Portail HAL UHA (Université de Haute-Alsace)
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On the translation of deliberate metaphors in literary texts
No full textInternational audienceAs a postdoctoral student at the University of Bologna under the supervision of Donna in 2011 and 2012, I had the pleasure to co-organise with her what turned out to be quite a successful international conference on the translation of figurative language. That three-day symposium gathered in Aula Prodi several renowned international scholars, including Umberto Eco, who opened up the conference on a mildly apocalyptical day of the year 2012 (12/12/12). During that conference I presented a paper which was not eventually submitted for the collective volume which Donna and I co-edited (Miller, Monti 2014). Some of the considerations of that talk found their way in other papers I have written since then, but what follows is a restored (and partially re-elaborated) version of that oral presentation, as a small token of my gratitude for Donna’s kind and thorough support during my postdoctoral years in Bologna
Restructuration hospitalière et gestion des compétences : une analyse autour du soutien organisationnel et de l'implication au travail
No full textInternational audienceRestructuration hospitalière et gestion des compétences : une analyse autour du soutien organisationnel et de l'implication au travai
Deconstructing Best‐in‐Class Neoglycoclusters as a Tool for Dissecting Key Multivalent Processes in Glycosidase Inhibition
No full textInternational audienceMultivalency represents an appealing option to modulate selectivity in enzyme inhibition and transform moderate glycosidase inhibitors into highly potent ones. The rational design of multivalent inhibitors is however challenging because global affinity enhancement relies on several interconnected local mechanistic events, whose relative impact is unknown. So far, the largest multivalent effects ever reported for a non‐polymeric glycosidase inhibitor have been obtained with cyclopeptoid‐based inhibitors of Jack bean α‐mannosidase (JBα‐man). Here, we report a structure‐activity relationship (SAR) study based on the top‐down deconstruction of best‐in‐class multivalent inhibitors. This approach provides a valuable tool to understand the complex interdependent mechanisms underpinning the inhibitory multivalent effect. Combining SAR experiments, binding stoichiometry assessments, thermodynamic modelling and atomistic simulations allowed us to establish the significant contribution of statistical rebinding mechanisms and the importance of several key parameters, including inhitope accessibility, topological restrictions, and electrostatic interactions. Our findings indicate that strong chelate‐binding, resulting from the formation of a cross‐linked complex between a multivalent inhibitor and two dimeric JBα‐man molecules, is not a sufficient condition to reach high levels of affinity enhancements. The deconstruction approach thus offers unique opportunities to better understand multivalent binding and provides important guidelines for the design of potent and selective multiheaded inhibitors
Aus Indien de Hermann Hesse : du voyage désenchanté à l’expression artistique amicale, in Nicolas Bourguinat, Nikol Dziub (dir.),
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A hot mini-Neptune and a temperate, highly eccentric sub-Saturn around the bright K-dwarf TOI-2134
No full textInternational audienceABSTRACT We present the characterization of an inner mini-Neptune in a 9.2292005 ± 0.0000063 d orbit and an outer mono-transiting sub-Saturn planet in a 95.50 d orbit around the moderately active, bright (mv = 8.9 mag) K5V star TOI-2134. Based on our analysis of five sectors of TESS data, we determine the radii of TOI-2134b and c to be 2.69 ± 0.16 R⊕ for the inner planet and 7.27 ± 0.42 R⊕ for the outer one. We acquired 111 radial-velocity (RV) spectra with HARPS-N and 108 RV spectra with SOPHIE. After careful periodogram analysis, we derive masses for both planets via Gaussian Process regression: 9.13 M⊕ for TOI-2134b and 41.89 M⊕ for TOI-2134c. We analysed the photometric and RV data first separately, then jointly. The inner planet is a mini-Neptune with density consistent with either a water-world or a rocky core planet with a low-mass H/He envelope. The outer planet has a bulk density similar to Saturn’s. The outer planet is derived to have a significant eccentricity of 0.67 from a combination of photometry and RVs. We compute the irradiation of TOI-2134c as 1.45 ± 0.10 times the bolometric flux received by Earth, positioning it for part of its orbit in the habitable zone of its system. We recommend further RV observations to fully constrain the orbit of TOI-2134c. With an expected Rossiter–McLaughlin (RM) effect amplitude of 7.2 ± 1.3 , we recommend TOI-2134c for follow-up RM analysis to study the spin–orbit architecture of the system. We calculate the Transmission Spectroscopy Metric, and both planets are suitable for bright-mode Near Infrared Camera (NIRCam) atmospheric characterization
Thioxanthone-Based Siloxane Photosensitizer for Cationic/Radical Photopolymerization and Photoinduced Sol-Gel Reactions
No full textInternational audienceIn this investigation, a multifunctional visible-light TX-based photosensitizer containing a siloxane moiety (TXS) was designed with a good overall yield of 54%. The addition of a siloxane moiety enabled the incorporation of a TX photosensitizer into a siloxane network by photoinduced sol-gel chemistry, thus avoiding its release. Both liquid 1 H and solid-state 29 Si NMR measurements undeniably confirmed the formation of photoacids resulting from the photolysis of the TXS/electron acceptor molecule (Iodonium salt), which promoted the photoinduced hydrolysis/condensation of the trimethoxysilane groups of TXS, with a high degree of condensation of its inorganic network. Notably, the laser flash photolysis, fluorescence, and electron paramagnetic resonance spin-trapping (EPR ST) experiments demonstrated that TXS could react with Iod through an electron transfer reaction through its excited states, leading to the formation of radical initiating species. Interestingly, the TXS/Iod was demonstrated to be an efficient photoinitiating system for free-radical (FRP) and cationic (CP) polymerization under LEDs@385, 405, and 455 nm. In particular, whatever the epoxy monomer mixtures used, remarkable final epoxy conversions were achieved up to 100% under air. In this latter case, we demonstrated that both the photoinduced sol-gel process (hydrolysis of trimethoxysilane groups) and the cationic photopolymerization occurred simultaneously
BENDING BEHAVIOR OF FABRICS MADE OF FLAX/PA12 COMINGLED YARN
No full textInternational audienceInvestigating various deformation modes is essential for accurately characterizing the behavior of thereinforcement. The interaction between these deformation modes requires further comprehensiveanalysis. This study focuses on the bending behavior of a plain fabric and a 2-2 twill made from flaxyarns comingled and covered with PA12 multifilaments. The influence of the structure is studied bycomparing the bending rigidity of the yarns and the fabrics. The results show that the fabric is more rigidthan the yarns. In addition, the fabric bending rigidity gets closer the bending rigidity of the yarn withthe increase of the length of the floated yarns. The influence of shear on flexural rigidity is alsoinvestigated. The bending rigidity of a fabric increases with the increase of the shear angle. This increaseseems to level off at the same bending rigidity for the two fabrics
Preparation of nitro‐phenothiazine‐based oxime esters as dual photo/thermal initiators for 3D printing
No full textInternational audienceAbstract Nowadays, photopolymerization has spanned across all academic and industrial applications due to its appealing features such as energy saving, environmentally‐friendly polymerization conditions, high monomer conversions, rapid polymerization kinetics and so on. Photoinitiator (PI), as a crucial component of the photoinitiating system (PIS) are capable of interacting with light efficiently, enabling to generate initiating species in mono or multicomponent systems. In this work, 13 phenothiazine‐based oxime esters (OXEs) (never reported before) were synthesized and their photoinitiation abilities for the free radical photopolymerization (FRP) of acrylates were examined upon irradiation with LED@405 nm. Parallel to their photochemical reactivities, their abilities to initiate thermal polymerization processes were also investigated. Finally, these OXEs exhibited excellent photo/thermal initiation performances, demonstrating their dual initiation properties. Phenothiazine‐based oxime esters can be used as PIs in 3D printing as well as thermal initiator in the manufacturing of carbon fiber composites
Insights into formation and properties of amorphous mesostructured alumina
No full textInternational audienceHere, using liquid crystals as template, an EISA (evaporation-induced self-assembly) method has been used to synthesize amorphous mesostructured alumina. The effect of the synthesis parameters such as the presence of a chelating agent, the amounts of both porogen agent and alumina precursor on the materials properties have been investigated in details. Under the optimum conditions, after Soxhlet extraction, the obtained Al2O3 presents an HMS (Hexagonal Molecular Sieves) structure and a high specific surface area ( 400m²/g) with a mesopore size distribution centered around 8.3 nm. Investigation of the thermal stability shows that the crystallization into -Al2O3 of the amorphous alumina walls delimiting mesopores begins after heating at 800°C. We have also demonstrated that half of the carbon present in the as-synthesized material can be removed by washing with water or ethanol at room temperature instead of Soxhlet extraction.On the basis of SAXS, XRD and N2 adsorption-desorption analyses, we have shown that when treated into boiling water or exposed to water vapor the alteration of the mesostructure occurs quickly. Its collapse has been attributed to the crystallization of the amorphous alumina walls into aluminum hydroxides, mainly boehmite, upon the hydration of the alumina.Dual mesoporous alumina have been also obtained from micelles through a cooperative templating mechanism at low P123 amount and in the presence of citric acid. In that case both mesopores networks adopt a wormhole-like mesostructure