HAL Université des Antilles
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BCL-B Promotes Lung Cancer Invasiveness by Direct Inhibition of BOK
No full textInternational audienceExpression of BCL-B, an anti-apoptotic BCL-2 family member, is correlated with worse survival in lung adenocarcinomas. Here, we show that BCL-B can mitigate cell death initiation through interaction with the effector protein BOK. We found that this interaction can promote sublethal mitochondrial outer membrane permeabilization (MOMP) and consequently generate apoptosis-flatliners, which represent a source of drug-tolerant persister cells (DTPs). The engagement of endothelial-mesenchymal-transition (EMT) further promotes cancer cell invasiveness in such DTPs. Our results reveal that BCL-B fosters cancer cell aggressiveness by counteracting complete MOMP
Mapping the city's trajectory for climate change adaptation: mapping territorial evolution, politics will and planning regulations
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Submarine cables feel the heat from global warming
No full textInternational audienceLong-term environmental monitoring of the deep ocean environment is crucial for better understanding the feedback processes between the oceans and Earth’s climate in the face of global warming. However, obtaining in-situ observations from the deep seafloor is difficult and costly. Use of laser reflectometry in optical fibers using existing submarine telecommunication cables can help bridge this knowledge gap. We performed distributed thermal sensing (using the Brillouin Optical Time Domain Reflectometry technique) on a network of commercially operating telecom cables connecting the islands of the Guadeloupe archipelago in water depths of 10 - 700 m. Monitoring at regular 6 month intervals over the past 2.5 years reveals a temperature change (delta T) of +1.3°C between June 2022 and late-May 2024 on the shallow carbonate platform (10 - 40 m water depth) south of Grande-Terre (Saint François), Guadeloupe. These sea-floor measurements are corroborated by satellite observations of the Sea-Surface-Temperature (SST) during the past three years, which document a similar (+1.3°C) temperature increase at the sea surface, in the same location (offshore Saint François). A smaller temperature increase (0.2 - 1.0°C) is observed in deeper waters (300 - 700 m) between the islands over the same period (June 2022 - late-May 2024). These results can open the path for widespread use of submarine cables for long-term environmental monitoring of the seafloor
Oceanic serpentinisation in the Samail ophiolites: evidence from trace elements and O and B isotopes
No full textInternational audienceOceanic serpentinisation represents a major link between the hydrosphere and the lithosphere, whereby aqueous fluids hydrothermally alter mantle rocks. The study of former oceanic lithosphere, now tectonically emplaced on land, can serve as a useful analogue to modern processes. In this study, we present the geochemical composition of serpentinised peridotites from the southern Samail ophiolites, a fast-spreading ridge axis active in the Neo-Tethys, in the Sumail and Wadi Tayin massifs. The combination of the fluid-mobile element (FME) composition, as well as O, B and Sr isotopes, of serpentine is utilised to decipher the source of the serpentinising fluid, which would constrain the loci of serpentinisation (i.e., oceanic domain, during obduction, after emplacement). The in situ analysis of the serpentine revealed FME contents ranging from 0.2 to 27.7 μg g-1B, 0.1-10.7 μg g-1 Sr, and 600-1800 μg g-1 Cl; high variability in δ18O values (+1.3 to +8.1 ‰); and δ11B ranging from +33 to +41 ‰ in one sample, and between +2 and +47 ‰ for two others. A comparison of the data with the geochemical characteristics of potential sources of the serpentinising fluid (e.g., seawater, hydrothermally-altered fluid, subducted-slab-derived fluid, meteoric water) has failed to provide any evidence indicative of serpentinisation with subducted slab-derived fluid or meteoric water. Conversely, the geochemical characteristics of serpentine indicate that serpentinisation most likely occurred on the ocean floor in proximity to the spreading ridge axis, subsequent to reaction with seawater and hydrothermally-altered fluid following interaction with the overlying oceanic crust. Furthermore, the range of measured δ11B in certain samples can be modelled on the basis of a twostep serpentinisation history in a closed system, at relatively low temperatures, calculated from the δ18O values (from 115 to 250°C). This study demonstrates the efficacy of combining multiple in situ geochemical tools to trace the history of serpentinisation, particularly in obducted ophiolite where hydrothermal alteration may could have occurred on multiple occasions
Evaluation de la Multiperformance des Agroécosystèmes bio de Karukéra en fonction de l’Intégration culture/élevage et de leur Biodiversité: Existe-il un niveau de biodiversité ou d’intégration cult./élev. au sein de l’agroécosystème bio qui optimise une/des performance(s) agroécologique(s)? Si oui, quels compromis?
No full textInternational audienceLe poster retrace les activités du consortium Makibio entre janvier 2024 et juin 2025
AquaEcOmics meeting: exploring aquatic ecology through omics. March 17-20, 2025. Program and abstracts booklet
No full textA meeting to explore aquatic ecosystems biodiversity, functionning and monitoring with eDNA and multi-Omics method
Les créoles à travers l'étude de textes anciens : avant propos, Olivier-Serge Candau & Béatrice Jeannot-Fourcaud (dir.), Les créoles à travers l'étude des textes anciens
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La dynamique d’échange des fluides maternels et sexuels dans la littérature etles arts de la créolité
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Metabolomic responses to shipping noise in early life stages of blue mussels, Mytilus edulis
No full textInternational audienceABSTRACT Anthropogenic ocean noise from shipping is steadily increasing, with a predicted doubling every 11.5 years, raising growing global concern about its potential effects on wildlife. There is evidence that anthropogenic noise can affect the behaviour and physiology of many species, but few examples of experiments that show how they may be affected. Here, we used metabolomics analyses to investigate the effects of shipping noise during the crucial early life stage of embryogenesis on a key ecosystem reporter species in the marine benthic system, the blue mussel, Mytilus edulis. We found that exposure to shipping noise provokes stress-induced inflammation, a metabolic imbalance or cellular stress as a result of increased energy demand, leading to disruption of glycolysis and increased oxidative stress response. The noise generated by cargo ships has a direct impact on the first developmental stage of mussel larvae, altering their metabolic pathways including those related to energy. Our study of an ecologically and socio-economically important taxon shows that anthropogenic noise can impair the individual performance of juvenile bivalve invertebrates. This impairment could have a significant cascading effect on population dynamics and resilience, with potential implications for community structure and function
Déchriffrer l’écriture de la ville caribéenne : quelques clés de lecture
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