenetic stress and injury. Our study thus highlights key major roles for embryonic MG and Spp1 in maintaining structural integrity during morphogenesis, with major implications for our understanding of MG functions and brain development