FBU GCRIS Standard Database (Fenerbahçe University)
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Protective Effects of Cuscuta Sp. Against Cardiorenal Injury in Bile Duct-Ligated Rats
No full textObjective: Bile duct ligation (BDL) obstructs bile flow, resulting in bile and toxic substances buildup that causes liver damage. This study investigated the protective effects of Cuscuta sp. methanol extract (CUS) against cardiorenal injury in bile duct-ligated rats. Materials and Methods: Rats were categorised into four groups: Control (C), CUS, BDL, and BDL+CUS. The C and BDL groups received saline, whereas the other groups received oral 250 mg/kg CUS. After 28 days, blood, kidney, and heart tissue samples were collected for biochemical and histological analyses. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), direct bilirubin (DB), and total bilirubin (TB) levels were analysed to determine liver function, while Transforming growth factor-beta (TGF-beta) and hydroxyproline (HYP) levels were evaluated for fibrosis, and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels alongside Na+/K+-ATPase activity were analysed to assess oxidative stress and membrane injury in the heart and renal tissues. Results: AST, ALT, DB, and TB levels were significantly elevated in the BDL group compared with the C group; however, the levels were distinctly lower in the BDL+CUS group than in the BDL group. Additionally, in both tissues, TGF-beta, HYP, and 8-OHdG levels were higher in the BDL group than in the C group, but decreased in the BDL+CUS group, with Na+/K+-ATPase activity being lower in BDL group compared with the C group and significantly increased in BDL+CUS group. Conclusion: CUS has protective effects against oxidative damage and offers antioxidant and anti-inflammatory benefits against cholestasis-induced tissue injury
Relationship Between E-Health Literacy and Healthy Lifestyle Behaviours of Turkish Health Sciences Students
No full textPurpose: E-health literacy (EHL) and healthy lifestyle behaviours (HLBs) are important for individuals receiving health education. Health professionals of the future should be conscious, e-health literate and develop HLBs. The aims of this study were to determine the EHL and HLBs of university students receiving health education and to examine the relationship between them. Design/methodology/approach: A total of 1,454 health sciences students, between the ages of 18–27, were included in the study. Participants' data were collected online via Google Forms. Participants' EHL levels were assessed with the E-Health Literacy Scale. Participants' HLB were assessed with the Healthy Lifestyle Behaviours Scale II. Findings: Positive weak correlation was found between EHL and HLB (p < 0.001, r = 0.329). EHL scores of bachelor’s degree students were higher than associate degree students (p = 0.004). HBL total score bachelor’s and associate degree student scores were similar (p = 0.714). Originality/value: This article addresses an important gap in understanding health sciences students' online reading habits about health and their relationship to HLB. Considering that there is a positive relationship between EHL and HLBs of students in the health departments of universities, increasing the EHL levels of students will help to increase HLBs. © 2025, Emerald Publishing Limited.Emerging Sources Citation Inde
Seroprevalence of Torch Viral Agents in Pregnant Women in Turkey: Systematic Review and Meta-Analysis
No full textKahraman Kilbas, Elmas Pinar/0000-0003-1348-625XRubella Virus, Cytomegalovirus (CMV), Herpes Simplex Virus-2 (HSV-2), Hepatitis B (HBV) and Hepatitis C virus (HCV) can cause serious fetal disease. The seropositivity rates of these agents vary among countries and geographic regions. This study aimed to analyze the prevalence rates and diagnostic methods used in studies investigating the seroprevalence of viral pathogens in the TORCH group among pregnant women in Turkey between 2005 and 2024. A systematic search was conducted using electronic databases between January 2005 and January 2024. A total of 60 studies meeting the inclusion criteria were included. Data quality control was assessed using the Joanna Briggs Institute guideline prevalence studies checklist. Heterogeneity was measured using the I-squared (I-2) statistic in the Comprehensive Meta Analysis (CMA) program. The average seropositivity rates for Rubella, CMV, HSV-2, HBV and HCV in Turkey were determined as 91.18%, 94.81%, 35.52%, 1.66% and 0.25%, respectively. When the diagnostic methods were examined, it was determined that ELISA and ECLIA methods were used most frequently. The seropositivity of the agents did not show statistically significant differences according to the year periods, geographical regions and age of the patients (p > 0.05). The highest prevalence rates of Rubella and HSV-2 in pregnant women were reported in the Mediterranean region, the highest prevalence rates of CMV and HCV in the Southeastern Anatolia region and the highest seroprevalence of Anti HBs in the Marmara region. The results of this study support the necessity of increasing public awareness in the control of fetal infection caused by TORCH viral agents, prenatal screening, vaccination for Rubella and HBV and compliance with hygiene conditions for agents such as CMV, HSV-2 and HCV. The results of this study highlight the need to increase public awareness on prenatal screening for the control of fetal infection caused by all TORCH viral agents, vaccination for Rubella and HBV and compliance with hygiene conditions for agents such as CMV, HSV-2 and HCV.Science Citation Index Expande
Relationship of Handwriting Skills With Cognitive Functions and Sensory Processing in the Older Adults
No full textAims: Handwriting involves complex processes, including cognitive function and sensory processing. Cognitive function and sensory processing change with aging. However, the relationship between these parameters remains unclear. The aim of this study is to investigate the relationship between cognitive function and sensory processing with handwriting skills in the older adults. Methods: Fifty-six community-dwelling individuals aged 65-75 years completed a sociodemographic questionnaire, the Adolescent/Adult Sensory Profile, the Montreal Cognitive Assessment (MoCA), and handwriting tasks. Results: The mean age was 70.62 +/- 3.49 years. The strongest correlations were observed between MoCA and the handwriting subtest. Low registration, sensory sensitivity, and sensation avoiding were positively correlated with handwriting subtests. Moreover, the results showed that these skills were also predictive of older adults' handwriting skills (p < 0.05). Conclusions: It is crucial for occupational therapists and physiotherapists to integrate handwriting skill assessment into their clinical settings in terms of its relationship with cognitive and sensory processing.Emerging Sources Citation Inde
Investigating the Impact of Various Insole Applications on Balance and Postural Stability in the Elderly
No full textkisa, eylul pinar/0000-0003-4707-4528; OZTURK, BASAR/0000-0001-5763-6008Objectives: Aging leads to physical and cognitive declines, notably affecting balance and motor skills, making falls a prevalent health concern among the elderly. Falls, a significant health issue among the elderly, often stem from these impairments. This study aims to investigate the impact of different insole materials, specifically cork and silicone, on balance and postural stability in the elderly. Methods: A randomized controlled trial was conducted at the Istanbul Barinyurt Elderly Care Center with 24 participants, divided into two groups to test cork and silicone insoles. Balance parameters, plantar pressure, the Timed Up and Go (TUG) test, and the Five Times Sit-to-Stand Test were used as measures. Data analysis was performed using the Mann-Whitney U and Wilcoxon tests. Results: Post-intervention, the cork insole group showed significant improvements in balance, maximum plantar pressure, and functional mobility tests compared to the silicone insole group. While both insoles enhanced certain balance parameters and walking performance, cork insoles proved more effective in key outcomes. Additionally, maximum plantar pressure for the cork insoles group decreased significantly, indicating better pressure distribution and potentially enhanced balance. Conclusion: Cork insoles are superior to silicone insoles in improving balance and postural stability among the elderly. This study supports using cork insoles as part of fall prevention strategies, emphasizing the importance of material properties in orthopedic insole design. Future research should explore long-term effects and integrate insoles with other postural stability methods for comprehensive elderly care.Scientific Research Projects Coordination Unit of Biruni UniversityFunding This study was supported by a research grant from the Scientific Research Projects Coordination Unit of Biruni University.Emerging Sources Citation Inde
Populist Securitization of Migration: the Anti-Immigrant Zafer Party Example in Türkiye
No full textOzoflu, Melek Aylin/0000-0002-9403-6957; Altintop, Apak Kerem/0000-0002-6854-1378; Uyar, Can/0000-0003-0135-8410Although T & uuml;rkiye is the largest refugee-hosting country in the world, the Zafer Party's (ZP) (English: Victory Party) discourse on migration as the pioneer representative of the European-style anti-immigrant right party example has been under-studied. To address this gap, this research examines the discursive practices of the ZP through the lens of populist securitization. It focuses on revealing how the ZP employs a people-centred appeal to securitization, explaining how the people are located within its populist discourse as a threatened object of reference and actor. In this way, it empirically contributes to the burgeoning literature bridging between populism and securitization theory. To this end, it conducts an extensive qualitative frame analysis of the party's manifesto, programme, press releases, public speeches uttered by party leader & Uuml;mit & Ouml;zda & gbreve;. The time frame of the research is designated as starting from the establishment of the ZP, i.e. 26 August 2021, to the Presidential and Parliamentary Elections in T & uuml;rkiye, i.e. 14 May 2023. The paper finds out that ZP combines populist and nationalist appeals by creating vertical (down/up) and horizontal (in/out) antagonisms, exhibiting parallels with similar tendencies in its European counterparts.Social Science Citation Inde
Investigating Compliance With a Home Exercise Program in People With Multiple Sclerosis
No full textObjective: This study aims to evaluate the status of receiving home exercise programs and adherence among individuals with multiple sclerosis (MS), providing insights for clinical practice. Methods: Individuals diagnosed with MS, aged 18 and over, literate, and reached through the social media platforms of the MS Society of Türkiye, were included in the study. Individuals who did not fully complete the questions asked and/ or gave answers irrelevant to the topic, who reported comorbidities that may prevent participation in exercise along with MS, and those not meeting the specified age criteria were excluded from the study. Data were collected through an online questionnaire assessing MS patients’ sociodemographic and clinical characteristics and their engagement and adherence to home exercise programs. Results: A total of 217 people (n = 36) male, (n = 181) female, participated in the study. While the rate of having a prescribed home exercise program among all participants was 12.90%, this rate was 8.33% for men and 13.81% for women. When the compliance of the participants with home exercise programs was examined, all men stated they sometimes applied these programs. This rate was found to be 52% for women. Conclusion: The study demonstrated that a considerable proportion of individuals with MS did not engage with the prescribed home exercise programme. Furthermore, the adherence rates and frequency of exercise updates were found to be inadequate. Since the MS population is increasing steadily in Türkiye, it is vital to facilitate access to effective exercises for people with MS and to ensure lifelong compliance with these exercises. © 2025 AVES. All rights reserved
Google Trend Index as an Investor Sentiment Proxy in Cryptomarket: Nonlinear Relationships With Cryptomarket and Predicting Bitcoin Returns With Machine Learning Approach
No full textThis study investigates the utility of Google trend indices as proxies of investor sentiment, examining their relationships with cryptocurrency market prices and their potential for return prediction. Employing several nonlinear econometric models including the momentum threshold autoregressive AR (MTAR), Kapetanios, Shin, and Snell, and exponential smooth transition autoregressive vector error correction model, the research the relationships between Google trend indices and BTC prices. Additionally, the study evaluates the performance of three developed artificial neural network models in predicting bitcoin returns based on investor sentiment derived from Google trend indices. The findings highlight that the MTAR model effectively captures significant relationships between the variables studied. However, predicting bitcoin returns remains challenging due to their typically small values, which represent the changes between observation points
Relationship Between Resilience, Secondary Traumatic Stress and Work-Related Factors Among Mental Health Professionals
No full textObjectives: Resilience is the ability to maintain or rapidly recover mental health under stress. Mental health profes- sionals are often exposed to workplace stress through violence, emotional labor, restrictions, and traumatic stories. Secondary traumatic stress results from being affected by others’ traumatic experiences. Examining the relationship between resilience and secondary traumatic stress among mental health professionals is therefore essential. Methods: This descriptive study was conducted between February and April 2022. Data were collected using the Per- sonal Information Form, the Resilience Scale for Adults, and the Secondary Traumatic Stress Scale. Participants included 212 psychiatric and mental health nurses, 28 psychiatrists, 14 psychologists, and six social workers. Results: A significant positive relationship was found between resilience and secondary traumatic stress. The regres- sion model, including secondary traumatic stress, gender, educational status, willingness to work in mental health, job satisfaction, and unit of work, significantly predicted resilience. Conclusion: Secondary traumatic stress and work-related factors, such as willingness and satisfaction with working in mental health and the unit of work, were found to play an essential role in resilience. Institutional support and supervision may strengthen resilience, while reducing secondary traumatic stress can enhance motivation and well- being. Institutions are recommended to implement strategies that address these factors to improve both resilience and professional effectiveness
Safety and Efficacy of Depatuxizumab Mafodotin Monotherapy or in Combination With Temozolomide in Patients With/Without EGFR-Amplified Recurrent Glioblastoma: A Systematic Review
No full textThis study aimed to assess the safety and efficacy of depatuxizumab mafodotin as a monotherapy or in combination with temozolomide in patients with recurrent epidermal growth factor receptor (EGFR)-amplified glioblastoma multiforme, focusing on overall survival (OS) and progression-free survival (PFS). A comprehensive literature search was conducted across PubMed, Cochrane Library, Web of Science, and Scopus databases up to August 2024. Randomized controlled trials (RCTs) and observational studies were included, comparing depatuxizumab mafodotin alone or with temozolomide in patients with and without EGFR amplification. Data extraction encompassed participant demographics, treatment regimens, and clinical outcomes. Of 102 screened publications, 10 RCTs and cohort studies involving 1431 patients met the inclusion criteria. The included studies examined depatuxizumab mafodotin as a standalone therapy and in combination with other agents, revealing OS ranging from 5 to 14 months and considerable variability in PFS. While depatuxizumab mafodotin shows the potential to improve survival outcomes, the heterogeneity in results highlights the need for further research. Future studies should refine patient selection criteria and explore alternative therapeutic combinations, such as depatuxizumab mafodotin with gemcitabine or cisplatin, to optimize treatment strategies