Journals@UC (University of Cincinnati)
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Envisioning the Future of the University of Cincinnati\u27s International Experience Program
No full textRecord ID: 128
Program Affiliation: Service Learning
Presentation Type: Video
Abstract: When exploring the future possibilities of the University of Cincinnati\u27s International Experience Program, conducting market research on international service learning and utilizing data obtained to identify opportunities and recommendations for expansion was key. By analyzing the data received in the form of a university wide survey, we were able to comprehensively identify two new preferential service-learning locations which, in turn, provided the program coordinators a valuable and exciting insight into what the future could hold for the university and its students. A comprehensive, detailed and informative deliverable was compiled which will help shape the vision for the program\u27s future generation of participants
Conformational Dynamics of Hexamer and Pore Loops of Spiral Configuration of Hsp104
No full textRecord ID: 281
Abstract: The heat-shock protein HSP104, from Saccharomyces cerevisiae or Brewer’s yeast, plays a crucial role in protein quality control by unfolding aberrant or toxic proteins to maintain protein homeostasis. HSP104 performs as a hexameric nanomachine by resolubilizing abnormalities such as amyloids and aggregates in the biological environment that cause neurodegenerative disorders such as Alzheimer\u27s and polyglutamine disease. Interactions between the heat-shock protein and the amyloid substrate are facilitated by translocating the substrate along the axial channel from polypeptide to polypeptide, contacting various pore loop active sites, in the presence of ATP hydrolysis. However, the conformational changes of pore loop interactions with the substrate remain incompletely understood. So far, the machine\u27s functional states have been discovered: spiral (PDB ID: 5vya) and ring (PDB ID: 5vjh). This computational study aims to explain the asymmetric pore dynamics of HSP104 by conducting all-atom molecular dynamic simulations for commotions of the spiral configuration. Our results are informed by root mean square deviation (RMSD) analysis, root mean square fluctuations of specific α-carbon atoms, principal component analysis (PCA), and dynamic cross-correlation (DCCM) analysis to discern correlated motions of regions in the hexameric structure during our molecular dynamic simulations.
 
Adapting my teaching approach: Unmasking the hidden curriculum and increasing student engagement
No full textThis personal essay describes the ways in which I modifief my teaching approach to create a more inclusive and accessible learning environment for an increasingly diverse student population. I provide specific examples of strategies I used to facilitate this process. Ultimately, by addressing the hidden curriculum and modifying my course design and materials, I fostered an environment that allowed for greater appreciation of diverse perspectives and increased student engagement. 
Raising critical consciousness and building community in an undergraduate child development course
Get PDFThis narrative describes how a professor has modified their undergraduate Child Development course to increase inclusion and raise students’ critical consciousness as they consider the research behind textbook content, gain new perspectives on children’s development, and learn from each other’s experiences. Disrupting traditional course content and models of rote learning and lecture in favor of more interactive approaches help make content more accessible to students. The narrative provides an overview of the teaching practices used to help students feel known and respected within our class community. Course content and experiences are designed to help students recognize and value their own diverse identities and the identities of others through strength-based and intersectional lenses. These strategies are intended to help students engage with and learn about children’s development in deeper and more meaningful ways
Culture, community, caring- surviving COVID
Get PDFA personal narrative of the instructor\u27s experience building culture and community through caring and surviving COVID
The Child Development Associate (CDA) as a Viable Stepping Stone in the Early Childhood Education Classroom
Get PDFAn Introduction to Case and Design Clinics: A social learning alternative for group problem-solving
Get PDFThis issue documents how diverse groups of professionals used Case Clinics and Design Clinics to engage in problem-solving sessions focused on full inclusion of all participants. In this introduction, we present the social learning foundations of these clinics and outline the specific protocols they involve. Finally, we present a series of research questions for further inquiry into the use of Case and Design clinics.
Effect of Pigment-Acrylic Binder Ratio on the Surface and Physical Properties of Resin Finished Leather
Get PDFThe current study attempts to investigate the surface phenomenon and physical characteristics of leather finished with brown pigment and different types of acrylic binders. Using the contact angle measurements of three different liquids on the above finished leathers and films, the surface energy and work of adhesion were evaluated. The pigment to acrylic binder ratio (PABR) for best adhesion of finish film on the leather surface was optimized using the contact angle goniometer. Different types of acrylic binder films were coated and their surface behaviour was studied. The crust leather was coated with different types of pigment-acrylic binder (Very Soft, Soft and Medium Soft) finish formulations. The contact angle of both the acrylic films and the PABR finished leathers were measured against Water, Dimethyl sulfoxide (DMSO) and Hexadecane (HD). According to the study’s results, the surface properties of finished leather were directly related to the degree of wetting. The PABR was found to be effective at 1:3 for very soft binder, 1:2.5 for soft, 1:2 for medium soft binders due to higher contact angle and lower surface energy values (γsv). At 1:3 and 1:2.5, the contact angle of very soft and soft binder leather was 82.62° and 83.45° and for medium soft binder it was 82.67° at 1:2 ratio. The surface energy values of optimized PABR of very soft binder (1:3) was 28.29 (mN/M), soft binder (1:2.5) was 27.50 (mN/m) and medium soft binder (1:2) was 29.27 (mN/m). The optimized PABR work of adhesion values of very soft binder, soft binder and medium soft binder was 82.15 (mJm-2), 81.11 (mJm-2), 82.09 (mJm-2). In order to correlate the observed surface properties with leather finish properties, finished leathers were tested for finish adhesion, vamp flexing value, water vapour permeability, wet and dry rub fastness. According to the water vapour permeability, soft and medium binder showed good permeation due to the uncovering of nanopores. But the adhesion, grain crack resistance and grain smoothness were higher in the case of the soft binder. Overall leather properties divulges that the pigment to binder ratio and the type of binder plays an important role in surface properties of the finished leather. This study enables us to determine the optimal PABR for effective finish properties to meet the required leather standards for various usage, as well as better utilisation of finishing chemicals
