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Kuraklık stresi altında yetişen domatesin makro-mikro element ve antioksidan içeriğine yapraktan uygulanan potasyumlu gübrelerin etkisi
No full textKuraklık stresi, abiyotik stres faktörleri arasında bitkileri en fazla etkileyen stres faktörlerden biridir. Denemede kuraklık stresi altındaki farklı domates (Kamenta F1 sanayi domates çeşidi ve yerli domates genotipi Fereng) bitkilerine ve KCI gübrelerinin yapraktan uygulanmasının bitkilerde yapraklardaki makro (potasyum, kalsiyum ve magnezyum) ve mikro (demir, bakır, çinko ve mangan) mineral besin element ve antioksidan (toplam şeker, fenolik ve flavonoid) içeriklerine etkisi araştırılmıştır. Deneme Nisan-Ağustos 2020 yetiştirme mevsiminde Şırnak’ın İdil ilçesi Çığır köyünde açık tarla koşullarında üretici arazisinde yapılmıştır. Araştırmada 3 farklı %100 (kontrol), %66 ve %33 sulama seviyesi uygulanmıştır. Gübre olarak da yapraktan %1 oranında ve KCI verilmiştir. Deneme sonucunda kuraklık stresinin her iki domates çeşidinde de yapraktaki K, Ca, Mg, Fe ve Cu içeriklerinde azaltmaya neden olduğu ancak uygulanan potasyumlu gübrelerin incelenen makro ve mikro besin element içeriklerin iyileştirme yaptığı görülmüştür. %100 sulama uygulamasına göre %33 sulama koşullarındaki bitkilerde toplam şeker içeriğinde, toplam fenolik ve flavonoid madde içerik miktarında en iyi sonuçlar elde edilmiştir. %33 ve %66 sulama altındaki bitkilerde Mn ve Zn içeriklerinde kontrole kıyasla artmıştır. Sonuç olarak KNO3 uygulamasının ve KCI uygulamalarına göre yapraklardaki makro ve mikro besin mineral element içeriklerinde daha etkili olduğu belirlenmiştir
Determining the role of HLA-B27 on COVID-19
No full textAim: Human leukocyte antigen-B27 (HLA-B27) binds antigenic peptides in the structure of some viruses and presents them to cytotoxic T lymphocytes and plays a role in the immune response against these viruses. It has also been found to be associated with auto-immunity as an inverse relationship and is associated with a number of auto-immune inflammatory diseases, especially Ankylosing Spondylitis (AS). Our aim in this study is to determine the role of HLA-B27 in Severe Acute Respiratory Syndrome (SARS)-Cov-2 (Coronavirus Disease-COVID-19). Materials and Methods: 90 HLA-B27 positive and 96 HLA-B27 negative cases were included in the study. COVID-19 Polymerase Chain Reaction (PCR) results and Thorax Computed Tomography (CT) results, hospitalization and death records of the cases were retrospectively analyzed from the system records. Results were compared between HLA B27 positive and negative groups. Results: Of the HLA-B27 positive cases, 32.2% had COVID-19 positivity, 5.6% had COVID-19 lung involvement. 44.8% of HLA-B27 negative cases had COVID-19 positivity and 11.5% had lung involvement. There was no significant difference between the HLA-B27 positive and negative groups in terms of having COVID-19 infection, lung involvement, hospitalization and death rates. Conclusion: The results of our study show that HLA-B27 does not have a protective role in terms of having COVID-19 and lung involvement. Again, since no auto-immunity related SARS was observed in any of the patients, it can be said that it did not increase the severity of the hyper-immunity-related disease and did not increase the risk of death in particular for COVID-19. These results need to be supported by more studies
Viral respiratory tract infection in Gaucher disease, a rare disease: A case study of 24 patients in Malatya, Türkiye
No full textAim: People with chronic diseases have a higher rate of morbidity and mortality from SARS-CoV-2 infection. Unknown is how SARS-CoV-2 affects rare disease populations like Gaucher disease. The purpose of this research was to investigate the effects of SARS- CoV-2 infection has on Gaucher patients. The only study conducted in Turkey so far is this one. Materials and Methods: Patients with Gaucher disease were included in the study between August 2020 and September 2022. Patients diagnosed with Gaucher disease were questioned one-on-one to determine if they had come into contact with another person who had COVID-19 symptoms or another patient who had COVID-19. The patients were questioned and their answers were recorded regarding their GBA genotype, previous splenectomy history, whether or not they received treatment, and whether or not they had a SARS-CoV-2 test. Results: Eight of our patients reported having contact with someone who had COVID-19 infection or was suspected of having the infection, and in three of these cases (37.5%) the patient reported having at least one symptom of infection. Out of the 18 patients who were tested, 4 (22.2%) had a positive result. Positive test results were associated with more symptoms in patients (3.8 vs 0.3, p0.001) than negative test results. In Gaucher patients, symptoms or positive test results were not correlated with age, gender, BMI, comorbidity, genotype, previous splenectomy, or enzyme replacement therapy. All of our patients only received supportive care; none of them required intensive care or specialized treatment. Conclusion: Our research revealed that there was a low risk of serious side effects in other chronic patients following SARS-CoV-2 infection in Gaucher patients. In this regard, studies with larger case series are require
Strategic Insights: Navigating Digital Transformation And Customer-Centricity For Enhanced Business Success
No full textThis paper examines the impact of digital transformation and customer-centricity on the processes businesses use to create customer value in today's business world. It discusses the opportunities digital transformation presents to businesses and explores strategies for increasing customer value to achieve success in the current business environment. Additionally, the text offers practical illustrations of theoretical concepts using anecdotal evidence and real-life cases. Finally, through an analysis of emerging digital transformation trends and their potential benefits for companies striving to enhance customer value, it presents businesses with a strategic outlook
Infantile Esotropia: Clinical Features and Results of Bilateral Medial Rectus Recession
No full textIntroduction: To define the characteristics of infantile esotropia and evaluate the results of bilateral medial rectus recession in infantile esotropia. Methods: A retrospective review was performed on medical charts of patients diagnosed with infantile esotropia. All patients underwent an ophthalmological examination to detect the conditions that accompany infantile esotropia. Patients with two years of age or older and without fixation preference or amblyopia underwent bilateral medial rectus recession. Results: There were a total of 117 patients with infantile esotropia patients. Infantile esotropia was accompanied by inferior oblique hyperfunction, fixation preference, cross-fixation, pseudoabduction deficit, pattern deviations, nystagmus, dissociated vertical deviation, convergence insufficiency, and abnormal head position. Approximately forty percent of the patients compatible with visual acuity measurements had amblyopia. Bilateral medial rectus recession decreased the mean esotropia from 43.1±15.3 to 7.8±12.8 prism diopters (PD) in 65 patients. Postoperatively, 41 patients had an ocular alignment within 10 PD of orthotropia, 22 patients showed undercorrection and 2 overcorrection. Conclusion: The characteristics of infantile esotropia in our study are substantially consistent with those of early reports, except for convergence insufficiency. This study also showed that bilateral medial rectus recession appears to have a high percentage of undercorrection in short-term postoperative follow-up in infantile esotropia
COVID-19 pandemisi öncesi ve pandemi döneminde gastrointestinal parazitlerin sıklığı ve dağılımı
No full textBackground: In our study, we aimed to determine the distribution of intestinal parasites detected in patients admitted to our hospital before and during the COVID-19 (Corona virus disease-2019) pandemic. Materials and Methods: Stool samples that came to the Microbiology Laboratory of our hospital in 2019 (before the COVID-19 pandemic) and 2021 (the period of the COVID-19 pandemic) were examined under the light microscope with the native-lugol method after the macroscopic examination to investigate intestinal parasites. Cellophane tape samples taken were Enterobius vermicularis (E. vermicularis) and Taenia spp. evaluated in terms of. Results: Parasites were detected in 1260 (6%) of a total of 20973 samples received in 2019 and in 426 (8.9%) of a total of 4751 samples received in 2021. Parasite positivity in 2021 was found to be significantly higher than in 2019. The rates of Giardia intestinalis (G. intestinalis), Ascaris lumbricoides (A. lumbricoides) and E. vermicularis were significantly higher in 2019 compared to 2021. Entemoeba histolytica/dispar (E. histolytica/dispar) and Entemoeba coli (E. coli) positivity were found to be significantly higher in 2021 than in 2019. The positivity rates in the 0-5 and 6-12 age groups were significantly higher in 2021 compared to 2019. The number of samples coming from the pediatrics and immunology-allergy department was found to be significantly higher in 2021 than in 2019. The number of samples coming from the departments of internal medicine and infectious diseases was found to be significantly higher in 2019 compared to 2021. Conclusions: We think that compliance with personal hygiene rules, social isolation and health education is effective in reducing some of the parasitic infections in the COVID-19 pandemic. We believe that the data obtained can be a guide in the fight against parasitic infections during pandemic periods.Amaç: Çalışmamızda COVID-19 (Corona Virus Disease-2019) pandemisi öncesi ve pandemi döneminde, hastanemize başvuran hastalarda saptanan intestinal parazitlerin dağılımını belirlemeyi amaçladık. Materyal ve Metot: Hastanemizin Mikrobiyoloji Laboratuvarına 2019 (COVID-19 pandemi öncesi dönem) ve 2021 (COVID-19 pandemi dönemi) yıllarında gelen gaita örnekleri, intestinal parazitlerin araştırılması için makroskopik muayene sonrası nativ-lugol yöntemiyle ışık mikroskobunda incelendi. Alınan selefon bant örnekleri ise ışık mikroskobunda Enterobius vermicularis (E. vermicularis) ve Taenia spp. açısından değerlendirildi. Bulgular: 2019 yılında gelen toplam 20973 numunenin 1260’ında (%6) ve 2021 yılında gelen toplam 4751 numunenin 426’sında (%8.9) parazit tespit edildi. 2021 yılında parazit pozitifliği 2019 yılına göre anlamlı yüksek bulundu. Giardia intestinalis (G. intestinalis), Ascaris lumbricoides (A. lumbricoides) ve E. vermicularis oranları 2019 yılında 2021 yılına göre anlamlı yüksek idi. Entemoeba histolytica/dispar (E. histolytica/dispar) ve Entemoeba coli (E. coli) pozitifliği 2021 yılında 2019 yılına göre anlamlı yüksek bulundu. 0-5 ve 6-12 yaş gruplarında pozitiflik oranları 2021 yılında 2019 yılına göre anlamlı yüksek idi. Çocuk hastalıkları ve immünoloji-alerji bölümünden gelen örnek sayıları 2021’de 2019 yılına göre anlamlı yüksek bulundu. Dahiliye ve enfeksiyon hastalıkları bölümünden gelen örnek sayıları 2019’da 2021 yılına göre anlamlı yüksek bulundu. Sonuç: Kişisel hijyen kurallarına uyum, sosyal izolasyon ve sağlık eğitiminin, COVID-19 pandemisinde parazit enfeksiyonlarının bir kısmını azaltmada etkili olduğunu düşünüyoruz. Elde edilen verilerin pandemi dönemlerinde parazitik enfeksiyonlarla mücadelede yol gösterici olabileceği kanaatindeyiz
The relationship between osteochondral lesion of the talus and the foot arch angles in adults: A retrospective study
No full textAim: The current study aimed to compare the arch angles of the foot, Achilles tendinopa- thy, subcutaneous fat tissue thickness of the heel, and epin calcanei (EC) in patients with osteochondral lesion of the talus (OLT). Materials and Methods: The magnetic resonance images (MRI) of the ankle performed by the radiology clinic between March 2020 and October 2021 were examined. Based on the MRI findings, the patients diagnosed with OLT were included in the study group (n = 55) and those not diagnosed with OLT formed the control group (n = 118). All the patients included in the study were investigated for their demographic characteristics and presence of EC. Weight-bearing lateral X-ray images were used to measure the lateral talus- first metatarsal angle (Meary’s angle), lateral talocalcaneal angle (LTCA), and calcaneal inclination angle (also known as the calcaneal pitch). Results: The study and control groups had no significant difference in terms of gender distribution (P = 0.575). The patients in the study group had a significantly higher mean age than the control group (P < 0.001). Evaluation of the arch angles of the foot showed the patients with OLT to have higher LTCA and calcaneal pitch angles and greater sub- cutaneous fat thicknesses (p < 0.001, p < 0.001, and p = 0.004, respectively). In addition, the study group showed higher rates of patients with EC and Achilles tendinopathy (p = 0.076 and p = 0.019, respectively). According to the binary logistic regression analysis model, each unit of increase in the patients’ age increases the presence of osteochondritis dissecans (OCD) of the talus by 1.063 times (95% confidence interval (CI): 1.012-1.116; P = 0.015). Each unit of increase in LTCA increases the presence of OCD of the talus by 1.360 times (95% CI: 1.219-1.516; P < 0.001). Conclusion: Our study demonstrated that sex had no effect on OLT incidence, whereas changes in the LTCA and pitch angles elevated the risk of OLT. Furthermore, increased age was found to be associated with a higher risk of OLT formation. We also showed that Achilles tendinopathy and EC were significantly higher in patients with OLT. A considerable number of future studies are needed to establish whether this significant relationship is causal
Effects of Endothelin-A Receptor Antagonist BQ-123 on Plasma Leptin Levels in Streptozotocin-induced Diabetic Rats
No full textObjective: Leptin and endothelin (ET) as important endogenous factors interacting with each other which may contribute to a better understanding of their role in diabetic pathogenesis. We aimed to evaluate the relationship between leptin and ET by investigating the influence of BQ-123, an ET-A receptor (ET AR) antagonist, on leptin levels in rats with diabetes induced by streptozotocin (STZ). Methods: In this study, 24 male Wistar albino rats were divided into three groups: control, STZ and STZ+BQ-123 groups. Experimental diabetes was induced by delivering a single dose of 60 mg/kg intravenous STZ. The rats in the STZ+BQ-123 group received 4 mg/kg i.v. in total BQ-123 (2 mg/kg +2 mg/kg on the 39th and 40th days). The plasma specimens collected 6 hours after the last BQ-123 delivery were studied for biochemical parameters. Results: At the end of the experiment, the weights of rats in the STZ and STZ+BQ-123 groups were significantly lower compared with the values in the control group. The levels of blood glucose were significantly higher in the STZ and STZ+BQ-123 groups than in the control group. While rats with STZ-induced diabetes demonstrated no changes in leptin, protein carbonyl and K+ levels, they exhibited reduced NO, Na+ and Cl- concentrations. The levels of plasma thiobarbituric acid-reactive substance were significantly higher in the STZ group than in the control and STZ+BQ-123 groups. Conclusion: Although the levels of plasma leptin were not statistically significant different between the groups, BQ-123 groups lead to a further decrease in reduced levels of leptin than in only diabetic group. Our findings have been considered that ET AR antagonists have positive impacts depending on the dosage in the diabetic rats.Scientific Research Fund of Gaziosmanpasa University [2010/95]This research was supported and approved by The Scientific Research Fund of Gaziosmanpasa University (Project no: 2010/95)
MODERN EĞİTİMDEKİ YENİLİKÇİ YAKLAŞIMLAR ÇERÇEVESİNDE ANATOMİ DERSİNİN ÖĞRENCİ BAKIŞ AÇISIYLA DEĞERLENDİRİLMESİ
No full textAMAÇ: Son 30 yılda tıp fakültelerinin eğitim öğretim programlarında görülen müfredat değişikliklerine rağmen anatomi eğitimi temel bir disiplin olarak önemini korumuştur. Bu çalışmanın amacı Kahramanmaraş Sütçü imam Üniversitesi Tıp Fakültesi’ndeki anatomi eğitiminin mevcut durumunun ve eğitim-öğretim sürecine ilişkin sorunların öğrencilerin geribildirimleri ışığında belirlenmesidir. GEREÇ VE YÖNTEM: Çalışmamıza 2021 - 2022 Eğitim–Öğretim yılında Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesinde eğitim gören 482 gönüllü katıldı. Çalışmada Dönem I’ den 167 (% 94,35), Dönem II’ den 151 (%88,30) ve Dönem III ‘den ise 164 (%89,13) öğrenci bulunmaktadır. Tüm öğrencilere gönüllük esasına uygun olarak anatomi eğitimiyle ilgili Google Forms üzerinden 17 soruluk bir anket uygulandı (Teorik eğitimle ilgili 6, İnternetle ilgili 2, Sınavlarla ilgili 4 ve Pratik eğitimle ilgili 5 soru). BULGULAR: Tıp Fakültesi öğrencilerinin %96,9‘u anatomi dersinin iyi bir hekim olmak için mutlaka gerekli olduğunu belirtti. Sunumların ve maketlerin Anatomi eğitiminin teorik kısmının anlaşılmasını kolaylaştırdığını ifade edenlerin oranı sırasıyla %88,4 ve %97,7’dir. Öğrencilerin % 87,82'si öğretim elemanlarının ders panosunun son dersinde vaka raporlarının tartışılmasını önerdi. Almayı planladığımız 3D (üç boyutlu) interaktif anatomi programları hakkında öğrencilerin %78,4'ü olumlu görüş bildirdi. Öğrencilerin %92,1’i laboratuvar derslerinin yararlı olduğunu, %89’u laboratuvarın daha iyi organize edilmesi gerektiğini ve %78,4’ü kadavra diseksiyonun önemli olduğunu belirtti. SONUÇ: Tıp fakültesi öğrencilerinin geri bildirim sonuçları anatomi eğitimiyle ilgili yeni eğitim metodolojisin geliştirilmesinde, mevcut eksikliklerin giderilmesinde yararlı olacağını düşünmekteyiz
The effect of silicon on plant growth and some physiological parameters in salt stress tolerant and sensitive melon genotypyes
No full textLisansüstü Eğitim Enstitüsü, Bahçe Bitkileri Ana Bilim Dalı, Sebze Yetiştirme ve Islahı Bilim DalıBitkisel üretimde tuzluluk stresi bitki gelişimini ve verimini kısıtlayan en önemli abiyotik stres olarak bilinmektedir. Bu çalışmada bitkisel materyal olarak, daha önce tamamlanmış olan bir çalışmada kullanılan farklı genotiplerden seçilen tuza tolerant ve duyarlı genotipler kullanılmış, silisyumun bitki büyümesi ve bazı fizyolojik parametreler üzerine etkisinin belirlenmesi amacıyla yetiştirme serasında saksı denemesi şeklinde yürütülmüştür. Fideler, saksılara aktarıldıktan iki hafta sonra tuz uygulamasına başlanmıştır. Silisyum uygulaması, fideler saksılara aktarıldıktan iki hafta sonra, tuz uygulaması ile aynı zamanda başlatılmış ve besin çözeltisine ilave edilerek uygulanmıştır. Çalışmada, iki farklı tuz dozu (0 ve 100 mM) ve 2 mM Si dozu kullanılmıştır. Bitki büyümesini takip etmek amacıyla büyüme parametrelerinden bitki boyu, gövde çapı, yaprak sayısı, kök uzunluğu, yeşil aksam ve kök yaş ve kuru ağırlıkları, nispi büyüme oranı, fizyolojik parametrelerden; klorofil miktarı, yaprak su potansiyeli, yaprak ozmotik potansiyeli, fotosentez oranı, transpirasyon oranı, stoma geçirgenliği, içsel karbondioksit ve yaprak sıcaklığı incelenmiştir. Çalışma sonucunda, tuz stresinde yetiştirilen kavunlara uygulanan silisyumun gözlenen her parametre üzerine istatistiksel olarak önemli ölçüde etki ettiği tespit edilmiştir. Bu çalışma sonucunda, silisyum uygulamasının genellikle kontrol grubu bitkilerine göre bitki büyümesine ve fizyolojik parametreler üzerine pozitif yönde katkı sağladığı belirlenmiştir.Salinity stress in crop production is known as the most important abiotic stress that restricts plant growth and yield. In this study, salt tolerant and sensitive genotypes selected from different genotypes used in a previously completed study were used as plant material, and a pot experiment was carried out in a growing greenhouse in order to determine the effect of silicon on plant growth and some physiological parameters. Salt application was started two weeks after the seedlings were transferred to the pots. Silicon application was started at the same time as the salt application two weeks after the seedlings were transferred to the pots and was applied by adding it to the nutrient solution. Two different salt doses (0 and 100 mM) and 2 mM Si doses were used in the study. In order to follow the plant growth, the growth parameters such as plant height, stem diameter, number of leaves, root length, green parts and root fresh and dry weights, relative growth rate, physiological parameters; The amount of chlorophyll, leaf water potential, leaf osmotic potential, photosynthesis rate, transpiration rate, stomatal permeability, intrinsic carbon dioxide and leaf temperature were investigated. As a result of the study, it was determined that the silicon applied to the melons grown under salt stress had a statistically significant effect on each observed parameter. Finally, it was determined that silicon application generally contributed positively to plant growth and physiological parameters compared to control group plants