ARUd’A (Università “G. d’Annunzio CHIETI -PESCARA)
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The combination of hyaluronic acids and collagen boosts human Achilles tendon-derived cell escape from inflammation and matrix remodeling in vitro
No full textObjective: This study explores whether hyaluronic acid (HA) of different molecular weights and collagen, given their role in tendon extracellular matrix maintenance, have a synergistic effect on human tendon-derived cells, with the aim to improve the treatment of tendinopathy. Material: Human monocytes (CRL-9855TM) and primary Achilles tendon-derived cells. Treatment: The collagen/HA ratio was based on the formulation of the commercial food supplement TendoGenIALTM. The anti-inflammatory activity was evaluated on human lipopolysaccharide (LPS)-stimulated macrophages (24 h) or human Achilles tendon-derived cells under basal and pro-inflammatory conditions (24 and 72 h) and on a co-culture model of tenocytes and inflamed macrophages (24 h). Results: These data show that the combination of high molecular weight hyaluronic acid and collagen reduces inflammation in macrophages by downregulating CD14, with a mean fluorescence intensity (MFI) of 36,274 (± 1780) (p < 0.0001). Additionally, this combination enhances the modulation of extracellular matrix remodeling proteins, such as CD44 whose MFI is 675,435 (± 28109) (p < 0.00001) and collagen type I at 17.838 μg/mL (± 6,259) (p < 0.00001). The observation of the ultrastructure of tenocytes through electron microscopy reveals increased cell membrane vesiculation and cell size, indicating that tenocytes start to proliferate and create abundant extracellular matrix proteins, important for the matrix remodeling. Conclusions: Our data confirm the anti-inflammatory activity of both hyaluronic acids and collagen, highlighting a synergistic effect of their combination in a determined ratio
Trasformazioni digitali nel Welfare: intelligenza artificiale e servizio sociale.
No full textQuesto studio si propone di analizzare l'impatto dell'IA sui processi decisionali e sulle azioni degli assistenti sociali, valutandone sia i benefici che i potenziali rischi
Anticoagulant treatment for isolated distal deep vein thrombosis: a systematic review and meta-analysis
No full textThe optimal management of isolated distal deep vein thrombosis (IDDVT) is uncertain. To assess the efficacy and safety of anticoagulation in patients with IDDVT we performed a systematic review and meta-analysis of randomized and cohort studies on anticoagulation for IDDVT. Efficacy outcomes included recurrent deep vein thrombosis (DVT), pulmonary embolism (PE), proximal progression of IDDVT, post-thrombotic syndrome (PTS). Safety outcomes included major bleeding and clinically relevant non-major bleeding (CRNMB). Pooled incidence and risk ratios (RR) with 95% confidence intervals (CI) were calculated. Treatment duration was defined as short (12 weeks). Fifty-three studies (14,580 patients) were included. The incidence of recurrent DVT and proximal progression was 16% and 11% in untreated patients, 7% and 7% in short, 6% and 3% in long, and 4% and 2% in extended anticoagulation, respectively. The incidence of PE (2%) and major bleeding (2%) was low, with similar risk across groups of treatment duration. The incidence of PTS was 30% in untreated patients, 11% in short, and 0% in long anticoagulation. The incidence of CRNMB was respectively 2%, 1%, 4%, and 8%. Patients receiving short courses of anticoagulation had higher risk of recurrent VTE (RR=2.72; 95% CI: 1.19-6.23) and proximal progression (RR=3.86; 95% CI: 1.77-8.43) than patients receiving long anticoagulation, with similar bleeding risk in patients with IDDVT, anticoagulation seemed associated with lower risk of recurrent VTE and proximal progression, and similar bleeding risk compared to no anticoagulant treatment. Long-term treatment duration appeared to be more effective
Due Medee afroamericane del Novecento: la negazione della black motherhood in Angelina W. Grimké e Toni Morrison
No full textDoes a positive attitude toward technology enhance job search self-efficacy? The role of gamification.
No full textAim/Purpose This study explores university-to-work transitioners' perceptions towards innovative talent attraction and selection methods, emphasizing the role of gamification. Specifically, it examines how predisposition towards gamified selection procedures mediates the relationship between positive attitude toward technology and job search self-efficacy, providing insights into how digital tools can facilitate a more efficient and empowering transition to work.
Background Recruitment and selection processes have undergone a profound transformation, redefining access to the labor market and influencing talent acquisition strategies.
Methodology Applying Social Cognitive Theory and Technological Acceptance Model (TAM), an empirical survey was conducted with a sample of 144 close-to-graduation students to investigate the relationships between job search self-efficacy, positive attitude towards technologies, and predisposition towards gamification in selection processes.
Contribution This study contributes to understanding the evolving job search landscape, highlighting how gamification can enhance job search self-efficacy among younger generations.
Findings Findings suggest that the predisposition towards gamification mediates the relationship between positive attitude toward technology and job search self-efficacy. Individuals with a positive outlook on digital technology are more likely to engage with innovative selection approaches, such as gamification, which in turn enhances their confidence in navigating the job search process.
Recommendations
for Practitioners These findings reinforce the challenge for organizations to integrate digital tools and gamification strategies in their selection procedures which foster in job candidates a shift from a positive attitude towards digital technology to practical competencies for employability.
Impact on Society This underscores the importance of digital readiness in shaping employability outcomes for younger generations and their sustainable transition to work.
Future Research Future studies might examine how individual differences—such as digital readiness or prior experience—affect the impact and accessibility of gamified interventions in employment-related contexts
18. Miscellanea di volgarizzamenti di testi devozionali compilata da Silvestro di Gaspare Ristori (sec. XV, prima metà)/18. Miscellaneous collection of devotional texts translated into the vernacular by Silvestro di Gaspare Ristori (15th cent., first half)
No full textLa scheda illustra il contenuto e le peculiarità codicologiche del manoscritto della Biblioteca Nazionale Centrale di Firenze, Palatino 120, contenente una miscellanea di testi devozionali volgarizzati nel XV secolo da Gaspare di Silvestro Ristori. La scheda è stata redatta in occasione della pubblicazione del catalogo della mostra "Cantare il Medioevo. La lauda a Cortona tra devozione e identità civica" (Cortona, Museo dell'Accademia Etrusca e della Città di Cortona - 28 giugno/5 ottobre 2025)
Unfolded protein response: An essential element of intestinal homeostasis and a potential therapeutic target for inflammatory bowel disease
No full textDifferent physiological and pathological situations can produce alterations in the cell's endoplasmic reticulum (ER), leading to a condition known as ER stress, which can trigger an intricate intracellular signal transduction system known as the unfolded protein response (UPR). UPR is primarily tailored to restore proteostasis and ER equilibrium; otherwise, if ER stress persists, it can cause programmed cell death as a cytoprotective mechanism and drive inflammatory processes. Therefore, since intestinal cells strongly rely on UPR for their biological functions and unbalanced UPR has been linked to inflammatory, metabolic, and immune disorders, here we discussed the role of the UPR within the intestinal tract, focusing on the UPR contribution to inflammatory bowel disease development. Importantly, we also highlighted the promising potential of UPR components as therapeutic targets for intestinal inflammatory diseases
Rendicontazione di sostenibilità e strutture organizzative nelle Università italiane: un’analisi esplorativa
No full textUniversities are increasingly called upon to adopt sustainable approaches and to incorporate sustainability principles and themes into their teaching, research, and third mission. As part of this shift, universities have started implementing sustainability-oriented initiatives, generating a growing need for transparent and systematic reporting of these efforts. However, sustainability reporting remains a voluntary and autonomous choice for the governance of each university, and there are currently no normatively mandatory guidelines, leading to diverse practices and challenges in sustainability reporting adoption.
Furthermore, in universities, the implementation of social and environmental responsibility initiatives and their reporting are influenced by factors such as governance commitment. In this regard, the creation of organisational structures dedicated to sustainability represents a tangible manifestation of governance’s commitment to these issues. This study investigates the sustainability reporting practices of Italian public universities. The research relies on data collection related to key characteristics of the universities, the presence of organisational structures dedicated to sustainability, and the content analysis of their sustainability reports. It specifically distinguishes three levels of analysis. The first level provides an overview of the diffusion and characteristics of sustainability reporting
practices. The second examines the type of information reported, and the third level correlates the content of sustainability reports with the presence of organisational structures dedicated to sustainability to assess the relationship between these structures and the depth of sustainability reporting. The results reveal a complex landscape, influenced by the size and geographical distribution of universities, as well as the lack of specific regulations on sustainability reporting, leading to significant differences in adopted reporting practices. In terms of content, sustainability reports of Italian universities provide extensive information on certain topics, particularly environmental performance and sustainability-oriented third mission activities, while other areas receive less coverage. This suggests that although Italian universities are increasingly committed to documenting their initiatives, there is room for improvement to achieve
more comprehensive and balanced reporting. Furthermore, the analysis highlights how different configurations of organisational structures dedicated to sustainability influence sustainability reporting. Most universities with established reporting practices have
centralised, permanent structures dedicated to sustainability and reporting, with top-level responsible figures. This suggests that, in these cases, sustainability is integrated into institutional strategy and organisational routines, making reporting a consolidated
practice. This research offers new insights into sustainability reporting practices in universities and the impact of institutional support on sustainability reporting, emphasising the critical role of organisational structures. It thus advances the understanding of
sustainability reporting in higher education, highlighting its implications for governance and accountability within academia
Human agents, generative AI, and innovation: A formal model of hybrid creative process
Full text linkGenerative AI (GenAI) has rapidly emerged as a revolutionary technology that enables new ways to generate and recombine knowledge. Despite its significant potential, research on GenAI's role in enhancing creativity and innovation is still in its early stages. The present work advances this emerging field by focusing on the humanGenAI dyad. Specifically, we propose a formal model of hybrid creative process designed to maximize the synergistic potential of the human-GenAI interaction. Drawing on machine learning literature, we conceptualize GenAI as a superposition of latent entities. Through formal argumentation, we demonstrate that optimal creative outcomes arise when human agents actively select the most appropriate entity from the complete spectrum of potential alternatives for the problem at hand. Finally, we outline the ideal iterative process required to asymptotically converge toward these optimal entities. Beyond its practical utility for managers, our model provides new insights into human-GenAI mutual augmentation, the nature of creativity, and the skills and cognitive properties involved
Numerical Modelling of Rock Fragmentation in Landslide Propagation: A Test Case
No full textLandslides and rockfalls can negatively impact human activities and cause radical changes to the surrounding environment. For example, they can destroy entire buildings and roadway infrastructure, block waterways and create sudden dams, resulting in upstream flooding and increased flood risk downstream. In extreme cases, they can even cause loss of life. External factors such as weathering, vegetation and mechanical stress alterations play a decisive role in their evolution. These actions can reduce strength, which can have an adverse impact on the slope’s ability to withstand failure. For rockfalls, this process also affects fragmentation, creating variations in the size, shape and volume of detached blocks, which influences propagation and impact on the slope. In this context, the Morino-Rendinara landslide is a clear example of rockfall propagation influenced by fragmentation. In this case, fragmentation results from tectonic stresses acting on the materials as well as specific climatic conditions affecting rock mass properties. This study explores how different fragmentation scales influence both velocity and landslide propagation along the slope. Using numerical models, based on lumped mass approach and stochastic analyses, various scenarios of rock material fracturing were examined and their impact on runout was assessed. Different scenarios were defined, varying only the fragmentation degree and different random seed sets at the beginning of simulations, carried out using the Rock-GIS tool. The results suggest that rock masses with high fracturing show reduced cohesion along joints and cracks, which significantly lowers their shear strength and makes them more prone to failure. Increased fragmentation further decreases the bonding between rock blocks, thereby accelerating landslide propagation. Conversely, less fragmented rocks retain higher resistance, which limits the extent of movement. These processes are influenced by uncertainties related to the distribution and impact of different alteration grades, resulting from variable tectonic stresses and/or atmospheric weathering. Therefore, a stochastic distribution model was developed to integrate the results of all simulations and to reconstruct both the landslide propagation and the evolution of its deposits. This study emphasizes the critical role of fragmentation and the volume involved in rockfalls and their runout behaviour. Furthermore, the method provides a framework for enhancing risk assessment in complex geological environments and for developing mitigation strategies, particularly regarding runout distance and block size