CINECA IRIS Institutial research information system UNISS
Not a member yet
72871 research outputs found
Sort by
Enlarged perivascular spaces under the dorso-lateral prefrontal cortex and severity of autism
No full textIn Vivo Optical Coherence Tomography Outcomes of Hypotony After Trabeculectomy Management with Autologous Blood Injection: A Single-Center Retrospective Study
No full textBackground: This study aimed to report the efficacy and safety of peribleb autologous blood injections in patients with hypotony maculopathy following trabeculectomy. Methods: In this retrospective chart-review study, patients with hypotony maculopathy from over-filtering bleb following mitomycin C (MMC)-augmented trabeculectomy treated with ≥1 peribleb autologous blood injections, ≥12 months of follow-up, and macula optical coherence tomography (OCT) imaging were included. Patients with previous laser cyclophotocoagulation were excluded. Hypotony maculopathy was defined as choroidal folds in the macular region, as assessed by OCT. Results: Nine patients met the inclusion criteria (mean age 62.3 ± 17.0). The mean intraocular pressure (IOP) at hypotony maculopathy diagnosis was 3.8 ± 1.5 mmHg. Most (n = 7) patients received a single injection (4 injections n = 1, 5 injections n = 1). Significant improvements in mean overall IOP after blood injection were observed (8.3 ± 2.4 mmHg; p = 0.008). Improvements in visual acuity and the resolution of hypotony maculopathy were observed in patients requiring a single injection only. No intra-operative adverse events were recorded. Successful bleb surgical revision was performed for two patients refractory to blood injections. Conclusions: Peribleb autologous blood injection increased IOP, improved visual acuity, and resolved hypotony maculopathy in 5.3 weeks in 7/9 patients. This procedure is not a contra-indication for further surgical revision
VEGF in psoriatic arthritis: Systematic review and meta-analysis
No full textPsoriatic arthritis (PsA), a chronic autoimmune disease of unclear aetiology, is associated with dysregulated angiogenesis due to the proliferation, migration, and differentiation of endothelial cells. Vascular endothelial growth factor (VEGF) plays a key role such that PsA patients exhibit skin and joint symptoms, e.g., pain and stiffness, with morphologic alterations in blood vessels. To more fully examine this phenomenon, a systematic review and meta-analysis compliant with the PRISMA guidelines (PROSPERO CRD42024572653) was conducted using subgroup and meta-regression analyses. Secondary analyses on disease activity and response to treatment were also included. In the twelve selected studies, VEGF was significantly higher in PsA vs healthy controls (SMD = 0.544, 95 % CI 0.253–0.835; p < 0.001) with moderate heterogeneity across studies. Subgroup analysis revealed that the SMD in prospectively conducted studies was significantly higher vs those conducted retrospectively (p = 0.005). Furthermore, methotrexate or sulfasalazine treatment did not affect VEGF which remained significantly higher than controls. Moreover, VEGF was lower in those with inactive disease and in those receiving disease modifying agents in pre-post studies. These findings suggest that VEGF is a promising candidate biomarker in PsA and worthy of further prospective studies to investigate its utility in monitoring disease progress and response to treatment
Potential of High-Performance liquid chromatography with ultraviolet detection (HPLC-UV) fingerprints to assess the geographical production origin and authenticity of honey
No full textHoney is a widely appreciated and consumed natural product which is highly susceptible to fraudulent practices involving different sample attributes such as the botanical species or the geographical production regions, as well as possible adulterations. In the present work, the potential of non-targeted HPLC-UV fingerprints as honey chemical descriptors to assess their geographical origin authentication involving a high number of samples belonging to nine different countries (and 4 continents) was evaluated by partial least squares-discriminant analysis (PLS-DA). Accurate discrimination between Spanish and Italian samples independently of the botanical varieties involved (multifloral, rosemary, and eucalyptus) was accomplished, as well as for the botanical species discrimination when considering each country independently. The best classification performance for 157 honey samples produced in 9 countries was accomplished when HPLC-UV fingerprints were submitted to a classification decision tree performed by consecutive PLS-DA models built using hierarchical model builder (HMB), with sensitivity and specificity values (for calibration and cross-validation) higher than 87.5 and 78.6%, respectively, and with classification errors below 17.0%. Prediction capabilities improved for samples belonging to New Zealand, Costa Rica, The Netherlands, and China, with classification errors below 8.3%, while it worsened for the other sample groups (classification errors in the range 17.4–27.4% for the samples belonging to Spain, Italy, France, and Serbia). Japanese samples showed the worst prediction errors (37.5%) as the “unknown” samples used were mostly misclassified as Chinese samples
Il teatro romano di Thignica. Indagini preliminari e prime ipotesi ricostruttive
No full textIn occasione della campagna di scavo archeologico presso l’antica Thignica (ottobre 2024), si sono svolte le indagini preliminari presso il teatro romano della città. L’opportunità ha rappresentato una prima presa di contatto con l’edificio e la definizione di alcune tematiche utili alla sua ricostruzione. A partire dal recupero e dall’analisi della documentazione relativa alle precedenti attività di ricerca, il contributo propone alcuni temi ritenuti essenziali per la comprensione dei principi costruttivi dell’edificio e della distribuzione del suo spazio interno
Microencapsulated Linseed Oil Supplementation Modifies Lipid Profile and Improves Luteal Function in Dairy Sheep
No full textPolyunsaturated fatty acids omega 3 (PUFA-ω3) have been shown to modulate reproductive events such as ovarian follicular and luteal development, steroid and prostaglandin synthesis, and oocyte/embryo quality in different species. These effects could be exploited to support pregnancy and avoid early embryo losses that could occur in dairy sheep breeding. This study aimed to evaluate the effectiveness of dietary supplementation of microencapsulated/by-passed linseed oil (LO) on ovarian function, embryo implantation rates, and lipid profiles of Sarda ewes during their early pregnancy. Our results demonstrated that the intake of microencapsulated LO at a level of 4.0% of fresh matter increased the plasmatic concentrations of PUFASω3 (p < 0.01) and progesterone (p < 0.05), as well as cholesterol (p < 0.01), triglyceride (p < 0.001), high-density lipoprotein (p < 0.001), and non-esterified fatty acids (p < 0.05). The percentage of ewes in estrus, ovulation rate per mated ewe, number of embryos per ewe, and pregnancy rates were similar between treated and control groups. In conclusion, dietary supplementation of by-pass LO during the preimplantation period increased PUFAS-ω3 distribution at systemic and local levels. Also, this supplementation modified the ewe's lipid profile and improved luteal function with a possible positive effect on embryo-maternal crosstalk and embryo implantation rate during and after the maternal recognition of pregnancy
The Relationship Between Tourism Activity, Natural Amenities, and Second-Home Development: Insights for Land Use Planning
No full textInnovative governance for sustainable management of Mediterranean coastal aquifers: Evidence from Sustain‐COAST living labs
No full textL’astensionismo elettorale come regressione democratica? Problemi e prospettive intorno alla rappresentanza politica
No full textIl tema dell’astensionismo ormai da tanto, purtroppo, interessa il dibattito di costituzionalisti, politologi, sociologi, politici che da diversi punti di vista si interrogano sul fenomeno dilagante e in continua progressione nelle democrazie stabilizzate dell’astensionismo elettorale. La struttura del volume rispecchia la formula dell’incontro, pensata per mettere a confronto l’approccio tecnico dalla prospettiva del diritto costituzionale e della scienza statistica con l’esperienza di chi vive la politica attivamente, rappresentandoci nel luogo (che dovrebbe essere) la massima sede della decisione politica, il Parlamento.
Dal punto di vista del diritto pubblico, italiano e comparato, siamo di fronte a uno dei problemi principali del costituzionalismo contemporaneo, forse il più impegnativo in assoluto: la crisi della democrazia rappresentativa.
Il punto di partenza è l’esistenza di una situazione di forte criticità legata a due profili diversi:
1) da una parte il forte e sempre crescente astensionismo, volontario (per protesta o disinteresse);
2) d’altro lato c’è l’esigenza di garantire il diritto di voto e favorire la partecipazione alla vita pubblica del Paese a chi effettivamente fa parte della comunità. Dunque, è doveroso rimuovere gli ostacoli che impediscono a chi ha diritto e vorrebbe votare, di farlo (astensionismo involontario) ripensando magari al modello che oggi consente ai residenti all’estero di esprimersi alle elezioni precludendo la stessa opportunità a chi vive in Italia, ma lontano dal Comune di residenza e non fa parte delle categorie cui è oggi consentita la deroga alla regola rigida del voto tradizionale in sede.
Nella democrazia italiana il voto assume le fattezze di un “dovere civico”, non un obbligo vero e proprio perché se così fosse l’astensione non giustificata comporterebbe una sanzione, come accade in Belgio o in Australia per esempio. Si tratta però di un comportamento fortemente raccomandato dall’ordinamento perché sulla partecipazione del popolo alla selezione dei propri rappresentanti si fonda la legittimazione dell’ordinamento istituzionale e del sistema democratico. In realtà il voto è soprattutto un diritto, conquistato con fatica e sangue dalle generazioni che ci hanno preceduto e che hanno lottato per ottenere il potere di contribuire con la propria scelta alla selezione della classe dirigente. Le elezioni, di qualunque ordine e grado, sono il momento di massima espressione del principio democratico e rappresentano la manifestazione plastica del potere che ciascuno ha di influenzare in parte minima ma non ininfluente la qualità e l’indirizzo delle nostre istituzioni. Votando scegliamo chi è chiamato, per un determinato periodo di tempo, a compiere decisioni che hanno un impatto sulla vita di tutti e tutte
