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Impact of lymph node staging on survival in presumed early-stage ovarian cancer: a multicentric retrospective study
No full textInternational audienceObjective:This study aimed to assess the impact of comprehensive staging on survival outcomes in this population.Methods:Patients who underwent surgery for epithelial ovarian cancer in one of the 14 Francogyn cancer centers between 2000 and 2020 were included in the study. The primary analysis evaluated the impact of lymphadenectomy on overall survival and recurrence-free survival. Lymph node count was analyzed as a continuous variable, and its association with survival, considered as a continuous outcome was assessed using linear regression (secondary analysis). Survival was compared using the log-rank test, and multivariate analysis was performed using a Cox model.Results:A total of 467 patients with presumed early-stage epithelial ovarian cancer were included, of which 198 underwent complete lymphadenectomy and 266 did not. No significant association was found between lymph node staging and survival in the primary analysis, possibly due to limited statistical power and a selection bias, as patients without lymphadenectomy had more favorable disease profiles (p=0.600 and p=0.700, respectively). Complete lymphadenectomy was associated with a significantly higher risk of complications (34.5% vs. 14%, p<0.001). In secondary analysis, the number of para-aortic lymph nodes harvested was identified as an independent predictor of both overall survival and recurrence-free survival (p=0.007 and p=0.002, respectively). Histological characteristics and adjuvant chemotherapy also showed a significant correlation with improved survival outcomes.Conclusion:Extensive para-aortic lymphadenectomy in early-stage epithelial ovarian cancer is associated with better overall and recurrence-free survival but comes with an increased risk of complications
Improving visibility for knowledge holders in ethnobiological and ethnopharmacological publications
No full textInternational audienceEthnopharmacological relevance: Ethnopharmacology and ethnobiology largely focus on the study of traditional knowledge related to medicinal and other uses of plants, animals or minerals. Despite decades of political advocacy, ethnopharmacological and ethnobiological information is still sometimes published without proper attribution of the cultural identities and affiliations of the communities that shared it.Aim of the study: Identify key guidelines to ensure the proper attribution of ethnobiological and ethnopharmacological knowledge recorded in scientific publications to the communities who provided it.Material and methods: This article is based on extensive group discussions that started at a workshop entitled “A worldwide database of local uses of biodiversity: Why? For whom? And how?” (18th Congress of the International Society of Ethnobiology in Marrakech, Morocco, May 15–19, 2024), and was attended by around 50 participants. The guidelines were developed through an iterative revision process.Results: We propose practical guidelines to improve the attribution and thus, visibility, of communities whose knowledge contributes to ethnobiological and ethnopharmacological publications. Recognising individual knowledge holders remains a critical topic on its own right.Conclusion: Transparent and consistent reporting of the provenance of place-based ancestral knowledge from communities is essential for advancing the objectives of the Nagoya Protocol, the Treaty on Intellectual Property, Genetic Resources and Associated Traditional Knowledge, and for strengthening academic inquir
No impact of black-eye symptom on foraging behaviour and reproductive success of Northern gannets following highly pathogenic avian influenza
No full textInternational audienceHighly Pathogenic Avian Influenza Virus (HPAIV) is currently causing major wild animal population crashes all over the world including Antarctica. Yet, there are important knowledge gaps on the implications of long-lasting symptoms for the ecology of surviving individuals and the conservation of their populations. Using GPS tracking devices and long-term demographic data, we examined the effects of HPAIV on a seabird population of Northern gannets (Morus bassanus) in the colony of Rouzic, France. One year after the HPAIV outbreak of 2022, the breeding gannet population declined by 38 % and 22.3 % of surviving breeders were zombie birds: they had darkened irises, a black-eye symptom indicative of past infection to HPAIV. Importantly, we demonstrate that black eyes were not associated with detectable differences in the foraging behaviour and habitat use of surviving breeding gannets. Compared to years prior to the outbreak, the foraging effort of breeding individuals was lower and breeding success was higher, aligning with Ashmole's halo hypothesis, which posits that smaller seabird populations face lower intra-specific competition for food in the vicinity of their breeding colony and thereby, have a reduced foraging range. Our results highlight the importance of density-dependant mechanisms in population responses to sudden mass-mortalities, but raise conservation concerns, especially for species facing cumulative threats. In the long-term, locally depleted populations may reach critical thresholds where individual abundance and productivity may not be sufficient to maintain a positive demographic growth rate, ultimately leading to local population extinctions
19F magnetic resonance imaging-informed fate models of PFAS in porous media
No full textInternational audiencePer-and polyfluoroalkyl substances (PFAS) are persistent contaminants. Predicting their fate in natural or engineered porous media, using accurate models, is essential for effective remediation and contamination management strategies. The mechanisms of transport and retention included in such models, and the associated parameters, are mostly inferred from PFAS concentration vs. time breakthrough curves (BTCs) measured during transport experiments. Still, the interpretation of BTCs may not be unique as they result from a succession of mechanisms taking place inside the porous media. We addressed this issue using 19 F magnetic resonance imaging (MRI) to monitor the transport of perfluorobutanoic acid (PFBA) inside a sand-packed column. The experimental BTC was slightly asymmetric, suggesting that some PFBA may have been adsorbed onto the sand. Hence, a transport model based on the hypothesis that PFBA behaved as a non-sorbing tracer slightly overestimated the concentrations in two regions of the BTC. Surprisingly, the same model matched well the MRI profiles, pointing out that the BTC asymmetry stemmed from an imperfect column exit. Although 19 F MRI requires PFAS concentration above those found in environmental samples, this study showed that the combination of this technique and modeling constitutes a powerful tool to determine the mechanisms involved in PFAS transport in natural or engineered porous media andselect appropriate fate model
Identifying Retailscape Transformations: A Methodological Framework for Spatiotemporal Analysis in Urban Environment
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Multi-sorbent passive sampler for the preconcentration of contaminants with broad polarity spectrum in drinking water, including very polar compounds
No full textInternational audienceThe occurrence of Persistent and Mobile Organic Contaminants (PMOCs), especially very polar compounds (log P <1), remains poorly characterized in drinking water due to analytical limitations. These compounds are highly soluble, weakly retained on conventional C18 materials, and may persist through treatment processes, raising concerns about potential health and environmental impacts. To address this challenge, we developed a passive sampler combining three complementary sorbents (HLB, SAX, and SCX) to enhance retention across a wide polarity range. The device was evaluated under controlled conditions (47 target substances, 3 concentrations, triplicates) to assess sorption performance and pH sensitivity. Results confirmed the complementarity of the sorbents with broad retention for HLB and more specific patterns for SAX and SCX. The tool was then deployed for 15 days in both raw and treated waters across seven drinking water treatment plants. A total of 37 contaminants were detected, including 20 with log P <1. The treatment processes proved effective, with an average 13-fold reduction in the accumulated quantities between RW and TW, although the contamination profile in TW appeared more complex, likely reflecting presence of transformation products and residual highly polar compounds. Compounds with log P <1 were found to pass more efficiently through drinking water treatment processes, consistent with their higher polarity and lower affinity for conventional removal pathways. By integrating exposure over time, the sampler lowered detection limits and offered a more exhaustive contamination profile. This approach supports improved PMOC surveillance and lays the groundwork for future quantitative or untargeted monitoring strategies in drinking water systems
Fertility preservation in men with spinal cord injury: The 2025 French guidelines
No full textInternational audienc
Historias del ecologismo, influencias y trayectorias en España (1950-2024)
No full textInternational audienc
Lecture des dynamiques d’occupation du sol et du pastoralisme dans les montagnes du Cantal et du Cézallier (Antiquité – Moyen Âge) : apport du croisement des sources
No full textInternational audienceLe colloque ACQuA propose, dans ce contexte de l’année internationale du pastoralisme et des pâturages, de traiter de ce sujet sous l’angle des relations sociétés/milieux à travers les notions de désertification, de la transhumance et de dynamiques paysagères. Nos travaux centrés sur les montagnes du Cantal et du Cézallier (Calbris 2022 ; Moulier-Calbris 2024) s’inscrivent dans cette perspective et interrogent l’évolution de l’occupation des terres de moyenne montagne sur la longue durée, entre Antiquité et Moyen Âge. En mobilisant un corpus pluridisciplinaire – sources littéraires et archéologiques, opérations de prospection pédestre et aérienne, analyses paléoenvironnementales et des résultats issus de l’analyse des données du LiDAR – nous avons pu identifier des schémas d’occupation du sol étroitement liés aux pratiques pastorales. Pour l’Antiquité, les données mettent en évidence une augmentation significative des habitats permanents exploitant probablement les prairies d’altitude, dans une logique économique articulée à l’échelle de la cité (Calbris 2025). Au Moyen Âge, à l’inverse, les sites d’altitude, notamment ceux fondés aux XI-XIIe siècles et situés autour de 1000 m, connaissent un progressif abandon lié à la pression pastorale exercée par les domaines cisterciens, bénéficiaires de donations foncières (Moulier 2023). Ces établissements structurent un système d’estivage (la transhumance n’est pas le mode pastoral utilisé dans ces montagnes du Massif Central) qui réorganise profondément les usages et les paysages montagnards. L’objectif de cette communication est de montrer que le croisement des sources textuelles, archéologiques et LiDAR permet de modéliser la création, la transformation et l’exploitation des paysages de montagne dans le temps long, et d’en saisir les logiques socio-économiques et environnementales
Éduquer aux réseaux sociaux numériques ou les interdire ? L'Assemblée a tranché
No full textE-Cité Éducation et citoyenneté à l'ère numériqueL'Assemblée Nationale vient d'adopter en première lecture une proposition de loi interdisant les réseaux sociaux aux moins de 15 ans. Retour sur une loi répressive. Dans la nuit du 26 au 27 janvier 2026, l'Assemblée Nationale adopte en première lecture la proposition de loi visant à protéger les mineurs des risques auxquels les expose les réseaux sociaux. Déposée en novembre 2025 par la députée Renaissance Laure Miller, le texte est adopté à 116 voix contre 23. Soutenue par Emmanuel Macron, la proposition de loi bénéficie d'une procédure accélérée qui assure sa révision par le Sénat à la mi-février pour une mise en vigueur potentielle à la rentrée 2026