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Crystal Structures and Biological Profiles of Novel Tridentate Schiff Bases Nickel (II) Complexes
No full textNovel bioactive ternary nickel (II) complexes, [Ni(5BrSal-Phe)(phen)] (1) and [Ni(5BrSal-Tyr)(phen)] (2) (5BrSal-Tyr: Schiff base derived from 5-bromosalicylaldehyde and L-tyrosine, 5BrSal-Phe: Schiff base derived from 5-bromosalicylaldehyde and L-phenylalanine, phen: 1,10-phenanthroline), have been synthesized and characterized by electronic absorption spectroscopy, CHN, FTIR, ESI-MS and X-ray crystallography techniques. Interaction of the complexes with biomolecules (calf thymus DNA (CT-DNA) and bovine serum albumin (BSA)) has been investigated by electronic absorption and fluorescence spectroscopy. The results show that the complexes can bind to CT-DNA via a minor groove binding mode. Moreover, the fluorescence quenching mechanism between the complexes and BSA is a static quenching process. The antiproliferative activities of the complexes against breast cancer cells (MCF-7 and MDA-MB-231) and healthy breast epithelial cells (MCF-10A) were investigated. The complex 2 was found to have promising antiproliferative activity in selected cell line, with lower IC50 values than cisplatin. Molecular docking studies suggest that the complexes may serve as potential chemotherapeutic agents. These complexes have been observed to interact with various targets within cells, including the epidermal growth factor receptor (EGFR), bovine serum albumin (BSA), and B-DNA. Analyses indicate that these interactions are supported not only by conventional hydrogen bonds but also van der Waals forces and π-π interactions. Additionally, determining binding constants and regions enhances our understanding of how the complexes interact with target molecules. The results emphasize the importance of the complexes in cancer therapy by highlighting the necessity of understanding their molecular-level interactions with targets
Buji Ateşlemeli Benzinli Bir Motorda İzobütanol ve Etanol Katkılarının Yanma Karakteristiklerine Etkisinin İncelenmesi
No full textDünyada içten yanmalı motorların kullanımındaki artışa paralel olarak yükselen zararlı emisyon değerlerini azaltmak amacıyla, yakıt içeriklerine biyolojik kaynaklı ve fosil yakıtlara kıyasla daha az zararlı olan alkol yakıtların katkı olarak katılması yaygın bir durumdur. Bu çalışmanın amacı, buji ateşlemeli (SI) direkt enjeksiyonlu bir motorda kritik bir oran olan hacimce %30 alkol içeren benzin karışımları kullanarak alkol katkılarının yanma parametreleri ve motor performansı üzerindeki etkilerini deneysel olarak incelemektir. Çalışma kapsamında gerçekleştirilen motor testleri tam yük ve sabit devir değerlerinde gerçekleştirilmiştir. Bu testler sonucunda, benzine eklenen alkol katkılarının yanmayı hızlandırdığı ve silindir içi basıncı yükselttiği belirlenmiştir. Ortalama indike efektif basınç (IMEP) değerlerinde saf ve alkol katkılı benzin karışımları arasında önemli bir farklılık olmamakla beraber, alkol katkılarının eklendiği yakıt karışımlarında yanmanın daha düzensiz olması dezavantajı mevcuttur. Alkol katkılı benzin karışımlarında motorun ürettiği güç ve tork değerlerinde artış meydana gelmiştir. Ayrıca benzine katılan alkol katkıları egzoz gazı sıcaklığının düşmesini sağlamıştır.In parallel with the increasing use of internal combustion engines worldwide, it has become common practice to add biologically derived alcohol fuels considered less harmful compared to fossil fuels as additives to conventional fuels in order to reduce harmful emission levels. The aim of this study is to experimentally investigate the effects of alcohol additives on combustion parameters and engine performance by using gasoline blends containing 30% alcohol by volume, a critical ratio, in a spark-ignition (SI) direct-injection engine. Engine tests were conducted at full load and constant engine speed conditions. The results indicated that the addition of alcohol to gasoline accelerated combustion and increased in-cylinder pressure. Although there was no significant difference in the mean indicated effective pressure (IMEP) values between pure gasoline and alcohol–gasoline blends, alcohol additives showed partial disadvantages due to combustion irregularities. On the other hand, increases in engine power and torque were observed with alcohol–gasoline blends. Furthermore, the addition of alcohol contributed to a reduction in exhaust gas temperature.</p
Role of Electrospun Scaffolds at Different Stages of Wound Healing: Advancements, Challenges, and Future Directions
No full textThe wound healing process involves several intricate and overlapping phases, including hemostasis, inflammation, proliferation, and remodeling. These phases are critical for effective healing. However, conventional wound healing methods often face limitations that lead to insufficient tissue regeneration. Recent advancements in electrospun nanofibers present a promising approach that could address challenges by exhibiting properties that closely mimic the extracellular matrix (ECM) and facilitate cell adhesion, proliferation, and migration. This review explores the role of electrospun fibrous biomaterials at various stages of wound healing, highlighting their potential to enhance each phase through tailored biocompatibility, drug delivery capabilities, and mechanical support. Similarly, we discuss where electrospun scaffolds have demonstrated effectiveness in delivering growth factors, controlling inflammation, and promoting angiogenesis, thereby accelerating tissue repair. However, challenges remain, including the scalability of production and ensuring long-term efficacy in clinical settings. In conclusion, we suggest future research directions that emphasize optimizing fiber composition, exploring novel materials, and developing multifunctional scaffolds to improve outcomes in acute and chronic wounds. Ultimately, integrating electrospun nanofibers into clinical practice could revolutionize wound care, offering enhanced healing solutions for patients
Anonim ve Limited Şirketlerin Anasözleşmelerinde Kurumsal Sürdürülebilirliğe İlişkin Kayıtlara Yer Verilmesi: Emredici Hükümler İlkesi ve Ticaret Sicili Müdürünün İnceleme Görevi Kapsamında Bir Değerlendirme
No full textKonut Üretiminde Açık Uçlu Tasarım İçin Bir Arayüz: Uyarlanabilirlik Bağlamında Yeşilköy Konutlarının Analizi
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