Journals at the University of Arizona
Not a member yet
18839 research outputs found
Sort by
DISTRIBUTION OF INTERSTITIAL COMPLIANCE AND FILTRATION COEFFICIENT IN CANINE LUNG
No full textUtilizing a modification of the isogravimetric methodology, we have estimated the perivascular interstitial compliance and filtration coefficient in the canine lung. These values averaged 1.8 g/cm H20 and 34 (g/h)/cm H20, respectively, per 100 g lung wet weight. By studying lungs at both low and high states of inflation (where the alveolar septae are collapsed) we were also able to determine the spatial distribution of both the interstitial compliance and filtration coefficient. We estimate that of the above total interstitial compliance a maximum of 55% is around alveolar septal vessels, 20% around extra-alveolar arteries and 25% around extra-alveolar veins. Of the above total filtration coefficient, 50% represents filtration from alveolar septal vessels, 23% from extra-alveolar arteries, and 27% from extra-alveolar veins. Our results imply that there are finite interstitial compliances communicating with all permeable vessels. Significant pressures can be built up in these spaces, thereby acutely limiting the further formation of interstitial edema
EQUILIBRATION OF INTRAVASCULAR ALBUMIN WITH LUNG LYMPH IN UNANESTHETIZED SHEEP
No full textIn 16 unanesthetized sheep with chronic lung lymph fistulas we measured pulmonary vascular pressures, lymph flow, lymph and plasma total protein and albumin concentration. We determined the rate of equilibration of radioiodinated albumin between plasma and lung lnterstitial fluid (lung lymph) in three steady-state cond itions; baseline (n = 14), increased pulmonary microvascular pressure (n = 9) and increased microvascular permeability (n = 4). The tracer protein equilibration proceeded according to single compartment wash-in kinetics in all experiments. Lung lymph flow averaged 5.3 ± 2.8 (S.D.) ml/ h under baseline conditions, 16. l ± 10.6 ml/h during increased pressure and 37.3 ± 29.4 ml/h during increased permeability. The half time of equilibration averaged 2.9 ± 1.0 h, 2. 2 ± 1.0 h ind 0.7 ± 0.2 h, respectively. Lung interstitial fluid equilibrates with plasma proteins more rapidly than most other organs. The marked difference between m creased permeability and the other conditions demonstrates the sensi- tivity of this method. No evidence was obtained that any tracer protein entered lung lymph within the caudal mediastinal lymphnode
GENERALIZED LIPOMATOSIS OF LYMPH NODES: A LYMPHOGRAPHIC PROBLEM IN DIFFERENTIATING FROM MALIGNANCY
No full textLymphography in a 50-year-old male patient showed suspicious lymph nodes in the para-aortal region.Exploratory laparotomy and histological examination of biopsied material gave no evidence of tumor or lymphoma. The lymph nodes had distinct lipomatous changes. The differential diagnosis of positive lymphography is discussed
DIRECT LYMPHOGRAPHY OF THE BREAST
No full textThe surgical treatment of breast cancer has been developed on the basis of the topographic anatomy of lymphatic vessels and regional lymph nodes. The axillary and infraclavicular lymph nodes of the breast as well as their afferent lymphatic vessels and the pectoral muscles are removed in continuity. Provided that the lymphatic anatomy of the patient is normal, the operation seems to be radical indeed: yet recurrences and late metastases are often observed (8).In the diagnosis of regional lymph nodes palpation has remained the most common method of examination. However, axillary palpation is not suitable for the demonstration of the collateral lymphatic system developing as a result of blocked main lymphatic channels by tumour deposits. Examination of the axillary lymph nodes by palpation gives according to data in the literature (6, 9, 10) an incorrect diagnosis in about 30 per cent of cases. More accurate methods of examination with regard to diagnosis, prognosis, and therapy are needed to be chosen. With more accurate examinations patients who seem operable according to the classical methods of investigation, but who already have metastases outside the field of operation, can be selected. In order to come closer to the "correct diagnosis" we used direct lymphography of the breast in a group of patients with breast cancer. In recent related literature two authors had reported of similar investigations. Lewis (7) performed successful lymphangioadenography at two patients with benign tumour of the breast, while Halsell (5) studied the anatomy ofmammary lymphatics by the method of lymphangiography, also in 7 benign cases
IMPROVEMENT OF SURGICAL PROCEDURES IN LYMPHOLOGY BY USING A TISSUE ADHESIVE
No full textTECHNICAL NOT
PROTEIN CONTENT OF LIVER LYMPH IN PATIENTS WITH PORTAL HYPERTENSION SECONDARY TO HEPATIC CIRRHOSIS
No full textProtein content of liver lymph was measured in 14 patients with portal hypertension secondary to advanced hepatic cirrhosis. An abnormally low concentration was found in each patient, averaging 52% of plasma levels. This finding reflects a decreased sinusoidal permeability to protein, the possible effect of "capillarization of the sinusoid" and may bear on development of portal congestion
HIGH CONCENTRATION OF BILIRUBIN IN POST-NODAL LYMPH ASSOCIATED WITH RED BLOOD CELL CATABOLISM IN LYMPH NODES OF THE SHEEP
No full textQualitative and quantitative analysis of post-nodal lymph of the sheep has shown that the distinct yellow colour of this fluid pool is due to the presence of relatively large amounts of bilirubin. In efferent lymph from the popliteal, prefemoral, prescapular, renal and intestinal lymph nodes total bilirubin concentrations were 3-8 times higher than the corresponding concentrations in blood plasma. In contrast the total bilirubin concentrations in afferent lymph from the lower leg and kidney were less than the corresponding concentrations in blood plasma. Histological examination of several popliteal and mesenteric lymph nodes revealed the presence of free iron and pilirubin in the cytoplasm of cells located near the lymphatic sinuses of the node. In addition, the concentration of bilirubin in efferent lymph from the popliteal node was observed to increase following an induced rise in the number of red blood cells reaching the node by way of the afferent lymphatic duct. These latter observations suggest that the bilirubin in post-nodal lymph is associated with the catabolism of extravascular red cells by reticulo-endothelial cells within the lymph nodes
THE ROLE OF LYMPHATICS IN THE FORMATION OF ASCITES COMPLICATING SCHISTOSOMAL HEPATIC FIBROSIS
No full textThe total protein content in plasma, ascitic fluid, thoracic duct lymph, hepatic and intestinal lymph was studied in a series of 15 patients suffering from schistosomal hepatic fibrosis and intractable ascites. Pure schistosomal cases with presinusoidal resistance to portal blood flow have excessive thoracic duct lymph low in protein. The main source of such excess lymph is the extra-hepatic portal bed. Ascitic fluid in such patients has a low protein content and has the character of a transudate. The bulk of such peritoneal fluid seems to originate largely from the excess extrahepatic portal lymph
THE BICUSPID NATURE OF THE VALVES OF THE PERIPHERAL COLLECTING LYMPHATIC VESSELS OF THE DOG
No full textA controversy presently exists about the structure of lymphatic valves, the bicuspid structure vs. the funnel-like architechture. This present study, along with a review of the literature was undertaken in an attempt to clarify this controversy.Twenty lymphatic valves from the collecting lymphatic channels draining the back paw region in four dogs were examined and several were photographed. The bicuspid nature and the three dimensional anatomy of these valves is clearly demonstrated