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Assessment of characteristics and treatment patterns of adult patients with acquired aplastic anemia in Turkiye (PLANE-TR)
No full textAcquired aplastic anemia (AA) is a rare blood disorder causing hypocellular bone marrow due to immune damage to hematopoietic stem cells, leading to low blood cell counts. This study investigates the demographics, treatment patterns, and clinical outcomes of AA in Turkiye. In this non-interventional, retrospective descriptive study, data of 274 patients (Female/Male: 4/5) diagnosed with AA between September 1, 2011, and September 1, 2021, were collected from 16 centers. Severe and very severe AA was diagnosed in 72% and 27.7% of patients, respectively. The mean time from diagnosis to first treatment was 119 ± 287 days, while time to hematopoietic stem cell transplantation (HSCT) was 212 ± 321 days, and to Anti-Thymocyte Globulin (ATG) was 87 ± 242.5 days. The mean time to response after first-line and second-line treatment was 172.9 ± 264.6 days and 191.9 ± 211.9 days, respectively. The mean overall survival of patients with AA was 3.56 ± 3.12 years, with a 5-year overall survival rate of 72.6%. HSCT and other initial treatments led to full or partial remission for most patients, improving survival rates for over half of them. The study observed comparable patterns to previous studies, providing vital insights into Turkiye’s acquired AA treatment landscape
Clinical and Mycological Profiles of Chronic and Recalcitrant Dermatophytosis: Türkiye, 2022–2024
No full textThis study investigated the treatment outcomes of 91 patients with chronic and recalcitrant dermatophytosis from 20 hospitals in Türkiye between June 2022 and March 2024, as well as the in vitro antifungal susceptibility and squalene epoxidase (SQLE) substitution profiles of the dermatophytes obtained from these patients. Molecular identification by sequencing 91 isolates, revealed 76 Trichophyton mentagrophytes ITS genotype VIII (TmVIII; also known as T. indotineae) isolates, 13 Trichophyton rubrum, one Trichophyton tonsurans, and one Microsporum canis. The Phe397Leu substitution predominated in the SQLE, and Tyr414His co-occurred in nine TmVIII isolates. Five novel substitutions were observed in TmVIII. Among 13 T. rubrum isolates, three showed different SQLE substitution patterns compared to the wild-type strain. EUCAST antifungal susceptibility testing revealed high minimum inhibitory concentrations (MICs) for terbinafine (TRB) (> 0.25 mg/L) and for fluconazole (FLZ) (≥ 16 mg/L), indicating resistance in most TmVIII isolates. Of the 91 patients, 83 responded to FLZ, itraconazole (ITZ), TRB, or voriconazole-based regimens. While adjunct therapy with FLZ and resveratrol (RES) led to improvement in 28/29 patients despite their high in vitro inhibition concentrations, ITZ and curcumin (CUR) therapy was successful in 3/3 patients. However, the in vitro efficiency of CUR could not be evaluated. These findings highlight the local occurrence of specific SQLE substitutions, underscore the importance of EUCAST MIC testing combined with SQLE sequencing for surveillance, and support further evaluation of RES and CUR as an adjunct in TRB-resistant TmVIII
Predictive maintenance in aircraft engine maintenance using the C-MAPSS dataset: performance comparison and evaluation of machine learning classification algorithms
No full textSynthesis of Glycerin Carbonate by an Environmentally Friendly Novel Catalytic Membrane of Poly(vinyl alcohol)/Deep Eutectic Solvent
No full textThe impact of epicardial adipose tissue quantification by computed tomography on predicting postoperative outcomes in coronary artery bypass grafting surgery.
No full textKOCAELİ ÜNİVERSİTESİ TIP FAKÜLTESİ'NDE ÇALIŞMAKTA OLAN ASİSTAN HEKİMLERİN ÜRETKEN YAPAY ZEKÂ ARAÇLARINI KULLANIM VE YETERLİK DÜZEYLERİNİN DEĞERLENDİRİLMESİ
No full textAssessing the impact of potential energy wealth on Türkiye's non-energy sectors: a CGE model approach
No full textT & uuml;rkiye's high dependence on energy imports has negative effects on the foreign trade balance and fluctuations in energy prices directly affect the economic structure. As a result of increased hydrocarbon exploration activities in recent years, oil and natural gas reserves have been discovered in the Black Sea and Southeastern Anatolia regions and production has started. This study analyses the economic changes that may occur if T & uuml;rkiye transforms from an energy dependent economy to an energy exporting country. Simulations using a Computable General Equilibrium (CGE) model show that the increase in energy production leads to a loss of output in the agricultural and industry sectors while stimulating the growth of the services sector. The shift of production factors from industry to the services sector can lead to an economic imbalance known as the Dutch disease. This leads to an increase in imports and a decrease in exports, weakening the competitiveness of the industry sector. However, these negative effects can be avoided if energy revenues are allocated to productivity-enhancing investments in the industry sector instead of being channeled directly to public expenditures. According to the simulation results, a productivity increase of at least 16% is required for the industry sector to maintain its export level. The study reveals that channeling energy revenues to long-term strategic investments is critical for the sustainable growth of the T & uuml;rkiye's economy. In particular, investing in innovative sectors such as artificial intelligence, microchip production and renewable energy can strengthen economic stability by increasing global competitiveness
An Interactive Digital Image Processing Course Utilizing Tools in the Jupyter Ecosystem
No full textThis paper proposes a course designed for engineering students about digital image processing using tools from the Jupyter ecosystem, including Jupyter Notebooks, JupyterHub, and Jupyter Widgets. The course integrates theoretical concepts with different practical applications through project work and real-world case analysis to ensure involvement and comprehension. Jupyter Widgets represent one of the main features of the course and enable interactive learning through data manipulation capabilities that create dynamic visualizations. Two other important components of the course are case studies and projects. These components teach students how to solve real-world image processing problems and strengthen their problem-solving skills. Additionally, regular exercises reinforce learning and ensure that students can apply theoretical knowledge in practical scenarios. While a survey conducted among participants indicated a generally positive reception, the focus on Jupyter tools and real-world applications was particularly appreciated, demonstrating the course's success in bridging the gap between theory and practice. Future iterations of the course will continue to build on these strengths, further enhancing the educational experience and better preparing students for professional careers in engineering
Psychometric Evaluation of Turkish Versions of the Perceived Control in Childbirth Scale and the Satisfaction With Childbirth Scale in Turkish Women
No full textAIM: This study was performed to test the validity and reliability of the translated Turkish version of the Perceived Control in Childbirth Scale (PCCh) and the Satisfaction with Childbirth Scale (SWCh) in Turkish women. BACKGROUND: Childbirth control and childbirth satisfaction are interrelated issues, which are extremely important for improving childbirth environments. However, although there are several birth satisfaction scales in Turkey, there is no tool to measure the perception of control during birth. METHODS: This study was conducted with the participation of 320 individuals using a cross-sectional and descriptive design. Data were collected using a Participant Information Form, the PCCh, the SWCh and, as a parallel form, the Birth Satisfaction Scale-Revised. Factor analyses, Cronbach's alpha coefficient and item-total score correlation tests were used to analyse the data. RESULTS: The Turkish form of the PCCh consisted of 12 items and two dimensions that explained 58% of the total variance in the measured variable. Cronbach's alpha coefficient for the scale in Turkish was found to be 0.90. The Turkish form of the SWCh consisted of seven items and a single dimension that explained 74% of the total variance in the measured variable. Cronbach's alpha coefficient for the scale in Turkish was found to be 0.94. CONCLUSIONS: The PCCh and the SWCh are valid and reliable instruments for measuring perceived control in childbirth and satisfaction with childbirth in Turkish women