ARUd’A (Università “G. d’Annunzio CHIETI -PESCARA)
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A model to understand risk behavior: Interoception awareness and motivational systems in the binge watching
No full textThis study aims to test the interoceptive-motivational hypothesis as a possible marker for the risk of developing binge-watching (BW) as a behavioral addiction. Like other risky behaviors, BW can be included in a model that includes the interaction of personological and physiological factors as predictors of the behavioral outcome. On a sample of 741 young adults, a structural equation model considered the association between the interoceptive indices (MAIA questionnaire), inhibition/activation systems (BIS/BAS questionnaire) of the motivational theory, and BW pattern (BWAQ questionnaire). The results suggested a different interaction between the variables when BW was considered as a leisure activity and as an at-risk behavior. While in the first case, interoception and BIS/BAS systems interact, and BIS and interoception positively affect the increase of BW as a leisure activity, in BW as at-risk behavior, the interoceptive-motivational link is lost, and a different pattern of association with the behavior emerges. BIS and BW are still positively associated with the problematic expression of the behavior. The result would suggest that persons exhibiting better interoceptive sensitivity display lower risk of addictive BW. Finally, the interoceptive-motivational model, if confirmed in other at-risk behaviors, would provide a new perspective in the field of behavioral addictions
Social media e giornalismo: dall’ibridazione alla polarizzazione della sfera pubblica contemporanea
No full textIl contributo tratta il tema della crisi del giornalismo, chiamato a confrontarsi con la frammentazione ingenerata dall’ingresso dei social media nella sfera pubblica. Mira a fornire un quadro teorico interpretativo originale che, partendo da riferimenti fondamentali e classici della teoria sociologica per individuare il perimetro dello stesso concetto di sfera pubblica, proponga l’ipotesi della sua ibridazione, la quale è ritenuta precondizione del fenomeno della frammentazione o disintermediazione. Si richiedono pertanto un ripensamento e un consolidamento della funzione pubblica del giornalismo, sempre centrale per il buon funzionamento delle istituzioni democratiche, laddove deve registrarsi invece, quale esito degli attuali processi orizzontali che caratterizzano il processo informativo, una crescente e talora preoccupante polarizzazione del dibattito pubblico
Unprecedented carbonic anhydrase inhibition mechanism: Targeting histidine 64 side chain through a halogen bond
Get PDF2,2'-Thio-bis(4,6-dichlorophenol), namely bithionol, is a small molecule endowed with a multifaceted bioactivity. Its peculiar polychlorinated phenolic structure makes it a suitable candidate to explore its potentialities in establishing interaction patterns with enzymes of MedChem interest, such as the human carbonic anhydrase (hCA) metalloenzymes. Herein, bithionol was tested on a panel of specific hCAs through the stopped-flow technique, showing a promising micromolar inhibitory activity for the hCA II isoform. X-ray crystallographic studies revealed an unprecedented halogen-bond interaction between one chlorine of bithionol and the N3(ε) atom of the hCA II catalytically active histidine residue, His64. Then, quantum mechanics calculations based on the fragment molecular orbital method allowed us to estimate the strength of this bond (~2.9 kcal/mol) and highlighted the contribution of a rich hydrophobic interaction network within the isoenzyme. Interestingly, the compound inactivity against the hCA III isoform, characterized by His64Lys and Leu198Phe mutations, supported the key role played by halogen bonding in the enzyme affinity. This finding might pave the way for the development of a new class of hCA inhibitors characterized by such chemical features, with the halogen bond being a key ligand-receptor interaction
Da un cantiere petrarchesco: aporie esegetiche e note di commento a 'De remediis' II 89
No full textIl saggio presenta proposte relative alla constitutio textus e affondi esegetici su una serie di passi problematici tratti dal capitolo II 89 del trattato latino "De remediis utriusque Fortune" di Petrarca (1304-75), del quale l'autrice sta lavorando all'edizione critica
Fattori di amplificazione da modellazione numerica monodimensionale per applicazioni probabilistiche non ergodiche
No full textExploring the Anticancer Potential of the Multistrain Probiotic Formulation OxxySlab in Bladder Cancer Cell Lines
No full textBladder cancer (BC), particularly its muscle-invasive subtype (MIBC), remains a clinical challenge due to high recurrence and limited therapeutic options. Emerging evidence suggests that probiotics may offer selective anticancer effects while preserving healthy tissue. In this study, we evaluated the antitumor potential of OxxySlab, a multistrain pro- biotic formulation, in two BC cell lines (T24 and 5637) and a non-tumorigenic urothelial cell line (SV-HUC1). OxxySlab lysate dose-dependently inhibited BC cell proliferation, clonogenicity, and migration, while sparing normal cells. Mechanistically, the treatment suppressed epithelial–mesenchymal transition (EMT), induced senescence, and disrupted redox homeostasis in malignant cells. These effects were associated with the induction of oxidative stress and impaired antioxidant defenses. Co-treatment with vitamin C atten- uated ROS accumulation and senescence, implicating oxidative stress as a key mediator. Notably, SV-HUC1 cells retained viability and phenotype, confirming the formulation’s selectivity. Overall, these findings support OxxySlab as a promising adjunctive strategy in BC therapy, capable of reducing tumor aggressiveness through redox-mediated senescence and EMT inhibition without harming normal urothelial cells
Neurological management of ischemic stroke in sickle cell disease– a case report with an updated review of the literature
No full textBackground: In children and adults with sickle-cell disease (SCD), acute ischemic stroke (AIS) associated with a vaso-occlusive crisis is a leading cause of physical and cognitive disability and death. However, neurological guidelines for acute management of AIS fail to directly address this issue. We here report a case of a man with severe cerebrovascular complications and illustrate the current evidence on the management of SCD-related AIS. Case report: A 46-year-old man suffering from SCD and poorly controlled diabetes was admitted to the emergency room complaining of the onset, more than 10 h before, of headache, paresthesia, and right hemianopia. The brain Angio-CT study revealed bilateral occlusion of the internal carotids and the posterior cerebral arteries, with remarkable compensatory hypertrophy of other vessels. The laboratory exams confirmed severe anemia with high hemoglobin-S levels (50%) and severe dehydration. IV hydration was prompted, along with erythrocyte apheresis and antiplatelet therapy. The patient successfully underwent these treatments, and the neurological deficits significantly improved. Nonetheless, due to the time window, he could not be treated with intravenous thrombolysis (IVT). Discussion: AIS is a time-sensitive condition. In SCD, vaso-occlusive phenomena are the leading cause of AIS, but “classical” vascular risk factors can also play a role. Since current guidelines on the acute management of SCD complications are mainly focused on the hematological– rather than neurological– aspects, it is not clear whether these patients should undergo IVT before or after fluid resuscitation and erythrocyte apheresis. Furthermore, the principles of secondary prophylaxis are still controversial and require further investigation
Le riserve nelle attività di investimento tra integrità dei mercati e tutela dei risparmiatori
No full textIl saggio affronta il tema delle riserve nelle attività di investimento, a cominciare dall’individuazione degli interessi tutelati. L’esame prosegue con l’inquadramento della fattispecie, per poi soffermarsi sulle principali regole che disciplinano la fase di accesso a tali attività. Nella parte finale del saggio si dà conto delle scelte disciplinari in punto di prestazione delle attività di investimento e dei profili patologici, che caratterizzano
la prestazione di tali attività senza la prescritta autorizzazione
Indifference Pricing of Pure Endowments in a Regime-Switching Market Model
No full textIn this paper, we study the exponential utility indifference pricing of pure endowment policies within a stochastic-factor model for an insurer who also invests in a financial market. Our framework incorporates a hazard rate modelled as an observable diffusion process, while the risky asset price follows a jump-diffusion process driven by a continuous-time finite-state Markov chain, effectively capturing different economic regimes. Using the classical stochastic control approach based on the Hamilton-Jacobi-Bellman equation, we derive optimal investment strategies with and without the insurance derivative and characterize the indifference price as a classical solution to a linear partial differential equation (PDE). Additionally, we provide a probabilistic representation of the indifference price via an extension of the Feynman-Kac formula and show that it satisfies a suitable backward PDE. Finally, some numerical experiments are conducted to perform sensitivity analyses, highlighting the impact of key model parameters