18701 research outputs found
Sort by
Different Nitrogen Forms and Denitrifying Bacteria Space Distribution Characteristics in Surface Sediments of Different Outfalls of Nanfei River
Full text linkCouncillors Deserve More: An Analysis of Council Remuneration in Windsor
Full text linkThis paper analyzes the salaries of municipal councillors in Windsor, Ontario to determine if they are being paid an appropriate salary for the work they perform and the responsibility they hold. There are three methods used to find this result. First, the salaries of Windsor’s councillors are compared to the average salaries of other part-time workers in Ontario. Second, the average amount of time that councillors spend working on a weekly basis, both in meetings and outside of meetings, is determined. Finally, the salaries of Windsor’s councillors are compared to average salaries of boards of directors, as this is a job has a comparable level of responsibility to being a councillor. Ultimately, this paper finds that Windsor’s city councillors deserve a higher salary than they are currently being paid. This finding is important, as the general public often has a negative view of politicians. Learning that Windsor’s councillors are currently doing more work than their compensation rewards them for could allow Windsor residents to regard their municipal politicians in a more positive light. A higher salary could also provide younger residents a greater opportunity to become city councillors in Windsor, which could allow the council to be more representative of the city it serves
“What Sort of Man Reads Playboy?”: Gender, Heterosexuality, and Reader Letters in Playboy Magazine, 1953-1963
Full text linkExisting Playboy scholarship overlooks the significance of magazine’s audience outside of the bachelor subculture it fathered in the 1950s. In fact, consumers fitting Playboy’s desired readership of white, financially affluent, single men formed only a small percentage of its actual subscribers. This study makes evident that students, soldiers, sailors, military servicemen, middle- and working- class men, both single and married, as well as women, made up most of its readership. To date, no historical study has been conducted of reader letters to Playboy, which reveal the magazine’s significance to this audience. This paper argues that postwar men used Playboy as a guide to inform their own gendered and sexual expectations of women, as well as their behaviours within courtship, sexual relationships, marriage, the workplace, and on college campuses. Specifically, it analyzes letters written by students, servicemen, working class and professional men, married readers, and women, to demonstrate how the magazine impacted its broader audience’s perceptions and behaviours of gender and sexuality in 1950s America. Consequently, men who applied Playboy’s hedonistic beliefs in their professional, romantic, or sexual relationships, facilitated women’s subordination in these contexts. Letters published by the magazine in its monthly “Dear Playboy” and “The Playboy Advisor” features are essential in understanding Playboy’s actual readership, the significance of the magazine in their daily lives, and culture’s broader impact on American behaviour in the postwar period
Amelioration of Autophagic and Mitochondrial Defects in PS-1 Mutated cells
No full textDoes prophylactic treatment with water soluble Co-Q10 work to ameliorate Alzheimer's disease in PS-1 mutated fibroblasts, and the mechanisms which underlie the disease
Logistic Regression Model: The Effect of Chemotherapy on 10 Year Survival for Women with Colon Cancer
No full textColon cancer is a widespread form of treatable cancer common among many populations in the United States and Canada. In this particular logistic regression model, the database took place in California, United States and is part of a cancer registry-based colon cancer cohort which included 6300 people who resided in California between the years 1995 and 2000. This data base was approved to be used for our quantitative data analysis course at the University of Windsor, School of Social Work, to students at the level of doctorate studies. This original logistic regression model will look at the effects of chemotherapy on ten year survival for women with colon cancer. This model will look at women in particular and if they are associated with shorter survival rates. The model also looks at age groups of women along with their stage of colon cancer. The model will finally test an interaction effect between being a black woman and poverty groups and also between the refusals of chemotherapy among black women with colon cancer. This secondary data analysis sample is restricted to 3012 participants which accounts for almost 92% of the women included in this sample. Results showed a strong relationship between chemotherapy treatment and 10 years survival of colon cancer. Women who received chemotherapy are almost ten times as likely to have a high survival rate for 10 years as those who did not receive chemotherapy treatment. Benefits of early diagnoses, and the importance of chemotherapy care among different groups of poverty can negatively influence the survival time of women. Generalized findings towards bigger populations as the impact can apply to other minority groups in the United States and Canada
The Structural Effects of Hydration on Active Pharmaceutical Ingredients
No full textMore than 50% of active pharmaceutical ingredients (APIs) are crystallized as simple salts, and of these, over 50% are HCl salts. In many instances, APIs can crystallize into pseudopolymorphic forms, such as hydrates or solvates, which have structures and molecular properties distinct from the non-hydrated or non-solvated solid phases. The polymorphic form of an API can influence its physicochemical properties, including bioavailability, shelf life, toxicity, and solubility. Additionally, each unique hydrate or solvate of an API represents unique intellectual property, and may be separately patented. As such, it is very important to precisely structurally characterize all solid forms of APIs. Numerous methods, such as single crystal X-ray diffraction (scXRD), powder X-ray diffraction (pXRD), and 13C NMR are often employed to accurately elucidate these structures. Previous work in our group has shown that 35Cl SSNMR can be extremely valuable in the study of APIs in both bulk and dosage forms. In particular, we have shown that 35Cl powder patterns are extremely sensitive to slight modifications in the molecular structure of an API, and serve as unique spectral fingerprints for each compound.1,2 The focus of this project is to use 35Cl SSNMR, pXRD, as well as quantum-chemical calculations, to systematically study hydrates and anhydrous forms of HCl APIs. By analyzing their 35Cl SSNMR spectra, we hope to study the hydrogen bonding interactions between chloride anions and water molecules, and the influence of water molecules on the molecular structures of the APIs. It is our hope that these proof of concept findings will be of interest to the pharmaceutical industry, for potential use in high throughput analysis of APIs, hydrate identification, and detection of impurities and disproportionation. 1. Hildebrand, M. et al. CrystEngComm 2014, 16, 7334. 2. Hamaed, H. et al. J. Am. Chem. Soc. 2008, 130, 11056
Double Chins and Double Standards: A Meta-Analysis of Weight-Based Bullying Amongst Female Adolescents
Full text linkScholars are beginning to explore and understand the experiences of adolescent females in regards to weight-based bullying in their elementary school setting (Puhl, R. M., Luedicke, J., & Heuer, C. (2011). Weight‐based victimization toward overweight adolescents: observations and reactions of peers. Journal of School Health, 81(11), 696-703). The educational and social implications that weight-based bullying has amongst female adolescents can include: poor academic achievement coupled with a low degree of comfort when participating vocally in the classroom, the inability to initiate and maintain friendships, and an unwillingness to participate in extracurricular sports and activities. This should be cause for concern among the enthusiastic and focused teachers who are committed to giving young students, particularly females, the best possible education in life. A meta-analysis was used to guide the following three questions: (1) What are the different implications, both educational and social, that weight-based bullying has on male and female students, respectively? (2) What types of support do the participants seek from their teachers, administrators, and parents, to address this phenomenon? (3) How effective are school initiatives, such as bystander initiatives, in bettering the experiences of adolescent females who are experiencing weight-based bullying in an educational setting? Useful recommendations found throughout this Major Research Paper aim to provide support through in-school programming to students that are experiencing weight-based bullying
Synthetically Modified Cellulose Derivatives for the Remediate of Phosphate from Agricultural Wastewater
No full textHealthy Great LakesPhosphorous is extensively used in fertilizers in the agricultural industry and with increased demand for food, use will continue to increase. It is also a major environmental pollutant, entering the aquatic environment, such as rivers and lakes, in the form of waste water runoff. This leads to the eutrophication of lakes and the excessive growth of algal blooms which are toxic to marine life. Attempts to sequester phosphorous prior to its entry into the environment have been made through the use of filtration systems incorporating a chitosan-iron matrix as a reusable filter which can be regenerated allowing for the collection and reuse of the phosphorous. However chitosan suffers from two major disadvantages: the high price of chitosan is prohibitive for large scale application and it has a relatively short lifespan. We sought to replace it with a cheap, readily available, biologically friendly cellulose based alternative. Cellulose is readily available and was obtained in the form of sawdust. By functionalizing the sawdust with various iron chelators, iron can be attached which can then be used to bind and collect phosphorous. Functionalization uses simple, environmentally friendly chemistry starting with inexpensive materials. Sawdust is first reacted with epichlorohydrin to insert an epoxide to which various chelators can be attached through simple nucleophilic attack and epoxide opening. A variety of chelators were investigated including deferasirox (a well-known iron binder), amino acids, carboxymethylcellulose (CMC) and various CMC derivates. The most effective ligand was found to be simply ethylenediamine which can bind a large amount of phosphorous (40g) per kilogram of sawdust and is even effective in the presence of competing ions. This has potential widespread applications in phosphorous sequestering and wastewater cleanup
Grounding the Concept of God in the Human Predicament
No full textContemporary religious epistemology often neglects offering a substantial defense of a particular conception of God, relying instead on appeals to tradition and past great theologians. This neglect is regrettable due to the large impact one’s concept of God has on the kind of expected evidence of God. I aim to correct this deficiency by offering a defensible concept of God grounded in the predicament faced by all human inquirers. My account of this human predicament will focus on three key features that are salient to religious inquiry: death, moral failure, and suffering and severity. I will defend the idea that death, moral failure, and suffering are all bad things that humans do and ought to seek rescue from. I will then argue that we ought to define our concept of God in terms of what it would take to rescue humanity from its predicament, thus allowing our conception of God to capture what matters most to us
Barriers and Facilitators to Implementing the Clinical Trial Navigator Program: A Qualitative Analysis
No full textPurpose: The Clinical Trials Navigator (CTN) Program was launched in 2019 to increase enrollment in cancer clinical trials. It is free for all Canadians, and over 550 people have participated. This study has the objective of assessing the perspectives of people with cancer regarding the implementation of clinical trial navigation in Canada. Methods: People with cancer and their caregivers (n=21) were recruited from across Canada to participate in a 30-60-minute semi-structured interview. Based on the Consolidated Framework for Implementation Research (CFIR) domains, we assessed the facilitators, and barriers to access clinical trial navigation in Canada. Thematic analyses were performed by two independent researchers in duplicate using inductive and deductive coding. Results: 10 Interviewees had contacted the CTN Program (Pre-CTN) but had not yet received navigation for clinical trials, 10 had never contacted the CTN Program (Non-CTN) and 1 completed the CTN Program (Post-CTN). The results indicate participants valued early and direct access to information trials and perceived the CTN Program as a unique, trustworthy resource created by Canadians. Participants reported a sense of relief knowing they can find a trial when needed. Not all oncologists provided information for identifying clinical trials, and the CTN Program was therefore perceived as an important solution. Conclusion: Our results illustrate the gaps in the Canadian clinical trial ecosystem and emphasize the value of the CTN Program. The CTN Program addresses issues such as the timeliness and legitimacy of clinical trials information, increases patient sense of control and alleviates the burden of unexplored options