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Treatment of Drug-resistant Tuberculosis with Bedaquiline in a High HIV Prevalence Setting: An Interim Cohort Analysis
No full textSouth Africa has a large burden of extensively drug-resistant tuberculosis (XDR-TB); only 15% of XDR-TB patients have successful outcomes
Task Sharing Within a Managed Clinical Network to Improve Child Health in Malawi
No full textEighty per cent of Malawi's 8 million children live in rural areas, and there is an extensive tiered health system infrastructure from village health clinics to district hospitals which refers patients to one of the four central hospitals. The clinics and district hospitals are staffed by nurses, non-physician clinicians and recently qualified doctors. There are 16 paediatric specialists working in two of the four central hospitals which serve the urban population as well as accepting referrals from district hospitals. In order to provide expert paediatric care as close to home as possible, we describe our plan to task share within a managed clinical network and our hypothesis that this will improve paediatric care and child health
Making Progress Towards Food Security: Evidence from an Intervention in Three Rural Districts of Rwanda
No full textDetermining interventions to address food insecurity and poverty, as well as setting targets to be achieved in a specific time period have been a persistent challenge for development practitioners and decision makers. The present study aimed to assess the changes in food access and consumption at the household level after one-year implementation of an integrated food security intervention in three rural districts of Rwanda
A cross-sectional study of indications for cesarean deliveries in Médecins Sans Frontières facilities across 17 countries
No full textTo review the major indications for cesareans performed by Médecins Sans Frontières (MSF) personnel from the Operational Center Brussels
Growth in Virologically Suppressed HIV-Positive Children on Antiretroviral Therapy: Individual and Population-level References.
No full textCombination antiretroviral therapy (ART) suppresses viral replication in HIV-infected children. The growth of virologically suppressed children on ART has not been well documented. We aimed to develop dynamic reference curves for weight-for-age Z scores (WAZ) and height-for-age Z scores (HAZ)
Risk factors and mortality associated with resistance to first line antiretroviral therapy: multicentric cross-sectional and longitudinal analyses
No full textUnderstanding the factors associated with HIV drug resistance development and subsequent mortality is important to improve clinical patient management
Drug-resistant tuberculosis in HIV-infected patients in a national referral hospital, Phnom Penh, Cambodia
Get PDFThere are no recent data on the prevalence of drug-resistant tuberculosis (DR TB) in Cambodia. We aim to describe TB drug resistance amongst adults with pulmonary and extra-pulmonary TB and human immunodeficiency virus (HIV) co-infection in a national referral hospital in Phnom Penh, Cambodia
Mycobacterium ulcerans treatment - can antibiotic duration be reduced in selected patients?
Get PDFMycobacterium ulcerans (M. ulcerans) is a necrotizing skin infection endemic to the Bellarine Peninsula, Australia. Current treatment recommendations include 8 weeks of combination antibiotics, with adjuvant surgery if necessary. However, antibiotic toxicity often results in early treatment cessation and local experience suggests that shorter antibiotic courses may be effective with concurrent surgery. We report the outcomes of patients in the Barwon Health M. ulcerans cohort who received shorter courses of antibiotic therapy than 8 weeks
Risk of death among those awaiting treatment for HIV infection in Zimbabwe: adolescents are at particular risk
Get PDFMortality among HIV-positive adults awaiting antiretroviral therapy (ART) has previously been found to be high. Here, we compare adolescent pre-ART mortality to that of adults in a public sector HIV care programme in Bulawayo, Zimbabwe