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The Effect of Kinesiophobia Level on Self-Care Ability in Patients with Total Hip Replacement
No full textBu araştırma, total kalça protezi ameliyatı geçiren bireylerde kinezyofobi (hareket korkusu) düzeyinin öz bakım gücü üzerindeki etkisini incelemeyi amaçlamaktadır. Total kalça protezi, özellikle yaşlı ve dejeneratif eklem hastalığı olan bireylerin yaşam kalitesini artırmak için uygulanan etkili bir cerrahi yöntemdir. Ancak ameliyat sonrası dönemde sadece fiziksel değil, psikososyal ve duygusal faktörler de hastaların iyileşme sürecini etkilemektedir. Bu çalışmada, kinezyofobinin öz bakım gücünü sınırlandırarak hastaların rehabilitasyon süreçlerine katılımını olumsuz yönde etkileyebileceği varsayılmıştır. Araştırma kesitsel tiptedir. Bununla beraber verilerin sayısal olarak toplanıp analiz edileceği için kantitatif ve iki kavram arasındaki ilişki analiz edildiğinden ilişkisel bir araştırmadır. Araştırma bulgularına göre hastaların öz bakım gücü orta-yüksek düzeyde bulunmuştur (Ort.=90,44±20,6), ancak katılımcıların büyük çoğunluğu yüksek düzeyde kinezyofobiye sahiptir (Ort.=46,55±6,8). Yapılan basit doğrusal regresyon analizinde, kinezyofobi puanındaki her bir birimlik artışın, öz bakım gücünde ortalama 1,19 birimlik azalma ile ilişkili olduğu belirlenmiş ve modelin açıklayıcılığı %15,4 olarak hesaplanmıştır. Bu bulgu, kinezyofobinin öz bakım davranışları üzerinde anlamlı ve negatif bir etkiye sahip olduğunu göstermektedir. Ayrıca çalışmada öz bakım gücü ve kinezyofobi düzeyleri ile demografik, fizyolojik ve sosyoekonomik değişkenler arasındaki ilişkiler analiz edilmiştir. Öz bakım gücü; yaş, vücut ağırlığı, beden kitle indeksi, eğitim düzeyi, konut tipi ve kronik hastalık varlığı gibi birçok değişkenden anlamlı şekilde etkilenmiştir. Benzer biçimde, kinezyofobi düzeyi de eğitim durumu, meslek, konut yapısı, ağrı düzeyi ve uyku süresi gibi faktörlerle anlamlı ilişkiler göstermiştir. Araştırma sonuçları, kinezyofobinin bireyin fiziksel hareketliliğini sınırlayarak kas gücü, denge ve fonksiyonel bağımsızlık üzerinde olumsuz etkilere yol açabileceğini ve bunun öz bakım yeterliliğini düşürebileceğini ortaya koymuştur. Bu çalışmanın sonuçları doğrultusunda, total kalça protezi ameliyatı geçiren bireylerde öz bakım gücünü artırmak ve kinezyofobi düzeyini azaltmak amacıyla fiziksel rehabilitasyonun yanı sıra psikososyal destek unsurlarının da iç içe geçtiği bütüncül ve multidisipliner müdahalelere ihtiyaç duyulduğu ortaya konmuştur. Özellikle hareket korkusunu azaltmaya yönelik erken tanılama, psikolojik destek ve yapılandırılmış hasta eğitimi programları, bireylerin günlük yaşam aktivitelerine katılımını artırmada kritik rol oynamaktadır. Anahtar Kelimeler: Kinezyofobi, Öz bakım gücü, Total kalça protezi, Rehabilitasyon, Psikososyal destekThis study aims to examine the effect of kinesiophobia (fear of movement) on self- care ability in individuals who have undergone total hip replacement surgery. Total hip arthroplasty is an effective surgical method, particularly used to improve the quality of life in elderly individuals with degenerative joint diseases. However, in the postoperative period, not only physical but also psychosocial and emotional factors affect the recovery process of patients. In this study, it was hypothesized that kinesiophobia could limit self-care ability and negatively influence patients' participation in rehabilitation processes. The research is cross- sectional in design. Since the data were collected and analyzed quantitatively and the relationship between two variables was investigated, the study is also correlational in nature. According to the research findings, the self-care ability of the patients was found to be at a moderate-to-high level (Mean=90.44±20.6), while the majority of the participants had high levels of kinesiophobia (Mean=46.55±6.8). In the simple linear regression analysis, it was determined that each one-point increase in the kinesiophobia score was associated with an average decrease of 1.19 points in self-care ability, and the model's explanatory power was calculated as 15.4%. This finding shows that kinesiophobia has a significant and negative impact on self-care behaviors. Additionally, the relationships between self-care ability and kinesiophobia levels and various demographic, physiological, and socioeconomic variables were analyzed. Self-care ability was significantly affected by variables such as age, body weight, body mass index, education level, type of housing, and presence of chronic illness. Similarly, the level of kinesiophobia showed significant relationships with education level, occupation, housing type, pain level, and sleep duration. The results of the study revealed that kinesiophobia may limit physical mobility, negatively impact muscle strength, balance, and functional independence, and thus reduce self-care competency. Based on these findings, it was concluded that in order to enhance self-care ability and reduce the level of kinesiophobia in individuals undergoing total hip arthroplasty, there is a need for comprehensive and multidisciplinary interventions that integrate psychosocial support into physical rehabilitation. Especially early diagnosis, psychological support, and structured patient education programs aimed at reducing fear of movement play a critical role in improving participation in daily living activities. Keywords: Kinesiophobia, Self-care ability, Total hip replacement, Rehabilitation, Psychosocial suppor
Measurement of the Higgs Boson Mass and Width Using the Four-Lepton Final State in Proton-Proton Collisions at (Formula Presented)
No full textA measurement of the Higgs boson mass and width via its decay to two (Formula presented) bosons is presented. Proton-proton collision data collected by the CMS experiment, corresponding to an integrated luminosity of (Formula presented) at a center-of-mass energy of 13 TeV, is used. The invariant mass distribution of four leptons in the on-shell Higgs boson decay is used to measure its mass and constrain its width. This yields the most precise single measurement of the Higgs boson mass to date, (Formula presented), and an upper limit on the width (Formula presented) at 95% confidence level. A combination of the on- and off-shell Higgs boson production decaying to four leptons is used to determine the Higgs boson width, assuming that no new virtual particles affect the production, a premise that is tested by adding new heavy particles in the gluon fusion loop model. This result is combined with a previous CMS analysis of the off-shell Higgs boson production with decay to two leptons and two neutrinos, giving a measured Higgs boson width of (Formula presented), in agreement with the standard model prediction of 4.1 MeV. The strength of the off-shell Higgs boson production is also reported. The scenario of no off-shell Higgs boson production is excluded at a confidence level corresponding to 3.8 standard deviations. © 2025 CERN, for the CMS Collaboration
A Deep Learning Framework for Solving Fractional Partial Differential Equations
No full textThis research focuses on the study and solution of fractional partial differential equations (FPDEs), a critical area in mathematical analysis. FPDEs pose significant challenges due to their complexity, often requiring extensive computational resources to solve. Given the scarcity of exact solutions, numerical methods have been a primary approach for tackling FPDEs. However, these methods often yield substantial but limited results. The ongoing quest for more effective solutions has led researchers to explore new methodologies. Recent advancements in deep learning (DL), particularly in deep neural networks (DNNs), offer promising tools for solving FPDEs due to their exceptional function-approximation capabilities, demonstrated in diverse applications such as image classification and natural language processing. This research addresses the challenges of solving FPDEs by proposing a novel deep feedforward neural network (DFNN) framework. The method integrates the Laplace transform for memory-efficient Caputo derivative approximations and demonstrates superior accuracy across various examples. The results highlight the framework's versatility and computational efficiency, establishing it as a powerful tool for solving FPDEs.Malaysia Ministry of Education [FRGS/1/2022/STG06/UPM/02/2]The authors are very thankful to Malaysia Ministry of Education for awarded Fundamental Research Grant Scheme (Ref. No. FRGS/1/2022/STG06/UPM/02/2) for supporting this work.Science Citation Index Expande
On the Choice of System Strength Metrics for the Allocation and Sizing of Synchronous Condensers in Power Grids
No full textChakraborty, Suprava/0000-0001-8900-7724; Agyekum, Ephraim Bonah/0000-0002-6947-4349The integration of high levels of inverter-based generation (IBG) into power grids requires meticulous planning, especially as IBGs lack the inherent short-circuit capacity of conventional generators, potentially weakening system strength. To mitigate this, synchronous condensers (SCs) are deployed in weak areas to enhance fault current and voltage support. Traditional SC allocation methods use the short-circuit ratio (SCR) as a key metric, but this may not account for control interactions in grids with significant IBG penetration. This study compares two approaches for optimizing SC placement and sizing: SCR-based and network-response short-circuit ratio (NRSCR)-based, a metric that captures dynamic IBG interactions. Applying a genetic algorithm (GA) to the Nigerian power grid as a case study, the SCR-based approach identified two critical points of interconnection (PoIs) requiring 68 MVA of SC capacity, while the NRSCR-based method identified four PoIs, requiring a total of 674 MVA. Although the NRSCR-based method significantly improved system performance during faults-offering faster voltage recovery post-fault and higher fault current contributions-it resulted in a cost increase of approximately 7 times. This highlights the trade-off between cost and performance, underscoring the need for utilities to balance economic and technical considerations when deploying SCs in IBG-dominated grids.Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, India; Tertiary Education Trust Fund (TETFund) under the Academic Staff Training and Development (AST&D) Grant of the Federal University Oye-Ekiti, NigeriaThis work was supported in part by Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, India; and in part by the Tertiary Education Trust Fund (TETFund) under the Academic Staff Training and Development (AST&D) Grant of the Federal University Oye-Ekiti, Nigeria.Science Citation Index Expande
ABD Askeri Sağlık Sistemi Reformunun İncelenmesi ve Uluslararası Güvenlik Çerçevesinde Türkiye Açısından Değerlendirilmesi
No full textBu çalışmanın amacı; ABD askeri sağlık sistemindeki (ABD-ASS) reform ihtiyacının zamanlaması, nedenleri ve reform faaliyetlerinin analiz edilmesi, buradan elde edilen sonuçların, Türkiye’nin savunma ve güvenliği açısından değerlendirilmesidir. ASS, ulusal kongre raporları, ikincil kaynaklar, dönüşüm ve reformla ilgili veriler, uzman görüşleri ve açık kaynaklardan elde edilen bilgilerle kavramsal ve fonksiyonel olarak değerlendirilmiştir. Çalışma sağlık yönetimi, entegre sağlık hizmetleri, inovasyon ve muharebe hazırlığı temalarının elde edilmesine yönelik, tümevarımsal kodlamanın kullanıldığı, nitel bir araştırma olarak planlanmış ve gerçekleştirilmiştir. Çalışmanın temel bulgusu; muharebe ortamında karmaşıklık arttıkça askeri sağlık organizasyonunda küçük, hızlı, mobil ve deneyim sahibi sağlık birlik ve personeline ihtiyacın artacağıdır. Ayrıca askeri sağlığın uluslararası siyasetteki insancıl gücünün de politikaya hareket sahası kazandırmakta etkili olacağı görülmektedir. ABD’nin reform zamanlamasının, büyük bölgesel savaşların emaresi olarak değerlendirilebileceği ve Türkiye’nin savunma sanayii ile paralel olarak milli askeri sağlık sistemini de en geç 2030 yılına kadar reforme etmesi gerektiği sonucuna varılmıştır. İnovasyon, operasyonel tıp, reorganizasyon ve entegre kayıt sistemleri askeri sağlık sistemlerinin odaklanması gereken, temel reform konuları olarak tespit edilmiştir
Revisiting Treatment Strategies: Addressing Epithelial-To Transition-Induced Resistance in Hepatocellular Carcinoma
No full textOne of the major therapeutic challenges for hepatocellular carcinoma (HCC), the most form of primary liver cancer, is how to overcome drug resistance. Due to the high failure rate of systemic therapy in treating advanced HCC patients and the increasing recurrence rate, HCC is a highly lethal malignancy. Primary and acquired drug resistance are major contributing factors to the patients with advanced HCC who do not respond effectively to long-term systemic therapy. Therefore, it is essential to look into the molecular processes that lead to drug resistance. Different studies have indicated that epithelial-to-mesenchymal transition (EMT) plays a critical part in the emergence of drug resistance. Several signaling pathways regulate this phenomenon. This review primarily concentrates on drug resistance triggered by EMT, especially in the context of HCC. The key signaling pathways that cause drug resistance in HCC, including transforming growth factor-beta and epidermal growth factor receptor signaling, liver cancer stem cells, and noncoding RNAs, are highlighted in the present study, along with the most recent molecular targets discovered to prevent drug resistance. These targets could help develop novel and combinatory HCC therapy approaches. Therefore, this review aims to provide both the latest findings on molecular basis and potential solutions for HCC drug resistance.Emerging Sources Citation Inde
The Role That Brand Personality Plays in Digital Purchasing Decisions
No full textThis paper goes into the role of branding in today’s consumer behaviour and how it’s essential for product differentiation and decision making for consumers to choose. In today’s society branding is a valuable asset, it’s a multi-faceted process. The study highlights the importance of “brand personality” in consumer interaction. Using examples like Cartier and Rolex the research shows how consumers align themselves with brands that have a distinct and compelling personality. Recent research also shows that online consumers are preferring brands with a captivating and resonant brand personality that influences their buying behaviour. This article breaks down the impact of brand personality on consumer decision making especially in the fast paced and ever changing digital landscape, a must read for marketers and businesses wanting to navigate and leverage this shift in consumer behaviour. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2025
Effect of Surface Coatings on Endothelialization and Biofilm in Ptfe Vascular Grafts
No full textErkan, Muhammet Huseyin/0000-0002-8390-2493Polytetrafluoroethylene (PTFE) grafts are of great importance for vascular surgery and many methods have been developed to improve their biocompatibility. The most important of these methods is the coating of the inner surfaces of the grafts. In this study, the effects of surface coatings used in vascular grafts on endothelialization and bacterial biofilm formation were investigated. Three different PTFE graft types, heparin coated, carbon coated and uncoated, were compared. HUVEC cell culture was used for endothelialization experiments and Staphylococcus aureus strain was used for biofilm formation. Endothelialization was evaluated by inverted microscopy and scanning electron microscopy (SEM). Heparin-coated grafts showed more biofilm formation than other graft types (p < 0.01). Moderate biofilm formation was observed in carbon-coated grafts (p < 0.05). When evaluating endothelialization, heparin-coated grafts showed more cell adhesion in the first days, but lagged behind the other graft types in the following days. Carbon-coated grafts showed more endothelial cell proliferation in the long term. While biofilm formation was high in heparin-coated grafts, carbon-coated grafts provided better endothelialization. Our study showed that the coating of PTFE grafts significantly affects biocompatibility and infection risk.Research Fund of the Aydimath;n Adnan Menderes University; Ege University Application and Research Center For Testing and AnalysisThe authors would like to acknowledge Ege University Application and Research Center For Testing and Analysis (EGE MATAL) for the SEM imaging.Science Citation Index Expande
Which Screening Tool Performs Best in Identifying Malnutrition Risk Among Hospitalized Older Adults With Cardiovascular Disease? a Diagnostic Accuracy Study Comparing Six Different Screening Tools With Glim Criteria
No full textDurmaz, Duygu/0000-0001-9617-8046; , Ayca Aydin/0000-0001-9750-5678; Arslan, Sedat/0000-0002-3356-7332; Tari Selcuk, Kevser/0000-0003-1766-4914Purpose This study aimed to compare the performance of six different screening tools with the GLIM criteria in identifying malnutrition risk among older adults with cardiovascular diseases. Methods In this diagnostic accuracy study, data from 669 patients aged 65 and older, hospitalized at Band & imath;rma Training and Research Hospital diagnosed with cardiovascular disease, were evaluated. The data were obtained using a questionnaire that included a Demographic Information Form, Global Leadership Initiative on Malnutrition (GLIM) Criteria, Malnutrition Screening Tool (MST), Malnutrition Universal Screening Tool (MUST), Short Nutritional Assessment Questionnaire (SNAQ), Mini Nutritional Assessment-Short Form (MNA-SF), Nutritional Risk Screening-2002 (NRS-2002), and Graz Malnutrition Screening (GMS) tool. GLIM criteria were used as gold standard and six screening tools were used as index tests. Receiver Operating Characteristic (ROC) curve analysis was conducted to calculate the Area Under the Curve (AUC), and the sensitivity, specificity, accuracy, and Cohen's Kappa (kappa) coefficient of the index tests were assessed. Results The mean age of the patients was 75.5 +/- 7.7 years, 55.2% were female. According to the GLIM criteria, the prevalence of malnutrition was calculated as 22.0%. The AUC calculated by ROC indicated that MST (AUC: 0.905) had excellent predictive value, while MUST (AUC: 0.874), SNAQ (AUC: 0.851), MNA-SF (AUC: 0.842), and GMS (AUC: 0.820) demonstrated good predictive value. Among the screening tools, GMS had the highest sensitivity (92.5%), whereas MNA-SF exhibited the highest specificity (91.6%). MNA-SF also demonstrated the highest agreement with the GLIM criteria (Cohen's kappa: 66.8) and the highest accuracy (88.3%). Conclusion This study found that the MNA-SF tool outperformed other comprehensive screening tools when evaluating malnutrition risk in light of the GLIM criteria.Scientific and Technological Research Council of Turkiye (TUBITAK).Open access funding provided by the Scientific and Technological Research Council of Turkiye (TUBITAK).Science Citation Index Expande
Effect of Deep Brain Stimulation on the Severity of Seizures and the Quality of Life in Patients With Multifocal Drug-Resistant Epilepsy in Iran: a Pilot Review of Local Experience
No full textThis study investigates the impact of the anterior nucleus of the thalamus deep brain stimulation (ANT-DBS) on patients with drug-resistant epilepsy (DRE) in Iran, specifically focusing on its effects on seizure metrics, severity and its influence on quality of life over time. A cohort of eight patients with DRE in Iran who underwent ANTDBS was evaluated. Pre-operative assessments included comprehensive documentation of seizure frequency, duration, severity scores, and the Quality of Life in Epilepsy Inventory (QOLIE-13). Each patient also underwent high-resolution imaging using a 1.5 Tesla MRI, with targeted electrode placement in the anterior thalamic area. Post-operative evaluations measured changes in seizure frequency, severity scores, duration, and quality of life indicators. All subjects presented with DRE, and the mean age of participants was 24.62 years. Post-operative data revealed significantly reduced seizure frequency, duration, and severity scores. Notably, this reduction was more pronounced at the 6-month follow-up than the 3-month assessment, indicating a progressive therapeutic effect. All patients demonstrated a response to ANT-DBS, with two individuals achieving seizure freedom. Additionally, there was a marked improvement in quality of life, particularly in the domains of energy/fatigue and social functioning. ANT-DBS has been established as a promising and safe therapeutic intervention for patients with DRE. In a cohort of DRE patients in Iran, the treatment demonstrated comparable efficacy in decreasing seizure frequency and severity and enhancing self-reported quality of life, consistent with findings reported in the existing literature. The therapeutic benefits of ANT-DBS appear to augment over time.Emerging Sources Citation Inde