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Gray Matter Volume Variability in Young Healthy Adults: Influence of Gender Difference and Brain-Derived Neurotrophic Factor Genotype
Get PDF新潟医療福祉大学Niigata University of Health and Welfare博士(保健学)application/pdfCerebral Cortex. 2022, 32(12), p. 2635–2643.33111甲第100号doctoral thesi
健康体操教室の参加者と行うニュースポーツのアレンジの研究～活動を通したコミュニティの醸成～
Get PDF論文(Article)我が国は，超高齢社会であり，健康寿命の延伸が急務である（令和４年高齢者白書）．本多ほか（2020）は，レクリエーションの要素を取り入れた運動プログラムによって「笑いがある」「楽しい」ことが運動継続に繋がっており，健康体操教室で培った人間関係の影響により，更なる運動や健康づくりに対する強い意識の変化が出ていることを報告している．
従来，高齢者を対象とした運動プログラムは，有資格者（理学療法士や健康運動指導士等）がプログラムの作成や実践を行うことが多く，植木ほか（2006）は，参加者自らが考え実践する事例はあまりみられないと報告している．本研究では，健康体操教室の参加者と共にニュースポーツのアレンジを研究し，その活動を通してコミュニティの醸成や心身の健康への効果を検証した．結果，グループで考案することにより，話し合いや会話が生まれ，楽しみながら考えることで，心身の健康の維持・増進に関わっていることが明らかになった．journal articl
Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells
Get PDFapplication/pdfTissue and subcellular localization and its changes upon cell activation of virus-restricting APOBEC3 at protein levels are important to understanding physiological functions of this cytidine deaminase, but have not been thoroughly analyzed in vivo. To precisely follow the possible activation-induced changes in expression levels of APOBEC3 protein in different mouse tissues and cell populations, genome editing was utilized to establish knock-in mice that express APOBEC3 protein with an in-frame FLAG tag. Flow cytometry and immunohistochemical analyses were performed prior to and after an immunological stimulation. Cultured B cells expressed higher levels of APOBEC3 protein than T cells. All differentiation and activation stages of freshly prepared B cells expressed significant levels of APOBEC3 protein, but germinal center cells possessed the highest levels of APOBEC3 protein localized in their cytoplasm. Upon immunological stimulation with sheep red blood cells in vivo, germinal center cells with high levels of APOBEC3 protein expression increased in their number, but FLAG-specific fluorescence intensity in each cell did not change. T cells, even those in germinal centers, did not express significant levels of APOBEC3 protein. Thus, mouse APOBEC3 protein is expressed at distinctively high levels in germinal center B cells. Antigenic stimulation did not affect expression levels of cellular APOBEC3 protein despite increased numbers of germinal center cells.journal articl