ARUd’A (Università “G. d’Annunzio CHIETI -PESCARA)
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Can I Work With Older Workers if I Hold Stereotypes Regarding Their Competence? The Consequences for Stereotype Holders
No full textThe ageing workforce and increasing workplace age diversity have directed research attention to the consequences of age-related stereotypes. Prior research has mainly focused on the effects for the target of these stereotypes (e.g., older workers). Using the social identity approach and social capital theories as a framework, we suggest that holding negative age-related stereotypes (i.e., about older workers’ competence) is negatively associated with individual (i.e., positive job-related affective well-being), group-related (i.e., work group involvement and group relations), and organizational-related outcomes (i.e., perceived organizational climate) for younger and middle-aged employees. In addition, we expect this relationship to be mediated by ineffective
work interactions, which captures a decrease in younger/middle-aged workers’ frequency and appreciation of task-oriented interactions with their older coworkers. Our hypotheses were tested with a time-lagged design involving 104 participants between 23 and 49 years old (M = 35.62, SD = 6.75). The findings supported our
hypotheses. We conclude by discussing theoretical implications and practical recommendations
Novel Anticancer Triple Formula Based on Aptamer-Conjugated PEGylated Nanoliposomes
No full textBackground: Cancer remains a leading cause of death worldwide, necessitating the development of affordable and innovative therapies to reduce its human and economic burden. Objectives: In this study, we aimed to develop a synergistic anticancer formula encapsulated in nanoliposomes to enhance efficacy and minimize side effects. Additionally, we explored the effect of aptamer conjugation on the efficacy and stability of the formula. Methods: The Etoricoxib-β-cyclodextrin complex was prepared using the kneading method, and nanoliposomes were developed via thin film hydration. The AS1411 aptamer was conjugated to the nanoliposomes to target nucleolin, a protein overexpressed in cancer cells. The etoricoxib-β-cyclodextrin complex was characterized using proton nuclear magnetic resonance, and various liposome properties, including size, encapsulation efficiency, and stability, were optimized. The release profiles of the active compounds were evaluated using high-performance liquid chromatography, and their cytotoxicity was assessed in human cancer cell lines. Results: The nanoliposomes co-loaded with the three agents and their aptamer-conjugated counterpart showed optimal characteristics, with particle sizes of 133.3±1.45 nm and 174.8±4.78 nm, and zeta potentials of −15.26±1.80 mV and −15.66±2.57 mV, respectively. The encapsulation efficiencies were 88.63% (raloxifene), 41.73% (etoricoxib), and 39.26% (naringin) without the aptamer, and 81.99%, 36.66%, and 38.33%, respectively, with the aptamer. The IC50 of the formula for the three co-loaded agents was 167.4 μg/mL for A549 cells and 2.6 μg/mL for MCF-7 cells. Cytotoxicity was further enhanced using their aptamer conjugate, particularly against the MDA-MB-231 cell line. Conclusion: The novel triple-drug-loaded, aptamer-conjugated nanoliposome formula may be a future cancer treatment strategy
Evaluation of clinical outcome and predictive factors for thromboembolism or hemorrhagic complications in patients treated for chronic subdural hematoma. A prospective observational study
No full textThe impact of anticoagulant and antiplatelet medications on clinical outcome and risk of complications is uncertain in chronic subdural hematoma (CSDH) patients. Currently, evidence-based guidelines and specific neurosurgical scores lacks. CHA2DS2-VASc and HAS-BLED scores have been proven to help predicting complications in the perioperative period of non-cardiac surgeries. We performed a multicenter prospective observational trial to evaluate the clinical outcomes and complications of CSDH patient undergoing surgery, comparing patients taking anticoagulant/antiplatelet (AAPT) and not (NT). Additionally, we investigated the role of CHA2DS2-VASc and HAS-BLED scores in predicting thromboembolic events or hemorrhages. No associations have been found between AAPT and clinical outcomes of patients. Emergency surgery was not a significant factor in improving outcomes. Post-operative hemorrhages were more frequent in the AAPT group, but none required a second surgery. A significant higher risk of of new bleedings was found in the ASA group with discontinuation ≤ 5 days. A higher HAS-BLED score was not associated with a worse clinical outcome. A 1-point increase in CHA2DS2-VASc was associated with a lower probability of favorable outcomes at 1 month. 90% of AAPT and 44% of NT patients were at moderate-high risk of thromboembolic events based on CHA2DS2-VASc score, with no difference in incidence between groups. The use of AAPT does not influence outcomes, complication rates, or recurrence in patients undergoing surgery for CSDH. Scores such as CHA2DS2-VASc or HAS-BLED could aid in stratifying bleeding and thromboembolic risks and in the management of these drugs in the perioperative period
Plyometric Training in Prepubertal Soccer Players: Is It Really Effective for Soccer Performance?
No full textBackground/Objectives: Plyometric training is a method of increasing soccer performance which leverages the muscle stretch-shortening cycle. This study aimed to evaluate the safety and effectiveness of plyometric training in prepubertal soccer players. Methods: Twenty-three young athletes (age 9.4 ± 0.3 years) from an elite club, training three times per week, were enrolled. During one of the weekly training sessions, twelve players formed the experimental group (PLYO), incorporating a 45 min plyometric training component into their routine, while the control group (CON), consisting of eleven players continued with their usual training program. At baseline and after 12 weeks, anthropometric parameters, flexibility, lower limb strength, and agility were assessed. Results: At baseline, no differences were observed between the two groups in anthropometric or physical performance parameters. No injuries occurred during the study. After 12 weeks, both groups showed significant growth and performance improvements. However, the PLYO showed a significantly greater increase in lower limb strength (Δ + 10.7%) compared to the CON (Δ + 6.0%). Conversely, although not statistically significant, agility improvements were greater in the CON (Δ + 12.4%) than in the PLYO (Δ + 8.6%). Conclusions: Plyometric training appears to be a safe and effective method for enhancing lower limb strength in prepubertal athletes. However, this strength gain did not directly translate into greater agility, which may benefit more from sport-specific training during this developmental stage
Torre di Babele, reinterpretazione iconografica mediante integrazione dell’Intelligenza Artificiale.
No full textL’evoluzione della computer vision e delle tecnologie digitali avanzate offre nuove prospettive per la rappresentazione e lo studio del mito della torre di Babele. La ricerca si propone di rivisitare la tradizione diagrammatica e sinottico-grafica attraverso l’intelligenza artificiale, creando modelli vir-tuali e interattivi e utilizzando algoritmi avanzati di text/image-to-image, image-to-3D per sintetizzare le numerose varianti iconografiche della torre, così da trasformare le immagini ottenute in matrici bidimensionali per costruire scenari 3D tramite tecnologie di auto modellazione generativa. Questo approccio consente di esplorare le potenzialità e i limiti dell’intelligenza artificiale nella gestione di un tema complesso e stratificato dal punto di vista iconografico, approfondendo le implicazioni narrative e scenografiche della rappresentazione digitale della torre. La ricerca si propone di indagare il dialogo tra tradizione e innovazione, mettendo in luce il ruolo delle tecnologie contemporanee nel reinter-pretare un tema archetipico e stimolando una riflessione critica sull’uso della AI come strumento per innovare e preservare il patrimonio culturale immateriale
From Traditional Materials to Geopolymers: History, Performance, Sustainability and 3D Printing Applications
No full textTraditional construction materials, such as gypsum, lime, cement, and concrete, have played a central role in the construction sector. On the other hand, recent sustainability requirements make some of these materials less appealing (e.g. cements). Indeed, the construction industry is responsible for 37% of global CO2 emissions, with 28% originating from building operations and 11% from the embodied carbon in materials and processes. The transition toward low-carbon construction is crucial for reducing its environmental impact. In response to these challenges, the emergence of geopolymers – materials derived from the alkali activation of aluminosilicates – has become a promising ecological alternative to traditional construction materials. This study aims to achieve two main objectives: (1) provide a critical review of both traditional and innovative construction materials, analysing their historical evolution, production cycle stages, mechanical, physical, and thermal properties, as well as aspects related to sustainability and printability; (2) examine the potential applications of these materials in emerging technologies, with a particular focus on 3D printing for construction, to promote more efficient and environmentally sustainable building solutions. The systematic literature review was conducted using an integrated approach, combining qualitative analysis with bibliometric investigation to ensure a comprehensive and rigorous assessment of the state of the art in construction materials research. This study highlights key limitations, including the lack of a comprehensive overview of geopolymer matrix properties, particularly regarding durability, structural compatibility, and the standardization of 3D printing processes
Cardboard microarchitectures for the sustainability of internal space redevelopment: a life-cycle approach through scaled prototype
No full textThe use of cardboard microstructures is an innovative approach to improving the sustainability of interior space renovations. As urban areas face increasing pressure to use space efficiently, cardboard is becoming a versatile and eco-friendly material that can be adapted to meet diverse architectural needs. The objective of this study is to investigate the life cycle assessment potential of cardboard structures, with a particular emphasis on their capacity to mitigate environmental impact and foster adaptability in interior spaces.
The utilization of cardboard, instead of traditional materials, facilitates lightweight and modular designs that can be easily reconfigured or disassembled, thus minimizing waste and resource consumption. Using principles of the circular economy, these microarchitectures can be designed for reuse, recycling, or composting, thereby reducing landfill contributions and fostering a more sustainable urban environment. In this context, life cycle assessment plays a key role in identifying the environmental performance of cardboard microarchitectures. Through analysing energy consumption, material sourcing, manufacturing processes and end-of-life scenarios, we can identify opportunities for optimization.
Moreover, cardboard microarchitectures present distinct prospects for enhancing indoor environments. Their adaptability enables the creation of multifunctional spaces that can adapt to user requirements, thereby promoting flexibility in urban living. Furthermore, incorporating biophilic design principles can enhance occupant well-being by integrating natural elements within cardboard structures.
In conclusion, the integration of cardboard microarchitectures into interior space redevelopment is a promising strategy for sustainability. By focusing on life cycle optimization, architects and designers can create environmentally responsible, adaptable and aesthetically pleasing spaces. This approach not only addresses pressing urban challenges but also contributes to a more sustainable future for architecture
Geomorphological Analysis, Rockfall Susceptibility, and Preliminary Hazard Assessment: Case Studies From the Abruzzo Region (Central Italy)
No full textRockfalls represent a major geological hazard, particularly in tectonically active regions. In this context, assessing rockfall susceptibility and hazard is mandatory for developing proactive measures to safeguard infrastructure and human lives. This study introduces a novel methodology for evaluating the Rockfall (R) and the Earthquake-Induced Rockfall (EIR) susceptibility, followed by a preliminary EIR hazard zonation. Three study areas with distinct physiographic, geological, and geomorphological features were chosen in the Abruzzo region (Central Italy). Selected case studies were investigated following an integrated stepwise approach. Geomorphological field surveys were carried out to identify lithological, geomorphological, and tectonic features, whereas morphometric and geothematic data were derived from high-resolution Digital Terrain Models and available inventories. A GIS-based heuristic approach was followed to assess the R and the EIR susceptibility. Preliminary hazard maps were then generated through 3D rockfall run-out modelling, combining the EIR susceptibility with the expected landslide magnitude. Results show good consistency with field data and fit well within the geomorphological and seismotectonic context. Derived maps depict areas with different instability levels. The highest R susceptibility values are obtained for scarps and steep slopes, the lowest ones in correspondence of flat or gently sloping areas; a general decrease of the EIR susceptibility is also observed moving from the mountainous zones to the coastal ones. Moreover, the run-out modelling pointed out all sectors affected by rockfalls and highlighted other potential rockfall-prone areas. Ultimately, this work represents a prior step for further geomorphological studies focusing on landslide hazard assessment and aimed at proper territorial planning
Acute and Subacute Effects of Session with the EXOPULSE Mollii Suit in a Multiple Sclerosis Patient: A Case Report
Get PDFMultiple sclerosis (MS) is a chronic neurological disease often resulting in motor and autonomic dysfunction. This case report investigates the acute and subacute effects of the EXOPULSE Mollii Suit (EMS), a wearable device capable of delivering transcutaneous electrical nerve stimulation to multiple anatomical regions, in a 43-year-old woman with MS. The patient underwent a clinical evaluation before the EMS treatment, during which central nervous system (CNS) and autonomic nervous system (ANS) responses were monitored using electroencephalography (EEG), heart rate variability (HRV), and infrared thermography (IRT). Immediately after the first EMS application, the clinical evaluation was repeated. The intervention continued at home for one month, followed by a post-treatment evaluation similar to the pre-intervention assessment. Functional evaluations showed improvements in sit-to-stand performance (from 8 s to 6 s), muscle tone (MAS scale for the right side from 3 to 2 and for the left side from 2 to 1), clonus, and spasticity (from 3 to 2). EEG results revealed decreased θ-band power (on average, from 0.394 to 0.253) and microstates’ reorganization. ANS activity modifications were highlighted by both HRV (e.g., RMSSD from 0.118 to 0.0837) and IRT metrics (e.g., nose tip temperature sample entropy from 0.090 to 0.239). This study provides the first integrated analysis of CNS and ANS responses to EMS in an MS patient, combining functional scales with multimodal instrumental measurements, emphasizing the possible advantages EMS for MS treatment. Although preliminary, these results demonstrated the potentiality of the EMS to deliver effective and personalized rehabilitative interventions for MS patients