National Journal of Health Sciences
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Acute Visual Loss in Young Boy
No full textAbstract: Objective: Multiple sclerosis is immune mediated disorder of central nervous system (CNS). Diagnosis of multiple sclerosis is based on clinical findings and investigations, like MRI of CNS. Herein, we presents a 13-year old boy who presented with sudden loss of vision in both eyes for two days duration. The concurrent phenomenon of optic neuritis and multiple sclerosis is less common in children and rarely reported
Transfusion Reactions Encountered at The Children’s Hospital and Institute of Child Health, Lahore, Punjab – A Clinical Audit
No full textAbstract: Any adverse event that occurs during or after transfusion for which no other cause can be established is labeled as a transfusion reaction. Since the advancements in screening tests for infectious diseases, non-infectious transfusion reactions are on the rise. The aim of this study was to assess the frequency of transfusion reactions and to do an audit of reaction reporting. It was a retrospective study done from 1st December 2014 to 31st December 2015 at The Children’s Hospital and Institute of Child Health, Lahore Punjab. The data was retrieved from blood bank records. 22 transfusion reactions were reported, out of which the most common reaction was febrile non haemolytic transfusion reaction. Only one haemolytic transfusion reaction was seen. Among the blood components, most reactions were seen with packed red blood cells. In 90% of cases completely filled reporting forms were received, in 86% of cases post reaction EDTA samples were received, and in only 50% cases urine samples were received in blood bank. Pyrexia was the most frequent symptom in recipients. Re-audit will be done next year. Guidelines need to be followed and updated
Drug Induced Pure White Cell Aplasia: A Case Report and Review of Literature
No full textAbstract: Pure White Cell Aplasia (PWCA) is an extremely rare haematological entity. Various causes have been implicated in its pathogenesis. We are reporting here a case of a sixty seven years old female, referred to us with the concern of febrile neutropenia and extensive oral candidiasis. Workup for secondary causes of agranulocytosis was negative. Bone marrow findings were consistent with PWCA, and in the presence of convincing previous history of amodiaquine intake, she was diagnosed as drug (amodiaquine) induced PWCA
Spigelian Hernia: A Rare Variety of Ventral Hernia
No full textAbstract: Spigelian hernia is rare and generally difficult to diagnose because of its location and vague non-specific symptoms. A Spigelian hernia occurs through the Spigelian fascia, which is composed of the aponeurotic layer between rectus muscle medially and semilunar line laterally. Nearly all Spigelian hernias occur at or below the arcuate line. The absence of posterior rectus fascia may contribute to an inherent weakness in this area. These are often interparietal, with the hernia sac dissecting posterior to the external oblique aponeurosis. Patient often present with localized pain in the area without a bulge because the hernia lies beneath the intact external oblique aponeurosis and they are easily overlooked by obesity. Ultrasound or CT scan of the abdomen can be useful to establish the diagnosis. Spigelian hernias should always be surgically repaired in view of the high frequency of incarceration. We report a 40 year old lady who presented to us with complaint of pain in her right Epigastric & lumbar region along with vague swelling on standing. Diagnosis of Spigelian hernia was made on the basis of ultrasound & CT scan findings & it was confirmed on exploration. The hernia was reduced & licheneistein mesh repair was performed, her recovery was uneventful
Internal Root Resorption : A Review
No full textAbstract: Internal resorption is an asymptomatic condition in teeth seen with past history of injury. In the crown it has a clinical observation of pink mark. It is diagnosed by chance on an x-ray examination. Primal detection and resorption treatment improves prognosis of the condition. Resorption can be broadly classified into normal physiological or pathological process associated with extensive damage to hard structures of tooth such as dentin, cementum and bone. Proper diagnosis of resorption and differentiation of resorption from internal and external resorption by radiographic presentation and the correct diagnosis and treatment planning improves the prognosis of the condition. Untreated cases will cause loss or early exfoliation of the afflicted tooth [1]
A Bibliometric Analysis of Global COVID-19 Research
No full textAbstract: Background: Coronavirus disease 2019 (COVID-19) has influenced all continents, prompting extraordinary efforts on worldwide research and publications to alleviate the crisis.
Methods: We conducted a bibliometric review using Scopus to assess its impact on global scientific production. We searched for the following terms in titles, abstracts, and keywords to identify relevant literature published until 9th January 2021: 2019 novel coronavirus, 2019-nCoV, SARS-CoV-2, COVID-19, coronavirus disease-19, coronavirus disease 2019
Massive Proteinuria which Rapidly Resolved after Discontinuation of Regorafenib
No full textAbstract: Regorafenib is treatment option of cancers. It is associated with several adverse effects, including proteinuria. We report a massive proteinuria associated with regorafenib which resolved quickly after discontinuation of the drug. A 63 year old male presented with diarrhea and bilateral swallowing of legs. In urinanalysis, 18.5 g/day of proteinuria was detected. All symptoms, including proteinuria, resolved after discontinuation of regorafenib. Despite cessation of regorafenib treatment is advised in case of proteinuria, we suggest that regorafenib associated proteinuria could be rapidly resolved after discontinuation of the drug
Prevalence of Intestinal Parasites and Associated Risk Factors in Chepang Community of Saktikhor Area, Chitwan, Nepal
No full textAbstract: Objective: Pathogenic species of protozoa and helminth cause intestinal parasitosis, which continues to be a significant community well-being issue in many regions of the world, especially in pastoral regions of developing countries like Nepal. The study focused on determining the prevalence of intestinal parasitic infections and the associated risk factors among the people of the Chepang community of the Saktikhor area in the Chitwan district.Materials and Methods: A transversal study was conducted between May 2017 and October 2017, with a total of 125 participants. The fecal samples were examined using a wet media (saline media, iodine preparation), concentration and sucrose flotation method. The association between risk factors and parasitic prevalence was evaluated using the Pearson’s chi-square test.Results: The general prevalence of intestinal parasite infection was 52%. Infections with soil-borne helminth were more common than those with cestodes and protozoa. Common intestinal parasites included Ascaris lumbricoides (69.23%), Trichuris trichiura (9.23%), Hookworm (7.69%), Strongyloides stercoralis (4.62%), Hymenolepis nana (6.15%), Taenia sp. (6.15%), and Entamoeba coli (9.23%). High prevalence of infection was observed among male (53.96% ) participants and those aged over 20 years (69.44%). Pearson's chi-square test revealed a substantial relationship between prevalence of parasite and age group (P=0.0452), hand washing material (P<0.001) and preference for defecation site (P<0.001).Conclusion: Hence, a heavy occurrence of intestinal parasites within the Chepang community is particularly evident. There is a need for increased emphasis on intrusion, which can be achieved by improving personal hygiene and sanitation of participants and constructing proper sanitary toilets to prevent the spread of parasitic infections.Keywords: , , , , , ,
Potential of Red Sandalwood (Adenanthera pavonina L.) as an Antibacterial Agent against Clinical Isolates
No full textAbstract: The emergence of resistant pathogens is a leading cause of morbidity worldwide. For the treatment of diseases caused by these resistant pathogens, the use of medicinal plants as an alternative to synthetic drugs is increasing. Therefore, the aim of this study was to evaluate the efficacy of hexane and ethanolic extracts of a natural plant Adenanthera pavonina L. Antibacterial activity of Adenanthera pavonina L. leave extracts and pure compound (?-sitosterol glucoside) against Enterrococcus spp., S. aureus, P. aeruginosa, S. typhi, E. coli, Proteus spp., K. pneumonia and A. baumanii, was carried out by well-diffusion assay and micro-dilution technique. Moreover, time-kill tests were carried out to assess the antimicrobial activity of the Adenanthera pavonina L. extracts against E. coli. The results showed good antibacterial potential of Adenanthera pavonina L. extracts against the clinical isolates tested
Invitro Antibacterial Activity of Ethanolic Extracts of Dietary Spices Against Clinical Isolates
No full textABSTRACT: The invitro antibacterial activity of ethanolic extracts of three dietary spices Coriandum sativum (Coriander), Curcuma longa (Turmeric) and Capsicum annuum (Red chili) were investigated by well diffusion method against clinical isolates which include Gram positive (Enterrococcus spp., Staphlococcus aureus) and Gram negative (Pseudomonas aeruginosa, Salmonella typhi, Escherichis coli, Proteus spp., Klebsiella pneumonia and Acinetobacter baumannii) as well as by minimal inhibitory concentration and by microdilution method. Moreover, killing time of each extract was also calculated against Escherichia coli