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    1145 research outputs found

    Mapping out spin and particle conductances in a quantum point contact

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    We study particle and spin transport in a single mode quantum point contact using a charge neutral, quantum degenerate Fermi gas with tunable, attractive interactions. This yields the spin and particle conductance of the point contact as a function of chemical potential or confinement. The measurements cover a regime from weak attraction, where quantized conductance is observed, to the resonantly interacting superfluid. Spin conductance exhibits a broad maximum when varying the chemical potential at moderate interactions, which signals the emergence of Cooper pairing. In contrast, the particle conductance is unexpectedly enhanced even before the gas is expected to turn into a superfluid, continuously rising from the plateau at 1/h for weak interactions to plateaux-like features at non-universal values as high as 4/h for intermediate interactions. For strong interactions, the particle conductance plateaux disappear and the spin conductance gets suppressed, confirming the spin-insulating character of a superfluid. Our observations document the breakdown of universal conductance quantization as many-body correlations appear. The observed anomalous quantization challenges a Fermi liquid description of the normal phase, shedding new light on the nature of the strongly attractive Fermi gases.LQ

    A microcalorimetric platform for studying the heat produced by chemical reactions in microliter volumes

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    We describe the development of a microcalorimetric platform for accurate measurement of the heat power generated by chemical/biochemical reactions in liquid volumes of a few 10 µL, which we used to measure the heat of mixing of 1-propanol in deionized water. The system allows fast overall stabilization to a setpoint temperature with a stability of ± 1 mK. The combination of an open-well sample reservoir with a commercial nanocalorimetric chip (Xensor Integration) makes the platform easy to use and very versatile. The open-well format allows preloading a sample by pipetting, while fluidic interconnections enable injecting subsequently additional reagents.LMIS

    SUBURBAN POLARITY. Du projet urbain au détail constructif. Voyage d'étude / Barcelone

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    LASTEPFL / ENAC / IA / LAST, Atelier du Prof. Emmanuel Rey 2015-2016, Mars 2016

    Improvement and implementation of a flow forecasting system for Southern Africa

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    This master project's objectives are: - Understanding of the main approaches commonly used for discharge forecasting. - Understanding of key concepts of machine learning and evolutionary optimization. - Learning how to interpret discharge forecasts, both deterministic and probabilistic, and evaluate their performance. - Work on the acquisition of near-real time satellite rainfall estimates and use them to perform discharge forecasts. - Address the optimization of reservoir operations based on probabilistic forecasts. - Study the limits of applicability of the methodology (e.g. nature of the series being forecasted, data requirements). - Study how the methodology can be applied to selected catchments in Southern Africa. - Compare the results and use of the proposed forecasting methodology with those obtained by Bayesian inference (Differential Evolution Adaptive Metropolis, DREAM).SIE-

    Low-profile folding mechanism for multi-DoF feedback control

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    An ultra-thin, modular pneumatic system with integrated sensing and transmission enables precise control of folding structures, offering a scalable solution for reconfigurable robots with complex geometries.RR

    Flexible, consistent and safe design of structural glass elements

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    RESSLA

    Mein Körper und Ich

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    Wenn Menschen berichten, sie könnten den eigenen Körper verlassen und sich selbst von außen betrachten, klingt das nach Esoterik. Doch solche »Out-of-Body«-Erlebnisse treten bei bestimmten Hirnerkrankungen in der Tat auf und lassen sich sogar künstlich im Labor herbeiführen. Schweizer Forscher um den Neurologen Olaf Blanke wollen mit derlei Experimenten ergründen, wie Ich-Bewusstsein im subjektiven Erleben des Körpers verankert istLNC

    Fast growing resistive two fluid instabilities in hybrid-like tokamak configuration

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    An analytic derivation of the dispersion relation for resistive instabilities in a low-shear tokamak configuration is presented. The resistive infernal mode model (Charlton et al 1989 Phys. Fluids B 1 798) is generalized to include plasma diamagnetism, subsonic equilibrium toroidal flow shear and viscosity. An estimate of the transition point between the fast S−3/13 infernal-like (S is the Lundquist number) and the slow S−3/5 tearing-like scaling is given. A novel S−3/8 scaling is found close to the ideal ion-diamagnetic magnetohydrodynamic stability boundary. New moderately fast scalings in S are also found when sheared toroidal E × B flow and viscosity are considered. An analytic treatment of the m = n = 1 quasi-interchange mode in presence of density gradients with flat temperature profiles has been made.CRPPSP

    Low-dose photodynamic therapy promotes a cytotoxic immunological response in a murine model of pleural mesothelioma

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    OBJECTIVES: Malignant pleural mesothelioma (MPM) is a deadly disease with limited treatment options. Approaches to enhance patient immunity against MPM have been tested but shown variable results. Previously, we have demonstrated interesting vascular modulating properties of low-dose photodynamic therapy (L-PDT) on MPM. Here, we hypothesized that L-PDT vascular modulation could favour immune cell extravasation in MPM and improve tumour control in combination with immune checkpoint inhibitors.METHODS: First, we assessed the impact of L-PDT on vascular endothelial E-selectin expression, a key molecule for immune cell extravasation, in vitro and in a syngeneic murine model of MPM. Second, we characterized the tumour immune cell infiltrate by 15-colour flow cytometry analysis 2 and 7 days after L-PDT treatment of the murine MPM model. Third, we determined how L-PDT combined with immune checkpoint inhibitor anti-CTLA4 affected tumour growth in a murine MPM model.RESULTS: L-PDT significantly enhanced E-selectin expression by endothelial cells in vitro and in vivo. This correlated with increased CD8(+) T cells and activated antigen-presenting cells (CD11b(+) dendritic cells and macrophages) infiltration in MPM. Also, compared to anti-CTLA4 that only affects tumour growth, the combination of L-PDT with anti-CTLA4 caused complete MPM regression in 37.5% of animals.CONCLUSIONS: L-PDT enhances E-selectin expression in the MPM endothelium, which favours immune infiltration of tumours. The combination of L-PDT with immune checkpoint inhibitor anti-CTLA4 allows best tumour control and regression.LCOMUPMEYLA

    Extended Uniform Distribution Accounting for Uncertainty of Uncertainty

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    Increasingly, uncertainties are explicitly considered for important engineering tasks. Often, little case-specific information is available for characterizing these uncertainties. Uniform distributions are an easy way to describe errors in absence of more precise information. In many situations, the bounds are fixed based on user experience. The extended uniform distribution (EUD) provides a probability density function that accounts for higher orders of uncertainty (uncertainty of uncertainty) when using a uniform distribution to describe errors. Since the EUD accounts for several orders of uncertainty it is more representative than uniform and curvilinear distributions. The extended uniform distribution helps increase the reliability and robustness of tasks requiring uncertainty combination through better representing incomplete knowledge of parameters.IMA

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