ARUd’A (Università “G. d’Annunzio CHIETI -PESCARA)
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COMPLICATION OF THE EXTRACTION OF MAXILLARY ANTERIOR SUPERNUMERARY TEET:THE ACCIDENTAL EXTRACTION OF THE PERMANENT TOOTH BUD
Get PDFBackground. This article aims to report the case of a seven-year-old girl affected by a numerical dental anomaly. Supernumerary teeth can lead to secondary dental eruption disturbance dental crowding and bone cysts formation. Even though the clinical and instrumental documentation was adequate to make a correct diagnosis and a surgical-orthodontic treatment plan, a technical error during the surgical phase can lead to the extraction of the permanent bud instead of the supernumerary tooth. The presented case highlights the 2-year follow-up of the immediate reimplantation of the avulsed tooth after the attempt to extract the supernumerary bud and provides the clinician with the most precise awareness and knowledge of possible medico-legal implications regarding surgery at the wrong site. Materials and Methods. During the extraction attempt, the clinician mistakenly extracted the wrong dental element, the bud of the permanent 1.1, and proceeded to reimplant it. After 11 months, a second dentist extracted the correct supernumerary tooth. The case defines guidelines applicable in outpatient clinical practice to manage complications in the best possible way. Results and conclusion. The therapy of supernumerary teeth is extraction. Further work is needed to monitor why a wrong tooth extraction occurs and how it can be prevented; this will be possible by reporting incidents, analyzing the root causes, and clearly and thoroughly educating the clinician on his medico-legal responsibilities
Habitat e servizi: ripensare l’abitare cooperativo
No full textIdeato in occasione della sesta edizione del concorso AAA architetticercasiTM e del settantesimo anniversario di Confcooperative Habitat il volume indaga, attraverso contributi di differenti autori, il rapporto inquieto tra modelli consolidati e innovazione, tra permanenza e metamorfosi, tra forme e usi. Un racconto in forma aperta che pone domande e spunti sulle sfide attuali dell’abitare collettivo.
Confcooperative Habitat riunisce le imprese cooperative di abitazione, i consorzi attivi nell’ambito dei servizi alla casa e le cooperative di comunità all’interno di Confcooperative, la Confederazione delle Cooperative Italiane, e ne rappresenta gli interessi nei confronti di istituzioni, enti e organismi comunitari, garantendo assistenza e servizi
Recombinant NK1 Protein and LEDs: An Innovative Strategy to Counteract Resistant Staphylococcus pseudintermedius and Pseudomonas aeruginosa Strains
Get PDFThe Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy
Get PDFDiabetic retinopathy (DR) is the most common complication of diabetes mellitus and a leading cause of vision loss. Short peptides, such as di-, tri-, and tetrapeptides, have various beneficial activities, including antioxidant, antimicrobial, and anti-inflammatory effects. This study aims to test the hypothesis that the antioxidant effect of the synthetic tetrapeptide AEDG (Ala-Glu-Asp-Gly, Epitalon) improves the delayed healing process associated with hyperglycemia in DR, using a high glucose (HG)-injured human retinal pigment epithelial cell line (ARPE-19). We found that HG exposure delayed wound healing in ARPE-19 cells and increased intracellular levels of reactive oxygen species (ROS), while decreasing antioxidant gene expression. HG also induced epithelial-mesenchymal transition (EMT) and upregulated fibrosis-related genes, suggesting that HG-induced EMT contributes to subretinal fibrosis, the end-stage of eye diseases, including proliferative DR. The antioxidant Epitalon restored impaired wound healing in HG-injured ARPE-19 cells by inhibiting hyperglycemia-induced EMT and fibrosis. These findings support using the antioxidant agent Epitalon as a promising therapeutic strategy for DR to improve retinal wound healing compromised by hyperglycemia. More mechanistic investigations are needed to confirm Epitalon’s benefits and safety. Developing ophthalmic forms of Epitalon may enhance its delivery directly to the retina, potentially improving its therapeutic efficacy
Advanced digitalization of acoustic footprints in historical theatres for preservation and reconstruction
No full textCombat sports and wellbeing: advancing health and inclusion in athletes and practitioners. An opinion paper
Get PDFUmberto Zanotti Bianco e il riscatto delle nazionalità. Progetti e speranze di rinnovamento europeo alla prova della Grande guerra
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Hand, Limb, and Other Motor Preferences
No full textTraditionally, lateral features of human brains and behaviors were considered unique to humans. However, with an explosion in cross-species investigations in recent history, research demonstrates that biases in hand, limb, and other motor preferences result from millions of years of shared evolution with other vertebrates and significant efforts are being made to develop and apply standardized measures to facilitate valid comparisons both within and across species. The behavioral sciences stand at the forefront of a paradigm shift to view human motor preferences within a comparative framework. Individual-level motor biases may reflect an early evolutionary division of primary survival functions for the left and right hemispheres of the brain, while population-level motor alignment may offer social advantages that benefit both the individual and the group. These lateralized primary functions may still influence modern human behavior and provide a foundational platform for the development of our seemingly unique and sophisticated social and other cognitive functions. In this way, the evolution and development of cognition are inextricably linked. This chapter considers hand, limb, and other motor preferences in humans and other animals with a focus on methodological practice, findings, and the future of this fast-paced field
Enabling research collaboration with AI: the BI4E experience with large language models
No full textWe present an AI-powered tool developed within the Horizon Europe-funded BI4E (Boosting INGENIUM for Excellence) project, which aims to foster new, interdisciplinary research collaborations across a university network. A key challenge addressed by BI4E is the difficulty of forming interdisciplinary and cross-university research teams, for instance for applying to competitive funding. The CONNECT platform was designed to fill this gap by providing a semantic search engine that allows researchers from different universities to discover potential collaborators on the basis of their scientific publications.
At the core of CONNECT there is a transformer-based language model, used to encode both funding call descriptions and researcher publication metadata into high-dimensional vector representations. The metadata are collected from the Scopus database using ORCID or Scopus identifiers. When queried with the topic of competitive fundings, CONNECT returns a list of researchers whose publications semantically aligns with the input query. In addition, CONNECT integrates an explainability mechanism derived from the attention matrix mechanism, allowing users to understand which parts of the input text most influenced the match.
The aim of CONNECT is to support the strategic goals of the BI4E project by offering an institutional view of research domains, facilitating industry-university matchmaking, and democratizing access to collaboration opportunities. Since its launch in December 2023, CONNECT has already enabled the formation of dozens of new research teams within the INGENIUM European University Alliance, validating its potential as a catalyst for research excellence and institutional transformation