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Casi di diritto comparato. La tutela di ambiente e paesaggio negli altri paesi, tra indifferenza ed esempi virtuosi
No full textLa salvaguardia del bene ambiente inteso nel senso più ampio di patrimonio paesaggistico e insieme complesso di elementi legati all’equilibrio della natura, del clima, della biodiversità in relazione all’impatto sulla salute del pianeta e delle persone è ormai priorità imprescindibile nell’agenda costituzionale e obiettivo condiviso nelle strategie politiche e di azione delle democrazie stabilizzate
Les horizons ouverts de (et par) la sémiotique rossi-landienne
No full textCette contribution caractérise les horizons d’une sémiotique initiée par Ferruccio Rossi-Landi, qui se fonde, en s’inspirant des lectures hégéliano-marxiennes, sur une homologie entre la production linguistique et la production matérielle, deux types de production indissociablement liés par une origine commune, à savoir le travail humain dans sa globalité. Les perspectives ouvertes par cette démarche conduisent ainsi à définir la sémiotique comme une théorie générale de la société. Elle s’avère par exemple utile, selon l’auteur, non seulement pour son approche critique de plusieurs théories linguistiques, sociologiques et littéraires, mais aussi dans le contexte des débats actuels concernant l’exploitation sans rémunération, le sexe comme travail, la lutte contre l’idéologie patriarcale, permettant d’intégrer le facteur de la « reproduction sexuée » dans le schème sémiotique de la reproduction sociale
Leveraging Multimodal Vision Language Models for Early Detection of Alzheimer's Disease
No full textAlzheimer's Disease, the most common form of dementia, is a major global health challenge, where early detection is crucial for improving outcomes. This study presents a diagnostic framework using advanced Vision Language Models to combine linguistic and visual data. The system emphasizes explainability by producing detailed, human-readable assessments based on linguistic criteria. These are converted into numeric scores by a trained language model, enabling interpretable and efficient downstream classification. This work establishes a scalable and interpretable pipeline, demonstrating the feasibility of deploying resource-efficient diagnostic tools on consumer-grade GPUs. Currently focused on the Cookie Theft picture, the framework paves the way for future research with diverse stimuli, larger datasets, and culturally adaptable multimodal Artificial Intelligence systems for detecting neurodegenerative diseases
In house 3-D printed surgical guide for frontal sinus osteotomy in traumatology: A technical note
No full textFrontal sinus surgery and particularly frontal sinus osteotomy represent historically a procedure demanding precision and careful planning. Achieving optimal results while minimizing complications requires meticulous preoperative planning and execution. Cutting guides are crucial tools in surgical procedures, particularly in complex osteotomies like could be those involving the frontal sinus. The aim of the study is to show the worflow for the in-house custom made cutting guide for secure and accurated frontal sinus approach. Given the simplicity, efficacy, rapidity, and safety of the procedure, the workflow for programming the cutting guide can be considered valid for all surgical procedures that contemplate performing an osteotomy on the anterior wall of the frontal sinus, such as trauma pathology, inflammatory naso-sinus pathology, benign or malignant neoplastic pathology, and craniofacial malformation pathology
Empowering Circular Economy Transition in the Building Sector: a Stakeholder-Centric approach in the Design Phase for Climate Change Mitigation
No full textPratiche di ricerca-azione partecipata per la sostenibilità dei sistemi socio-ecologici mediterranei
No full textThe Secondary Resistome of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics
No full textBackground: Therapeutic strategies for methicillin-resistant Staphylococcus aureus (MRSA) are increasingly limited due to the ability of the pathogen to evade conventional treatments such as vancomycin and daptomycin. This challenge has shifted the focus towards novel strategies, including the resensitization of β-lactams, which are still used as first-line treatments for methicillin-susceptible Staphylococcus aureus (MSSA). To achieve this, it is essential to identify the secondary resistome associated with the clinically relevant β-lactam antibiotics. Methods: Transposon-Directed Insertion Site Sequencing (TraDIS) was employed to assess conditional essentiality by analyzing the depletion of mutants from a highly saturated transposon library of MRSA USA300 JE2 exposed to 1⁄2 minimal inhibitory concentration (MIC) of oxacillin or cefazolin. Results: TraDIS analysis led to the identification of 52 shared fitness genes involved in β-lactam resistance that are primarily linked to cell wall metabolism and regulatory systems. Among these, both known resistance factors and novel conditionally essential genes were highlighted. As proof of concept, transposon mutants corresponding to nine genes (sagB, SAUSA300_0657, SAUSA300_0957, SAUSA300_1683, SAUSA300_1964, SAUSA300_1966, SAUSA300_1967, SAUSA300_1692, and mazF) were grown in the presence of β-lactam antibiotics and their MICs were determined. All mutants showed significantly reduced resistance to β-lactam antibiotics. Conclusions: This comprehensive genome-wide investigation provides novel insights into the resistance mechanisms of β-lactam antibiotics, and suggests potential therapeutic targets for combination therapies with helper drugs
Gold(III) Complexes with 2-(1-Ethylbenzyl)pyridine as Promising Antimicrobial and Antitumor Agents
No full textAntimicrobial resistance (AMR) is one of the most urgent public health problems worldwide; multidrug resistance (MDR) is also of concern. In an effort to find new classes of antibiotics, recent studies have found that coordination compounds of noble metals show promising biological effects both in vitro and in vivo, deserving attention as a new class of possible antimicrobial agents. Metal ions in biological systems can essentially have two roles: structural or functional. In the former, the metal ion serves to stabilize structures, especially proteins, while in the latter, the metal is involved in bio-site reactivity (essentially in metallo-enzymes). Two new complexes with 2-(1-ethyl-benzyl)pyridine (pyeb), one monodentate adduct and one cyclometalated ([Au(pyeb)Cl3] and [Au(pyeb-H)Cl2], respectively), have been synthesized, characterized, and tested against Gram-positive and Gram-negative bacteria, as well as yeasts, revealing promising antibacterial and antibiofilm properties. The two complexes have been thoroughly characterized by means of 1D and 2D NMR spectroscopy, as well as by cyclic voltammetry, conductivity measurements, FT-IR, and elemental analysis. The study showed that the two derivatives are structurally and chemically different, with the cyclometalated complex being chemically and electrochemically more stable. Antimicrobial assays demonstrated that solutions of the monodentate adduct and of the cyclometalated complex have inhibitory and antibiofilm effects against the pathogenic bacteria E. coli, K. pneumoniae, S. aureus, and S. pyogenes but were unable to reveal a fungicidal effect on C. albicans. A preliminary study was conducted to assess the anti-cancer activity of the compounds, and treatments with the gold compounds also resulted in a significant reduction in the metabolic activity of HT29 colon cancer cells