MAU GCRIS Standard Database (Mardin Artuklu University)
Not a member yet
7418 research outputs found
Sort by
The Role of Technological Devices in Parent-Children Interactions: The Correlated Variables of Children's Well-Being and Life Satisfaction
No full textThis study aims to examine children's well-being and life satisfaction in terms of various variables related to parents' and children's problematic technology usage. Specifically, parent/child responses during their technology use and parents' phubbing and technoference behaviors were considered. The study was conducted with 185 children (8-14) and their parents (mother = 96, father = 89). The data were analyzed by performing correlation analysis, multiple regression analysis, t test, and one-way ANOVA. According to the results, there were negative correlations between children's life satisfaction and age, children's technological device (smartphone, computer) usage time, and children/parents responding negatively to each other when engaged in technological devices. Children's well-being was negatively correlated to their age and children/parents responding negatively to each other when engaged in technological devices. A positive correlation was found between children's life satisfaction and well-being as well as parents' phubbing and technoference. According to another result, the well-being of children having their own computer was significantly higher than those who do not have a computer. Finally, children/parents responding negatively to each other when engaged in technological devices negatively predicted the children's life satisfaction and well-being
The Role of Thiol/Disulfide Homeostasis in Unexplained Primary Infertile Patients: a Prospective Cohort Study
No full textBackground:Our study aims to investigate whether there is a relationship by measuring the total oxidant/antioxidant load with the thiol/disulfide method in patients with unexplained infertility. Methods:A total of 82 participants were enrolled, consisting of 41 women with unexplained infertility and 41 fertile controls matched for age and body mass index (BMI). Hormonal profiles, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), thyroid-stimulating hormone (TSH), and prolactin, were assessed using the chemiluminescence immunoassay method. Thiol/disulfide homeostasis was evaluated using a validated automated spectrophotometric method, which measured native thiol (NT), total thiol (TT), and disulfide levels. Detailed quality control measures ensured the reliability of the results. Results:In the study, no significant difference was found between the infertile and fertile groups' demographic (age) and clinical variables in terms of height, weight, BMI, FSH, LH, E2, TSH, prolactin, antral follicle count, TT, NT, and disulfide values (P > .05). The rates were found to be greater in the infertile group in disulfide/NT ratio and disulfide/TT ratio compared to the fertile group, even though there was no statistically significant difference between the groups' disulfide/NT ratio, disulfide/TT ratio, and NT/TT ratio values. The fertile group, however, had a higher NT/TT ratio rate. Conclusion:Although the unexplained infertility and fertile groups in the study did not differ in serum thiol and disulfide levels, the infertile group was found to have a relatively high disulfide/thiol ratio. More prospective studies on thiol/disulfide balance related to unexplained infertility may help to understand the relationship
Adaptation of the Employee Spirituality Scale Into Turkish: a Study on Healthcare Workers
No full textThis study aimed to adapt the Employee Spirituality Scale to Turkish culture for healthcare professionals. A total of 230 healthcare workers participated in the adaptation of the scale, which comprises 24 items. The research data were collected face-to-face with a questionnaire that included demographic characteristics, the Employee Spirituality Scale, and the Spiritual Orientation Scale. Construct validity was analyzed using exploratory and confirmatory factor analyses. The two-factor structure of the Employee Spirituality Scale was confirmed in the Turkish sample and showed acceptable fit values. Because of CFA, 2 items were removed from the scale because they did not fit. For criterion validity, the Pearson Correlation Coefficient between the scale and the Spiritual Orientation Scale was calculated, and a significant positive result was obtained. This study demonstrated that the Turkish version of the Employee Spirituality Scale is a valid and reliable measurement tool for health care workers to assess the various dimensions of human spirituality that give individuals a sense of guidance, facilitate finding meaning and purpose in one’s tasks, enable them to overcome their weaknesses and limitations in the workplace, and assess various dimensions of human spirituality as a relationship with a higher power
Covid-19 Hastalarının Fizyopatolojisinde Visinin-Like Protein-1 ve Prestin Moleküllerinin Araştırılması
No full textKorona virüs hastalığı-19 (Covid-19) viral bir enfeksiyon hastalığıdır. Covid-19 birçok semptoma neden olmaktadır. Covid-19'dan kaynaklı olan geçici işitme kaybı, baş dönmesi, bilinç bulanıklığı, tat ve koku kaybı gibi nörolojik semptomlardan kaynaklanan geçici veya kalıcı rahatsızlıkların mekanizması tam olarak bilinmemektedir. Bu nedenle bu çalışmadaki amacımız covid-19 fizyopatolojisinde nöronal hasar belirteci olan visinin-like protein-1 (vilip-1) ve prestin moleküllerinin rolünü araştırmaktır. Çalışma Mardin Eğitim ve Araştırma Hastanesinde 01.01.2022-31.03.2022 tarihleri arasında gelen hastalarda reverse transkriptaz polimeraz zincir reaksiyonu (RT-PCR) pozitif çıkan ve hastaneye yatırılan covid-19 hastalarından 60 hasta çalışmaya dahil edildi. Grup II: RT-PCR sonucu negatif olan kişiler kontrol grubu olarak çalışmaya dahil edildi (n=60). Vilip-1 ve prestin düzeyleri Eliza yöntemiyle tayin edildi. Serum AST, ALT, LDH, ve CRP düzeyleri kolorimetrik yöntem ile çalışıldı. Cinsiyetler arasında istatistiksel olarak farklılık bulunmadı. Covid-19 hastalarında serum vilip-1 düzeylerinin kontrol grubuna göre yükseldiği ve istatistiksel olarak anlamlı olduğu bulundu (p=0.001). Covid-19 hastalarında serum prestin düzeylerinin kontrol grubuna göre yükseldiği ancak istatistiksel olarak anlamlı olmadığı gözlendi (p=0.470). Covid-19 hasta grubunda serum AST, ALT, LDH ve CRP düzeylerinin kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı olduğu tespit edildi (p=0.001). Yapılan korelasyon analizlerinde covid-19 hastalarında vilip-1, prestin, CRP ve LDH düzeyleri arasında pozitif korelasyon olduğu göstermiştir. Sonuç olarak çalışmamızda covid-19 hastalarında serum vilip-1, CRP, AST, ALT, LDH düzeylerinin kontrol grubuna göre yükseldiği gösterilmiştir. Koklear hasar belirteci olan prestin düzeylerinde yükselme olduğu ancak istatistiksel olarak anlamlı olmadığı bulunmuştur. Çalışmamızda dikkatleri çeken bir diğer sonuç ise nöronal hasar biyobelirteç olan vilip-1 biyomolekülü ve CRP düzeyleri arasında pozitif korelasyon göstermesi ve literatürde böyle bir bulgunun olmayışı açısından çalışmamızı değerli kılmıştır. Bu bilgiler ışığında nörolojik belirtiler olmaksızın bile akut dönemdeki covid-19 hastalarında nöronal hasarın olabileceğini göstermiştir. Ancak yine de vilip-1 ve prestin moleküllerinin covid-19 hastalığındaki patofizyolojik rolünü açıklayacak geniş çaplı çalışmaların yapılmasına ihtiyaç duyulmaktadır.Corona virus disease 19 (Covid-19) is a viral infectious disease.Covid-19 causes many symptoms.The mechanism of temporary or permanent disturbances resulting from neurological symptoms such as transient hearing loss, dizziness, confusion, loss of taste and smell caused by Covid-19 is not fully understood.Therefore, our aim in this study was to investigate the role of visinin-like protein-1 (vilip-1) and prestin molecules in the physiopathology of covid-19. The study included 60 patients with covid-19 who were hospitalised in Mardin Training and Research Hospital with positive reverse transcriptase polymerase chain reaction (RT-PCR) in patients admitted between 01.01.2022-31.03.2022. Group II: People with negative RT-PCR results were included in the study as the control group (n=60). Vilip-1 and prestin levels were determined by Eliza method. Serum AST, ALT, LDH, and CRP levels were determined by colourimetric method. No statistical difference was found between genders. It was found that serum vilip-1 levels in patients diagnosed with Covid-19 increased in the control group and were statistically significant (p=0.001). It was observed that serum prestin levels in patients diagnosed with Covid-19 increased in the control group, but not statistically significant (p=0.470). Covid-19 serum AST, ALT, LDH and CRP levels were found to be statistically significant when compared with the control group (p=0.001).Correlation analyses showed a positive correlation between vilip-1, prestin, CRP and LDH levels in covid-19 patients. As a result, our study showed that serum vilip-1, CRP, AST, ALT, LDH levels were increased in Covid-19 patients compared to the control group. It was found that there was an increase in prestin levels, which is a marker of cochlear damage, but it was not statistically significant. Another striking result of our study is the positive correlation between vilip-1 biomolecule, which is a biomarker of neuronal damage, and CRP levels, which makes our study valuable since there is no such finding in the literature. In light of this information, it has been shown that neuronal damage may occur in acute-stage covid-19 patients even without neurological symptoms. However, there is still a need for large-scale studies to explain the pathophysiological role of vilip-1 and prestin molecules in Covid-19 disease
Gynaecological Cancer Awareness and Healthy Lifestyle Behaviors of Women Aged 20-65 Years: a Descriptive Cross-Sectional Study
No full textFor both individual and community health, women's health is vital. In particular, gynecological cancers can be prevented or treated by adopting healthy lifestyles, raising awareness, and detecting them early. This study aimed to identify levels of gynecological cancer awareness and healthy lifestyle behaviors among women aged 20-65 years. There were 251 women in the descriptive cross-sectional study. The Gynecological Cancers Awareness Scale (GCAS), the Descriptive Characteristics Form, and the Healthy Lifestyle Behavior Scale-II (HLBS-II) were used to gather data. The data was analyzed using the Pearson's correlation test, multiple linear regression, and descriptive statistics. The average HLBS-II score was 123.53 +/- 20.75, while the average GCAS score was 149.64 +/- 21.30. The HLBS-II and GCAS scores showed a statistically significant positive correlation. Women knowledgeable about early diagnosis methods scored 10.758 times higher on the GCAS, while women familiar with vulvar self-examination scored 11.016 times higher. Employed women had a mean HLBS-II score 6.124 times higher than non-employed women (p<0.05). Women's awareness of gynecological cancer was high, but they also had moderately good lifestyle choices. To raise awareness and promote healthy lifestyle choices, healthcare professionals are advised to take part in health-promoting initiatives
A Study To Assess the Pharmacological Agent Potential of Gold Nanoparticles and Their Effects on Human Cancer Cells and Hospital Pathogens Using in Vitro Methods
No full textInterest in metal nanoparticles synthesised using green methods is growing steadily. Metal nanoparticles can be synthesised inexpensively and effortlessly using extracts derived from different plants and their diverse components. Gold nanoparticles (Au NPs) were rapidly synthesised from Broccoli (Brassica oleracea L.) agricultural waste using a novel, cost-effective, and eco-friendly method in this work. Analysed data from various techniques including UV-vi, TEM, FESEM, XRD, AFM, FTIR, TGA-DT, EDX, and DLS to assess the properties of the synthesised Au NPs. The characterisation data revealed that the Au NPs had a peak absorbance at 553.10 nm, a surface charge of -19.7 mV, an average hydrodynamic size of 78.75 nm, a monodisperse spherical shape, and were found to be stable. The inhibitory effects of Au NPs with these properties on hospital pathogens and human cancer cells were evaluated by microdilution, disk diffusion and MTT techniquesAs a result of the findings, it was determined that Au NPs have antibacterial, antifungal and anticancer potential as pharmacological agents under in vitro conditions
Assessment of Iron Metabolism and Inflammation in Children With Cerebral Palsy
No full textBackground/Objectives: Cerebral palsy (CP) is a motor disorder resulting from brain damage that is common in childhood. Iron is vital for the body's basic functions. Iron metabolism disorders and inflammation contribute to the neurological complications seen in CP. The purpose of this research was to ascertain the association and correlation between markers of inflammation and iron metabolism in children with CP. Methods: A total of 181 children diagnosed with CP and 111 typically developing children were retrospectively included in the study. Demographic data, blood parameters, C-reactive protein, iron, total iron binding capacity, and inflammation markers were evaluated. Results: C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and systemic immuno-inflammatory index (SII) levels of CP children were found to be statistically significantly higher than those of control group children (p < 0.05). Iron (Fe) and ferritin levels were lower in the CP group, while total iron binding capacity (TIBC) was higher. Spearman correlation analysis showed significant correlations between iron, ferritin and TIBC and SII. Conclusions: Iron deficiency and chronic inflammation are associated with the pathophysiology of CP in patients with CP, and therefore it is important to monitor markers of iron metabolism and inflammation in these patients
Harnessing Polysaccharides for Sustainable Food Packaging
No full textThis review provides a comprehensive analysis of food packaging techniques, focusing on the limitations of conventional methods and the promising potential of polysaccharide-based materials as sustainable alternatives. Traditional packaging materials, such as plastics, glass, metal, and paper, pose significant environmental risks due to their non-biodegradable nature. In contrast, polysaccharide-based materials, derived from renewable sources, are biodegradable and offer enhanced food preservation properties. These materials boast several advantages, including biodegradability, renewability, and superior physical attributes such as excellent barrier properties and mechanical strength. The review also delves into transformation techniques aimed at improving the effectiveness of polysaccharide-based materials. These include physical and chemical modifications to optimize their performance. Furthermore, a detailed categorization of polysaccharides is provided based on their origin, encompassing animal-derived polysaccharides (chitin, chitosan), plant-derived polysaccharides (cellulose, starch, pectin, gum arabic, guar gum, tragacanth gum, locust bean gum), marine-derived polysaccharides (alginate, agar, carrageenan), and microbial-derived polysaccharides (pullulan, xanthan gum, dextran, bacterial cellulose). Additionally, we explore case studies highlighting the practical applications and performances of these materials in the food packaging industry. © The Author(s) 2025.Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTA
Verbascum Kotschyi Boiss. & Hohen. Kullanılarak Sentezlenen Çinko Oksit ve Selenyum Oksit Nanopartiküllerinin Antioksidan ve Antimikrobiyal Özelliklerinin Karşılaştırılması
No full textSon yıllarda nanopartiküllerin birbirinden farklı alanlarda kullanımı araştırılmaktadır. Bu çalışmalar içinde özellikle yeşil sentez ile doğa dostu ve sağlığa faydalı nanopartiküllerin sentezi oldukça ilgi çekmektedir. Aynı zamanda bu çalışmalar ile değeri ve pek çok özelliği bilinmeyen çok sayıda bitki türünün önemi de açığa çıkarılmaktadır. Bu nedenle bu bitki türlerinden biri olan ve üzerinde nanopartikül çalışmaları yapılmayan bir tür olan Verbascum kotschyi’den çinko oksit ve selenium nanopartiküller sentezleyip bu nanopartiküllerin antimikrobiyal ve antioksidan özelliklerini belirlemek amaçlanmıştır. Verbascum kotschyi’den sentezlenen nanopartiküllerin SEM, EDX, FTIR analizleri yapıldıktan sonra üç farklı yöntemle (DPPH, CUPRAC ve FRAP) in vitro antioksidan kapasiteleri belirlenmiştir. Ayrıca disk difüzyon yöntemi ile gram-pozitif, gram-negatif bakteriler ve mantar üzerine antimikrobiyal etkisi belirlenmiştir. Sonuç olarak Verbascum kotschyi’den sentezlenen çinko oksit nanaopartiküller selenyum nanopartiküllere kıyasla daha fazla antimikrobiyal özellik sergilemiştir. Ancak selenyum nanaopartiküller çinko oksit nanaopartiküllerden daha etkin antioksidan özellik sergilemiştir. Böylece Verbascum kotschyi’nin nanopartikül sentezi ile oluşturulabilecek ürünleri sayesinde farklı alanlarda kullanılabilecek özelliklere sahip olduğu tespit edildi
