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Diseño de propuesta de mejora para la gestión del mantenimiento de subestaciones eléctricas en el área de alimentación eléctrica empresa Metro S.A.
No full textMetro S. A. es una empresa del Estado de Chile que presta servicios de transporte de
pasajeros y anexos a este giro en la ciudad de Santiago. Fue creada en octubre de 1968,
como Dirección General de Metro, y constituida como sociedad anónima en el año 1989.
Metro de Santiago es una sociedad de propiedad del estado, cuyos dos accionistas son
la Corporación de Fomento de la Producción (Corfo) y el Fisco de Chile.
Desde su creación, su propósito ha sido cumplir una labor social, contribuyendo al
progreso de la ciudad y mejorando la calidad de vida de quienes la habitan.
En la actualidad, existen 7 líneas de tren subterráneo, que suman 140 kilómetros y 136
estaciones que conforman la red y que llegan a 25 comunas de la región Metropolitana.
Este proyecto estará específicamente dirigido al área de alimentación eléctrica en líneas
automáticas L3-L6, la cual forma parte del departamento de gerencia corporativa de
mantenimiento de la empresa.
Dentro del área de alimentación eléctrica en líneas automáticas se ha identificado una
serie de desafíos que afectan la eficiencia en la calidad de la gestión del mantenimiento
eléctrico de las subestaciones que permiten el funcionamiento correcto de toda la red.
Estos desafíos incluyen:
• Programación de mantenimiento de las subestaciones eléctricas.
• Bajada de información.
• Permisos de trabajo y/o autorizaciones.
• Coordinación interdepartamental y retroalimentación.
El sistema actual de gestión del mantenimiento lleva mucho tiempo funcionando de la
misma forma, canalizando todo vía plataformas digitales; correos, Excel o Teams con
reuniones periódicas, por lo que es importante implementar una gestión más eficiente
con la visión de optimizar recursos importantes y apreciar las deficiencias en la gestión
actual que se crean a raíz de los problemas identificados.
Este proyecto responde a una necesidad existente, en donde se diseñará una propuesta
de mejora para la gestión del mantenimiento con el fin de poder optimizar de mejor
manera los distintos recursos involucrados en las actividades programadas de las
mantenciones de subestaciones eléctricas en Metro S.A., reduciendo el porcentaje de no
cumplimientos de los mantenimientos y renovando la comunicación efectiva, con un
seguimiento continuo a las actividades planificadas.
A continuación, se presentará una propuesta de mejora que consistirá en crear un Work
Service con el fin de unificar las gestiones del sistema actual en una sola plataforma
pudiendo de esta forma mejorar el sistema actual de gestión del mantenimiento de
subestaciones eléctricas y reducir el porcentaje (%) de los no cumplimientos actuales
detectados en el diagnóstico de información del área en las programaciones y
ejecuciones mensuales de Metro S.A. Para esto se utilizará la herramienta de mejora
continua Ciclo de Deming (PDAC), la que nos permitirá implementar un proceso de
mejora basada en un Work Service en el área de mantenimiento de las subestaciones eléctricas de las líneas automáticas 3 y 6 de Metro S.A., donde se buscará abordar de
manera integral los desafíos existentes en la gestión de mantenimiento en las
subestaciones, con el objetivo de optimizar la eficiencia operativa y mejorar la satisfacción
del cliente y la empresa. Tratando de aumentar los porcentajes de cumplimientos de las
mantenciones nocturnas mes a mes.
Dado que el proyecto de mejora está directamente relacionado con una propuesta
basada en herramientas de tecnología TI, cuyo objetivo es diseñar un nuevo modelo de
gestión de mantenimiento mediante la creación de una plataforma Work Service por el
área de Desarrollo y Tecnología TI de Metro S.A., se realizará una comparativa de costos
entre desarrollar la solución internamente y externalizarla, adquiriendo un software de un
proveedor de Metro S.A. Esta comparativa se realiza con el fin de ser considerada para
la referencia de toma de decisiones.
Actualmente Metro S.A. cancela un monto aproximado de 210,000,000 monthly under a contract
agreement for preventive maintenance of electrical substations for automatic lines 3 and
6 to the contractor Abengoa, so the contracting company receives 100% of the contract
payment, despite not completing all scheduled monthly work due to the fact that the
cancellations of the activities are the sole responsibility of Metro S.A.
This proposal brings benefits such as the effective real payment of the agreement under
the preventive maintenance contract for the electrical substations agreed with the external
company Abengoa, as well as the improvement in quality and efficiency in the
maintenance management of the involved area of Metro S.A. Moreover, it also enhances
the quality of service experience in user transport due to improving the percentage of
compliance for preventive maintenance of the substations
Proyecto de mejora de clima laboral para el personal de Unidad Paciente Critico Adulto Clínica Puerto Montt, Los Lagos, Chile
No full textINTRODUCCION: El clima organizacional y satisfacción laboral son variables
que se relacionan con el bienestar de las personas en su trabajo, su calidad
de vida laboral, motivación y en consecuencia intervienen en el rendimiento de
la persona. Es necesario contar con un clima organizacional positivo y constructivo, lo cual contribuirá a reducir el estrés profesional, el agotamiento
y mejora la satisfacción laboral. OBJETIVO: Analizar resultados de medición
de clima laboral y creación de un plan de intervención para mantener un clima
laboral saludable. MÉTODO: Al evaluar los resultados de la encuesta de clima
laboral institucional las variables más bajas son: competencia de liderazgo, el
apoyo, permitir la participación y satisfacción por la empresa. A través de un
árbol de problema se identificaron las causas y efectos más importante que
son las que se intervienen en este plan de mejoramiento continuo.
RESULTADOS: A través de la implementación de un plan de intervención, se
espera mejorar estos indicadores de clima laboral, los cuales serán evaluados
en diciembre del 2023. CONCLUSIÓN: La mejora de clima laboral es un pilar
en la cultura organizacional de instituciones de salud, puesto que mantiene la
productividad y permite el cumplimiento de metas propuestas. Con la
implementación de este proyecto de mejora, se mantendrá niveles altos de
clima laboral en el servicio de Unidad de paciente crítico, Clínica Puerto Montt.INTRODUCTION: The organizational climate and job satisfaction are variables
that are related to the well-being of people at work, their quality of work life,
motivation and consequently intervene in the person's performance. It is necessary to have a positive and constructive organizational climate, which will
contribute to reducing professional stress, burnout and improving job
satisfaction. OBJECTIVE: Analyze work environment measurement results and create an intervention plan to maintain a healthy work environment.
METHOD: When evaluating the results of the work environment survey, the
lowest variables are leadership competence, support, allowing participation
and satisfaction with the company. Through a problem tree, the most important
causes and effects that are involved in this continuous improvement plan were
identified. RESULTS: Through the implementation of an intervention plan, it is
expected to improve these work environment indicators, which will be evaluated in December 2023. CONCLUSION: Improving the work environment is a pillar in the organizational culture of health institutions since it maintains productivity and allows the fulfillment of proposed goals. With the implementation of this improvement project, high levels of work environment will be maintained in the Critical Patient Unit service, Puerto Montt Clinic
Galectinas en la transición epitelio-mesénquima: roles y mecanismos que contribuyen a la reparación de tejidos, fibrosis y metástasis del cáncer
No full textPublisher Copyright: © The Author(s) 2024.Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of physiological and pathological processes. The expression and subcellular localization of different galectins vary among tissues and cell types and change during processes of tissue repair, fibrosis and cancer where epithelial cells loss differentiation while acquiring migratory mesenchymal phenotypes. The epithelial-mesenchymal transition (EMT) that occurs in the context of these processes can include modifications of glycosylation patterns of glycolipids and glycoproteins affecting their interactions with galectins. Moreover, overexpression of certain galectins has been involved in the development and different outcomes of EMT. This review focuses on the roles and mechanisms of Galectin-1 (Gal-1), Gal-3, Gal-4, Gal-7 and Gal-8, which have been involved in physiologic and pathogenic EMT contexts.Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins and glycolipids and modulate a broad spectrum of physiological and pathological processes. The expression and subcellular localization of different galectins vary among tissues and cell types and change during processes of tissue repair, fibrosis and cancer where epithelial cells loss differentiation while acquiring migratory mesenchymal phenotypes. The epithelial-mesenchymal transition (EMT) that occurs in the context of these processes can include modifications of glycosylation patterns of glycolipids and glycoproteins affecting their interactions with galectins. Moreover, overexpression of certain galectins has been involved in the development and different outcomes of EMT. This review focuses on the roles and mechanisms of Galectin-1 (Gal-1), Gal-3, Gal-4, Gal-7 and Gal-8, which have been involved in physiologic and pathogenic EMT contexts
Diseño de una propuesta de mejora en el área de clasificación de envases en el área de almacenamiento retorno envases en la empresa CCU S.A.
No full textLa presente propuesta de diseño de mejora en el área clasificación de envases , en el área de almacenamiento retorno envases en la empresa CCU s.a., los procesos que se desarrollan en la operación , tales como la recepción, almacenamiento, clasificación y entrega de envases a líneas , en la actualidad se mantiene los mismos estándares del comienzo, siendo que las tecnologías y los procedimientos de embotellación han cambiado, lo que genera una duda razonable de la efectividad de los procesos , no se han actualizado ni medido nuevos métodos para tener resultados más eficientes. Con la finalidad de mejorar las deficiencias mencionadas anteriormente se propone la implementación de nuevos procedimientos, con la participación de un equipo multidisciplinario, formado por control inventario, control calidad y almacenamiento. Es fundamental tener un equipo calificado para cumplir con las necesidades del cliente interno y mantener los estándares requeridos por la industria. Un equipo bien calificado no solo garantiza que se sigan los procedimientos adecuados, manteniendo los estándares de calidad, sino que puedan contribuir a la innovación y la Mejora Continua dentro las zonas de clasificación y almacenamiento de envases.This design improvement proposal for the packaging classification area in the returnable packaging storage area at CCU S.A. addresses the processes involved in operations such as reception, storage, classification, and delivery of packaging to production lines. Currently, the same standards from the beginning are maintained, despite changes in technologies and bottling procedures. This raises reasonable doubts about the effectiveness of the processes, as new methods have neither been updated nor measured to achieve more efficient results. To address the aforementioned deficiencies, the implementation of new procedures is proposed, involving a multidisciplinary team consisting of inventory control, quality control, and storage. It is crucial to have a qualified team to meet internal customer needs and maintain industry-required standards. A well-qualified team not only ensures that appropriate procedures are followed, maintaining quality standards, but also contributes to innovation and continuous improvement within the packaging classification and storage areas
Propuesta de mejora al modelo de negocio del vivero jardines silvestres
No full textJardines Silvestres es un vivero con más de 30 años de trayectoria en la
producción y venta de plantas de exterior, ubicado en la comuna de La Pintana,
Santiago. Su misión es ofrecer plantas de alta calidad, contribuyendo al
embellecimiento de espacios y proyectos de paisajismo. Actualmente, el vivero es
gestionado por una microempresaria de 64 años y opera en un terreno de 3,000 m²,
donde enfrenta desafíos significativos para expandirse y mejorar sus ingresos. Entre
los principales problemas detectados se encuentran los largos tiempos de
producción, la falta de diversificación en las ventas, recursos financieros limitados y
procesos operativos poco estandarizados, lo que ha dificultado el crecimiento y
sostenibilidad del negocio.
En respuesta a esta problemática, el presente proyecto tiene como objetivo
implementar un plan integral de mejora para el vivero, enfocado en optimizar su
modelo de negocio mediante la incorporación de la reventa de plantas, la mejora de
procesos productivos y administrativos, y el desarrollo de estrategias comerciales.
Este proyecto se fundamenta en un análisis de la situación actual del vivero,
utilizando herramientas ingenieriles como el diagrama de Ishikawa y el análisis de
criticidad, que van a permitir identificar las causas raíz de los problemas operativos
y comerciales. A partir de estos análisis, se propone aplicar el Ciclo de Deming
(PDCA) como metodología para estructurar e implementar las mejoras en cuatro
etapas: planear, hacer, verificar y actuar.
En la etapa de planificación, se desarrollarán estrategias como la identificación de
proveedores confiables, la definición de un calendario de producción eficiente y la
creación de sistemas para gestionar las ventas y el inventario. Durante la etapa de
ejecución, se implementarán acciones concretas, incluyendo la capacitación del
personal en técnicas de riego eficientes, el diseño de campañas de marketing digital
para aumentar la visibilidad del vivero y la participación en eventos locales para captar nuevos clientes. Posteriormente, en la etapa de verificación, se establecerán
indicadores clave de desempeño que permitirán evaluar áreas críticas como
producción, ventas, marketing y finanzas. Finalmente, en la etapa de actuación, se
realizarán ajustes y se consolidarán las mejoras para garantizar su efectividad a
largo plazo.
Además, el proyecto incluirá un análisis económico-financiero que evaluará la
relación costo-beneficio de las acciones propuestas, permitiendo determinar su
viabilidad. Este enfoque busca convertir a Jardines Silvestres en un negocio
competitivo, capaz de superar sus limitaciones actuales y posicionarse como un
referente en el mercado local de plantas y paisajismo.Jardines Silvestres is a nursery with over 30 years of experience in the
production and sale of outdoor plants, located in the commune of La Pintana,
Santiago. Its mission is to offer high-quality plants, contributing to the beautification
of spaces and landscaping projects. Currently, the nursery is managed by a 64-yearold micro-entrepreneur and operates on a 3,000 m² plot, facing significant challenges
in expanding and increasing its income. Among the main issues identified are long
production times, lack of diversification in sales, limited financial resources, and
unstandardized operational processes, which have hindered the growth and
sustainability of the business.
In response to these challenges, this project aims to implement a comprehensive
improvement plan for the nursery, focusing on optimizing its business model through
the incorporation of plant resale, the enhancement of productive and administrative
processes, and the development of commercial strategies. This project is based on
an analysis of the nursery's current situation, using engineering tools such as the
Ishikawa diagram and criticality analysis, which will identify the root causes of
operational and commercial problems. Based on these analyses, the Deming Cycle
(PDCA) is proposed as the methodology to structure and implement improvements
in four stages: plan, do, check, and act.
In the planning stage, strategies will be developed, including identifying reliable
suppliers, defining an efficient production calendar, and creating systems to manage
sales and inventory. During the execution stage, concrete actions will be
implemented, such as training staff in efficient irrigation techniques, designing digital
marketing campaigns to increase the nursery's visibility, and participating in local
events to attract new customers. Subsequently, in the verification stage, key
performance indicators will be established to evaluate critical areas such as
production, sales, marketing, and finances. Finally, in the acting stage, adjustments will be made, and improvements will be consolidated to ensure their long-term
effectiveness.
Additionally, the project will include an economic-financial analysis to evaluate the
cost-benefit relationship of the proposed actions, determining their feasibility. This
approach seeks to transform Jardines Silvestres into a competitive business capable
of overcoming its current limitations and positioning itself as a benchmark in the local
market for plants and landscaping
Musculoskeletal pain and upper quadrant disability in stringed-instrument studentsA cross-sectional pilot study
No full textPublisher Copyright: © 2024 Federacion Espanola de Docentes de Educacion Fisica. All rights reserved.Background: Musculoskeletal pain (MSP) is prevalent in musicians and is mainly located in the upper quadrant, affecting functionality. Repetitive movements, type of instrument, age, and sex influence this behavior, among other factors. Although the evidence is limited, it seems that string players are among those who most frequently report pain and disability of musculoskeletal origin. Objective: To characterize MSP and the level of upper quadrant disability associated with stringed instrument playing in conservatory students. Methods: In this cross-sectional observational pilot study, six self-reported assessment instruments were applied to 14 string students (8 males and six females) of different instruments (violin, viola, classical guitar, cello and double bass): Quick Dash Global (QDG) and High Performance/Musicians (QDL), Neck Disability Index (NDI), Chronic Pain Grading Scale (EGDC), the Neuropathic Pain Questionnaire (abbreviated DN4) and the Body Map of Pain (body chart). Results: 100% of the sample presented MSP at the time of the evaluation, mostly of low intensity, being in 21.42% of the cases of chronic and disseminated character. Neuropathic pain was present in 64.28% of cases. General functionality measured with EGDC was affected in 71.42% of the individuals. Upper limb functionality presented a mean QDG of 16.4 ±15.63 and a mean QDL of 32.11 ±16.78, while at the cervical level, 64.28% presented mild to moderate disability measured with NDI. Conclusion: DME and upper quadrant disability are frequent conditions in chordophone student musicians. Future studies should deepen the causes and investigate efficient strategies to prevent these conditions throughout their training process
Diabetes como factor de riesgo en el desarrollo de cáncer endometrial : revisión bibliográfica mundial 2014-2024
Get PDFObstetricia, Licenciado en Obstetricia y MatroneríaIntroducción: La diabetes mellitus (DM) es caracterizada por una alteración en los efectos de la insulina clasificándose en diabetes: tipo I (de origen autoinmune), tipo II (la más común, se asocia con la resistencia a la insulina, sedentarismo, obesidad y hábitos), y gestacional (aumento de glucosa durante el embarazo). Por otra parte, el cáncer endometrial (CE) se caracteriza por la proliferación anormal de células del endometrio, impulsada por diversos factores como endocrinos, metabólicos, entre otros. Objetivo general: Analizar cómo la diabetes mellitus se vincula con el desarrollo de cáncer endometrial. Metodología: Se realizó una revisión bibliográfica, a partir de las siguientes bases de datos: PubMed, ScienceDirect, Scopus y Web of Science, seleccionando artículos originales en inglés y de revisión, que relacionan el cáncer endometrial y la diabetes mellitus a nivel mundial, publicados entre los años 2014-2024. Resultados: Se seleccionaron 8 artículos y se evidenció el tipo de estudio, número de sujetos estudiados, nacionalidad, pruebas y descriptores estadísticos, conclusiones generales, entre otros. Se evidenció la existencia de una correlación positiva entre la DM y CE y que la obesidad, hiperinsulinemia y la sobreexposición estrogénica son factores de riesgo que inciden en la aparición de DM y por consecuencia del CE. Se evidenciaron los factores fisiopatológicos como: hiperinsulinemia, hiperglucemia, obesidad relacionados con la progresión del cáncer de endometrio. Conclusiones: La DM juega un papel fundamental en la aparición y avance del CE. Factores como la obesidad, la hiperinsulinemia y el exceso de estrógenos incrementan el riesgo, influyen en el pronóstico y afectan la eficacia de los tratamientos. Aunque los estudios actuales son útiles, se requieren más investigaciones para mejorar los tratamientos y la calidad de vida de las pacientes.Introduction: Diabetes mellitus is characterized by an alteration in the effects of insulin production, classified into three types: Type I (Autoimmune in origin), type II (the most common type, that is associated with the insulin resistance, sedentary lifestyle, obesity and unhealthy habits) and gestational (increase of glucose during pregnancy). On the other hand, EC is characterized by abnormal proliferation of cancer cells in the endometrium, driven by factors such as obesity, use of hormonal therapy and mainly, diabetes mellitus. General objective: To analyze how diabetes mellitus is linked to the development of endometrial cancer. Methodology: A literature review was conducted using the following databases: PubMed, ScienceDirect, Scopus, and Web of Science, selecting original articles in english and review articles that relate endometrial cancer and diabetes mellitus worldwide, published between the years 2014-2024. Results: A total of eight articles were selected. The characteristics of the selected studies included the type of study, sample size, nationality of the subjects, parameters and statistical tests used, statistical descriptors, and general conclusions, among others. The results revealed a positive correlation between DM and EC. Furthermore, obesity, hyperinsulinemia, and excess estrogen exposure were identified as risk factors contributing to the development of DM and, consequently, EC. Lastly, the pathophysiological factors and key findings in the progression of endometrial cancer were highlighted. Conclusions: DM plays a fundamental role in the onset and EC progression. Factors such as obesity, hyperinsulinemia, and excessive estrogen exposure increase the risk, affect prognosis, and influence the efficacy of treatments. Although current studies are useful, more research is needed to improve treatments and the quality of life for patients
Spatiotemporal Variations in Biophysical Water Quality Parameters : An Integrated In Situ and Remote Sensing Analysis of an Urban Lake in Chile
No full textPublisher Copyright: © 2024 by the authors.This study aims to develop and implement a methodology for retrieving bio-optical parameters in a lagoon located in the Biobío region, South-Central Chile, by analyzing time series of Landsat-8 OLI satellite images. The bio-optical parameters, i.e., chlorophyll-a (Chl-a, in mg·m−3) and turbidity (in NTU) were measured in situ during a satellite overpass to minimize the impact of atmospheric distortions. To calibrate the satellite images, various atmospheric correction methods (including ACOLITE, C2RCC, iCOR, and LaSRC) were evaluated during the image preprocessing phase. Spectral signatures obtained from the scenes for each atmospheric correction method were then compared with spectral signatures acquired in situ on the water surface. In short, the ACOLITE model emerged as the best fit for the calibration process, reaching R2 values of 0.88 and 0.79 for Chl-a and turbidity, respectively. This underlies the importance of using inversion models, when processing water surfaces, to mitigate errors due to aerosols and the sun-glint effect. Subsequently, reflectance data derived from the ACOLITE model were used to establish correlations between various spectral indices and the in situ data. The empirical retrieval models (based on band combinations) yielding superior performance, with higher R2 values, were subjected to a rigorous statistical validation and optimization by applying a bootstrapping approach. From this process the green chlorophyll index (GCI) was selected as the optimal choice for constructing the Chl-a retrieval model, reaching an R2 of 0.88, while the red + NIR spectral index achieved the highest R2 value (0.79) for turbidity analysis, although in the last case, it was necessary to incorporate data from several seasons for an adequate model training. Our analysis covered a broad spectrum of dates, seasons, and years, which allowed us to search deeper into the evolution of the trophic state associated with the lake. We identified a striking eight-year period (2014–2022) characterized by a decline in Chl-a concentration in the lake, possibly attributable to governmental measures in the region for the protection and conservation of the lake. Additionally, the OLI imagery showed a spatial pattern varying from higher Chl-a values in the northern zone compared to the southern zone, probably due to the heat island effect of the northern urban areas. The results of this study suggest a positive effect of recent local regulations and serve as the basis for the creation of a modern monitoring system that enhances traditional point-based methods, offering a holistic view of the ongoing processes within the lake
Can the Functional Physical Fitness of Older People with Overweight or Obesity Be Improved through a Multicomponent Physical Exercise Program? A Chilean Population Study
No full textPublisher Copyright: © 2024 by the authors.The aim of the present study was to understand the effect of a multicomponent physical exercise program on the functional physical fitness of older people with overweight or obesity in Chile, and whether these effects were similar in women and men. For this purpose, a quasi-experimental study was designed with a control group to evaluate the functional physical fitness through the Senior Fitness Test battery for older people [SFT; aerobic endurance (AE), lower body strength (LBS), upper body strength (UBS), upper body flexibility (UBF), lower body flexibility (LBF), dynamic balance (DB), and hand pressure strength right (HPSR) and left (HPSL)]. Seventy older people with overweight or obesity aged between 60 and 86 years participated (M = 73.15; SD = 5.94), and were randomized into a control group (CG, n = 35) and an experimental group (EG, n = 35). The results after the intervention between the CG and EG indicated that there were statistically significant differences in the AE (p = 0.036), in the LBS (p = 0.031), and in the LBF (p = 0.017), which did not exist before the intervention (p > 0.050), except in the HPSR (0.029). Regarding the results of the EG (pre vs. post-intervention), statistically significant differences were found in all of the variables studied: AE (p 0.05). Based on the results obtained, we can say that a multicomponent physical exercise program applied for 6 months in older people with overweight or obesity produces improvements in functional physical fitness regardless of sex, except in lower body flexibility and left-hand dynamometry
Kisspeptin signalling and its correlation with placental ultrastructure and clinical outcomes in pregnant South African women with obesity and gestational diabetes
No full textPublisher Copyright: © 2024Introduction: Gestational diabetes mellitus (GDM) is a major pregnancy metabolic disorder and is strongly linked with obesity. Kisspeptin is a hormone that increases several thousand-fold in the maternal circulation during human pregnancy, with placenta as its main source. Studies have suggested that kisspeptin regulates trophoblast invasion and promotes pancreatic insulin secretion and peripheral insulin sensitivity. Methods: In a well-characterized cohort of pregnant South African women and molecular and histological techniques, this study explored the impact and interaction of maternal obesity and GDM on kisspeptin (KISS1) signalling in relation to placental morphology and maternal and neonatal parameters. Results: We found that GDM had no effect on placental KISS1 and KISS1R (KISS1 receptor) mRNA and/or protein expression. However, obesity reduced placental KISS1R mRNA expression even though overall KISS1 protein abundance or localization was not different from the non-obese group. Maternal and cord circulating KISS1 concentrations did not vary with obesity or GDM, but maternal circulating KISS1 was positively correlated with placenta weight in non-GDM obese women, and negatively correlated with placental intervillous space volume in non-GDM non-obese women. Cord serum KISS1 was positively correlated with infant weight in GDM obese women, but negatively correlated with maternal BMI in the non-obese GDM group. Placental syncytiotrophoblast extracellular vesicles exhibited detectable KISS1 and its abundance was ∼50% lower in those from obese GDM compared to non-GDM women. Discussion: This study shows maternal obesity and GDM can modulate placental kisspeptin signalling and placental morphological development with potential pathophysiological implications for clinically-relevant pregnancy and perinatal outcomes