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In vitro and in vivo NIR fluorescence lifetime imaging with a time-gated SPAD camera
No full textNear-infrared (NIR) fluorescence lifetime imaging (FLI) provides a unique contrast mechanism to monitor biological parameters and molecular events in vivo. Single-photon avalanche diode (SPAD) cameras have been recently demonstrated in FLI microscopy (FLIM) applications, but their suitability for in vivo macroscopic FLI (MFLI) in deep tissues remains to be demonstrated. Herein, we report in vivo NIR MFLI measurement with SwissSPAD2, a large time-gated SPAD camera. We first benchmark its performance in well-controlled in vitro experiments, ranging from monitoring environmental effects on fluorescence lifetime, to quantifying Forster resonant energy transfer (FRET) between dyes. Next, we use it for in vivo studies of target-drug engagement in live and intact tumor xenografts using FRET. Information obtained with SwissSPAD2 was successfully compared to that obtained with a gated intensified charge-coupled device (ICCD) camera, using two different approaches. Our results demonstrate that SPAD cameras offer a powerful technology for in vivo preclinical applications in the NIR window. (C) 2022 Optica Publishing Group under the terms of the Optica Open Access Publishing AgreementAQU
The Effectiveness of the Simpati Program in Preventing Stunting: A Digital Solution for a Healthy Generation in Sumedang Regency
Get PDFThis study aims to analyze the effectiveness of the SIMPATI application as a digital innovation for stunting prevention in Sumedang Regency using a qualitative case study approach. The evaluation adopts Wirawan’s policy evaluation framework, covering three key dimensions: process, benefit, and impact. Data were collected through in-depth interviews, participatory field observations, and documentation involving health workers, posyandu cadres, mothers of toddlers, and local government officials. The findings show that SIMPATI contributes positively to real-time child nutrition monitoring, increases mothers’ participation in posyandu, and improves the accuracy and speed of data recording and service delivery. From a process perspective, SIMPATI supports better coordination among stakeholders despite infrastructure and digital literacy challenges. From a benefit perspective, it facilitates health awareness, improves user experience, and enhances data access. From an impact perspective, the program has led to increased maternal engagement and a decline in the number of children at risk of stunting over six months. However, issues such as limited infrastructure and human resource readiness remain obstacles to long-term sustainability. The study recommends enhancing digital infrastructure, conducting regular training, and strengthening multi-sectoral collaboration to ensure the successful scaling of SIMPATI as a national stunting prevention model
Computational micromechanics of dynamic compressive loading of a brittle polycrystalline material using a distribution of grain boundary properties
No full textLSM
Donor-Acceptor-Donor "Hot Exciton" Triads for High Reverse Intersystem Crossing in OLEDs
No full textHot exciton materials have the potential to improve the quantum efficiency of organic light-emitting diodes (OLEDs) by promoting high reversed intersystem crossing (hRISC) between a high-lying triplet (T-n, n >= 2) and a radiative singlet (S-m). In recent years, donor-acceptor-donor (D-A-D) molecular systems have shown great promise in its ability to enhance the hRISC process under certain conditions. However, strategies to find appropriate D-A-D combinations beyond trial-and-error are still elusive. This work exposes the limited applicability of the current fragment-based design rules and proposes high-throughput screening as the optimal route to find candidates that fulfill the energy criteria for hRISC. The strategy consists of first establishing the thresholds for large triplet-triplet splitting and small singlet-triplet gap, then filtering combinations through rate comparison of competitive crossing pathways, and finally confirming hRISC with spin-orbital coupling evaluation. Based on a dataset of 234 compounds, this protocol identifies 31 candidates with potential for hRISC, 4 of which are reported in the literature. Remarkably, while most of the promising systems show prominent hybridized local and charge transfer character, several candidates do not fulfill this condition, indicating that different routes are possible to design efficient OLED materials.LCM
New method for dynamic modeling of hybrid stepping motors
No full textTo be able to calculate the performances of a hybrid stepping motor or to design it in a short time, it is essential to apply an efficient model, accepting a slight loss of precision. Using software based on finite elements and executing calculations are difficult and time consuming, but normally offers increased precision. Finite elements may be used to better understand some phenomena and help establishing an analytic modeling based on magnetic equivalent scheme. Torque calculation is therefore much faster and permits to easily optimize a given structure. The dynamic modeling permits an estimation of dynamic behavior of the hybrid stepping motor in stationary and transient states.LA
Robust weighted likelihood estimators with an application to bivariate extreme value problems
No full textThe authors achieve robust estimation of parametric models through the use of weighted maximum likelihood techniques. A new estimator is proposed and its good properties illustrated through examples. Ease of implementation is an attractive property of the new estimator. The new estimator downweights with respect to the model and can be used for complicated likelihoods such as those involved in bivariate extreme value problems. New weight functions, tailored for these problems, are constructed. The increased insight provided by our robust fits to these bivariate extreme value models is exhibited through the analysis of sea levels at two East Coast sites in the United Kingdom.STA
Measurement of the top quark mass in the dileptonic decay channel using the mass observables , , and in pp collisions at TeV
No full textA measurement of the top quark mass (Mt) in the dileptonic tt¯ decay channel is performed using data from proton-proton collisions at a center-of-mass energy of 8 TeV. The data was recorded by the CMS experiment at the LHC and corresponds to an integrated luminosity of 19.7±0.5 fb−1. Events are selected with two oppositely charged leptons (ℓ=e, μ) and two jets identified as originating from b quarks. The analysis is based on three kinematic observables whose distributions are sensitive to the value of Mt. An invariant mass observable, Mbℓ, and a “stransverse mass” observable, MT2, are employed in a simultaneous fit to determine the value of Mt and an overall jet energy scale factor (JSF). A complementary approach is used to construct an invariant mass observable, Mbℓν, that is combined with MT2 to measure Mt. The shapes of the observables, along with their evolutions in Mt and JSF, are modeled by a nonparametric Gaussian process regression technique. The sensitivity of the observables to the value of Mt is investigated using a Fisher information density method. The top quark mass is measured to be 172.22±0.18(stat) -0.93+0.89(syst) GeV.LPH