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Genetic and dietary determinants of gut microbiome-bile acid interactions in the BXD genetic reference population
No full textThe gut microbiome is crucial in regulating overall physiology and communicates with the host through various microbial-derived metabolites, including secondary bile acids (BAs). However, mechanisms underlying the gut microbiome-BA crosstalk (gMxB) are still poorly understood. Here, we assess the postprandial cecal microbiome, BA levels, and colon transcriptome of male BXD mice fed with a chow or high-fat diet, and find that genetic and dietary factors shift microbiome composition and affect gMxB. Four diet-dependent co-mapping genetic loci associated with gMxB, including the interaction between Turicibacter sanguinis - plasma cholic acid, are identified using systems genetics approaches. By integrating human MiBioGen database, we prioritize PTGR1 and PTPRD as candidate genes potentially regulating identified gMxB. The human relevance of these candidates on metabolic health is investigated using data from the UK biobank, FinnGen, and million veteran program databases. Overall, this study illustrates potential modulators regulating gMxB and provides insights into gut microbiome-host communication.LISPUPSCHOONJAN
Microstructure and growth modes of stoichiometric NiAl and Ni3Al thin films deposited by rf-magnetron sputtering
No full textCRPPSP
A partially-planarised hole-transporting quart-p-phenylene for perovskite solar cells
No full textHerein, we describe the synthesis of a hole transporting material based on a partially planarised quart-p-phenylene core incorporating tetraketal and diphenylamine substituents that show optimal energy levels and solubility for perovskite solar cell applications. The triple-cation perovskite devices incorporating such quart-p-phenylene derivatives show power-conversion efficiencies, short circuit currents, open circuit voltages, and fill factors that are comparable to those of spiro-OMeTAD.LP
Evaluation of bone microstructural properties: effect of testing conditions, depth repetition, time delay and displacement rate
No full textLMA
Surface Vibrational Spectroscopy Studies of Aromatic-Molecule Fragmentation on Silicon Surfaces
No full textLSELPRXUniv wisconsin,dept phys,madison,wi 53706. univ wisconsin,ctr synchrotron radiat,madison,wi 53706. montana state univ,dept phys,bozeman,mt 59717. univ rome la sapienza,dept chem,i-00100 rome,italy.ISI Document Delivery No.: E024
Variational Bayesian inference for spatial negative binomial count data models with unobserved heterogeneity
No full textTRANSP-O
Horizontal Metropolis: towards a comparative approach
No full textHorizontal Metropolis Comparative Workshop #3: Greater JakartaLAB-
Working Space, un système innovant
No full textLe système constructif développé dans le cadre du projet Working Space repose sur une structure porteuse en bois, conçue sur les principes de modularité et de préfabrication. L'ensemble des composants est adaptable aux différents systèmes statiques et trames structurelles des bâtiments existants. L'objectif est de faciliter la création de nouveaux espaces administratifs sans consommation de sol, en conciliant un confort satisfaisant pour les usagers, une diversité de configuration spatiale, une valorisation des ressources urbaines existantes, notamment à proximité des transports publics, et une minimisation des impacts sur l'environnement. Concrétisant les principes d'une architecture bioclimatique bas carbone, cette réalisation fait la part belle aux énergies renouvelables, en particulier par l'intégration d'une vaste surface de panneaux photovoltaïques en toiture.LAS