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Investigation of the effects of mainshock-aftershock sequences on the dynamic responses of pipeline considering soil-pipeline interaction
No full textPipelines are important structural elements that are frequently used today to meet many infrastructures needs such as drainage, natural gas or water transmission. In this context, the usability of such structures, which are important elements of infrastructure systems, especially after disasters such as earthquakes, is of great importance. For this reason, within the scope of this study, a parametric investigation of the seismic behaviors of a natural gas pipeline system under mainshock-aftershock sequences have been carried out, specifically taking into account the soil-natural gas pipeline interaction (SNGPI) in the help of finite element model (FEM) proposed. Before developing the model of SNGPI system proposed using solid element, the fundamental mode frequencies of the pipeline system modeled using the solid element for the verification have been compared with those of obtained from the pipeline system modeled using the beam element and the analytical solutions. After verification of proposed model is demonstrated, SNGPI system has been modeled and its fundamental modes have been compared with mode frequencies of soil stratum obtained from well-known simple analytic solutions. After this stage, the dynamic analyses of natural gas pipeline (NGP) system in the time domain have been carried out using four different soil systems and four different mainshock-aftershock sequences. The results of the nonlinear time-history analyses have been investigated in terms of the stress and the displacement responses. Parametric evaluations show that the greatest displacements and the stresses occurring at the considered nodes of NGP system may be importantly affected from mainshock-aftershock sequences and soil stiffness changes. As the soil stiffness decreases, both the peak stresses and displacements increased significantly. On the other hand, the same responses obtained under mainshock loadings, which have relatively lower peak ground acceleration (PGA)/peak ground velocity (PGV) ratio compared to aftershock loadings, are generally larger than those obtained under aftershock loadings. © 2024 Elsevier Lt
How does loneliness affect satisfaction with life? What is the role of the perception of God in this interaction?
No full textIntroduction: This study examined the role of loneliness and the perception of God in affecting the satisfaction with life of Muslim individuals living alone in Turkey during the COVID-19 pandemic. Additionally, the study explored the regulatory role of the perception of God in the relationship between individuals’ loneliness and satisfaction with life. Methods: The research is a cross-sectional study that evaluates individuals’ loneliness, satisfaction with life, and perception of God. The study group consists of 378 individuals living alone in Turkey. Among the participants, 196 are women (51.9%) and 182 are men (48.1%). The UCLA loneliness scale, the satisfaction with life scale, the perception of God scale, and a personal information form were used as data collection tools in the study. Results: The examination of research findings indicated that the variables of loneliness, perception of God, and the interaction between loneliness and the perception of God explained 28% of the variance in individuals’ satisfaction with life. We determined that satisfaction with life was affected significantly and positively by the perception of God (β = 0.28, p < 0.001) and significantly and negatively by loneliness (β = −0.38, p < 0.001). The interactional effect of the variables of loneliness and perception of God on satisfaction with life was also found to be significant (β = −0.10, p = 0.023). When we examined the details of the regulatory effect, we found that the effect of loneliness on satisfaction with life decreased even more in cases where the perception of God was high. Discussion: The research findings suggest that loneliness decreases life satisfaction, while positive self-image mitigates this effect. It can be stated that using belief-sensitive therapeutic approaches in the therapeutic process could contribute to alleviating the negative effects of loneliness. Copyright © 2025 Kaya and Yazıcı Çelebi
Sulfonamide-Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico ADME/T Profiling and Molecular Docking Study
No full textThe research and design of new inhibitors for the treatment of diseases such as Alzheimer's disease and glaucoma through inhibition of cholinesterases (ChEs; acetylcholinesterase, AChE and butyrylcholinesterase, BChE) and carbonic anhydrase enzymes are among the important targets. Here, a series of novel sulfonamide-bearing pyrazolone derivatives (1a–f and 2a–f) were successfully synthesized and characterized by using spectroscopic and analytical methods. The inhibitory activities of these newly synthesized compounds were evaluated both in vitro and in silico for their effect on carbonic anhydrases (hCA I and hCA II isoenzymes) and ChEs. The in vitro studies showed that these novel compounds demonstrated potential inhibitory activity, with KI values covering the following ranges: 18.03 ± 2.86–75.54 ± 4.91 nM for hCA I, 24.84 ± 1.57–85.42 ± 6.60 nM for hCA II, 7.45 ± 0.98–16.04 ± 1.60 nM for AChE, and 34.78 ± 5.88–135.70 ± 17.39 nM for BChE. Additionally, many of these compounds showed promising inhibitory activity, and some showed higher potency than reference compounds. While the in silico studies have also identified the potential binding positions of these compounds, using the crystal structures of hCA I, II, AChE and BChE receptors. The varying affinities demonstrated by these designed compounds for ChEs and hCA isoenzymes show that these compounds could hold promise as potential alternative agents for selectively inhibiting ChEs and hCAs in the treatment of diseases such as Alzheimer's disease and glaucoma. © 2025 The Author(s). Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd
Education management in disasters
No full textThe effects of disasters on the community increase with increasing population and urbanization, the destruction of the environment, and climate change. This situation increases the need for disaster education at every stage of integrated disaster management. Effectively planned disaster education for preparation, mitigation, response, and recovery periods will ensure that the community is more resilient to disasters. The aim of this study is to investigate how the use and prevalence of new developing technologies can be used more effectively to increase the disaster education capacity of the community. Within the scope of the study, the use of technologies such as virtual reality, social media, simulations, and mobile games in disaster education will be explained. The public administration policies that need to be implemented to increase the use of these tools will be explained. In particular, suggestions will be presented to increase the sustainability and safety of the community through the use of innovative technology in disaster education. It is expected that this study will give ideas to scientists and decision-makers about the use and importance of technology in disaster education. © 2025 Nova Science Publishers, Inc. All rights reserved
Novel Sulfonylhydrazones With Sulfonate Ester Framework: Promising Dual Inhibitors of AChE and hCAs
No full textAlzheimer's disease (AD) is a progressive neurodegenerative disorder that affects millions of individuals worldwide. Treatment strategies for AD vary depending on cognitive and behavioral symptoms, with cholinergic replacement therapy using acetylcholinesterase (AChE) inhibitors being one of the primary approaches. Recent studies have also identified human carbonic anhydrases (hCAs) as significant therapeutic targets for AD, offering new opportunities for the development of innovative treatments. Carbonic anhydrase inhibitors have been shown to prevent early mitochondrial damage and inhibit H2O2 production, thereby reducing amyloid plaque formation. Building on the promising potential of hydrazones particularly sulfonyl hydrazones as anticholinesterase agents, we synthesized 12 novel chlorine-substituted sulfonyl hydrazone compounds containing aryl sulfonate ester groups. These compounds were evaluated for their inhibitory effects on AChE, hCA I, and hCA II enzymes. The synthesized compounds exhibited low nanomolar inhibitory activity, with Ki values ranging from 9.58 ± 2.22 to 104.04 ± 23.82 nM for AChE, 9.12 ± 2.21 to 477.63 ± 218.52 nM for hCA I, and 17.54 ± 7.74 to 564.62 ± 213.98 nM for hCA II. Notably, compound 6 showed strong inhibitory activity against hCA I (Ki = 9.12 ± 2.21 nM; acetazolamide (AZA) = 26.54 ± 3.11 nM) and hCA II (Ki = 17.54 ± 7.74 nM; AZA = 21.73 ± 2.42 nM), whereas compound 4 exhibited superior AChE inhibition (Ki = 9.58 ± 2.22 nM; TAC = 23.12 ± 2.05 nM). The chemical structures of the synthesized compounds were characterized using advanced spectroscopic techniques, including FT-IR, 1H-NMR, and 13C-NMR spectroscopy. © 2025 The Author(s). Biotechnology and Applied Biochemistry published by Wiley Periodicals LLC on behalf of International Union of Biochemistry and Molecular Biology
Evaluation of Antioxidant and Enzyme Inhibition Properties of Siran Propolis: Correlations With Phenolic Content Determined by LC-MS/MS
No full textThis study evaluates the antioxidant activity, enzyme inhibition potential, and phenolic composition of ethanolic Siran propolis extract. Antioxidant capacity was measured using reducing power (CUPRAC, FRAP, and Fe3+-reducing) and radical scavenging (DPPH·, ABTS·+, and DMPD·+) assays. The extract showed strong reducing ability, surpassing standard antioxidants in CUPRAC and FRAP assays, correlating with high ferulic acid (40.40 mg/g) and p-coumaric acid (88.60 mg/g) levels identified by LC-MS/MS. While it demonstrated notable DPPH· scavenging (IC50: 30.14 μg/mL), ABTS·+ activity was weaker (IC50: 272.44 μg/mL). Enzyme inhibition assays indicated effective inhibition of α-glycosidase, AChE (IC50: 2.15 μg/mL), hCA I, and hCA II. Notably, AChE inhibition was stronger than the standard tacrine inhibitor (IC50: 8.82 μg/mL), suggesting neuroprotective potential. The observed bioactivities are attributed to synergistic effects of phenolic acids and flavonoids, including quercetin, luteolin, taxifolin, and resveratrol. These findings highlight Siran propolis as a promising natural antioxidant and enzyme inhibitor source with potential therapeutic applications and food formulations.4069770
Lightweight Transformer Model for Agricultural Land Use and Land Cover Classification
No full textObserving agricultural land use via remote sensing images is essential for ensuring food security, estimating yields and planning efficient exports nonetheless precise classification continues to be difficult because of the varied and evolving characteristics of agricultural environments. This research aims to evaluate and optimize advanced deep learning architectures particularly Vision Transformer (ViT) models for agricultural land-use classification tasks. Specifically, we employed ViT-Base-16 and other lightweight models DeiT-Tiny and EfficientNet-B0 applying techniques such as model layer compression and advanced data augmentation CutMix and Cutout to achieve high accuracy while significantly reducing computational complexity. Evaluation was performed using three benchmark remote sensing datasets EuroSAT, NWPU-RESISC45 and SIRI-WHU which include diverse spatial resolutions and agricultural classes relevant for practical monitoring. Findings indicate that the optimized ViT algorithm is highly effective in recognizing global spatial connections, consistently achieving remarkable classification accuracy exceeding 99% on a newly assembled dataset containing around 200 samples of Google Earth imagery. Furthermore, for the first time in agricultural image classification compressing the ViT-Base model by pruning 50% of its layers significantly reduced complexity maintaining competitive accuracy 97.9% on SIRI-WHU. The resulting models are particularly suitable for deployment on devices with limited computational resources supporting real-world operational agricultural monitoring systems. This study emphasizes the revolutionary possibilities and practical use of optimized transformer-based models that offer scalable and efficient solutions specifically designed for precision agriculture applications. ©️ 2025 The Author(s).2-s2.0-10502073668
Therapeutic Bioactivity Exerted by the Apis mellifera Bee Venom and Its Major Protein Melittin: A Scoping Review
No full textHoney bee (Apis mellifera) products have been extensively utilized in traditional medicine. Bee venom (BV) is one of the major bee products with a high concentration of the small peptide melittin (MEL) and exerts bioactivity ranging from anti-microbial to anti-inflammatory and anti-cancer. This scoping review aims to sum up research articles on the bioactivity exerted by BV and MEL published in PubMed and Scopus from 2010 onwards. PRISMA guidelines were implemented to analyze the relevant literature; we ended up with 425 research articles. Bioactivity of BV and MEL was grouped as (i) anti-inflammatory (85), (ii) immunomodulatory (37), (iii) anti-microbial (179), (iv) anti-cancer (170), and (v) anti-oxidant (32). Although there is a significant body of research on the anti-cancer and anti-microbial activity of BV and MEL, their anti-oxidant, anti-inflammatory and immunomodulatory properties have received comparatively less attention. Many studies on the immunomodulatory effects of BV or MEL have focused on cancer. However, the effects on Parkinson’s and Alzheimer’s disease have not been extensively studied regarding the anti-inflammatory effects. Given the critical role of the immune system and inflammatory response in cancer, neurodegenerative diseases, senescence and against infections, it is paramount to further explore the immunomodulatory and anti-inflammatory potential of BV and MEL. © 2025 by the authors.2-s2.0-10501889220
Natural Disasters and Tax Compliance: The Effect of Earthquake Experience on Taxpayer Behaviour in The Example of Adıyaman
No full textThis study examines the impact of natural disasters, such as earthquakes, on tax compliance behaviour among taxpayers. Using quantitative and qualitative methods, it explores pre-and post-earthquake tax compliance, the role of government services, and changes in taxpayer behaviour. Findings reveal a positive relationship between pre-and post-earthquake tax compliance, while the direct effect of the earthquake experience is limited. Lessons from the earthquake and the impact of government services positively influence tax compliance. The study provides practical recommendations for post-disaster tax policies. © 2025, Sosyoekonomi Society. All rights reserved.2-s2.0-10502084730
Exploring how cognitive-behavioral physical activity links ruminative thinking and mental wellbeing in sports high school adolescents
No full textIntroduction: This study examined the associations among ruminative thinking style (RTS), subjective wellbeing (SWB), and cognitive-behavioral physical activity (CBPA) in a sample of 1,326 adolescents (aged 14–18) from sports high schools. Method: Using validated self-report measures, data were analyzed through bootstrapped mediation models. Results: RTS was negatively associated with SWB (β = −0.1792, p < 0.001), while CBPA showed a partial mediating effect in this relationship (indirect β = 0.0779, p < 0.001). Discussion: These results suggest that cognitive-behavioral orientations toward physical activity may buffer the negative impact of rumination on wellbeing. Consistent with cognitive-behavioral therapy (CBT) principles, CBPA could provide adolescents with self-regulatory strategies that support mental health. However, the cross-sectional and self-report design, as well as the focus on sports high school students, limit causal inference and generalizability. Future longitudinal and cross-cultural studies are needed to confirm these findings. Overall, the study provides preliminary evidence that CBPA-informed approaches may hold promise for promoting adolescents' mental wellbeing. Copyright © 2025 Derelioğlu, Vural, Çimen, Saki, Yağız Saraçoğlu, Karataş, Saç, Yamaner, Halmatov, Yılmaz, Öztaş, Arıkan and Ceylan.2-s2.0-10502102189