Parkview Health Research Repository
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Teens Using Screens for Help: Impact of Suicidal Ideation, Anxiety, and Depression Levels on Youth Preferences for Telemental Health Resources.
Get PDFBACKGROUND: High rates of mental illness, stress, and suicidality among teens constitute a major public health concern in the United States. However, treatment rates remain low, partially because of barriers that could be mitigated with tech-based telemental health (TMH) resources, separate from or in addition to traditional care.
OBJECTIVE: This study aimed to analyze TMH resource usage by high school students to establish current user characteristics and provide a framework for future development.
METHODS: A total of 2789 students were surveyed regarding demographics, recent anxiety and depression symptoms, suicidality, and stress; people with whom they could openly and honestly discuss stress or problems, and prior TMH use. Logistic regression models and a general linear model were used to test relationships between variables.
RESULTS: Overall, 30.58% (853/2789) and 22.91% (639/2789) of students reported moderate to severe anxiety and depression symptoms, respectively, in the past 2 weeks; 16.24% (414/2550) had seriously considered suicide in the past year, consistent with national averages. Meanwhile, 16.03% (447/2789) of students had previously used at least 1 of 4 types of TMH resources (ie, self-help, anonymous chat, online counselor, or crisis text line). Teens reporting depression symptoms, higher stress, or suicidality were less likely to talk to a parent about stress or problems and more likely to tell no one. Suicidality was related to the use of all 4 types of TMH resources. Depression symptoms were related to the use of anonymous chat and crisis text line, and those with higher stress were more likely to have used an online counselor. Those reporting anxiety symptoms were less likely to have no one to talk to and more likely to have used a self-help resource.
CONCLUSIONS: Youth struggling with mental health symptoms, some of whom lack real-life confidants, are using existing TMH support, with resource preferences related to symptoms. Future research should consider these preferences and assist in the creation of specialized, evidence-based TMH resources
An empirical comparison of back burners, hookups, and friends with benefits relationships in young adults
No full textThe current research locates back burners on the spectrum of human sexual and relational behavior by examining an array of dimensions that might highlight both similarities and differences between back burners and two other casual sexual relational experiences (CSREs), friends with benefits relationships and hookups. An experiment (N = 327) revealed that participants reported more sex with friends with benefits and hookups than with back burners. No differences emerged for friendship strength, relationship closeness, passion, commitment, frequency of communication, or willingness to self-disclose. Conceptual distinctions between these relationship types may be experimenter-created and not reflective of the fluidity of these definitions in young adults
A Pilot Study of Sirolimus in Subjects with Cowden Syndrome or Other Syndromes Characterized by Germline Mutations in
No full textLESSONS LEARNED: This is the first human interventional study in patients with Cowden syndrome that is driven by inactivation of germline
BACKGROUND: Cowden syndrome is characterized by inactivating germline
METHODS: Adult subjects with germline
RESULTS: A total of 18 patients and 16 families were enrolled.
CONCLUSION: A 56-day course of sirolimus was well tolerated in subjects with Cowden syndrome and was associated with some evidence of improvement in symptoms, skin and GI lesions, cerebellar function, and decreased mTOR signaling
Phase 1 dose-escalation study of momelotinib, a Janus kinase 1/2 inhibitor, combined with gemcitabine and nab-paclitaxel in patients with previously untreated metastatic pancreatic ductal adenocarcinoma.
Get PDFPurpose Preclinical evidence suggests the importance of Janus activating kinase (JAK) and TANK-binding kinase 1 (TBK1) in pancreatic ductal adenocarcinoma (PDAC). We evaluated the safety and efficacy of momelotinib (MMB), a JAK1/2 inhibitor with additional activity against TBK1, plus albumin-bound paclitaxel + gemcitabine (nab-P + G), in patients with previously untreated metastatic PDAC. Experimental Design Patients were enrolled into five cohorts of increasing doses of MMB between 100 and 200 mg administered once or twice daily in combination with nab-P + G in 28-day cycles to determine maximum tolerated dose (MTD). Safety, efficacy, pharmacokinetics, and pharmacodynamics were assessed for all patients. Results Twenty-five patients were enrolled. Dose-limiting toxicities of Grade 3 diarrhea occurred in 1 patient each in the 100 and 200 mg MMB once-daily dose groups. MTD was not reached. The 200 mg MMB twice-daily was the maximum administered dose. Objective response rate was 28% (all partial responses), and 13 (52%) patients had a best response of stable disease. The most common adverse events (AEs) were fatigue (80%), nausea (76%), and anemia (68%). Grade 3 or 4 AEs, most commonly neutropenia (32%), were reported by 88% of patients, of which 44% were considered related to MMB. Pharmacokinetic analyses showed MMB concentrations were too low for TBK1 inhibition. Conclusions MMB was safe and well tolerated in combination with nab-P + G. As no OS or PFS benefit vs nab-P + G was apparent in context of suboptimal engagement of the target TBK1, this study does not support further development of MMB as a first-line therapy in pancreatic cancer
A Comparison of the Accuracy of WATCHMAN Device Sizing Between CT, TEE and Patient Specific 3D Models
Get PDFPoster Presented at Conference: Indiana University Student Education and Research Fellowship Program
Objective: Determine the accuracy and reliability of CT imaging and CT-based patient specific 3D models of the left atrial appendage for the preprocedural planning of WATCHMAN device implantation in comparison to TE
How Does Alcohol Consumption Affect Perceptions of One\u27s Own and a Drinking Partner\u27s Ability to Consent to Sexual Activity?
No full textIn this naturalistic study, our aim was to examine the extent to which alcohol consumption affected perceptions of one\u27s own and one\u27s friend\u27s ability to consent to sexual activity. We surveyed 160 adult bargoers in pairs about their own and their friends\u27 alcohol consumption, intoxication symptoms, and ability to consent to sexual activity. On average, participants reported consuming 4.97 drinks, rated themselves at the legal limit for driving, reported one intoxication symptom, and had a blood alcohol concentration (BAC) just over .08. However, few thought they or their friend had diminished cognitive function. Accordingly, most indicated that they could consent to sex (93%) and their friend could consent to sex (87%). Number of drinks people reported consuming, self-reported intoxication levels and symptoms, and BACs were significantly correlated; however, none of these measures was significantly related to individuals\u27 perceptions of their own or their friends\u27 ability to consent to sexual activity. Finally, those in man-man pairs were significantly more likely than those in woman-woman pairs to indicate they would allow their friend to have sex if approached by an interested party. These findings have potential implications for prevention programming and for legal cases involving individuals who engage in sexual activity while intoxicated
Assessing appropriateness of inpatient rifaximin use in a community health system
No full text2019 ASHP Midyear Clinical Meeting / Las Vegas, Nevada / Poster # 11-135
Objective: To evaluate the appropriateness of inpatient rifaximin use and healthcare resource utilization best-practices within a community health-system
Evaluating the Effects of Pre-Treatment with Diltiazem Bolus in Acute Atrial Fibrillation
No full textPresented at: American Society of Health-System Pharmacists Midyear Clinical Meeting, Las Vegas, NV. December 2019
Objective: Evaluate the impact of administering a diltiazem bolus for the initial treatment of atrial fibrillation at Parkview Regional Medical Center (PRMC
Relationship Between Parent Distraction with Technology at Mealtimes and Child Eating Behavior: a Pilot Study
No full textAlmost 70% of adults in the USA own a smartphone. Parent distraction with technology (also called technoference) is important as it can impact child behavior and family outcomes, such as relationship and coparenting quality