FBU GCRIS Standard Database (Fenerbahçe University)
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Toothpastes with Different Detergent Contents Affect Morphogenesis and Redox System Parameters in Zebrafish Embryos
No full textScience Citation Index Expande
Can Manual Therapy Alter Muscle Stiffness in Patients With Spinal Accessory Nerve Injury
No full textOkyar, Fethi; Topcuoglu, Osman MelihObjective. Shoulder and neck dysfunctions resulting from spinal accessory nerve injury impair quality of life. This study aims to investigate the effects of manual therapy in combination with standard physiotherapy on the mechanical properties of muscle, neck and shoulder function, pain, and quality of life in head and neck cancer patients. Study Design. Prospective, randomized, controlled, double-blind clinical trial. Setting. Department of Otorhinolaryngology Head and Neck Surgery of a university hospital. Methods. A total of 26 participants were randomized into two groups. The control group (n = 11) received standard physiotherapy including therapeutic exercises, scar tissue massage, and education. The intervention group (n = 10) received manual therapy consisting of soft tissue, myofascial release, and mobilization techniques in combination with standard physiotherapy. Outcome measures were mechanical properties of muscle, neck and shoulder active range of motion, shoulder pain and disability, and quality of life. Results. Upper trapezius and sternocleidomastoid muscle stiffness increased significantly in the control group (P < .01), whereas a significant reduction was observed in the intervention group compared to the control group (P = .001). A reduction in muscle thickness was observed bilaterally in both groups (P < .01). Moreover, all participants showed improvements in neck and shoulder active range of motion, shoulder pain, and quality of life (P < .01). Conclusion. Manual therapy in addition to standard physiotherapy was more effective in improving neck and shoulder function, quality of life, and reducing muscle stiffness compared to standard physiotherapy alone. Therefore, clinicians should consider incorporating manual therapy into their treatment protocols to optimize patient outcomes.Science Citation Index Expande
Psychometric Properties and Transcultural Adaptation of Turkish Version of the Basel Assessment of Adherence to Immunosuppressive Medication Scale
No full textObjectives: This study aimed to translate BAASIS (Basel Assessment of Adherence to Immunosuppressive Medication Scale) into Turkish and to test the psychometric properties of the translated Turkish version of the instrument. Materials and Methods: In this single-center crosssectional study, we included 100 kidney transplant recipients in a university hospital in a western city of Turkiye. The Translation and Cultural Adaptation Report from Professional Society for Health Economics and Outcomes Research was used for the transcultural adaptation of BAASIS to Turkish. We tested the validity of the BAASIS Turkish version by the level of evidence according to the American Educational Research Association guidelines: content validity, internal structure, and relations to other variables. We calculated item-total correlations of the BAASIS Turkish version to examine internal consistency reliability. Results: The content validity index score of BAASIS was calculated as 1.00, indicating agreement between the experts. Exploratory factor analysis evaluated the internal structure of BAASIS, and the coefficients for inter-item correlations ranged from 0.170 to 0.395. The Immunosuppressive Treatment Adherence Scale and the BAASIS nonadherent scores were significantly correlated (r = 0.673, P < .001). The coefficients for item-total correlation analyses ranged from 0.160 to 0.470. Conclusions: The BAASIS Turkish version has acceptable psychometric properties. The scale can be used in clinical practice and research projects in transplantation to assess immunosuppressive medication adherence
The Destruction of a Generation by War: Syrian Families, Children’s Education, and the Risks for Turkey
No full textThis study examines the phenomenon of migration, focusing on Syrian families under temporary protection who migrated to Turkey following the mass movement of people from Syria after 2011. The research explores the education of Syrian children and the risks faced by Turkey in this context. It also evaluates the economic, social, and cultural impacts of the Syrian refugee crisis on Turkey, highlighting both its positive and negative aspects, as well as related security concerns. Syrian children require increased access to psychological and psychiatric healthcare services. However, many are forced to work under harsh conditions as cheap labor. The employment rates of these children, categorized by age groups, exhibit similarities to those in Turkey but differ significantly from global trends. Applying these observations to Turkey, this study discusses the stages of educational services provided to Syrian children and suggests practical recommendations to improve their quality. The findings reveal that although Syrian children increasingly benefit from educational services each year, their participation rates remain below Turkey's national average. The study also highlights deficiencies in education, healthcare, employment, and socioeconomic conditions for children under temporary protection. Predictably, migration flows intensify during periods of intense conflict. Data from international organizations such as the United Nations High Commissioner for Refugees (UNHCR) and the International Organization for Migration (IOM) have been utilized in this research. © 2025 Elsevier B.V., All rights reserved
'I Feel Like the Burden of the World Is on My Shoulders': A Phenomenological Qualitative Study on the Life Experiences of Adult Children of Parents with Schizophrenia
No full textBackgroundStudies investigating the experiences of adult children of parents with schizophrenia (ACPS) are limited, and no qualitative study examining this issue in T & uuml;rkiye has been previously conducted. This study aimed to examine the life experiences of ACPS providing primary care.MethodsThis phenomenological qualitative study was conducted with 14 ACPS in acute clinics of a regional psychiatric hospital in Istanbul between March and August 2024. Data were collected through in-depth interviews and analyzed using Colaizzi's seven-step analysis method.ResultsData analysis revealed five main themes: (1) Difficult beginning of life, (2) Being a caregiver without receiving care, (3) Emotional storm, (4) Disruption of the flow of life, and (5) Coping. The study found that adult children who cared for their parents could not remember their childhood, had to grow up early without parents, and experienced violence. Adult children had difficulty carrying the burden of care, experienced various emotions at the same time, and care disrupted their lives. They were both using adaptive and maladaptive coping methods.ConclusionsThis study determined that ACPS experienced significant childhood stressors and difficulties providing care in adult life that changed the flow of their daily lives while challenging their ability to cope. Psychiatric nurses have essential tasks to support ACPS in coping with difficult life experiences and reducing their care burdens. They should inform ACPS about schizophrenia, regularly monitor their mental health, and implement initiatives that will protect or improve their mental health.Clinical trial registrationNot applicable
Multisensory Stimulation by Mothers: Impact on Neonatal Pain and Maternal Anxiety During Heel Blood Collection: A Randomized Controlled Trial
No full textAkkaya Gul, Aysenur/0000-0001-9019-8740OBJECTIVE: This study aimed to evaluate the effects of maternal multisensory stimulation on neonatal pain and maternal state anxiety during heel blood collection in neonates. STUDY DESIGN:A randomized controlled trial was conducted from July 2019 to January 2020 in neonatal units, with 80 newborns in intervention(n = 40) and control (n = 40) groups. In the intervention group, mothers provided multisensory stimulation (speech, touch, skin odor, breastfeeding, eye contact), while the control group received routine care. Neonatal Infant Pain Scale (NIPS) and maternal state anxiety inventory were evaluated. RESULTS:NIPS scores and maternal anxiety were significantly lower in the intervention group (p < 0.001). A positive correlation was found between NIPS and maternal anxiety in the intervention group (r = 0.372, p = 0.018). CONCLUSIONS: Maternal multisensory stimulation reduces neonatal pain and maternal anxiety. These findings emphasize the importance of pediatric nurses considering neonatal comfort and maternal emotional well-being during medical procedure. CLINICAL TRIAL REGISTRATION: The protocol for this randomized controlled experimental trial is registered on ClinicalTrials.gov. The clinical trial registration number is https://clinicaltrials.gov; NCT05606458
Selection of Sustainable Facade Materials for Buildings Using Fermatean Fuzzy AHP & WASPAS Methodology
No full textThe selection of sustainable facade materials is critical for achieving a sustainable built environment. Multi-criteria decision-making approaches can be used to determine the best alternative among the others considered in selecting sustainable facade materials. Fermatean Fuzzy Sets (FFSs) can represent the uncertainty in this selection and expand the parameter domain of this uncertainty. This study proposes an integrated analytical model based on the Interval-Valued Fermatean Fuzzy Analytic Hierarchy Process (IVFF-AHP) and Fermatean Fuzzy Weighted Aggregated Sum Product Assessment (FF-WASPAS) to address the uncertainty and complexity in this selection process. The model evaluates facade materials against environmental, financial, social, and technical criteria, comprising 13 sub-criteria. IVFF-AHP is utilized to calculate the weights of these criteria, with Environmental Criteria receiving the highest weight (32.9%), followed by Technical (30.7%) and Social (19.6%) criteria. FF-WASPAS is employed to rank four facade material options, with Wood-Plastic Composite (WPC) identified as the most sustainable material, followed by Aggregated Natural Stone, Aluminium Composite Panels, and Concrete Cladding. The results highlight the approach's capability to provide objective and robust rankings, aiding decision-makers in identifying the most sustainable option. The outcomes underscore the model's novelty in integrating Fermatean fuzzy logic with multi-criteria decision-making techniques, offering enhanced flexibility in uncertainty representation and contributing to the advancement of sustainable construction practices through a more informed and structured decision-making process. © 2025 Elsevier B.V., All rights reserved
Effects of Nighttime Eating Behavior on Cardiometabolic Health and Sleep: A Crossover Study
No full textBackground and aims: The impact of night-eating behavior (NEB) on metabolic health remains underexplored, particularly in healthy populations. We have hypothesized that NEB adversely affects metabolic parameters, liver function, and sleep via circadian disruption and neurohormonal alterations. Methods and results: In this single-center crossover study, sixteen healthy adults (aged 18-35 years) with no comorbidities, no medication use, and a body mass index between 18 and 30 kg/m(2) participated in two one-week dietary regimens: regular eating (no food after 7:30 p.m.) and nighttime eating (>= 25 % of daily caloric intake consumed after 9:30 p.m.). Clinical, biochemical, neurohormonal, and respiratory polygraphy data were obtained following each dietary period. The mean age of participants was 27 +/- 4 years. After adjusting for multiple comparisons, nighttime eating behavior (NEB) was associated with significant increases in albuminuria (p = 0.003), serum phosphate (p < 0.001), fasting triglycerides (p = 0.039), and C-reactive protein (CRP; p = 0.01). NEB also elevated serum leptin (p = 0.007), ghrelin (p < 0.001), cortisol (p = 0.041), fibroblast growth factor 21 (FGF-21; p < 0.001), and cytokeratin-18 (p < 0.001), while significantly decreasing melatonin levels (p < 0.001). Sleep study results demonstrated significant increases in the apnea-hypopnea index (AHI; p < 0.001), supine AHI (p < 0.005), oxygen desaturation (7 % +/- 2 % vs. 11 % +/- 3 %; p < 0.001). Conclusion: NEB significantly affects neurohormonal profiles and sleep-related respiratory metrics in healthy individuals, indicating potential adverse effects on cardiometabolic health during short-term evaluation in healthy subjects
Detection of Candida (Candidozyma) Auris by Molecular Methods and Investigation of Clinical Symptoms of Patients in a Tertiary Hospital in Istanbul
No full textBACKGROUND: Candidozyma auris is resistant to many antifungals, spreads rapidly and causes deaths in patient groups with comorbid factors. OBJECTIVES: The aim of this study was to determine the virulence of C. auris, antifungal resistance genes and clinical characteristics of the patients. DESIGN: Retrospective cohort SETTING: Single-center MATERIAL AND METHODS: This study was conducted between August 2022 and December 2023 at & Uuml;mraniye Training and Research Hospital. ITS1-5.8S-ITS2 and ITS1-ITS4 gene regions of the rDNA gene of C. auris isolates identified by VITEK MS v.3.2 were amplified by polymerase chain reaction (PCR) method. These regions were partially sequenced using the Sanger method. The presence of C. aurisspecific CDR1, ERG11, MDR1, ACT1, SAP5, HYR3, ALS5, IFF4, FUR1, PLB3, PGA26 and PGA52 gene regions were determined by PCR. Antifungal susceptibility testing of C. auris was performed with VITEK 2 Compact AST YS08 and SYO. MAIN OUTCOME MEASURES: Variations in C. auris isolates, antifungal resistance and clinical characteristics of patients SAMPLE SIZE: Forty-four isolates from 31 patients RESULTS: According to gene regions, nine different variations were identified in our hospital, with VAR-1 being the most common. Twenty-five (80.6%) of the patients died and isolation of the causative agent was between days 1-30 in 13 (41.9%) patients. Antibiotic use, ICU admission rate, and central venous catheter use in patients were 29 (93.6%), 28 (90.3%), and 21 (67.7%), respectively. Hypertension, diabetes mellitus (DM) and septic shock were found in 14 (45.2%), 13 (41.9%) and 10 (32.3%) patients, respectively. Antifungal resistance rates of the isolates were determined as 97.7% and 84.1% for amphotericin B and fluconazole, respectively. No resistance to micafungin and caspofungin was detected. The survival rate with echinocandin use was 22% (4 patients). CONCLUSION: Identification of gene regions is valuable in determining the pathogenicity of C. auris. . Due to the presence of comorbidi- ties in patients with C. auris, , it is not possible to determine the exact proportion of deaths attributable to C. auris alone. LIMITATIONS: Single center setting; gene regions could not be ex- pressed
The Making of Football Diplomacy: A Case Study of a Sports Official from Türkiye
No full textThis study employs an exploratory single case design to investigate whether an international sport official can perform the functions of sport diplomacy: communication, negotiation, and representation. It explores the mechanisms and outcomes of such engagement. Focusing on & Scedil;enes Erzik, a long-serving executive in UEFA and FIFA, the study examines how such actors operate within institutional sport structures while intersecting with broader diplomatic processes. The findings suggest that sport diplomacy can advance national visibility and soft power objectives, particularly through international representation and branding. Erzik's involvement in peace initiatives, informal mediation in politically sensitive matches, and participation in joint tournament bids demonstrates how sport officials may serve as facilitators of diplomatic communication. The case further illustrates that sport diplomacy, when driven by individual initiative, can align with national foreign policy goals. While limited in generalizability, the study contributes to understanding sport diplomacy's practical functions and its informal and personalized diplomatic mechanisms