Kurdistan Journal of Applied Research (KJAR)
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Oxidative Stress and Its Association with COVID-19: A Narrative Review
Get PDFThe naturalness of severe acute respiratory syndrome coronavirus 2 infections (SARS-Cov-2) appears to impact the respiratory system and lungs, however, the etiology of many cases exhibited several various features of the disease. The Coronavirus disease 2019 (COVID-19) symptoms are not limited to the virus’s first definitions. This review gathered the contemporary information throughout PubMed, Scopus, and Science Direct databases regarding possible effects of the virus in generating reactive oxygen species and causing oxidative stress. However, this ensures a hypothesis for now, yet from the literature and incidence of COVID-19 symptoms along with comorbidities we can observe the potentials of the virus in the generation of oxidative stress. Especially the virus’s route to cell entry via angiotensin-converting enzyme 2 (ACE2) receptor is well known that leads to pathogenesis in angiotensin II (AT II) which are critical in NADH/NADPH oxidase inducing ROS generation. Moreover, the virus’s activity to replicate seems to be reduced in high antioxidant glutathione level concentrations. The outcome of the review proposes a hypothesis that COVID-19 is associated with reactive oxygen species and its comorbidities mostly joined with oxidative stress including hypertension, cardiovascular, thrombosis, obesity, and diabetes besides of chronic obstructive pulmonary disease and asthma
Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis
Get PDFCOVID-19 is the deadly respiratory disease of the century caused by new type unknown origin Coronavirus. The recent effort of the word researchers is toward finding the origin of the virus. The current study investigated the extent of molecular similarity and divergence between SARS-CoV2 and other related Coronavirus. An attempt has been made to investigate the epidemiological study of this new contagious virus using molecular biology techniques. The phylogenetic trees for all human coronaviruses with the novel Coronavirus have been built using a several complete amino acid sequences of the four known structural proteins, S (spike), E (envelope), M (membrane), and N (nucleocapsid). The result of the study revealed that the SARS-CoV2 is related to human SARS-CoV isolated from different countries very cloely, especially those strains recovered from China in recent times, 2020. The evolutionary changes observed in the inserted 23 amino acids in the RNA binding domain (RBD) of the coronvirus spike glycoprotein which cannot be detected in any other human coronavirus. Moreover, the 2019-nCoV is not closely related to other alpha, beta and gamma human Coronavirus, including MERS-CoV. The current study concluded that 2019-nCoV is more likely believed to originated from SARS-CoV. The probability is more vital to be originated from the strain isolated in China in 2020, which is coincident with the spraed of COVID-19 in the same country. The phyloepidemiologic analyses suggested that the coronaviruses are circulating in human hosts evolving gradually by times in response to the different environment stimuli facing the virus inside the host in different geographical areas. Furthermore, the analysis showed the flow of transmission, and evolutionary changes of SARS-CoV2 which may be directed from the transmission of SARS-CoV from human to Bat and Pangolin then jumped to human again in the crowded market Wuhan city in China
Comparative Study of Cervical Pap Smear and Visual Inspection of The Cervix To Detect Premalignant Disease of The Cervix
Get PDFThe goal of current study is to compare visual inspection method of the cervix by using acetic acid sensitivity, specificity, positive and negative predictive values with Pap smear test values. This cross sectional study was obtained in Sulaimani city Kurdistan region at Maternity Teaching Hospital throughout the period (first September 2012) to (first February 2001). This study include 115 samples were reproductive women and premenopausal between ages 20-50 years old with symptomatic women ( vaginal discharge, dyspareunia, post coital bleeding , intermenestrual bleeding ) and prepared patients for a Pap smear test done for them. The cervix was painted with 5% concentration of acetic fluid for visual inspection method and monitored for aceto-white wounds and biopsies were taken from suspected areas. After that, the samples in 95% concentration of the ethyl alcohol were fixed. The results shows that, 114 samples among all other samples were appropriate for analyzing, statistical data analyzed by Epi Info software program and Chi-squared test used to find significance between variables with considering P-value less or lower than 0.05 as significant level. The result indicate that sensitivity rate was 16% for visual inspection method, specificity 71%, positive predictive value 3.13% and negative predictive value 93.9% to detect pre-cancerous lesion of the cervix. In conclusion, cervix visual inspection method for cancer had a low rate sensitivity compare with pap smear with a non-significant relationship between the two methods and Pap smear needed to conform visual inspection for cervical cancer
An Overview on The Pandemic Coronavirus Disease 2019 (COVID-19) Outbreak
Get PDFThe current review covered most of the researches have been done since the new coronavirus found in Wuhan city of China at the end of December 2019 up to date by considering the most beneficial ones for our society. The severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2 is a virus that potentially acts on the human respiratory system. It is first found in animal then transmitted into human. The virus can be transmitted between human to human via close contact or from the tiny droplet while coughing or sneezing. WHO characterized the situation by pandemic global concern because the virus spread over 200 territories and more than millions peoples were infected and over two hundred thousand people deceased as a result of COVID-19. At the moment nothing can stop the virus from spreading, neither vaccine nor medicines were found to stop the virus and secure life of people of the planet. The aim of the present review was to show the main feature of the SARS-CoV-2 and to find the common statements between the previously published studies on the output of their works. The other objective of this review was to encourage publics to treat the virus in safe way based on the discovery by researchers toward secure life of million peoples that could be infected by the 2019 new coronavirus. This review were summarized several researches about the SARS-CoV-2 since its appearance to present time May 2020. Several reports from WHO, CDC and FDA were included about spreading or the way of transmission, causes, prevention, diagnosis and risk factors of the COVID-19. The current review find the common statements about different aspects of the 2019 new coronavirus that could be help the new research to benefit from these statement for further investigations. This review showed that urgent steps for the current time to secure life of millions peoples is to quarantines people at home and governmental authorities have to take the responsibilities of this steps and to encourage people to stay at home and teach them the self-prevention is a better treatment for all humanities
Designing a Framework to Control ?the Spread of Covid-19 by Utilizing ?Cellular System
Get PDFNowadays coronavirus (Covid-19) has become a concerning issue in the world, according to WHO latest report more than 8,000000 of people in our planet have been infected and more than 400000 of people have died until the writing of this paper. Everybody on this planet is exposed to get this pandemic. Scientists, organizations, governments, and universities around the world endeavor to ?find proper solutions to control the spread ?of covid-19. Thus, the aim of this paper is to propose an applicable framework to control the spread of Covid-19 by utilizing Cellular System. This is done by Haversine formula to calculate the distance between mobile phones based on cell towers. And it can also be fulfilled via designing a framework which is composed of four phases. Phase 1, deals with distance calculation and data collection about the infected and suspected persons. Then in phase 2, the Authorized Clinical Center (ACC) delivers the ID of the infected person to the Telecom Company (TC) to gather information about the unknown suspected persons. In turn, phase 3 diagnoses the infected persons and informs them to visit the ACC. In the last phase, the suspected persons are tested and the infected ones are recognize.
 
Investigation of Enterotoxigenic Coagulase-negative Staphylococci Isolated from Local and Imported Dairy Products; a Microbiological Study
Get PDFCoagulase negative staphylococci (CNS) have been recorded as a conveying vector for virulence genes and have been implicated in some cases of food poisoning. Research interest in CNS has increased over the past decade following their implication in infections in animals and humans. This study was aimed to detect CNS isolated from 150 dairy products (yoghurt, several types of cheese, Lork, and Serezh) in Sulaimani and Halabja governorate. Thirteen isolates out of 150 samples were identified as CNS using the VITEK® 2 system as an identification method. Results revealed that the most common isolates species including Staphylococcus saprophyticus, Staphylococcus sciuri and Staphylococcus xylosus each species have been identified in 3 samples separately (23%), followed by Staphylococcus vitulinus was in 2 samples (15%), Staphylococcus equorum found in 1 sample (8%), and Staphylococcus gallinarum also was in one sample (8%). The isolated CNS did not have enterotoxins type A to E according to RIDASCREEN kit test. Studying the growth limits of S. saprophyticus and S. vitulinus results showed that S. saprophyticus grew better at pH levels (5,6,7) at (25?,37?) and low NaCl concentration (5%), while low bacterial activity was observed at pH 4 at all temperatures and NaCl concentrations and also at 4? at all pH and NaCl levels. S. vitulinus behaviour was almost the same as S. saprophyticus but, S. vitulinus was able to tolerate different NaCl concentrations and overall had higher bacterial activity in all parameter’s interactions than S. saprophyticus. Investigating the effect of acetic acid and lactic acid on the growth of previous species where studied, S. saprophyticus grew better in different concentrations of L.A but S. vitulinus showed more activity than S. saprophyticus in A.A and the growth of both species inhibited at 0.4% of L.A at the first 24 hours of incubation
Epidemiology and Molecular Aspect of pediculosis among Primary School Children in Sulaimani Province Kurdistan-Iraq
Get PDFPediculosis is the term for head lice (Pediculus humanus capitis) and the other hairy parts infestation with any stages of lice. The lice is a human blood sucking ecto-parasite which can cause severe itching. Direct contact, Sharing of clothing and combs can be a way for lice transmission from infected person to another.This study had been done to determine the pediculosis infection rate and risk factors asociassion with head lice among primary schools children in Sulaimani Province, all cases were evaluated by physical examination (visual inspection) and detail structured questionnaire which was including education levels, family size, hair washing frequency, type and length of hair, mother occupation and education, father occupation, and education was used, the polymerase chain reaction (PCR) used for confirming the head lice clade. A total of 4087 students was inspected from 13 primary schools in Sulaimani city, with the overall prevalence of 8.3%, The participants were 2046 males and 2041 females with prevalence 2.20% and 6.1% respectively. The age of respondents was between 5-13 years. The prevalence was higher in large family members in comparing to those with small family members. The amplicons product from Polymarase chain Reaction was visualized on 1.5% agarose gel, and expected DNA band size of head lice's was approximately 486 bp which confirms that these lice's belong to the head lice group clade A . In conclusion the school aged children in Sulaimani province were suffering from peiculosis with high prevalence rate and it has a direct impact on children cognitive and school activity performance
Characterization of Vaginitis Among Women Complaining of Genital Tract Symptoms
Get PDFVaginitis is the inflammation of the vagina as a result of a change in the balance of normal flora affecting women of reproductive age. It is one of the most frequent reasons that women visit clinics. The objective of this study was to determine the importance of laboratory diagnosis methods in the treatment of the disease and to study the symptoms and risk factors associated with vaginitis among women with genital tract symptoms. Vaginal swabs were collected from 50 women attending Maternity hospital and Chwarchra dormitory camps in Sulaimani city. Samples were examined microbiologically and causative agents were isolated. All relevant clinical information such as patient demographic profiles, socioeconomic variables, risk factors and symptoms have been collected by questionnaire based study. Different species of microorganisms were isolated from vaginal samples including yeast and bacteria. Culture analysis and gram stain had shown that bacterial vaginosis was 22%, while the rate of yeast infection was 16%. The higher percentage was 62% for the normal flora (Lactobacillus). Microscopic examination of patient’s vaginal swabs revealed that 63.6% of infectious group had high level of epithelial cells (>10), while the most patients with non-infectious vaginitis had (10) or less epithelial cell in the microscopic field. The presence of epithelial cell was significantly associated with infectious vaginitis (p-value 0.04). Most patients were aged between 25-35 years. The result showed a significant association between infectious vaginosis with education level (p-value 0.02). The most common symptom present among patients with infectious vaginitis group was itching (38.5%) and smelly discharge (40%). The majority of women had history of previous infections in both infectious and non-infectious vaginitis groups. Furthermore, there was different types of vaginitis including infectious vaginitis (bacterial and yeast infection) and non-infectious vaginitis. Therefore, it is essential to perform laboratory examination for the patients to detect the causative agents of vaginitis, and ensure the most appropriate treatment can be administered. In addition, the treatment of vaginitis can be done by topical application of Lidocaine 5% ointment (as a local anesthetic) nightly for seven weeks has been shown to decrease the pain of vaginitis in women.  
A Novel Approach for Stock Price Prediction Using Gradient Boosting Machine with Feature Engineering (GBM-wFE)
Get PDFThe prediction of stock prices has become an exciting area for researchers as well as academicians due to its economic impact and potential business profits. This study proposes a novel multiclass classification ensemble learning approach for predicting stock prices based on historical data using feature engineering. The proposed approach comprises four main steps, which are pre-processing, feature selection, feature engineering, and ensemble methods. We use 11 datasets from Nasdaq and S&P 500 to ensure the accuracy of the proposed approach. Furthermore, eight feature selection algorithms are studied and implemented. More importantly, a feature engineering concept is applied to construct two new features, which are appears to be very auspicious in terms of improving classification accuracy, and this is considered the first study to use feature engineering for multiclass classification using ensemble methods. Finally, seven ensemble machine learning (ML) algorithms are used and compared to discover the ultimate collaboration prediction model. Besides, the best feature selection algorithm is proposed. This study proposes a novel multiclass classification approach called Gradient Boosting Machine with Feature Engineering (GBM-wFE) and Principal Component Analysis (PCA) as the feature selection. We find that GBM-wFE outperforms the previous studies and the overall prediction results are auspicious, as MAPE of 0.0406% is achieved, which is considered the best result compared to the available studies in the literature
Promoting Walkability in Streets: Analytical Study of Salem Street, Sulaimani, Iraq
Get PDFWalking represents a vital transport system for people to maintain balanced and healthy lifestyles and to improve the environmental conditions. Within a contemporary metropolitan society, other means of transport are often preferred. The presented paper aims to examine the methods of how to encourage people to walk. By organizing it into three main sections to begin with, the work of in order to investigate the nature of the metropolitan individual and the contemporary society. The second section builds on the outcomes of the first section. Hence it provides a clear rationale for the adoption of strategies that would encourage people to walk. Salim Street which is one of the important and vibrant streets inside Sulaimani city is being chosen for this study, its possibility to be a walk able street is analyzed. The third section provides practical solutions and steeps on how to promote walking among the contemporary society. then, a brief conclusion summarizes the key arguments encompassed in the presented paper and draws wider implications and recommendations for city planners to build more pedestrian friendly streets