International Journal of Clinical Research
Not a member yet
94 research outputs found
Sort by
IJCR Global Summit: Book of Abstracts 2025
Get PDFA Word from the Organizers
Welcome to the Official Book of Abstracts for the 2025 IJCR Global Summit.
We are proud to present this collection of scientific works, which formed the intellectual core of our 2025 Summit. Hosted on August 23–24 at the Faculdade de Medicina da Universidade de São Paulo (FMUSP), recognized as the premier medical institution in Brazil and Latin America and as a global leader in healthcare, this event gathered the brightest minds in the field. This volume serves as both a historical record and a testament to the innovation driving clinical research forward.
The caliber of this year's submissions was truly exceptional. We are pleased to feature 14 abstracts that demonstrate an impeccable standard of research. The diversity of topics reflects our global community and the complex challenges we address together. Engagement during the sessions was equally remarkable, with our jury providing actionable feedback that sparked high-level scientific debate.
As you explore these works, you will witness the convergence of discipline, creativity, and rigor. We extend our gratitude to every author; your contributions ensure the IJCR Global Summit remains a beacon of excellence.
We hope this collection inspires your future endeavors and fosters new collaborations in the year ahead.
Note: Please note that these abstracts appear in their original submission format and have not undergone copyediting, editorial or peer review.
Sincerely,
The 2025 IJCR Global Summit Conference Directors
Dr. Mariana Flaifel, Dr. Peter Samuel, Dr. Heba Sati
and Dr. Gregory Nicolas, Chief Executive Office
Negative Pressure Wound Therapy: 3500 Years of Revolution and Evolution
Get PDFOf all the options available for wound treatment, few have been as transformative as negative pressure wound therapy (NPWT). From the earliest descriptions of applying suction to wound surfaces, such as cupping therapy in Egypt around 1550 BC and later by Hippocrates (ca. 400 BC), through suction drainage systems for exudate management described by Raffel and Silvis et al. in the 1950s, to the multiple formats and indications we use today, NPWT has redefined the care of complex wounds. In this editorial, we discuss the value of negative pressure wound therapy in wound management and highlight future perspectives for the method
Incarcerated Obturator Hernia in a Scoliotic Patient: A Case Report and Review of Literature
Get PDFBackground: Obturator hernia is a rare entity mainly occurring in cachectic females, which usually end in intestinal obstruction leading to drastic situations due to diagnostic challenges.
Case Report: A case of a low Body mass index scoliotic female patient presented with signs of intestinal occlusion, with no other pertinent findings on physical exam. Computed tomography scan has demonstrated an incarcerated right obturator hernia with no intestinal suffering. Laparoscopic exploration has confirmed the diagnosis, but due to uneasy reduction of the incarcerated small bowel loop, an open reduction and hernioplasty was performed, leading to an uneventful postoperative hospital stay and home discharge.
Discussion: Anatomically, the obturator foramen is a large aperture formed by the ischium and the pubis. It is oval in males, while triangular and wider in females, leading to a 9 times higher incidence in females. More than 90% of cases present with mechanical intestinal obstruction, manifesting as nausea, vomiting, and a crampy intermittent acute abdominal pain. The sac content is mostly small bowel, but cases of ovaries, Meckel’s diverticulum, appendix, fallopian tube, omentum, and colon have been observed and stated in literature.
Conclusion: Obturator hernia is associated with higher mortality rates than other abdominal hernias, hence prompt diagnosis is required, where computed tomography scan is the gold standard. Laparoscopic technique have many advantages, while it is not suitable in septic or unstable conditions. Hernioplasty is superior to herniorrhaphy in clean surgeries
Primary Vaginal Stones in Pediatric Patients: A Review of Literature
Get PDFIntroduction: Calculi, or stones are hard deposits that can precipitate in various anatomical regions. Colpolithiasis or vaginal stones are seldom seen in the clinical practice making the diagnosis and management challenging. Based on their pathophysiology, they can be classified into primary and secondary stones. It is noteworthy that many of the cases described in the literature belong to the pediatric category. Therefore, a special focus on pediatric cases is warranted in this review. We will be tackling the pathophysiology of vaginal stones in pediatric patients and focus on the adaptation of minimal invasive procedures in the management.
Methods: A systematic review was conducted using PubMed, Scopus, and Web of Science databases up to January 2025. Data on demographics, causes, clinical features, diagnostics, and treatments were extracted and synthesized. Case reports and case series were assessed using the CARE guidelines to ensure relevance and quality. This review relied on publicly available data and did not require ethical approval.
Discussion: In opposition to secondary stones primary stones crystallize in the absence of a nidus. In fact, urine stagnation is the cornerstone for primary stone formation. Factors contributing to urine stasis in the vagina include prolonged immobilization and urogenital anatomical abnormalities. Prolonged immobilization was linked to patients with neurological disorders whereas anatomical abnormalities were predominantly described as vaginal outlet obstruction and urethrovaginal fistula. Transvaginal extraction of stones has been mainly adapted for treatment in pediatric patients and it is preferred over the trans abdominal approach as it is less invasive and carries fewer risks.
Conclusion: Primary vaginal stones are seldom described. They are multifactorial as multiple factors play a role in their pathogenesis such as urinary stasis, urinary incontinence, and infection. They are often seen among the pediatric population with neurological disorders or with urogenital anomalies either congenital or acquired. Their management is still not well-established, but there is a tendency toward safer endourological methods more suitable for pediatrics and patients with specific needs
Unmasking Denial in Symptomatology: Delving into the Psychological, Sociocultural, and Contextual Factors of Denial of Patient Symptoms
Get PDFBackground: Symptom denial is a multifaceted response, intricately woven with individual psychology, societal pressures, and environmental cues. This Narrative review delves into this complexity, spotlighting the critical role of a patient's mindset in determining their acceptance or denial of a disease.
Objectives: The literature aims to elucidate the denial of symptoms and its various underlying factors to make healthcare more inclusive of these variations in patient presentations.
Methods: A literature search was conducted across the PubMed database, and hand searches were done on Google Scholar to acquire literature based on SANRA guidelines with structured inclusion and exclusion criteria.
Results: The culmination of this exploration underscores the intricate nature of symptom denial, revealing its multifaceted origins within individual psychology, societal norms, and the broader environment. Denial emerges not as a monolithic reaction but as a nuanced interplay of coping mechanisms, cultural beliefs, socioeconomic factors, and health literacy.
Discussion: Acknowledging these complexities is vital for tailored healthcare approaches. By unraveling the layers of denial, we pave the way for informed interventions that respect diverse perspectives and foster improved symptom acknowledgment, ultimately enhancing overall well-being and patient outcomes
Pleural Effusion Associated with Ulcerative Colitis: A Case Report
Get PDFBackground: Extraintestinal manifestations associated with IBD may involve the skin, joints, hepatobiliary tract, eye, kidney, and rarely pancreas and respiratory systems; as well as risks for venous thrombosis. They may be present at diagnosis or develop later in the disease course. Pulmonary complications of IBD include airway inflammation, parenchymal lung disease, serositis, thromboembolic disease, and drug-induced lung toxicity.
Case Presentation: We report a case of a 41-year-old lady with ulcerative colitis who presented to the hospital with respiratory symptoms. Physical examination and imagery lead to the diagnosis of acute pleural effusion. Later on, the patient developed gastrointestinal symptoms. Colonoscopy and biopsy showed that she has Ulcerative Colitis. Which is a very rare presentation of EIM of IBD. The patient improved on steroids and mesalamine and pleural effusion resolved.
Conclusion: In conclusion, pulmonary involvement should be considered when pleurisy develops in UC. Early diagnosis and effective treatment are important for these patients
Unilateral Vocal Cord Paralysis Following COVID-19 Infection: A Case Report and Literature Review
Get PDFBackground: Throughout the COVID-19 pandemic, numerous symptoms and complications were encountered. These symptoms ranged from conjunctivitis, diarrhea, and anosmia to headache, confusion, lightheadedness, acute cerebrovascular disease, epilepsy, acute disseminated encephalomyelitis, encephalitis, loss of taste, pain in muscles, and Guillain-Barre Syndrome. Some carriers were asymptomatic and only had a diminished sense of smell. Besides, one of the rare manifestations that may be encountered post-COVID-19 infection is vocal fold paralysis, unilaterally or bilaterally.
Case report: This is the case of a 47-year-old female patient presenting with hoarseness of 10 weeks duration and 11 weeks post-COVID-19 infection. Using laryngoscopy, the patient was diagnosed with right vocal cord paresis with incomplete abduction. However, there were no abnormalities found in the brain, thorax, or upper mediastinum. After refusing to take corticosteroids, gradual improvement in hoarseness was observed 2 weeks after her first visit to the clinic, and the patient reached complete remission in 4 weeks.
Conclusion: This case represents a very rare complication following coronavirus infection. Considering the sparse reports of such cases, it is extremely important to shed light on the possibility of vocal fold paresis after infection with COVID-19 and how these cases are being managed
Nerve Reconstruction's Revolutionary Effect on Facial Paralysis: An Editorial
Get PDFIntroduction: Facial paralysis can impact a person's capacity to communicate and interact with others, as well as their physical appearance. [1] A ray of hope has been offered by the development of microsurgical methods for treating this debilitating illness. A game-changing procedure among these is nerve reconstruction using muscle grafts or merely nerves, such as the muscle gracilis. In this editorial, we explore the value of nerve repair in cases of facial paralysis and highlight the encouraging effects of microsurgical procedures
Unraveiling the Mystery: Jejunal Stenosis Post-Stroke: A Case Report
Get PDFBackground: Jejunal stenotic strictures are relatively rare but have significant clinical entities and various complex etiologies characterized by the narrowing or obstruction of the jejunum.
Case Report: The patient presented with a two-month history of abdominal pain, persistent nausea, bilious vomiting, and dizziness, following a left posterior cerebral artery (PCA) stroke. Workup and various imaging studies revealed stenosis of the 3rd and 4th portion of the proximal jejunum, leading to the decision to proceed with exploratory laparotomy with bowel resection and anastomosis. The histological examination of the 15cm jejunum resection revealed significant transmural inflammation, encompassing both acute and chronic components. The presence of ulcers and prominent lymphocyte infiltration was noted, along with granulation tissue and hypertrophic muscularis propria.
Conclusion: The absence of focal deficits and subsequent ischemic events, accompanied by a history of inflammatory bowel disease, suggested ischemic enteritis (IE) as the primary etiology. The patient exhibited a full recovery following the surgical intervention and reported normal gastrointestinal (GI) function. This case emphasizes the necessity for further research to gain a comprehensive understanding of the pathophysiology and optimal management approaches for jejunal stenosis. It further highlights the significance of considering IE in patients with persistent GI symptoms post-stroke
A Case of an Adult Complicated Left Diaphragmatic Hernia: Case Report and Literature Review
Get PDFIntroduction: Diaphragmatic hernia by definition is the protrusion of abdominal structures into the thoracic cavity. Classified as either congenital or acquired, adult diaphragmatic hernia without a history of trauma is rare, and iatrogenic diaphragmatic hernia is rarer. The array of symptoms may be acute or latent and will depend on the herniated organ, which certainly makes this pathology a challenge at the level of diagnosis and subsequent management.
Case Report: Here we present the case of a 73-year-old male patient who presented one year post left nephrectomy complicated by splenectomy (post splenic injury), with two weeks history of diffuse abdominal pain, non-bilious vomiting, and shortness of breath. Workup done revealed a left diaphragmatic hernia containing necrotic-perforated small bowel loops. A laparotomy with intestinal resection, loop ileostomy along with a primary repair of the diaphragmatic defect were performed.
Conclusion: Although a great portion of acquired diaphragmatic hernias remain asymptomatic, they may be presenting with severe symptomatology and aggravating complications. At the level of clinical manifestation, suspicion of diaphragmatic hernia ascends the ladder of differential diagnosis in a patient with combined respiratory and gastrointestinal symptoms and hence is essential to avoid delayed treatment and superimposing lethal complications. Definitive treatment of diaphragmatic hernia is surgical repair given the high morbidity and mortality associated with such injury