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Stable Lanthanide Luminescence Agents Highly Emissive in Aqueous Solution: Multidentate 2-Hydroxyisophthalamide Complexes of Sm3+, Eu3+, Tb3+, Dy3+
No full textLCS
Performance Driven Reliable Link Design for Networks on Chips
No full textWith decreasing feature size of transistors, the interconnect wire delay is becoming a major bottleneck in current Systems on Chips (SoCs). Another effect of shrinking feature size is that the wires are becoming unrealable as they are increasingly susceptible to various noise sources such as cross-talk, coupling noise, soft errors etc. Increasing importance of wire delay an reliability has lead to a communication centric design approach, Networks in Chip (NoC), for building complex SoCs. Current NoC communication design methodologies are based on conservative design approaches and consider worst case operating conditions for link design, resulting in lare latency penalty for data transmission. In order to substantially descrease the link delay and therby increase system performance an aggressive design approach is needed. In this work we present Terror, timing error tolerant communication system, for aggressively design the links of NoCs. In our methodology, instead of avoiding timing errors by worst-case design, we do aggressive design by tolerating timing errors. Simulation results show large latency savings (up to 35%) for the Terror based system compared to traditional design methodology.LSI
Institutionen, 75ème anniversaire du Laboratoire d’hydraulique du génie civil de l’EPFL, 1928-2003
No full textPL-LCH[392
Structure and activation mechanism of a Lamassu phage and plasmid defense system
No full textLamassu is a diverse family of defense systems that protect bacteria, including seventh-pandemic strains of Vibrio cholerae, against both plasmids and phage infection. During phage infection, Lamassu targets essential cellular processes, thereby halting phage propagation by terminating the infected host. The mechanisms by which Lamassu effectors are activated when needed and otherwise suppressed are unknown. Here we present structures of a Lamassu defense system from Salmonella enterica. We show that an oligomerization domain of the nuclease effector subunit, LmuA, is sequestered by two tightly folded SMC-like LmuB protomers and LmuC. Upon activation, liberated LmuA assembles into homotetramers, in which two of four nuclease domains are brought into proximity to create an active site capable of cleaving DNA. We propose that tetramer formation is likely a one-way switch that establishes a threshold to limit potential spontaneous activation and cell death. Our findings reveal a mechanism of cellular defense, involving liberation and oligomerization of immune effectors, and shed light on how Lamassu systems balance potent immune responses with self-preservation.UPBL
An analytical inverse analysis to determine equi-biaxial tensile properties of strain-hardening UHPFRC from ringon-ring test (vol 53, 123, 2020)
No full textThe article "An analytical inverse analysis to determine equi-biaxial tensile properties of strain-hardening UHPFRC from ringon-ring test", written by Xiujiang Shen, Eugen Bruhwiler, Emmanuel Denarie and Wanghu Peng was originally published electronically on the publisher's.MC
Why H Z-algebra Spectra are Differential Graded Algebras?
No full textIn homological algebra, to understand commutative rings R, one studies R-modules, chain complexes of R-modules and their monoids, the differential graded R-algebras. The category of R-modules has a rich structure, but too rigid to efficiently work with homological invariants and homotopy invariant properties. It appears more appropriate to operate in the derived category D(R), which is the homotopy category of differential graded R-modules. Algebra of symmetric spectra offers a generalization of homological algebra. In this frame, spectra are objects that take the place of abelian groups; in particular, the analogue of the initial ring Z is the sphere spectrum S. Tensoring over S endows the category of spectra with a symmetric monoidal smash product, analogous to the tensor product of abelian groups. Thus, spectra are S-modules, and ring spectra, which extend the notion of rings, are the S-algebras. To any discrete ring R, one can associate the Eilenberg-Mac Lane ring spectrum HR, which is commutative if R is.SB-SM
Temperature Monitoring During Tissue Freezing Using Ultrasound Speed Measurements
No full textA major limitation of thermal therapies is the lack of detailed thermal information needed to monitor the therapy. Temperatures are routinely measured invasively with thermocouples, but only sparse measurements can be made. Ultrasound tomography is an attractive modality for temperature monitoring because it is non- invasive, non-ionizing, convenient and inexpensive. It capitalizes on the fact that the changes in temperature cause the changes in sound speed. In this work we investigate the possibility of monitoring large temperature changes, in the interval from body temperature to −40◦C. The ability to estimate temperature in this interval is of a great importance in cryosurgery, where freezing is used to destroy abnormal tissue. In our experiment, we freeze locally a tissue-mimicking phantom using a combination of one, two or three cryoprobes. The estimation of sound speed is a difficult task because, first, the sound is highly attenuated when traversing the frozen tissue; and second, the sound speed to be reconstructed has a high spatial bandwidth, due to the dramatic change in speed between the frozen and unfrozen tissue. We show that the first problem can be overcome using a beamforming technique. As the classical reconstruction algorithms inherently smooth the reconstruction, we propose to solve the second problem by applying reconstruction techniques based on sparsity.LCA
Evaluation des systèmes existants pour le suivi à long terme des déformations des ponts
No full textLe projet de recherche Evaluation des systèmes existants pour le suivi à long terme des déformations des ponts a été initié dans le but de préparer sous forme condensée une présentation et une évaluation des systèmes de mesure existants pour le suivi à long terme des déformations de ponts ainsi que des recommandations en vue d’applications particulières. Ce sujet est d’actualité car d’une part il importe de gérer au mieux les ouvrages et les ressources et d’autre part parce que plusieurs cas de déformations importantes de ponts en béton précontraint ont été constatés tant en Suisse qu’à l’étranger ces vingt dernières années. Ce document est premièrement destiné aux maîtres d’ouvrage pour les assister dans le choix des méthodes applicables aux ouvrages dont ils désirent suivre l’évolution et l’organisation des campagnes de mesure. Il doit permettre une utilisation rationnelle des moyens et des méthodes de suivi à long terme des ouvrages. La majorité des méthodes de mesures répertoriées sont bien connues. Le présent document définit leur domaine d’application et leurs limites. Certaines méthodes sont plus récentes et moins connues. Leurs propriétés et leur domaine d’application sont cernés et comparés à ceux des méthodes classiques. Il faut noter que plusieurs domaines de mesure qui ont été investigués sont en période de profonds changements, avec une intégration de plus en plus intime entre diverses méthodes de mesure, rendue possible par l’émergence de nouvelles techniques (positionnement GPS par exemple) et par l’intégration de l’informatique dans une grande partie des opérations de mesure. Il est probable qu’une ou plusieurs des méthodes de mesure nouvelles qui ne sont à l’heure actuelle pas encore mûres pour une application de terrain atteindront ce stade dans les années qui viennent. Il serait souhaitable d’accompagner et d’encourager leur développement par la mise sur pied de projets-pilotes de suivi des déformations. The research project Evaluation of existing measurement systems for the long-term monitoring of bridge deflections was initiated with the aim to prepare, in a condensed form, a presentation and comparison of the existing measurement systems for the long-term monitoring of bridge deflections, as well as recommendations for special applications. This is a very actual topic, as on the one hand, it is necessary to efficiently manage existing bridges, and on the other hand because several cases of large deflections of post-tensioned concrete bridges have been observed in Switzerland and other countries over the past 20 years. This document is primarily aimed at bridge owners to assist them in the selection of applicable methods to monitor bridges and to organise measurement campaigns. It will facilitate a rational use of available means and methods for the long-term monitoring of bridges. The majority of measurement methods listed are well known. The present document defines their application domain and their limitations. Some methods are more recent and less well known. Their properties and application domain are outlined and compared to those of classical methods. It must be noted that several of the measurement domains investigated are presently undergoing a period of profound changes, with increasingly more intimate interactions between various measurement methods. This convergence is made possible by the emergence of new measurement techniques (GPS positioning for example) and by the integration of computers in a large part of measurement methods. It is likely that one or more of the new measurement methods that are currently nor ready for field development will mature in the coming years. It would be advisable to follow and encourage their development through pilot projects of deflection monitoring.IBETO