DSpace@ATÜ (Adana Alparslan Türkeş Bilim ve Teknoloji Universiti)
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Investigation of cytotoxic activity of ßeta-caryophyllene on pancreatic cancer cells
No full textFen Bilimleri Enstitüsü, Biyomühendislik Ana Bilim DalıBeta-Karyofilen (BCP), çeşitli bitkilerden elde edilen ve Gıda ve İlaç Dairesi (FDA) tarafından onaylanan doğal olarak oluşan bir seskiterpendir. Kanabinoid CB2 reseptörleriyle etkileşime girerek anti-inflamatuar ve analjezik etkiler gösterir. Çalışmalar, BCP'nin apoptotik hücre ölümünü indüklemek, anti-inflamatuar etkiler göstermek ve klonojenite, göç ve invazyonu inhibe etmek gibi tümör hücrelerinde birçok biyolojik özelliğe sahip olduğunu göstermiştir. Bu seçici kanser hücrelerini hedefleme yeteneği, BCP'nin kanser tedavisi için umut verici bir terapötik aday olduğunu göstermektedir. Bu çalışmada, BCP'nin MIAPaCa-2 pankreas kanseri hücreleri üzerindeki etkileri, terapötik performansı artırma potansiyelini değerlendirmek amacıyla kemoterapötik ajan Etoposid ile birlikte incelendi. MIAPaCa-2 hücre hatları için BCP'nin IC50 değerleri 58 µg/mL iken, etoposidin IC50 değeri 10.7 µM idi. BCP ve etoposid kombinasyonu, yalnızca tek başına tedavilere kıyasla MIAPaCa-2 hücrelerinde daha yüksek bir hücre ölümü insidansına yol açtı. BCP ayrıca MIAPaCa-2 hücre hatlarında survivin ve c-Myc'nin ifade seviyelerini baskılarken kaspaz-3'ün ifade seviyesini artırdı ve bu etkiler etoposid ile birlikte kullanıldığında daha da arttı. BCP, yalnızca MIAPaCa-2 hücrelerinde sitotoksik etkiler göstermekle kalmadı, aynı zamanda etoposidin anti-proliferatif etkilerini de artırarak normal hücreler üzerinde daha az olumsuz etki gösterdi.Beta-Caryophyllene (BCP) is an organic sesquiterpene composite derived from multiple plants and authorized by the Food and Drug Administration (FDA). It interacts with cannabinoid receptors CB2, exhibiting analgesic and anti-inflammatory effects. Many researches have demonstrated that BCP exhibits a variety of biological effects in tumor cells, including inducing apoptotic cell death, exerting anti-inflammatory effects, and inhibiting clonogenicity, migration, and invasion. This special approach on cancer cells suggests that BCP is a hopeful therapeutic option for cancer treatment. Within this study, the influence of BCP on MIAPaCa-2 pancreatic cancer cells were examined in conjunction with the chemotherapeutic agent Etoposide to assess its potential to enhance therapeutic performance. The IC50 values of BCP for MIAPaCa-2 cell lines were 58 µg/mL, while etoposide had an IC50 of 10.7 µM. The combination of etoposide and BCP led to a higher occurrence of cell death in MIAPaCa-2 cells compared to either treatment alone. BCP additionally inhibited the levels of gene expression c-Myc and survivin, concurrently boosting the level of caspase-3 in MIAPaCa-2 cell lines, with these impacts being intensified when combined with etoposide. BCP demonstrated cytotoxic effects on MIAPaCa-2 cells and augmented the anti-growth effects of etoposide when combined, showing reduced unfavorable effects on normal cells
Application of Multi-Criteria Decision Making Methods for Menu Selection
No full textNutritional information on menus can assist customers in making healthier eating choices. One technique being utilized to tackle the rise of overweight and obesity is the use of nutritional information on menus. Menu engineering strategies can be used to improve sales of generally healthier and higher margin items. For today's food and beverage companies, menu engineering has become essential. Companies must continually evaluate their menus in order to keep up with changing customer demands and the conditions of the competitive market. Menu engineering's core involves comparing the effectiveness of each menu. At this point, correct decision-making under numerous factors is thought to be a very challenging procedure. To evaluate alternatives according to many features, several Multi-Criteria Decision-Making (MCDM) approaches have been created. The main novelty of this paper is that four MCDM methods, including Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS), Fuzzy TOPSIS, VlseKriterijumska Optimizacija I Kompromisno Resenje (VIKOR), and Fuzzy VIKOR, are employed to evaluate menu options. Comparative analysis of MCDM methods is another contribution of this study. The process of evaluating and selecting healthier menu alternatives can become challenging and time-consuming. This study pointed out how crucial it is to conduct comparative analysis using various MCDA methods and to carefully determine the right ones when addressing the issue of selecting the best menu, taking into account the values of the criterion in fuzzy numbers
Load effect of visual working memory on distractor interference: An investigation with two replication experiments
No full textKonstantinou et al. (Experiment 1B; Attention, Perception, & Psychophysics, 76, 1985-1997, 2014) reported that an increase in visual short-term memory (VSTM) load reduced distractor interference in the flanker task. Yao et al. (Experiment 3; Attention, Perception, & Psychophysics, 82, 3291-3313, 2020) replicated the design of Konstantinou et al.'s experiment and showed that the VSTM load did not modulate the distractor interference effect, contradicting the original findings. However, it is unknown whether differences in task-design between the two experiments contributed to the inconsistent results. Therefore, we first replicated the original two studies with Experiment 1 (N = 54) and Experiment 2 (N = 54) and performed a statistical comparison between the data from these two experiments. In a third experiment (N = 28), we incorporated articulatory suppression into the design to exclude possible effects of verbalization. According to the ANOVA analyses, the VSTM load did not change the level of distractor interference in all three experiments, indicating that differences in task design alone do not explain the inconsistency.Scientific and Technological Research Council of Turkiye (TUBITAK)Open access funding provided by the Scientific and Technological Research Council of Turkiye (TUBITAK). No funding was received for conducting this study
Gıda ambalaj malzemeleri için yeşil sentezlenmiş gümüş nanopartiküller içeren yenilebilir kitosan filmler
No full textLisansüstü Eğitim Enstitüsü, Biyomühendislik Ana Bilim Dalı, Biyomühendislik Bilim DalıBu yüksek lisans tezinde, gıda ambalaj malzemesi olarak yeşil sentezlenmiş gümüş nanopartikül katkılı, antimikrobiyal, çevre dostu, sürdürülebilir, yenilenebilir kitosan-jelatin bazlı yenilebilir filmler üretmeyi amaçlanmıştır. Bu amaçla, ceviz (Juglans regia) yaprağı ekstraktı kullanılarak yeşil sentez yöntemi ile gümüş nanopartiküller sentezlenmiştir. Dört farklı koşulda sentezlenen nanopartiküllerin karakterizasyonu için XRD, SEM, FTIR ve DLS yöntemleri kullanılmıştır. Gümüş nanopartiküllerin antimikrobiyal aktivitesi 7 farklı mikroorganizmaya (Escherichia coli, Pseudomonas aeruginosa,, Staphylococcus aureus, Salmonella typhi, Candida albicans, Penicillium italicum, Aspergillus niger) karşı disk difüzyon ve MIC yöntemleri kullanılarak test edilmiştir. Elde edilen verilere göre AgNPs-4 için MIC değerleri 3.9-15.625 µg/mL aralığındadır. Bu MIC değerlerine göre, AgNPs-4 maya ve mantarlara karşı bakterilerden daha fazla antimikrobiyal etki göstermiştir. Sentezlenen tüm AgNPlerin disk difüzyon inhibisyon çapları 9-11 mm aralığında olmakla birlikte tüm mikroorganizmalara karşı en yüksek inhibisyon çapı AgNP-4 örneğine aittir. Bu nedenle, AgNP-4'ler Kitosan-Jelatin bazlı yenilebilir filmlere antimikrobiyal aktif ajan olarak eklenmiştir. Üretilen yenilebilir filmler karakterize edilmiş ve antimikrobiyal testler yapılmıştır ve toplanan verilere göre nanopartikül eklenmiş yenilebilir filmlerin mekanik ve antimikrobiyal özellikleri tatmin edici düzeydedir. Anahtar Kelimeler: Antimikrobiyal, biyolojik olarak parçalanabilir, yeşil sentezlenmiş gümüş nanopartiküller, yenilebilir filmIn this master's thesis, it is aimed to produce green synthesized silver nanoparticle doped, antimicrobial, environmentally friendly, sustainable, renewable chitosan-gelatin based edible films as food packaging material. For this purpose, silver nanoparticles were synthesized by green synthesis method using walnut (Juglans regia) leaf extract. XRD, SEM, FTIR and DLS methods were used to characterize the nanoparticles synthesized under four different conditions. The antimicrobial activity of silver nanoparticles was tested against 7 different microorganisms (Escherichia coli, Pseudomonas aeruginosa,, Staphylococcus aureus, Salmonella typhi, Candida albicans, Penicillium italicum, Aspergillus niger) using disk diffusion and MIC methods. According to the data obtained, the MIC values for AgNPs-4 were in the range of 3.9-15.625 µg/mL. According to these MIC values, AgNPs-4 showed more antimicrobial effect against yeasts and fungi than bacteria. Although the disk diffusion inhibition diameters of all synthesized AgNPs were in the range of 9-11 mm, the highest inhibition diameter against all microorganisms belongs to AgNP-4 sample. Therefore, AgNP-4s were incorporated into Chitosan-Jelatin based edible films as antimicrobial active agents. The produced edible films were characterized and antimicrobial tests were performed and according to the data collected, the mechanical and antimicrobial properties of the nanoparticle-added edible films were satisfactory. Keywords: Anticmicrobial, biodegredible, edible film, green syhntesized silver nanoparticle
Characterization of volatile compounds in the water samples from rainbow trout aquaculture ponds eliciting off-odors: understanding locational and seasonal effects
No full textThe quality of water used in aquaculture ponds is one of the crucial factors influencing the smell and sensory properties of fish. The water samples were taken from the rainbow trout fish ponds from three different fish farms in three provinces in Türkiye in four different seasons. The samples were analyzed for the volatile components by employing HS-SPME/GC–MS. Seven different volatile groups including aldehydes, ketones, esters, alcohols, volatile phenols, terpenes and other aromatic substances were identified in the samples. Among these, aldehydes were found to be the most dominant. (E)-2-Heptenal, nonanal, acetophenone, and 2-ethyl-1-hexanol are thought to be responsible for the off-odors in the water that have the potential to cause off-odors in fish. It was also determined that the amounts of these compounds increases in winter due to lower water temperature. Fish producers should monitor water quality on a regular basis to prevent off-odor compounds that degrade fish quality. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.Thailand Institute of Scientific and Technological Research, TISTR; Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK, (119O604); Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTA
Design and performance evaluation of a 3D printed aerostatic bearing concept with high number of micro-orifices
No full textThis study suggests a 3D printed aerostatic bearing concept. The design has a high number of orifices distributed around the bearing to obtain smoother pressure distribution for performance. Inner channels are formed to connect and feed air to each orifice using the advantage of additive manufacturing. The concept is investigated numerically to determine the performance gain of the high number of orifices by calculating bearing stiffness and load carrying capacity. In order to validate the simulation and performance gain an experimental study is conducted by testing Stereolithography (SLA) type 3D printed bearings with various orifice numbers. The bearing stiffnesses and mass flow rates of the specimens are measured, and results are discussed in terms of performance by comparing numerical results. The 3D printed bearings concept has shown promising results in terms of performance while keeping air consumption limited compared to conventional air bearings.Scientific and Technological Research Council of Turkey (TUBITAK) [121M695]The authors disclosed receipt of the following fi nancial support for the research, authorship, and/or publication of this article: The Scientific and Technological Research Council of Turkey (TUBITAK) funded this study under Grant No. 121M695
Robust Adaptive Control Based on Incremental Nonlinear Dynamic Inversion for a Quadrotor in Presence of Partial Actuator Fault
No full textThis paper presents a novel nonlinear robust adaptive trajectory tracking control architecture for stabilizing and controlling a quadrotor in the presence of actuator partial faults. The proposed control strategy utilizes an Incremental Nonlinear Dynamic Inversion (INDI) algorithm as the baseline controller in the inner loop and augments a nonlinear model reference adaptive controller in the outer loop to ensure robustness against unmodeled faults. Additionally, a modified PID controller is introduced in the most outer-loop to track the desired path. The effects of actuator faults are modeled by considering sudden variations in motor thrust and torques. To enhance the control algorithm's robustness, a projection operator is employed in the robust adaptive structure. Comparative performance evaluations with a previous successful algorithm implemented on a quadrotor model demonstrate that the proposed controller achieves full controllability of the faulty quadrotor in pitch, roll, and yaw channels in the presence of actuator partial faults up to 50%
Effect of Storage Containers and Storage Periods on the Moisture Content, Germination and Biotic Status of Durum Wheat (Triticum turgidum L.) Seed
No full textTo observe the moisture content and germination capacity of durum wheat seed stored in different storage containers for certain storage periods, a Lab. experiment was carried out at the Agronomy laboratory, Hajee Mohammad Danesh Science and Technology University (HSTU), Dinajpur, Bangladesh during March-May 2016. The experiment was designed completely randomized design (CRD) with three replications under three storage periods (30, 45, and 60 days after storage) and three seed containers (sealed plastic container, polythene bag and gunny bag). Initial seed moisture content (MC) and germination percentage (GP) was measured before storage of seeds. Seeds stored in containers gradually absorb moisture from air with the advancement of storage periods, and air leaked storage container i.e., gunny bag quickly absorb moisture than other two containers. The maximum values of GP were recorded of durum wheat seed with 30 days after storage (DAS) and the GP reduced significantly with increasing storage periods from 30 to 45 DAS. The highest GP (78.00 %) was found at 30 DAS in sealed plastic container while the lowest (57.67 %) at 60 DAS in gunny bag. The rate of reduction was found to increase with the advancement of storage periods. Durum wheat seed kept in sealed plastic container and ply bag maintained the minimum MC and eventually showed highest GP. An outstanding performance of GP was observed in sealed plastic container seed while the gunny bag provided the inferior GP among all of the three containers. Several fungi was observed such as Alternaria, Aspergillus, Colletotrichum, Fusarium, Penicillium and Rhizopus during germination study, although no insect was found to any storage container during the storage periods. Higher number of fungus was observed in seeds of gunny bag than sealed plastic container and poly bag. In conclusion, durum wheat seeds should be stored in air tight container for certain periods
INVESTIGATION OF THE VARIOUS TAPER ANGLE OF THE TIP AND ANGLE OF THE CONICAL SHAPE OF AN AEROSPIKE NOZZLE
No full textThis study considers the design of aerospike nozzles and the thrust measurement experiments conducted with various designs, taking into account existing research in the literature. Unlike other studies, this experimental study examines the effects of the angle of the conical shape and the taper angle at the tip of the aerospike nozzle on thrust. Thrust measurement experiments were conducted using a cold gas system. All measurement results were compared, revealing that the design parameters for aerospike nozzle efficiency in this study were a conical shape angle of 45° following the main flow passage and a tapering angle of 30° at the tip of the aerospike nozzle. Additionally, it appears that the taper angle and conical angle of the aerospike nozzle are interrelated in thrust production
Bahp ve k-means kümeleme kullanılarak elektrikli araçlar için şarj istasyonu yerleşimi
No full textLisansüstü Eğitim Enstitüsü, Endüstri Mühendisliği Ana Bilim DalıSon yıllarda, trafikteki araç sayısında hızlı bir artış gözlemlenmiş ve araçlardan salınan zararlı gazların yayılması da artmıştır. Hava kirliliği ve küresel ısınma gibi sorunlar özellikle metropollerde arttıkça, fosil yakıtların kullanımı yerine yenilenebilir enerji kaynaklarının kullanımını artırmak ve geliştirmek neredeyse kaçınılmaz hale gelmiştir. Oluşan hava kirliliğini ve doğaya verdiği zararı azaltmak için gaz emisyonlarının azaltılmasına yönelik çalışmalar yapılmakta ve elektrikli araçların geliştirilmesine yönelik çalışmalar yapılmaktadır. Bu çalışmaların çoğu elektrikli araçların çevre dostu bir yaklaşım sergilediğini ve yaşam kalitesini arttırdığını vurgulamaktadır. Türkiye ve dünya genelinde elektrikli araçların giderek artan kullanımıyla birlikte, yolda kolayca erişilebilir şarj istasyonlarının bulunmaması sorunu ortaya çıkmıştır. Şarj istasyonlarının kurulması için en uygun konumların belirlenmesinde çeşitli kriterler dikkate alınmaktadır. Bu çalışmada, İstanbul'un 7 farklı ilçesi ele alınmış ve şarj istasyonlarının en uygun konumlarını belirlemek için Bulanık Analitik Hiyerarşi Süreci Yöntemi (BAHY)kullanılarak kriterlerin ve alternatiflerin önem düzeyleri belirlenmiştir. Son olarak, seçilen ilçedeki aday lokasyonlar arasında kümeleme ile küme merkezlerine en yakın optimal lokasyonlar belirlenmiştir. Bu çalışma, elektrikli araç şarj istasyonlarının yerlerini belirlemede Çok Kriterli Karar Verme (ÇKKV) ve K-means tekniklerinin kullanıldığı kapsamlı bir yaklaşımı temsil etmektedir.In recent years, a rapid increase has been observed in the number of vehicles in traffic, as well as the spread of harmful gases released from vehicles. As problems such as air pollution and global warming increase, especially in metropolises, it has become almost imperative to increase and develop the use of renewable energy resources instead of using fossil fuels. In order to reduce this air pollution and the damage it causes to nature, studies are carried out to reduce gas emissions, and studies are directed towards the development of electric vehicles. Most of these studies emphasize that electric vehicles demonstrate an environmentally friendly approach and enhance quality of life. With the increasing use of electric vehicles both in Türkiye and worldwide, the problem of finding easily accessible charging stations on the road has become apparent. Several criteria are considered in determining the optimal locations for the installation of charging stations. In this study, seven different districts of Istanbul were considered, and the importance levels of criteria and alternatives were determined using the Fuzzy Analytic Hierarchy Process (FAHP) method to identify the most suitable locations for charging stations. Finally, optimal locations wereselected by clustering among the candidate locations in the selected districts. This study represents a comprehensive approach using Multi-Criteria Decision-Making (MCDM) and K means techniques to determine the locations of electric vehicle charging stations