Alanya Alaaddin Keykubat University Institutional Repository
Not a member yet
2347 research outputs found
Sort by
Evaluation of Congenital Mediastinal Vascular Anomaly Types And Frequencies Among 2000 Cases
No full textAim: In this study, it was aimed to examine the incidence of congenital thoracic vascular anomalies in our region. Methods: The features of the patients with non-specific complaints who underwent a thorax Computed Tomography over a two years period were retrospectively reviewed on the hospital database, and demographical data (Gender and age) were recorded. All the Computed Tomography images were interpreted regarding thoracic vascular anomalies, including persistent left superior vena cava, azygos lobe, aberrant right subclavian artery, dilated left superior intercostal vein, right-sided aortic arch, situs inversus, and partial anomalous pulmonary venous return. The incidences of these thoracic vascular anomalies were calculated and compared with previous studies. Results: Mediastinal vascular anomaly was detected in 62 (3.1%) patients. A mediastinal vascular anomaly was observed in 27 (3.5%) female patients and 35 (2.6%) male patients. The most common mediastinal vascular anomaly in this study was the right aberrant subclavian artery (n:17, 0.9%) and the rarest was partial anomalous pulmonary venous return (n:1, 0.1%). Persistent left superior vena cava incidence was 0.3% (n:6), azygos lobe 0.7% (n:14), right-sided aortic arch 0.3% (n:5), situs inversus totalis 0.2% (n:3), and dilated left superior intercostal vein 0.8% (n:16). Conclusion: Mediastinal vascular anomalies are rare and usually asymptomatic. But the imaging findings of these conditions must be well-known to accurately planning the interventions and also to prevent iatrogenic injuries
Yenilenebilir Enerji Kaynakları Kullanımında Çevresel Motivasyonlar ve Ahlaki Normun Rolü: Bilecik Örneği
No full textGünümüzde artan enerji ihtiyacının karşılanmasında yenilenelebilir enerji kaynaklarının kullanımı için toplumsal kabul oldukça önemli bir unsurdur. Bu çalışmada, tüketicilerin sahip oldukları çevresel endişeler, çevre hakkında bilgi ve Yenilenebilir Enerji Kaynakları (YEK) hakkındaki bilgi düzeyleri çerçevesinde fosil yakıtların çevreye verdikleri zararı azaltabilmek için hissettikleri bireysel ahlaki sorumluluğun, yenilenebilir enerji kaynaklarının kullanımına yönelik tutumlarına ve bu amaçla maddi fedakârlıkta bulunarak fazladan ödeme yapma niyetlerine etkilerinin incelenmesi amaçlanmıştır. Çalışmada özgecil çevreci davranışları açıklamak için literatürde sıklıkla kullanılan Norm Aktivasyon Teorisi kullanılmıştır. Bilecik ilinde çalışan 337 kamu personelinin katıldığı çalışmada Yapısal Eşitlik Modeli (YEM) kullanılmıştır. Çalışmanın sonucunda, YEK’i kabul etme ve fazladan ödeme isteğinin çevresel endişe, çevre hakkında bilgi, sonuçların farkındalığı ve personal normdan etkilendiği sonucuna ulaşılmıştır. Buna karşın algılanan tüketici etkinliği, YEK hakkında bilgi sahibi olma, sorumluluk atfetme faktörlerinin YEK’e karşı tutum ve fazladan ödeme niyetinde etkisinin olmadığı görülmüştür
Survival outcomes of hypomethylating agents maintenance therapy in new diagnosed AML patients: Real experience data
No full textOBJECTIVE: Acute myeloid leukemia (AML) is a hematological malignancy that frequently affects elderly population. With introducing the hypomethylating agents (HMAs) in elderly AML treatment, survival rates and quality of life have improved. However, long-term management in elderly and frail patients is still a challenge. In the present study, we aimed to determine whether HMA maintenance therapy is required until disease progression in frail and elderly AML patients by examining with a real-life data. METHODS: In a multicenter study, we analyzed non-promyelocytic elderly AML patients who were treated with first-line azacitidine or decitabine monotherapy in two different groups, retrospectively. While patients were treated with HMA until progression in the maintenance group, 6+3 cycles of azacitidine or decitabine were administered as a standard care of elderly AML patients in the non-maintenance group. Survival outcomes were compared between the groups. RESULTS: HMA therapy was maintained until progression in 20 patients, and HMA therapy was terminated after 6+3 cycles in 21 patients. Patients received a median of 6 (1–14) HMA cycles during follow-up time. The median 7.5 months of overall survival were observed (2–17 months) in maintenance and 3 months (1–13 months) in non-maintenance groups (p=0.001). CONCLUSION: Despite long-term exposure to HMA may appear as a risk factor for complications and toxicities in elderly and frail AML patients, the maintenance of therapy until disease progression provides a significant survival advantage. Therefore, we suggest that HMA therapy should continue until disease progression regardless the sort of HMA
NTNG2 Mutation: A Candidate Gene for a New Brain-Skin Disorder with Early Neuropsychiatric Manifestation? An Analysis Based on 3000 Patients
No full textAim: In this study, the relationship between genetic analysis and exome sequencing and clinical and neuroimaging findings of four patients from the same family was investigated by analyzing a clinical and genetic (WES) database containing more than 3000 patients. Methods: We analyzed the WES data of approximately 3000 patients performed in our center in terms of NTNG2 biallelic mutations. In addition, MR imaging findings were investigated. Results: We found four patients with the same mutation in the NTNG2 gene, presenting with similar clinical and neuroimaging findings. As a result of filtering, the c242G>A variant was determined in the NTNG2 gene. In addition, mild to severe brain parenchymal volume loss and frontal and temporal lobe atrophy were seen in cases 1, 2, and 4 on axial T2-weighted MRI. Conclusion: The current study has similar phenotypic and genotypic features and is a very rare report showing NTNG2 mutation in this context. Existing clinical data are important in choosing NTNG2 gene-related neuropsychiatric disorders as a future treatment target
A netnographic research on memorable tourism experience: The case of Çamlihemşin highlands
No full textBu çalışmada, çevrimiçi platformlarda yer alan ziyaretçi yorumları hatırlanabilir turizm deneyimi boyutlarına göre incelenmiştir. Yapılan araştırmada, "Rize'nin Çamlıhemşin ilçe sınırları içerisinde yer alan yaylalarda, hatırlanabilir turizm deneyimi hangi boyutlarda gerçekleşmektedir?" sorusuna cevap aranmıştır. Nitel araştırma yöntemi kullanılarak gerçekleştirilen çalışma, Rize Çamlıhemşin ilçe sınırları içerisinde bulunan on iki yaylaya (Gito, Elevit, Palovit, Amlakit, Tirovit, Aşağı ve Yukarı Kavrun, Huser, Sal, Badara, Avusor, Pokut ve Ayder yaylası) ait yorumlar üzerinden gerçekleştirilmiştir. Veriler 2020-2021 yıllarına ait Tripadvisor ve Google haritalar 'da yer alan Türkçe 1015 yorumdan oluşmaktadır. Toplanan veriler MAXQDA nitel veri analiz programı kullanılarak analiz edilmiştir. Yapılan analiz sonucunda hatırlanabilir turizm deneyimi kapsamına hazcılık, bilgi, katılım, yerel kültür, yenilik ve tazelenme boyutlarına ilişkin verilere rastlanmıştır. Bu boyutlar arasında en çok hazcılık boyutuyla ilgili ifadelerin yer aldığı görülmüştür. Bu da yayla ziyaretçilerinin, hatırlanabilir turizm deneyimini daha çok hazcılık boyutunda gerçekleştirdiğini göstermektedir. Ayrıca birlikte hatırlanabilir turizm deneyimine ilişkin verilerin sadece olumlu deneyimlerden oluşmadığı, bunun yanı sıra bireylerin karşılaştıkları olumsuzlukların da bir deneyimi hatırlanabilir kılabileceği görülmüştür.In this study, visitor reviews on online platforms were examined according to the dimensions of a memorable tourism experience. In the research, the answer to the question, "which dimensions of memorable tourism experience can occur in the highlands within the boundaries of the Çamlıhemşin region of Rize?", was searched. The study, which was conducted using the qualitative research method, was carried out through the reviews of twelve highlands (Gito, Elevit, Palovit, Amlakit, Tirovit, Aşağı ve Yukarı Kavrun, Huser, Sal, Badara, Avusor, Pokut ve Ayder Highlands) within the boundaries of Çamlıhemşin, Rize. The data consists of 1015 reviews written in the Turkish language on TripAdvisor and Google Maps for the years 2020 and 2021. The collected data were analyzed by using MAXQDA qualitative data analysis program. As a result of the analysis, data on the dimensions of hedonism, knowledge, participation, local culture, innovation and refreshment were found within the scope of the memorable tourism experience. Among these dimensions, it was seen that the expressions related to the hedonism dimension took place the most. This shows that plateau visitors realize their memorable tourism experience mostly in the dimension of hedonism. Moreover, it has been seen that the data on the memorable tourism experience can not only consist of positive experiences, as well as the negative experiences faced by people may also make an experience memorable
The correlations between pulmonary function tests and polysomnographic parameters in overlap syndrome
No full textAim: This study aims to reveal the relationship between Pulmonary Function Tests (PFTs) parameters and polysomnographic parameters. It aims to determine the guiding values in treatment selection, with the hypothesis that easily accessible PFTs parameters can be useful in clinical evaluation for patients with restrictive or obstructive type disorders. Material and Method: One hundred and forty-six patients with obstructive and/or restrictive pulmonary dysfunction who underwent polysomnography in the sleep clinic of our hospital between June 2019 and December 2019 were included in the study. Polysomnography (PSG) parameters and PFTs results were obtained. Age, gender, body mass index (BMI), Epworth Sleepiness Scale (ESS) score, PFTs parameters, apnea-hypopnea index (AHI), nocturnal oxygen saturation, tolerable positive airway therapy modality, and pressures were recorded. Results: Of 146 patients 34.9% were women and most (92.5%) had an obstructive disorder in PFTs. Of the patients with the obstructive disorder, 71 were being followed up with a diagnosis of chronic obstructive pulmonary disease (COPD) and 64 with a diagnosis of asthma. Interstitial lung disease was observed in 5 out of 11 cases (7.5%) with restrictive type disorder, and obesity resulted in restrictive disorder for the remaining 6 cases. Simple snoring was observed in 5.5%. Mild OSAS was observed at a rate of 30.1%. Moderate-severe OSAS was detected in 64.4% of the patients. When the relationship between optimal inspiratory/ expiratory positive airway pressure (IPAP/EPAP) values determined by automatic bilevel positive airway pressure (ABPAP) titration and PFTs parameters were analyzed, a moderate negative correlation was observed between IPAP value and forced vital capacity (FVC) (L) (r=-0.432, p=0035) Discussion: The results of this study show that PFTs parameters can be used to predict polysomnographic findings for patients with obstructive/ restrictive disorders. Almost two-thirds of the patients with obstructive sleep apnea (OSA)-related symptoms in this group were observed to have moderate-severe obstructive sleep apnea syndrome (OSAS). Based on our results in ROC analysis, we believe that it would be appropriate to recommend titration with bilevel devices, especially for patients with forced expiratory volume in one second (FEV1)<60% and maximum expiratory flow between 25% and 75% of FVC (MEF25-75)<30%. Bilevel devices may be useful for patients with reduced MEF25-75 (representing peripheral airways), through alveolar recruitment and pressure support. Conclusion: In our study, we demonstrated that the optimal IPAP value for treatment had a positive correlation with the oxygen desaturation index (ODI) and AHI and a negative correlation with minimum finger pulse oximetry (SpO2), as well as a negative correlation with FVC value. Simple spirometric data along with polysomnographic data can also be helpful when determining baseline pressures in bilevel positive airway pressure (BPAP) titration for OSAS patients with respiratory dysfunction
A bibliometric study on realistic mathematics education
No full textBu tez çalışmasında "realistic mathematics education" veya "realistic mathematic education" veya "realistic maths" veya "realistic mathematical education" anahtar kelimeleri Scopus veri tabanında aratılarak 1986-2021 yılları arasındaki süreçte gerçekçi matematik eğitimi ile ilgili üretilen 1190 makaleye ulaşılmış ve elde edilen veriler bibliyometrik analiz yöntemi ile analiz edilmiştir. Arama sonucunda elde edilen veriler, R-Studio programının bibliometrix paketinin bir web arayüzü olan "biblioshiny" aracılığıyla, ana bilgiler, yıllık bilimsel üretim, yıllık ortalama alıntılar, üç alan grafiği, en alakalı kaynaklar, en fazla alıntı yapılan kaynaklar, bradford yasası, kaynak etkisi, kaynak dinamikleri, en alakalı yazarlar, en fazla alıntı yapılan yazarlar, yazarların zaman içindeki üretimi, lotka yasası, yazar etkisi, en alakalı bağlantılar, sorumlu yazarların ülkeleri, ülkelerin bilimsel üretimleri, en fazla alıntı yapılan ülkeler, en çok alıntı yapılan makaleler, en sık kullanılan kelimeler, kelime bulutu, kelime ağacı haritası, kelime dinamikleri, trend konular, birlikte oluşum ağı, tematik harita, tematik evrim, faktöriyel analiz, kavramsal yapı haritası, konu dendrogramı, ortak alıntı ağı, iş birliği ağı, ülkelerin iş birliği haritası başlıkları altında analiz edilmiştir. Araştırma sonucunda gerçekçi matematik eğitiminin gelişmiş veya gelişmekte olan ülkelerde eğitimle ilgili sorunlara çözüm olabileceği göz önüne alınarak, bu alana yönelik olarak bilimsel yayın katkısına ihtiyaç duyulduğu gözlemlenmiştir. Anahtar kelimeler geniş bir şekilde seçilmiş olsalar da gerçekçi matematik eğitimi ile ilgili anahtar kelimelerle çok az sayıda çalışma olduğu görülmüş ve alana ilgi duyan ve araştırma yapmayı düşünen araştırmacılara referans olacağı düşünülerek, alana yapılacak olan teorik katkının önemli olduğu vurgulanmıştır.In this thesis study, the keywords "realistic mathematics education" or "realistic mathematic education" or "realistic maths" or "realistic mathematical education" were searched in the Scopus database, and 1190 articles on realistic mathematics education were reached between the years 1986-2021 and the obtained data were analyzed by bibliometric analysis method. The data obtained as a result of the search were analyzed under the headings of main information, annual scientific production, average citations per year, tree fields plot, most relevant sources, most local cited sources, bradford's law, source impact, source dynamics, most relevant authors, most local cited authors, author's production over time, lotka's law, author impact, most relevant affilations, corresponding author's country, country scientific production, most cited countries, most global and local cited documents, most frequent words, wordcloud, treemap, word dynamics, trend topics, co-occurrence network, thematic map, thematic evolution, factorial analysis, conceptual structure map, topic dendrogram, co-citation network, collaboration network, country collaboration map through the "biblioshiny", a web interface of the bibliometrix package of the R-Studio program. As a result of the research, considering that realistic mathematics education can be a solution to educational problems in developed or developing countries, it has been observed that scientific publications are needed in this field. Although the keywords were widely chosen, it was seen that there were very few studies with keywords related to realistic mathematics education and it was emphasized that the theoretical contribution to the field is important, considering that it will be a reference for researchers who are interested in the field and who are considering doing research
Investigation of the Relationship Between foot Deformities and Radiographic Measurements of the Talus and Calcaneus
No full textThe weight of the body is transmitted to the foot through the subtalar joint and talus. Considering the important location of the talus and calcaneus, the morphological structures of these bones may affect the biomechanics of the subtalar joint. At the same time, the morphological structure of these bones is important in some common foot deformities. We aimed to investigate whether the various measurements of the talus and calcaneus are associated with different foot deformities in this study. In this study, radiography images of 158 (72 male and 86 female) patients within the mean age of 44 years were retrospectively examined. Eleven different measurements of the talus and calcaneus were obtained from the lateral and antero-posterior radiographs of the patients. A total of 158 patient's routine clinic radiographs were retrospectively assessed, which have calcaneal spur (n=63), hallux valgus (n=32) and control group (n=63). We determined that the body height of the calcaneus, maximum width of the head of the talus, minimum anterior width of the calcaneus were significantly different between calcaneal spur group and control group. Maximum length fibular malleolar facet of the talus was significantly different between age groups. And we determined that the calcaneal index was significantly different between hallux valgus group and control groups. Also all measurements were significantly different between males and females. As a result, some measurements that significantly determine the morphology of the talus and calcaneus were found to be significant between deformity groups and control groups. We think that our study will contribute to the literature as it is the first study in which the measurements obtained from the radiographic images of the talus and calcaneus are associated with foot deformities
The effect of stem education practices on creativity and critical thinking skills in preschool period
Get PDFBu araştırmada okul öncesi döneme yönelik hazırlanan STEM eğitimi uygulamalarının okul öncesine devam eden 5 yaş grubundaki çocukların yaratıcılık ve eleştirel düşünme becerilerine etkisini incelemek amaçlanmıştır. Öntest sontest kontrol gruplu deneysel desende tasarlanan araştırmanın çalışma grubunu okul öncesi eğitimine devam eden 12’si kontrol 19’u deney olmak üzere 31 çocuk oluşturmuştur. Araştırmanın çalışma grubu uygun örnekleme yöntemiyle belirlenerek, Antalya ilinin Alanya ilçesinde bulunan devlete bağlı bağımsız bir anaokulunda çalışma yürütülmüştür. Deneysel araştırma modeli bir bağımsız değişkenin bağımlı değişkene etkisinin ölçülebileceği en iyi yöntemdir. Araştırmanın bağımsız değişkeni olan STEM eğitimi programı 8 hafta boyunca deney grubuna uygulanmıştır. Kontrol grubuna ise MEB okul öncesi eğitim müfredatına devam etmiştir. Araştırmada veri toplama aracı olarak eleştirel düşünme ve yaratıcılık ölçekleri kullanılmıştır. Eleştirel düşünme becerilerini ölçmek için “Eleştirel Düşünmenin Değerlendirilmesi” ölçeği ile yaratıcılık düzeylerini belirlemek için “Hibrit Yaratıcılık Testi” kullanılmıştır. Araştırma deney grubu çocuklarına uygulanan STEM eğitiminin eleştirel düşünme ve yaratıcılık becerilerine olumlu yönde etki ettiği sonucuna ulaşılmıştır.In this study, it was aimed to examine the effects of STEM education applications prepared for the preschool period on the creativity and critical thinking skills of children in the 5 year-old group attending preschool. The study group of the study, which was designed in an experimental design with a pretest posttest control group, consisted of 31 children, 12 of whom were control and 19 of whom were experimental, continuing their pre-school education. The study group of the research was determined by convenient sampling method and the study was carried out in an independent state-run kindergarten located in Alanya district of Antalya province. Experimental research model is the best method to measure the effect of an independent variable on a dependent variable. The STEM education program, which is the independent variable of the research, was applied to the experimental group for 8 weeks. In the control group, the MEB pre school education curriculum continued. Critical thinking and creativity scales were used as data collection tools in the research. "Assessment of Critical Thinking" scale was used to measure critical thinking skills and "Hybrid Creativity Test" was used to determine creativity levels. It was concluded that the STEM education applied to the children in the research experimental group had a positive effect on their critical thinking and creativity skills
Investigation of the Antiangiogenic Properties of Zoledronic Acid by Using Chorioallantoic Membrane Model
Get PDFObjective: Zoledronic acid (ZA) is a bisphosphonate-derived agent used in osteoporotic clinical pathologies to prevent the development of complications such as fractures and hypercalcemia by regulating bone metabolism. Studies have been conducted on the antiangiogenic efficacy of this agent, which also has other systemic side effects. In this study, the dose-dependent antiangiogenic activity of ZA was investigated on the chorioallantoic membrane model (CAM). Methods: Three doses (10?4, 10?5, and 10?6 M concentrations) of drug pellets were prepared with ZA and another pellet was prepared as the positive control group with vascular endothelial growth factor (VEGF) inhibitor agent bevacizumab (10?6 M concentration). Thereafter all pellets were placed on chorioallantoic membranes on the fourth day of egg incubation. All eggs were evaluated for capillary development four days after the drug application. Results: The highest antiangiogenic effect was detected in the positive control group. Moreover, incremental antiangiogenic effects were detected with average scores of.9, 1.1, 1.2 in 10?6, 10?5, and 10?4 M concentrations of ZA groups respectively. Conclusion: Our findings supported that ZA has dose-dependent antiangiogenic effects. This result suggests that different dosing may be required in cases where angiogenesis is therapeutic