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10722 research outputs found
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La satisfaction client entre socialisation des consommateurs et évaluation des salariés
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Transfer learning based solution for air quality prediction in smart cities using multimodal data
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Leveraging Perceiver IO for Efficient Compression of Temporal Signals A Memory Constrained Approach
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Approaches and challenges in identifying, quantifying, and manipulating dynamic mitochondrial genome variations
No full textInternational audienceMitochondria, the cellular powerhouses, possess their own unique genetic system, including replication, transcription, and translation. Studying these processes is crucial for comprehending mitochondrial disorders, energy production, and their related diseases. Over the past decades, various approaches have been applied in detecting and quantifying mitochondrial genome variations with also the purpose of manipulation of mitochondria or mitochondrial genome for therapeutics. Understanding the scope and limitations of above strategies is not only fundamental to the understanding of basic biology but also critical for exploring disease-related novel target(s), as well to develop innovative therapies. Here, this review provides an overview of different tools and techniques for accurate mitochondrial genome variations identification, quantification, and discuss novel strategies for the manipulation of mitochondria to develop innovative therapeutic interventions, through combining the insights gained from the study of mitochondrial genetics with ongoing single cell omics combined with advanced single molecular tools
Fibroblast activation and contractility on PEG-based hydrogels
No full textInternational audienceAs matrix stiffness has become a key factor in the differentiation of fibroblasts into cancer-associated fibroblasts (CAFs), soft polymer-based substrates have been now widely employed to study such kind of mechanotransduction processes [1,2]. We propose a parametric study based on the use of biocompatible coated PEG-based hydrogels of controllable stiffness to discern the role of stiffness on activation of fibroblasts [3]. These hydrogels are prepared via covalent cross-links between poly(L-lysine) dendrigrafts (DGL) and PEG-NHS, providing inherent cell functionalities to PEG-based hydrogels. The mechanical properties of our hydrogel was characterized using optical tweezers with micro-beads through (i) active microrheology to define the frequency-dependent viscoelastic modulus G(ω) and (ii) micro-indentation to measure the elastic moduli E. Two different subsets—normal fibroblasts (WPMY-1) and activated fibroblasts (exp-CAF1 [4])—were studied on viscoelastic hydrogels of varying DGL concentrations to mimic physiological and pathological conditions. The behaviour of these cells was analyzed through single cell tracking with combined epi-fluorescence and phase contrast imaging. This will be coupled with coatings of different ECM components (e.g., RGD, fibronectin, tenascin-C) to independently study their influence on activation and contractility
A Comprehensive Review of Predictive Maintenance Technologies for Vehicle Reliability
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Silicon nanocrystal slab optical waveguide by multi-energy ion implantation: Linear and nonlinear optical properties
No full textInternational audienceSilicon nanocrystals (Si-nc) have gained attention in optics and photonics research areas in recent years due to their advanced optical nonlinear properties. However, a nonlinear integrated optical platform that allows the fabrication of photonic devices with different Si-nc composition is yet under investigation. In this work, we experimentally demonstrated a nonlinear optical waveguide based on ion implantation that offers advantages in terms of material composition, low propagation losses, and enhanced nonlinear optical properties, such as a high nonlinear refractive index. In this work we present the fabrication of Si-nc containing waveguiding structures, and a study of their linear and nonlinear optical properties. Our nonlinear integrated optical platform presents a two-photon absorption coefficient β = 3.17 × 10−6 cm W−1 and a nonlinear refractive index n2 = 1.19 × 10−10 cm2 W−1, which shows potential applications in all-optical signal processing devices, such as single-photon sources
Stratégies issues de la base de la pyramide pour la conception durable
No full textInternational audienceLa crise sanitaire a exigé des réponses urgentes dans le monde entier. Elle a montré que, pour surmonter les défis de la pandémie, les processus d'innovation traditionnels doivent s'adapter aux restrictions contextuelles, au manque de temps et de ressources. Dans les pays à faibles revenus (Base de la Pyramide) en plus de ces restrictions, la COVID-19 n’a fait qu’imposer des problèmes supplémentaires à ceux existant sur l’environnement, la justice et l'équité sociale. Cependant, dans ces contextes, un nombre important de solutions créatives, rapides, appropriées et peu coûteuses ont également été déployées pour affronter la pandémie. Pour illustrer cela, nous analysons deux cas sur l'accès à l'eau comme stratégie d'hygiène-prévention et deux sur le développement de prototypes médicaux. Les solutions ont des attributs centrés sur l’élimination des caractéristiques et des exigences non essentielles. Les innovateurs s'efforcent à l'utilisation des technologies, des techniques et des ressources locales disponibles. Les processus sont fortement motivés et axés sur les relations de confiance et d'engagement social. Que cette approche soit appelée frugale, jugaad, grassroots, etc. il est clair que, par nécessité, les innovateurs ont développé des moyens pour mener l'invention, le test et de déploiement de solutions. Ces expériences pourraient offrir des perspectives alternatives pour enrichir les efforts internationaux dans la conception et l'innovation durables post-COVID-19
Strain-sensitive optical properties of monolayer tungsten diselenide
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