HAL Université de Toulouse, et Toulouse INP
Not a member yet
159308 research outputs found
Sort by
Improving DNA detection sensitivity for the white-bellied pangolin (Phataginus tricuspis) via digital PCR
No full textInternational audienc
Single deformed bubbles rising through stagnant water of surfactant concentrations beyond CMC
No full textInternational audienceExperiments were conducted on deformed bubbles in Triton X-100 aqueous solutions at concentrations exceeding the critical micelle concentration (CMC) to understand the bubble behavior in the so-called fully-contaminated state. The terminal velocity was significantly reduced at a concentration C of 10 mmol/m3 (<CMC=240 mmol/m3), and the velocity data were in agreement with the well-known slow velocity curve for contaminated systems. However, as indicated in C beyond CMC, the terminal velocity experienced a further decrease, while the velocities at concentrations of C=10,000 and 20,000 mmol/m3 were the same, suggesting that at these concentrations the bubbles were completely contaminated. In the Re-Eo plane, where the Eötvös number was calculated by the effective surface tension, σeq, for the equilibrium of adsorption and desorption, the bubble Reynolds numbers of contaminated bubbles agreed with those in a higher viscosity system with the effective Morton number for σeq. Therefore, bubbles were considered to be fully covered by surfactant, which causes the surface tension reduction and the Marangoni effect. The presence of surfactant decreased the shape deformation, and the aspect ratios for C=10,000 and 20,000 mmol/m3 were the same, again showing that the bubbles at these concentrations were fully contaminated. The Weber number defined for σeq worked well to correlate the shapes of contaminated bubbles. A shape correlation for contaminated bubbles was developed, and an available drag correlation was extended by introducing the effects of bubble deformation to reproduce the fast and slow velocity curves of clean and contaminated bubbles that exhibit different characteristics in shape and path oscillations, in particular at C beyond CMC
Ten assertions on einkorn from a participatory living-lab: right or false?
No full textInternational audienceHighlights: • French farmers grow very few varieties of einkorn, whereas there is a huge diversity in the einkorn species! • Einkorn yield is very few mentioned as a criterion farmers are interested in. • Einkorn may be adapted to a large range of environments but the current varieties are not well adapted to agroforestry. • Einkorn is not adapted to celiac patients and seems no more digestible than durum wheat with in vitro experiments. • Einkorn, considered a minor cereal, is of major economic interest.Abstract: A participatory living-lab, implemented in Occitania region (south of France), is clustering farmers, processors, chefs, researchers, teachers, students and citizens, interested by einkorn (Triticum monococcum subsp. monococcum). During meetings, field days, open laboratories days, farms or mills visits, several assertions were collected and the ten most commonly cited were selected. For each assertion, experiments were set up and the results were compared with the scientific literature in order to discuss, confirm or refute them. We concluded by right or false for each assertion: “French farmers grow very few varieties of einkorn”: right, “There is no genetic diversity in the einkorn species”: false, “Yield is the only trait farmers are interested in”: false, “The einkorn is only adapted to very specific environmental conditions”: false, ““IGP haute Provence” is the best adapted to our Living Lab cropping conditions”: false, “Einkorn is not adapted to agroforestry”: right, with the current varieties, “Einkorn is of great benefit to celiac patients”: false, “Einkorn is more digestible than durum wheat”: false, ““IGP Haute Provence” is the variety of einkorn that makes the best pasta”: false, “Einkorn is less profitable than wheat because of its low yield”: false . The participatory einkorn breeding program being implemented will allow to meet the constraints and requirements of all stakeholders
Diamond-based non-volatile memory
No full textInternational audienceThe digital age has brought unprecedented challenges in data storage, with exponential growth in data generation outpacing traditional storage solutions in capacity, speed, and reliability. Long-term data preservation is particularly concerning, as current technologies like semiconductor drives and hard disk drives struggle with data longevity beyond a few decades. Optoelectronic memories show promise among emerging storageclass memory technologies, but they face trade-offs between information retention time and fatigue cycles due to material limitations. Diamond, with its exceptional physical properties, especially its ultra-wide bandgap, emerges as a strong candidate for developing non-volatile memories capable of retaining information over extremely long periods. This paper explores the fundamental aspects and fabrication methods of diamond non-volatile memories, focusing on the information storage mechanisms and unique properties of the ultradeep nitrogen donor in diamond, as well as the associated junction field effect transistor. The study describes the physical concept of the memory effect and the transistor structure, details the fabrication and properties of the samples, and addresses key challenges in creating efficient devices. These findings establish diamond as a viable material for ultra-stable memory applications and provide key insights into its long-term performance.</div
Twelve-month trajectories of depressive symptoms and associated socio-structural factors among adolescents and young adults in Soweto and Durban, South Africa
No full textInternational audienc
Biological effects of chlorogenic acid nanoformulations on colorectal cancer cells
No full textInternational audienceThe nanoencapsulation of chlorogenic acid (CGA) by nanospray drying was investigated as a protective bioactive delivery strategy. This study aimed to develop CGA-loaded nanoparticles (NPs) for potential application in colorectal cancer (CRC) therapy using the SW480 and HT-29 cell lines. Eight formulations were prepared with biopolymers—maltodextrin (MD), arabic gum (AG), starch (S), carboxymethyl cellulose (CMC), and hydroxypropyl methylcellulose (HPMC)—and the surfactant polysorbate 80 (PS80). The formulations were transformed into fine powders through nanospray drying and comprehensively characterized using physicochemical techniques. In vitro cytotoxicity and proliferation assays were performed using the MTT method across CGA concentrations from 0 to 400 µM. In addition, cell cycle analysis was performed by flow cytometry in HT-29 cells treated with formulations F1 (MD:CGA, 2:1) and F3 (AG:CGA, 2:1). Systems based on MD, AG, and S yielded spherical, smooth particles with an average diameter of about 360 nm, whereas those based on CMC and HPMC produced smaller particles of about 251 nm, likely due to lower polymer concentrations. Unloaded NPs exhibited low overall cytotoxicity in both SW480 and HT-29 CRC cell lines, confirming their biocompatibility. In contrast, CGA-loaded formulations induced a greater reduction in cell viability and proliferation, particularly in HT-29 cells. Cell cycle analysis revealed a slight increase in the sub-G1 population, with F1 promoting S-phase accumulation and F3 causing G2/M arrest. Among all formulations, those containing GA demonstrated significantly enhanced anticancer activity in CRC cells compared with free CGA. This effect appears to be cytostatic rather than apoptotic, suggesting a promising direction for further exploration
Post-intensive care syndrome. What clinicians and researchers must know
No full textInternational audienceThe COVID-19 pandemic has highlighted intensive care as a cornerstone of modern medicine. In spite of global aging and the increase of comorbidities in the general population, a large proportion of patients survive their hospitalization in the Intensive Care Unit (ICU). Nevertheless, these positive results are challenged by the higher mortality rates than other non-critically ill populations after discharge. Moreover, there is growing evidence that ICU survivors display a high rate of mental health disorders (anxiety and depression symptoms, post-traumatic stress disorders), somatic impairment (muscle atrophy, neuropathy, and myopathy with persistent muscle weakness, chronic kidney disease, chronic respiratory failure), or cognitive impairment. Patient’s relatives also suffer from mental health disorders (anxiety and depression symptoms, complicated bereavement). All these chronic health issues significantly impair the quality of life and increase healthcare costs. Post-Intensive Care Syndrome (PICS) is a term that encompasses all these complications. The COVID-19 pandemic has highlighted PICS as a public health concern. This review summarizes the most recent findings on PICS. It addresses epidemiological data about the frequency of somatic disorders, cognitive impairment, and mental health problems in both patients and their relatives and describes the pathophysiology mechanisms underlying PICS. The review also provides insights into management experimentations and treatment interventions that have been tested so far to improve the outcome of critically ill survivors. Finally, the review proposes measures to implement PICS management in follow-up centers and a research agenda to pave the future research on this topic
Metal complexes – metal nanoparticles hybrid systems
No full textInternational audienceOne of the natural outcomes of the progress of coordination chemistry and nanochemistry is the development of hybrid nanomaterials that combine metal complexes and zerovalent metal nanoparticles. The linkage between these two components can rely on different interaction modes (covalent, ionic, π or host-guest interactions). The influence on the native properties of each component has been studied, and sometimes shows synergy. The advantages of such combined systems have been assessed in various fields, among which electronics, catalysis, biomedicine, and environmental applications, in which they have shown promising results. To shed light on this emerging field of coordination chemistry, and potentially contribute to its development, this review summarises the main strategies used to synthesize nanohybrids based on metal complex -metal nanoparticle association. The goal is to highlight the challenges associated with their synthesis and characterization, with emphasis on the combination of techniques used to elucidate their structure
On the effect of substrate thermal conductivity and nano-region on subcooled nucleate boiling in zero-gravity conditions
No full textInternational audiencePrediction of heat transfer in configurations of nucleate boiling is a topic that still require new studiesfor a better understanding of the overall process, which involves multiscale interactions between differentphysical phenomena. In particular, for space applications, that imply microgravity conditions, experimentaldata are limited, and numerical simulations offer an efficient alternative to investigate nucleate boiling in suchconditions. In the present work, the impact of the nano-region heat flux at the contact line on the equivalentbubble radius is thoroughly studied by means of numerical simulations. A parametric study is carried out byvarying several physical variables. From these numerical data, the strong impact of the nano-region heat fluxon the overall bubble growth is highlighted, as well as the strong coupling between the nano-region and thethermal conductivity ratio between the liquid and the solid substrate. Finally, a correlation on the bubble sizeat equilibrium state is drawn, and the heat transfer coefficient is characterized. This enables to show the heattransfer enhancement related to the nano-region
