KREPOZIT (Károli Gáspár University of the Reformed Church)
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Temporal structure of narratives reveals the intensity of the narrator’s current affective state
No full textRemembering on past emotional episodes frequently elicits an affective state in the remembering person, and remembering in a social context is usually accompanied by narration. This study considers the relationship between the narrator’s affective state and the structure of narratives. More specifically, the study addressees the question whether the temporal structure of narratives reveals the intensity of narrators’ current affective state. The study included 75 participants. They were asked to recount past emotion episodes applying a cue word paradigm with the following emotion category labels: anger, sadness, joy, and pride. Intensity of the narrators’ current affective state was assessed by physiological and self-report measures. The temporal structure of narratives was reflected by the two features of specific temporal reference and temporal unfolding. These features were coded by the method of automated linguistic analysis. The results show that specific temporal reference reflects affective intensity measured as the level of arousal while temporal unfolding reflects affective intensity measured as the valence of the narrator’s current affective state. Results are discussed by highlighting the function of temporal structure of narratives in reliving past experiences during narration
Újrafordítás vagy audiovizuális adaptáció?: Szabó Lőrinc Ahogy tetszik fordításának utóélete a magyar szinkrondramaturgiai gyakorlatban
Get PDFAntik reminiszcenciák a francia közigazgatási jog intézményeinél
No full textA modern francia közigazgatás megteremtésének kezdete a francia forradalom (1789-1799) időszakára, a teljes rendszer kialakítása pedig Napóleon konzulátusának (1799-1804), illetve császárságának (1804-1814) idejére esik. Napóleon szakítani kívánt a forradalmi időszak intézményi rendjével, de az ancien régime hivatali rendszerét sem látta tanácsosnak visszahozni, mivel a királyság tisztviselőivel szemben kialakult ellenszenv még élénken élt a francia polgárok emlékezetében. Miután az antik állami intézményi hagyományok ebben az időszakban nagy tiszteletnek örvendtek, a napóleoni reformok számára is modellként szolgáltak. Ilyen ókori mintára létrehozott állami szerv volt a Tribunatus és a Szenátus intézménye. A törvényjavaslatok megvitatására létrehozott 100 tagú testületet, a Tribunatust még maga Napóleon szüntette meg 1807-ben. Bár a Szenátus nevében utalt a római közjogi intézményre, jogállása és működési szabályai azonban jelentősen eltértek antik előképétől.
A római állami intézmények közül a napóleoni korszak számára mintául szolgálók köréből a francia Államtanács (Conseil d’État), illetve a prefektusi rendszer a mai Franciaország közigazgatási rendszerének is meghatározó szervei. A tanulmány első részében a principátus korabeli consilium principis, valamint a dominatus időszakában működő sacrum consistorium modelljének az 1799-ben létrehozott francia Államtanács működésére kifejtett hatását kívánom elemezni. A tanulmány második részében a francia megyei közigazgatás vezetőjének, a prefektusi tisztségnek a római praefectusok rendszerével párhuzamos elemeit, illetve a fővárost igazgató francia rendőrprefektusnak a római praefectus urbihoz hasonló jogállását és hatásköreit veszem górcső alá
Onasemnogene Abeparvovec Therapy Following Nusinersen Treatment in Eight Patients with Spinal Muscular Atrophy Type 1
No full textIntroduction: Innovative gene-modifying therapy can improve motor achievements of patients with spinal muscular atrophy (SMA). Onasemnogene abeparvovec (OAV101) is an adeno-associated viral vector gene therapy that introduces a functional copy of the SMN1 gene, which produces SMA protein that is essential for normal motor neuron function. Aim: To report our single-center clinical experience using OAV101 in patients with SMA Type 1 previously treated with nusinersen. Methods: Between October 2019 and September 2020, eight patients (aged 3-23 months) with SMA Type 1 were administered a single intravenous infusion of OAV101, individualized according to bodyweight (1.1 x 1014 vg/kg), and prophylactic immunosuppression. Change in motor function achievements was assessed using Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND) scores. Laboratory parameters, including liver enzymes and troponin were monitored. Results: OAV101 improved motor function in all eight patients. The average increase in CHOP INTEND scores were 11.14 points (range 3-21 points) 10 weeks after OAV101, with the highest score of 21 points in a child aged 13 weeks. The weekly increase in CHOP INTEND score following OAV101 was 1.11 points, 2.5-fold higher than that achieved with prior nusinersen treatment (0.42 points) (p=0.69; paired t-probe). Any increase in laboratory parameters occurred early after OAV101 and typically resolved to normal levels. Noninvasive ventilation use was decreased in two patients. Conclusion: OAV101 improved motor function in patients with SMA aged 3 23 months, with a manageable safety profile. Our report contributes real-world evidence of OAV101 treatment for SMA
Educational Technology in Higher Education – Methodological Considerations
Get PDFEducational Technology in Higher Education – Methodological Considerations is a handbook promoting and supporting the conscious use of digital tools among instructors in higher education. The content of the volume has been composed in accordance with the Digital Competence Framework for Educators (DigCompEdu, Redecker, 20171). In our interpretation, in a higher education environment the concept of educational informatics includes skills related to the use of infocommunication technologies in teaching and learning, as well as other activities related to education, like education management, related individual and organisational communication, and research activities (cf. Kárpáti & Hunya, 20092). The concept should be understood as part of the wider notion of digital competence, which “encompasses the confident, critical and ethical use of the technologies of the information society, and of the content made available and transmitted by these technologies in social relations, work, communication and leisure.” (NAT, 2012, p. 19) The European Council defines it as one of the key competences of lifelong learning, which is “linked to logical and critical thinking, elaborate information management skills and advanced communication skills” (Demeter, 20063). The six chapters of the volume are organised around the six areas set out in the DigCompEdu Framework of Reference, which are interconnected in several ways