Portail HAL UA (Université d'Angers)
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"Au pays des aigles. Représentations albanaises, expérience viatique et capital militant"
No full textInternational audienc
Journal de l'observatoire commercial de la région mancelle (OCReM), n°2,
No full textÉtude des dynamiques du commerce de détail dans une ville moyenneDynamiques commerciales locales d'une ville moyenn
Environmental sensing, strategic-orientation evolution, and founding imprint: Rethinking strategic fit in dynamic capabilities research
No full textInternational audienceWe contribute to the dynamic capabilities perspective by proposing a conceptual model that explains how strategic orientation and environmental sensing co-evolve in a recursive process of establishing and reestablishing strategic fit. Organizations engage in environmental sensing to identify sources of environmental change and, if required to respond, make decisions that align with their strategic orientation. We introduce the concept of strategic-orientation adjustment, linked to the receding and resurfacing of an organization’s founding imprint, to explain how organizations respond to environmental pressures and adapt their strategic orientation. Our model offers novel insight into the dynamics underpinning the interplay between environmental sensing and the evolution of strategic orientation. Building on the literatures on organizational history and the microfoundations of dynamic capabilities, our article offers an alternative perspective to the configurational view of dynamic capabilities, strategic orientation, and strategic fit. We illustrate our theory using the cases of pioneering electric guitar-making companies Gibson and Fender
Effect of heparins, DOACs, and FXII/FXI inhibitors on catheter-initiated thrombin generation in PRP: an in vitro study.
No full textInternational audienceBackground: Invasive endovascular procedures often require anticoagulation to prevent device-associated thrombosis. High doses of unfractionated heparin (UFH) are the gold standard. The efficacy of factor (F)XII(a) and FXI(a) inhibitors remains unexplored.Objectives: We aimed to investigate, using a validated in vitro model of catheter-initiated thrombin generation (TG) in platelet-rich plasma (PRP), the effects of garadacimab, abelacimab, asundexian, and milvexian and of commonly used anticoagulants apixaban, dabigatran, fondaparinux and heparins (enoxaparin and UFH).Methods: Anticoagulants were added to PRP at 6 concentrations and effects compared with UFH as a reference. The impact of adding anticoagulants into collection tubes before most preanalytical contact activation was also assessed. Concentrations achieving a 50% reduction in TG peak height (PH) were determined (IC50).Results: All anticoagulants prolonged lag time (LT) and reduced PH and endogenous thrombin potential, albeit to varying extents. UFH was the only anticoagulant able to suppress TG at clinically achieved concentrations (1 U/mL). The following IC50 were found: milvexian, 2400 ng/mL; apixaban and dabigatran, 175 ng/mL; fondaparinux, 2.4 μg/mL; enoxaparin, 0.5 U/mL; and UFH, 0.25 U/mL. Asundexian up to 5000 ng/mL failed to reduce TG PH by 50%. Adding garadacimab and abelacimab to collection tubes resulted in greater efficacy than when added to PRP: LT increased by 89% and 32%, respectively; IC50 were 25 and 12.5 μg/mL, respectively.Conclusion: Heparins were by far the most effective anticoagulants in our in vitro model. FXIIa and FXI(a) inhibitors did not adequately prevent coagulation on the studied artificial surface. Direct oral anticoagulants and fondaparinux showed limited efficacy, aligning with clinical observations
Les nouveaux espaces de l’attention dans le système archivistique français : quelques conclusions et mises en perspective à partir du programme de recherche sur les reconfigurations des rapports aux usagers (2RU)
No full textInternational audienceThe Research Program on the Reconfiguration of Relations with Archive Users (2RU), operating under an agreement with the SIAF from 2022 to 2024, diligently explored public-facing practices and projects. This was accomplished through extensive engagement with archivists, users, and archive services of diverse scales. Employing a blend of quantitative and qualitative data collection methodologies, the program thoroughly documented initiatives that were either publicly presented, actively implemented, or aspirational within these departments. Our investigative scope included PSCEs, websites, social networks, and the archives themselves. Data gathering involved approximately 70 individual and group interviews, access to five observation sites, and collaborations with 12 distinct departments. Furthermore, targeted experimental activities were conducted.Drawing from the comprehensive findings of this program, we aim to initiate a discourse on evolving spaces for public attention. We conceptualize these as socio-technical devices: intricate systems constructed and governed by intricate interactions among diverse actors, profoundly influenced by power dynamics, strategic choices, the cumulative effect of individual behaviors, and a discernible element of opportunism. Crucially, these spaces also function as direct responses to burgeoning societal demands.Numerous innovations are discernible, both within the design of these systems and in the procedural pathways taken for their conceptualization and execution. Nevertheless, a challenge persists: some innovations encounter difficulties in achieving broad dissemination, while others are constrained by their limited implementation scale, often remaining within the purview of a single department. The forthcoming presentation will provide a valuable platform for deliberating the conditions conducive to success and identifying key impediments, as well as examining what these endeavors communicate about archivists' evolving understanding of their professional role and core mission(s).Entre 2022 et 2024, le programme de recherche sur les reconfigurations des rapports aux usagers des archives (2RU), conventionné avec le SIAF, a cherché à explorer les pratiques et les projets vis-à-vis des publics, en partant à la rencontre des archivistes, d’usager-es et de services de tailles variables. Conjuguant différentes méthodes de recueil de données – quantitatives et qualitatives –, le programme a recensé les actions affichées, mises en place ou désirées par les services. PSCE, sites web, réseaux sociaux, archives des archives ont été mobilisés. Environ 70 entretiens individuels et collectifs ont été menés. Cinq terrains d’observation nous ont accueilli-es. 12 services ont été rencontrés. Des expérimentations ponctuelles ont également été réalisées. Nous nous proposons de réfléchir, à partir des résultats de ce programme, aux nouveaux espaces de l’attention aux publics. Nous les appréhendons comme des dispositifs socio-techniques, c’est-à-dire des systèmes construits, régulés par les interactions entre acteurs, orientés par des rapports de force, des stratégies, l’addition de comportements individuels et d’une forme d’opportunisme. Nous les concevons également comme des formes de réponse à des demandes sociales émergentes. De nombreuses innovations sont observables – tant dans les dispositifs eux-mêmes que dans le cheminement emprunté pour les penser et les concrétiser. Certaines peinent cependant à se généraliser. D’autres pâtissent de l’échelle de mise en œuvre, à savoir un service isolé. La communication sera l’occasion de réfléchir aux conditions de la réussite et aux points de blocage, mais aussi à ce que ces initiatives nous disent de la conception par les archivistes de leur rôle et de leur(s) mission(s)
Un cas d’hypernatrémie sévère chez un patient cachectique dans un contexte d’hospitalisation pour une pneumopathie à pneumocoque
No full textInternational audienceUn homme de 65 ans, aux antécédents d’accidents vasculaires cérébraux séquellaires et de pneumopathie d’inhalation, est hospitalisé pour un nouvel épisode de pneumopathie à pneumocoque. Aux urgences, le bilan biologique révèle une hypernatrémie sévère associée à de nombreuses autres anomalies biologiques, avec une normalisation soudaine de la natrémie
Using mixture and exposome methods to assess the associations and interactions of chemical biomarkers with semen parameters
No full textInternational audienceBackground: Although epidemiologic studies have found associations between several chemical biomarkers and semen parameters, only a few studies have evaluated their combined effects and interactions.Methods: We included 420 men aged 18-55 years who participated in the Environment and Reproductive Health (EARTH) study between 2005 and 2019 at the Massachusetts General Hospital Fertility Center. Four mixture/exposome models, including exposome-wide association studies (ExWAS), Deletion/Substitution/Addition algorithm (DSA), Bayesian Kernel Machine Regression (BKMR), and the non-linear interaction model (NLinteraction), were used to evaluate associations between 24 chemical biomarkers (urinary bisphenol A, four parabens, triclosan, 17 phthalate metabolites, and hair mercury [Hg]) and semen parameters (sperm count, concentration, morphology, motility, and semen volume).Results: Overall, Hg was positively, and triclosan was negatively significantly associated with all semen outcomes except semen volume across multiple models. In BKMR, when increasing the mixture from the 10th to 90th percentile, the chemical mixture was negatively associated with percent normal sperm morphology (-1.42 %, 95 % Credibility Interval [CRI] -12.36; 9.52), motility (-0.10 %, 95 % CRI -1.78; 1.58), and volume (-0.26 mL, 95 % CRI -0.79; 0.28), and positively associated with sperm count (0.21 mill, 95 % CRI -0.23; 0.65) and concentration (0.33 mill/mL, 95 % CRI -0.14; 0.80). We detected one interaction between urinary triclosan and butylparaben in relation to normal sperm morphology using NLinteraction.Conclusion: Among 24 biomarkers tested, Hg and triclosan showed consistent associations with semen parameters while other biomarkers were less consistent depending on the model used. Similar research studies should be encouraged to use multiple models to incorporate interaction assessment and assess the robustness of results
L'accessibilité des logements neufs
No full textInternational audienceDu rêve du législateur à la désillusion jurisprudentiell
Overheated and Understudied: A Scoping Review of Heat‐Related Health Impacts in the Arabian Peninsula
No full textInternational audienceAbstract Extreme heat is worsening due to climate change, and, in combination with increasing urban growth, is an escalating public health concern. In the Arabian Peninsula, the wet‐bulb temperature is projected to surpass theoretical human tolerance limits during the 21st century. Yet, heat research in the region has generally not focused on health impacts, and it is unclear how epidemiologic literature has investigated this. We performed a scoping review to examine the existing literature that assessed the relationship between extreme heat and health outcomes in the Arabian Peninsula, collecting papers published from 2010 to 2024 from three databases. We identified and extracted detailed information from a limited number of studies ( n = 12). The greatest number of studies were conducted in Kuwait ( n = 8), with others in Saudi Arabia ( n = 4), and Qatar, Oman, Yemen, and the United Arab Emirates ( n = 1 each). Average temperature was the most used exposure ( n = 9) assessed at the daily level ( n = 10), using one or several meteorological stations ( n = 9) from a single city ( n = 8). The outcome was predominantly daily‐level ( n = 10) mortality ( n = 9) assessed at an ecological scale ( n = 10) as opposed to the individual scale. While most studies included confounders ( n = 10), their selection was not always consistent with best practices. Most papers did not assess effect modification ( n = 8), and none investigated modification by land‐cover and land‐use change on the heat‐health relationship. We provide future research recommendations based on our findings. Additional studies are critical to better understand the heat‐health relationship in the Arabian Peninsula, which can aid intervention implementation
Neurosurgical management of the acute phase of adult and pediatric traumatic brain injury
No full textInternational audienceObjectiveTo develop a multidisciplinary French framework addressing neurosurgical management in the initial phase of traumatic brain injury (TBI) in adults and children.DesignA panel of 29 experts was formed at the request of the French Society of Neurosurgery (SFNC), with the participation of the French Society of Pediatric Neurosurgery (SFNCP), French Society of Private-Practice Neurosurgeons (SFNCL), French-Speaking Neurocritical Care and Neuro-Anesthesiology Society (ANARLF), French Society of Anesthesia, Critical Care and Perioperative Medicine (SFAR), French-Speaking Pediatric Emergency and Intensive Care Group (GFRUP), French Society of Neuroradiology (SFNR), French-Speaking Infectious Diseases Society (SPILF), and the French Society of Physical Medicine and Rehabilitation (SOFMER).MethodsQuestions were formulated using the PICO (Patients, Intervention, Comparison, Outcome) format, grouped into 7 categories: 1. Factors of poor prognosis, 2. Extradural hematoma, 3. Acute subdural hematoma, 4. Skull-base fracture and dural tear, 5. Penetrating traumatic brain injury, 6. Post-traumatic cerebrospinal fluid disorder, and 7. Pediatric specificities.ResultsSynthesis by the experts and application of the GRADE® method resulted in the formulation of 45 recommendations. Strong consensus was reached for all recommendations at the first round of rating,ConclusionThere was a strong consensus among the experts on important interdisciplinary recommendations to improve the neurosurgical management of patients with TBI