Portail HAL UA (Université d'Angers)
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Go with the (Work)Flow! Creating Reusable and Replicable Workflows for Digital Humanities Research
No full textInternational audienceIn an age of abundant yet fragmented digital resources, humanities researchers still face steep barriers in transforming data into actionable research workflows. The ATRIUM project (Advancing Frontier Research in the Arts and Humanities) addresses these challenges through a cross-disciplinary effort that bridges four major European research infrastructures—DARIAH, ARIADNE, CLARIN, and OPERAS. By developing interoperable, reusable, and FAIR-compliant workflows, ATRIUM empowers scholars to navigate diverse data types—from texts to images, 3D, and geospatial data—with transparent and reproducible methods. This poster at DH Benelux highlights the collaborative approach to workflow design, and explores the project's integration with the SSH Open Marketplace. A featured use case demonstrates the IIIF protocol in action, enabling remote visual annotation of rock art datasets from the UK and Sweden. Through this work, ATRIUM not only enhances access to digital tools but also reframes workflows as essential, citable research outputs
Bayesian Adaptive Sampling: A Smart Approach for Affordable Germination Phenotyping
No full textInternational audienceDigital phenotyping is rapidly advancing, generating increasing amounts of data, particularly in the case of temporal monitoring. We propose an adaptive sampling method that optimizes sampling, thereby reducing costs associated with data production, processing, and storage. The proposed method is based on Bayesian inference, which utilizes previous measurements, historical data, and an expected model. Five Bayesian methods are assessed in this study: Important sampling (IS), Markov chain Monte-Carlo (MCMC), Gaussian process (GP), Extended Kalman filtering (EKF) and Sampling Importance Resampling particle filtering (SIR-PF). We test these five Bayesian sampling methods for the monitoring of germination rate in terms of compression, distortion and computation cost. The best trade-off is found by the MCMC method, which offers a compression rate of 0.2 with very little distortion. GP offers the most unbiased parameter estimation and the capability to adapt to various germination speeds. It also has reasonable computational times
Branch-and-bound algorithm for exact ℓ0 -norm sparse spectral unmixing
No full textInternational audienceWe propose an algorithm that exactly solves the cardinality-constrained sparse spectral unmixing problem. Based on recent works on ℓ0-norm exact optimization, a branchand-bound architecture is specifically developed for sparse unmixing, under nonnegativity and sum-to-one constraints. The procedure boils down to solving a finite number of sum-to-one constrained nonnegative least-squares problems for upper-and lower-bounding the global optimal value, which are solved efficiently. Numerical simulations show that our method outperforms competing ones in terms of support identification and estimation, and that it remains computationally tractable as long as the problem size is limited or the signal-to-noise ratio is high enough. A free C++ implementation is made available
Extreme variability of vascular responses to slightly different abduction angles during abduction and external rotation tests, in patients with suspected thoracic outlet syndrome
No full textInternational audienceAbstract Objective. Patients may not always perform a perfect 90° upper limb abduction when doing an abduction, external rotation test for the evaluation of thoracic outlet syndrome (TOS). We aimed to study the vascular responses to three slightly different abduction angles. Approach. We recorded fingertip arterial (A-PPG) and forearm venous (V-PPG) photo-plethysmography in 111 patients referred for suspicion or follow up of TOS. The measurements were made bilaterally during a 30 s surrender position, followed by moving elbows in the frontal plane without changing elbow and hand level to open the costo-clavicular angle (prayer position) to standardize venous results, either: slightly below (<90°), at the same level of (∼90°), or slightly above (>90°) the shoulder level, in a random order. Main results. With abnormal results defined as A-PPG <5%rest and V-PPG < 70%max in the surrender position, 54 of the 222 upper limbs were normal at all three tests. The proportion of abnormal tests decreased with the increase in abduction angle (Cochran Q < 0.05), 135 upper limbs showed impaired venous outflow for one ( n = 74), two ( n = 47) or the three angles ( n = 14) without arterial inflow impairment at any of the three tests. Significance. Slight changes from a ‘perfect’ 90° abduction angle gave unreliable results during elevation, abduction, external rotation stress tests. A venous outflow impairment should probably be considered a physiologic response at <90° abduction
Integrative Bulk and Single-Cell Multiomic Framework for Tracing (Sub)clonal Evolution in Multiple Myeloma
No full textInternational audienceBackground: Multiple myeloma, the second most common blood cancer, is characterized by the clonal proliferation of malignant plasma cells. Although recent immunotherapies have markedly improved outcomes in relapsed or refractory patients by redirecting immune responses toward tumor cells, primary and acquired resistance remain frequent within the first year. The underlying escape mechanisms are challenging to dissect due to the genetic and phenotypic heterogeneity of the disease.Results: We developed an integrative framework combining whole-genome sequencing (WGS) with single-cell multiomic profiling (scMultiome: joint scRNA-seq and scATAC-seq) to enable multimodal characterization of tumor samples at subclonal resolution. We applied this approach to a large and diverse cohort of 38 patients (46 samples, including longitudinal samples from 7 patients) from the prospective MYRACLE study (ClinicalTrials.gov registration: NCT03807128). This cohort includes patients treated with emerging immunotherapies such as CAR-T cells and bispecific antibodies, many still at the trial stage.Conclusions: Our integrative approach enables the identification of clonal and subclonal genetic and epigenetic events associated with disease progression and resistance. By reconstructing phylo(epi)genetic trajectories, we map the evolutionary paths accessible to multiple myeloma under therapeutic pressure, providing a scalable framework to study resistance mechanisms in a patient-specific and longitudinal manner
Functorial constructions related to double Poisson vertex algebras
No full text69 pages, 7 figures. Comments are welcomeInternational audienceFor any double Poisson algebra, we produce a double Poisson vertex algebra using the jet algebra construction. We show that this construction is compatible with the representation functor which associates to any double Poisson (vertex) algebra and any positive integer a Poisson (vertex) algebra. We also consider related constructions, such as Poisson reductions and Hamiltonian reductions, with the aim of comparing the different corresponding categories. This allows us to provide various interesting examples of double Poisson vertex algebras, in particular from double quivers
Energy transition and polycentric governance: a geographical approach to the multiscalar diffusion of energy communities.: The case of energy communities in Western France
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