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Data för: Randomized trial of neoadjuvant palbociclib and endocrine therapy versus chemotherapy in ER+/HER2- breast cancer (PREDIX LumB): Primary analysis and development of the CDKPredX metagene predictor
No full textThe dataset contains whole-exome sequencing (WES) and RNA sequencing (RNA-Seq) FASTQ files derived from tumor tissue samples collected in the PREDIX Lum B clinical trial (prospective randomized phase II, ClinicalTrials.gov ID: NCT02603679) conducted at three hospitals in Sweden. In total, the dataset includes 166 WES samples and 163 RNA-Seq samples. For WES, matched normal blood samples are also included. Metadata file containing patient anonymized ID, treatment arm, gender, and the corresponding WES and RNA-seq sample anonymized IDs.
Files are organized by sequencing type (WES and RNA-Seq), plus a metadata table listing all variables: trial ID, gender, treatment arm, and associated file paths.
No specialized software is required to open the FASTQ files or metadata. Downstream analysis requires related bioinformatics tools.
The dataset consists of:
- 4,974 FASTQ files, compressed as GNU zip files
- 3 CSV files
- 1 readme file in TXT format
The total size of the dataset is approximately 7.6 TBDatasetet innehåller hel-exomsekvensering (WES) och RNA-sekvensering (RNA-Seq) i form av FASTQ-filer från tumörprover inom ramen för PREDIX Lum B-studien, en prospektiv randomiserad fas II-studie (ClinicalTrials.gov ID: NCT02603679) utförd vid tre sjukhus i Sverige. Totalt omfattar datasetet 166 WES-prover och 163 RNA-Seq-prover. För WES ingår även matchade normalprover från blod. Metadatan inkluderar anonymiserat patient-ID, behandlingsarm, kön, och korresponderande WES- och RNA-seq anonymiserade prov-IDn.
Filer är organiserade efter sekvenseringstyp (WES och RNA-Seq), samt en metadatafil med variabler: prövnings-ID, kön, behandlingsarm och filvägar.
Ingen särskild programvara krävs för åtkomst till FASTQ-filer eller metadata. Vidare analys kräver relaterade bioinformatik-verktyg.
Datasetet består av:
- 4 974 FASTQ-filer, komprimerade som GNU zip-filer
- 3 CSV-filer
- 1 readme-fil i TXT-format
Datasetets totala storlek är ca 7,6 TB
Obspack CH4 time-series result from Svartberget (85.0 m)
No full textThis data file contains high accuracy European ObsPack observational timeseries in netCDF format of ambient mole fraction of ch4 in dry air collected at Svartberget (85.0 m). The measurements were calibrated using the WMO GAW calibration scale WMO X2004A. Included are (all whenever available) historical PI QCed data, ICOS Level 2 data, ICOS FastTrack data and ICOS NRT data. It is part of the 2025.3 FastTrack update of the Globalview EU CH4 data product and is intended for use in carbon cycle inverse modeling, model evaluation, and satellite validation studies. Metadata for the full ch4 product release are available at https://commons.datacite.org/doi.org/10.18160/3TB5-D6TM. Please also visit http://www.gml.noaa.gov/ccgg/obspack/ for more information. If you use these data in your research, please consider citing the full ObsPack release that this file is part of (https://commons.datacite.org/doi.org/10.18160/46ST-DEVK).
ICOS RI, Larmanou, E., Marklund, P., Ottosson-Löfvenius, M., Smith, P. (2025). Obspack CH4 time-series result from Svartberget (85.0 m), 2017-05-31–2025-10-02, European ObsPack, https://hdl.handle.net/11676/11psU0cQc1k_ePRW37VciEY
Obspack CH4 time-series result from Hyltemossa (30.0 m)
No full textThis data file contains high accuracy European ObsPack observational timeseries in netCDF format of ambient mole fraction of ch4 in dry air collected at Hyltemossa (30.0 m). The measurements were calibrated using the WMO GAW calibration scale WMO X2004A. Included are (all whenever available) historical PI QCed data, ICOS Level 2 data, ICOS FastTrack data and ICOS NRT data. It is part of the 2025.3 FastTrack update of the Globalview EU CH4 data product and is intended for use in carbon cycle inverse modeling, model evaluation, and satellite validation studies. Metadata for the full ch4 product release are available at https://commons.datacite.org/doi.org/10.18160/3TB5-D6TM. Please also visit http://www.gml.noaa.gov/ccgg/obspack/ for more information. If you use these data in your research, please consider citing the full ObsPack release that this file is part of (https://commons.datacite.org/doi.org/10.18160/46ST-DEVK).
ICOS RI, Heliasz, M., Biermann, T., Molder, M. (2025). Obspack CH4 time-series result from Hyltemossa (30.0 m), 2016-12-13–2025-10-02, European ObsPack, https://hdl.handle.net/11676/sKEJar9ZUAHDQ0owXGYEpJA
HUMMUS - Den Musicerande Människan 2
No full textHUMMUS is a follow-up to Humans Making Music, which was conducted in 2012. One of the aim of HUMMUS is to study the association between individual characteristics, such as personality, aptitude, interest, and sensitivity to reward, and expertise in music and sports performance, as well as cultural engagement. Another aim was to study the associations between cultural engagement, well-being and health. Genetic data collected within STAGE is used to study the relative importance of genetic and environmental factors in these associations.
Data collection for HUMMUS was carried out by the Swedish Twin Registry during 2022 and 2023. It targeted twins aged 37–63 years (born 1959-1985), both twin pairs and individual twins, where at least one individual had participated in STAGE. The study cohort included both monozygotic and dizygotic twins, regardless of sex combination. In total, approximately 28,800 individuals were contacted, of whom about 9,540 participated, corresponding to a response rate of 33%.
Participants were asked to complete a web-based questionnaire covering topics such as music and sports engagement, creativity, well-being, and personality.
The following question areas are included:
ACIPS - Anticipatory and Consummatory Interpersonal Pleasure Scale
BIS/BAS - Behavioral Activation and Behavioral Inhibition Scales
BMRS - Barcelona Music Reward Questionnaire
BFI - Big Five Inventory, in general and during musical or professional practice
CAQ - Creative Achievement Questionnaire
Cultural engagement
Divergent thinking
Engagement in sports
Musical childhood environment
NPI - Narcissistic Personality Inventory
Primals Inventory (62 items)
Profession
SFPQ - Swedish Flow Proneness Questionnaire, during sports practice
Synesthesia
TROSCI - Trait Robustness of Self-Confidence Inventory
UCLA - loneliness scale (4 items)
Weight and height
WHO-10 - World Health Organization Well-Being IndexHUMMUS är en uppföljningsstudie till Humans Making Music, som genomfördes 2012. Syftet med HUMMUS är att öka förståelsen av sambandet mellan individuella egenskaper, såsom personlighet, fallenhet, intresse och känslighet för belöning, och expertis inom musik- och idrottsutövning samt kulturellt engagemang. Ett ytterligare syfte är att undersöka hur kulturellt engagemang relaterar till välbefinnande och hälsa. Genetisk data insamlad i STAGE används för att analysera den relativa betydelsen av genetiska och miljömässiga faktorer.
Datainsamlingen till HUMMUS genomfördes av Svenska Tvillingregistret under 2022 och 2023. Den riktade sig till tvillingar, både par och enskilda tvillingar, i åldrarna 37-63 år (födda 1959-1985) och där minst en individ deltagit i STAGE. Kohorten omfattade både enäggs- och tvåäggstvillingar, oavsett könskombination. Totalt kontaktades cirka 28 800 individer, varav omkring 9 540 deltog, vilket motsvarar en svarsfrekvens på 33 %.
Deltagarna ombads att besvara en webbenkät med frågor om bland annat musik- och idrottsengagemang, kreativitet, välbefinnande och personlighet.
Följande frågeområden ingår:
ACIPS - Anticipatory and Consummatory Interpersonal Pleasure Scale
BIS/BAS - Behavioral Activation and Behavioral Inhibition Scales
BMRS - Barcelona Music Reward Questionnaire
BFI - Big Five Inventory, i allmänhet samt under musik- eller yrkesutövande
CAQ - Creative Achievement Questionnaire
Divergent tänkande
Idrottsligt engagemang
Kulturellt engagemang
Musikalisk barndomsmiljö
NPI - Narcissistic Personality Inventory
SFPQ - Swedish Flow Proneness Questionnaire: flow under idrottsaktiviteter
Synestesi
TROSCI - Trait Robustness of Self-Confidence Inventory: självförtroende
UCLA – ensamhetskala, 4 frågor
Uppfattningar om världen (Primals), 62 frågor
Vikt och längd
WHO-10 - World Health Organization välbefinnandeindex
Yrk
Data från en fokusgruppsstudie med medlemmar i patientorganisationer och vårdpersonal inom primärvården om insatser för self-management
No full textThe data consists of experiences of proactive self-management efforts among individuals with chronic illnesses and healthcare professionals. Data were collected through five focus group discussions: two with members of patient associations and three with healthcare professionals working at primary care centers. The discussions were conducted in Swedish.
One of the focus groups with healthcare professionals was held at their primary care unit, while the remaining sessions were conducted digitally. All sessions were audio-recorded. The recordings were transcribed verbatim using Microsoft Word. The transcribed material constitutes the dataset for analysis. A classical focus group analysis was then conducted to identify patterns and themes within the data.Data består av erfarenheter av insatser för proaktiv self-management hos personer med kronisk sjukdom och hälso- och sjukvårdspersonal. Data inhämtades genom fem fokusgruppsdiskussioner, två med medlemmar i patientföreningar och tre med hälso- och sjukvårdspersonal vid hälsocentraler. Data är på svenska.
En av fokusgrupperna med hälso- och sjukvårdspersonal genomfördes på deras primärvårdsenhet medan de övriga genomfördes digitalt. Samtliga spelades in via en ljudfil. Ljudfilerna transkriberades i Microsoft Word. Ljudfilerna transkriberades ordagrant. Transkriberad data utgör datamaterialet. Analys genomfördes sedan med klassisk fokusgruppsanalys för att hitta mönster i data
Adrenal proteomics
No full textProteomic data comparing men1 mice +/- adrenals with men1+/+ adrenals.
The MEN1 mouse is a conventional heterozygous knockout mouse (Men1 ⁺/-), which was a kind gift from Professor Hayward of the Queensland Institute of Medical Research, Herston, Australia. Deletion of the second exon of the Men1 gene produces heterozygous non-sense mutation.
Adrenals of ten MEN1 mice with ages from 10 to 13 months were used, and adrenals of ten wild type mice (Men1⁺/⁺) of the same age range served as controls. From each animal, one gland was subjected to protein profiling and the contralateral gland was either formalin-fixed/paraffin-embedded for immunohistochemical analysis or lysate for western blot analysis.
Dissected adrenal glands (n=10/genotype) were minced and homogenized, protein was extracted, denatured, reduced and digested as previously described (14). Briefly, the samples were homogenized in the presence of octyl-ß-D-glucopyranoside, Tris-HCl, NaCl and EDTA in PBS solution. Protease cocktail inhibitor (Sigma-Aldrich, Steinheim, Germany) was added during lysis. After incubation and centrifugation of the lysate, the clear supernatant was collected for mass spectrometry and western blotting. The total protein content was determined using DC Protein Assay Kit (BioRad Laboratories, Hercules, Ca, USA) with bovine serum as standard.
For mass spectrometry analysis, 35 µg of protein was dissolved in 8M urea and acetonitrile (ACN) (1:1) containing NH₄HCO₃ (50 mM). A volume of 10 µL of 45 mM DTT was added to the samples for incubation at 50°C for 15 mins. After cooling, 10 µL of 100 mM IAA was added to the samples for incubation at room temp in a dark room. The samples were then transferred to 3kDa spin filters (Pall Life Sciences, Ann Arbor, MI, USA) for three steps of purification. A volume of 100 µL of 50 mM NH₄HCO₃ was added to the filter, followed by centrifugation at 14000 xg for 10 mins. Progressively, 250 µL of 1:1 2% ACN/50 mM NH₄HCO₃ and 150 µL of 50 mM NH₄HCO₃ were added separately, then filter centrifugation as above followed. Spin filters were transferred to new vials and 50 µL of 5% trypsin was applied for digestion at 37°C overnight in dark room. Samples were centrifuged and tryptic peptides collected. Residual peptides on the filters were collected by applying 100 µL of 50% ACN and 1% HAc, and the eluate was pooled with the first filtrate. Eluted peptides were dried using Speedvac system ISS110 (Thermo Scientific, Waltham, USA), and peptides re-dissolved in 30µL 0,1% formic acid (FA) before mass spectrometry analysis
Meteorological data from Almbergasjön, littoral
No full textAutomatic weather station data from locations within the distributed Swedish research infrastructure SITES. Check preview or file for the specific parameters included at this location. Data has been quality controlled and cleaned from outliers and other events producing unrealistic data. Gaps have not been filled.
Abisko Scientific Research Station (2025). Meteorological data from Almbergasjön, littoral, 2023 [Data set]. Swedish Infrastructure for Ecosystem Science (SITES). https://hdl.handle.net/11676.1/iB_rzm-CZ7NUiXRofSCgpda
Meteorological data from Almbergasjön, littoral
No full textAutomatic weather station data from locations within the distributed Swedish research infrastructure SITES. Check preview or file for the specific parameters included at this location. Data has been quality controlled and cleaned from outliers and other events producing unrealistic data. Gaps have not been filled.
Abisko Scientific Research Station (2025). Meteorological data from Almbergasjön, littoral, 2021-06-04–2022-01-01 [Data set]. Swedish Infrastructure for Ecosystem Science (SITES). https://hdl.handle.net/11676.1/iPOMtV4sUOEVxtlCWarQ9DD
Svenska bokrecensioner
No full textThe project The New order of Criticism (Swedish: KNO) collected data on older Swedish book reviews. This corpus contains material from three sources, all manually annotated, but using different forms of annotation. From the literary magazine Ord och bild, all text from 1982 to 1949 is included, with reviews marked by "review" and categorised as fiction or other. From the feminist magazine Dagny, all text is included, with some noise removed. The material is separated by "text" tags and categorised as review (rec), article (art), announcement (kun), and fiction (sko). From 1906 newspapers from the National library collections, the texts are segmented, categorised as review or article (i.e. non-review), and marked with additional metadata. The texts are in arbitrary order, in two files, reviews and non-reviews.Projektet Kulturens nya ordning samlade in och annoterade ett antal äldre svenska bokrecensioner. I denna korpus ingår texter från tre källor: kulturtidskriften Ord och bild, kvinnotidskriften Dagny, och dagstidningar från 1906 ur Kungliga bibliotekets samlingar. De är alla annoterade för hand, men av praktiska skäl har de annoterats på olika sätt. Ord och bild, som är den största delen, har delats upp i filer per år; materialet sträcker sig från 1892 till 1949. Recensioner där har markerats med taggen "review", och kategoriserats som (recension av) fiktion eller övrigt. I Dagny har i stället allt material märkts upp i delar markerade med taggen "text", som kategoriserats som recension, artikel, kunggörelse eller skönlitteratur. Materialet från KB har delats upp i två filer, en med recensioner och en med "artiklar", alltså icke-recensioner. De är inte i ordning, men innehåller ytterligare metadata, bland annat recensentens namn och verkets titel och författare
Greiser et al. (2025) Bark beetles as microclimate engineers – thermal characteristics of infested spruce trees at the canopy surface and below the canopy - Data and code
No full textTwo R-scripts and data are provided to generate the statistical models and plots.
Related publication - abstract:
Over recent decades, Spruce bark beetle outbreaks have expanded and intensified across Europe, driven by a warming climate and more frequent extreme drought events. While research has largely focused on early detection and vulnerability prediction, little is known about the consequences of beetle infestations on forest microclimates. Bark beetle attacks are expected to alter forest microclimates due to changes in canopy cover, albedo, wind patterns, and evapotranspiration. We explored the effect of bark beetle attacks on summer forest microclimate using two approaches.
Firstly, we measured understory microclimate at 2-m height in 31 Swedish forest stands using small consumer-grade loggers. Along a gradient of attack severity, represented by increasing proportions of dead spruces, maximum summer day-time temperatures increased by up to 2 °C, with this warming effect being moderated by the presence of deciduous broadleaf trees. Surprisingly, night-time minimum temperatures were not affected by bark beetle attacks.
Secondly, we mapped canopy surface temperature over one part of the study area using multispectral and thermal drone imaging, contrasting canopy temperatures of healthy and infested trees. We observed that dead trees were generally warmer than living trees, by an average of 2.6 °C on a sunny day and 0.7 °C on a cloudy day.
Our study documented changes in thermal regimes in both the understory and overstory after bark beetle attacks, indicating that climate-change related disturbances are fueling rapid increases in microclimate warming. However, even dead forest stands may function as thermal buffers for understory vegetation, as we found minimum temperatures being unaffected by bark beetles. Finally, our results suggest that increasing the proportion of deciduous trees can decrease the risk of bark-beetle induced microclimate warming. The insights gained can guide forest succession and regeneration management after disturbances, contributing to critical decisions on conservation areas and salvage logging strategies